Oxido-Reductive Stress and Alcoholic Liver Disease
DOI:
https://doi.org/10.12775/mbs-2013-0002Keywords
alcohol, oxido-reductive stress, reactive oxygen species (ROS), alcoholic liver disease (ALD)Abstract
Due to availability and relatively low price, alcohol is currently the most widely used intoxicant. Consuming excessive amounts of alcohol is associated with multiple health consequences, which include pathological changes in the liver leading to development of alcoholic liver disease. Responsible for the formation of the mentioned changes are among others: metabolic disorders, immune reactions and formation of cytokines, hypoxia of hepatocytes in the perivenular area of hepatic lobule and oxido-reductive stress. The aim of this paper is to present the mechanism of the oxido-reductive stress associated with long-term alcohol abuse. The knowledge and understanding of the mechanisms underlying this phenomenon may help to avoid the negative effects of alcohol consumption, before development of severe liver damage, induced by toxic effects of alcohol.References
World Health Organization: WHO Expert Committee on problems related to alcohol consumption, Genewa 2007.
Reuben A.: Alcohol and the liver. Curr. Opin. Gastroenterol., 2006; 22: 263-271.
Lieber, C.S.: Metabolism of Alcohol. Clin. Liver Dis., 2005; 9:1 - 35.[ http://dx.doi.org/10.1016/j.cld.2004.10.005]
Cichoż-Lach H., Grzyb M., Celiński K.: Nadużywanie alkoholu a alkoholowa choroba wątroby. Alkohol. Narkom., 2008; 21, 1: 55-62.
Bruha R., Dvorak K., Petrtyl J.: Alcoholic liver disease. World J. Hepatol., 2012; 4, 3: 81-90.
Koop D.: Alcohol metabolism's demaging effects on the cell. A focus on reactive oxygen generation by the enzyme cytochrome P450 2E1. Alcohol Res. Health, 2006; 29, 4: 274-280.
Zakhari S.: Overview: How is alcohol metabolized by the body? Alcohol Res. Health, 2006; 29, 4: 245-254.
Lieber C.S. Relationships between nutrition, alcohol use and liver disease. Alcohol Res. Health, 2003; 27, 3: 220-231.
Lieber C.S., DeCarli L.: Hepatic microsomal ethanoloxidizing system. J. Hepatol., 2004; 40: 198-202.
Czech E., Lewin-Kowalik J., Hartleb M.: Udział katalazy w mózgowym i pozamózgowym utlenianiu etanolu. Alkohol. Narkom., 2006; 19, 2: 169-182.
Jelski W., Grochowska-Skiba B., Szmitkowski M.: Dehydrogenaza alkoholowa i metabolizm alkoholu etylowego w mózgu. Post. Hig., 2007; 61: 226-230.
Jelski W., Chrostek L., Szmitkowski M.: Biochemiczne podstawy alkoholowego uszkodzenia wątroby. Pol. Merkuriusz Lek., 2006; 21, 124: 376-380.
Hirano T.: Alcohol consumption and oxidative DNA damage. Int. J. Environ. Res. Public Health., 2011; 8: 2895-2906. [http://dx.doi.org/10.3390/ijerph8072895]
Beerling D.J., Berner R.A.: Impact of a permocarboniferous high O2 event on the terrestrial carbon cycle. Proc. Natl. Acad. Sci. U S A, 2000; 97: 12428-12432.[ http://dx.doi.org/10.1073/pnas.220280097]
Wu D., Cederbaum A.: Alcohol, oxidative stress, and free radical damage. Alcohol Res. Health, 2003; 27, 4: 277-284.
Hartleb M., Czech E.: Alkoholowa choroba wątroby. Prz. Gastroenterol., 2007; 2, 2: 92-100.
Albano E.: Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol. Aspects Med. 2008; 29: 9-16. [http://dx.doi.org/10.1016/j.mam.2007.09.004]
Valko M., Leibfritz D., Moncol J. et al.: Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol., 2007; 39: 44-84. [http://dx.doi.org/10.1016/j.biocel.2006.07.001]
Toyokuni S. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol. Int., 1999; 49: 91-102. [http://dx.doi.org/10.1046/j.1440-1827.1999.00829.x]
Liochev S.I., Fridovich I.: The Haber-Weiss cycle - 70 years later: an alternative view, Redox Rep., 2002; 7: 55-57. [http://dx.doi.org/10.1179/135100002125000190]
Leonard S.S., Harris G.K., Shi X.L.: Metal-induced oxidative stress and signal transduction, Free Radic. Biol. Med., 2004; 37, 1921-1942.
French S.W., Morimoto M., Reitz R.C.: Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats. J. Nutr., 1997; 127: 907S-911S.
Berry C.E., Hare J.M.: Xanthine oxidoreductase and cardiovascular disease: molecular mechanism and pathophysiologucal. J. Physiol. (Lond), 2004; 555, 3: 589-606.
Cederbaum A.I., Lu Y., Wu D.: Role of oxidative stress in alcohol-induced liver injury. Arch. Toxicol., 2009; 83, 6: 519-548. [http://dx.doi.org/10.1007/s00204-009-0432-0]
Gunzerath L., Hewitt B.G., Li T.K. et al.: Alcohol research: past, present, and future. Ann. N Y Acad. Sci., 2011; 1216, 6648: 1-23.
Mann R.E., Smart G.R., Govoni R.: The epidemiology of alcoholic liver disease. Alcohol Res. Health, 2003; 27, 3: 209-219.
Kopczyńska E., Torliński L., Ziółkowski M: Wpływ uzależnienia od alkoholu na parametry stresu oksydacyjnego. Post. Hig., 2001; 55, 1: 95-111.
Kolios G., Valatas V., Kouroumalis E.: Role of Kupffer cells in the pathogenesis of liver disease. World J. Gastroenterol., 2006; 14, 12, 46: 7413-7420.
Schuckit M.A., Smith T.L.: The clinical course of alcohol dependence associated with a low level of response to alcohol. Addiction, 2001; 96: 903-910.[ http://dx.doi.org/10.1046/j.1360-0443.2001.96690311.x]
Weatherman R., Crabb D.W.: Alcohol and medication interactions. Alcohol Res. Health, 1999; 23: 40-54.
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