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Pedagogy and Psychology of Sport

Features of sorbilact-L-arginine-combined action on the kidneys’ volumoregulatory function of patients with purulent-septic complications
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Features of sorbilact-L-arginine-combined action on the kidneys’ volumoregulatory function of patients with purulent-septic complications

Authors

  • N. O. Maksymchuk Higher State Educational Institution of Ukraine «Bukovinian State Medical University»
  • V. M. Konovchuk Higher State Educational Institution of Ukraine «Bukovinian State Medical University»

DOI:

https://doi.org/10.12775/PPS.2018.003

Keywords

sorbilact, L-arginine, volumoregulatory function.

Abstract

The purpose of the work is to investigate the effect of combined use of sorbilact and L-arginine on the kidneys’ volume-regulatory function of patients with endogenous intoxication syndrome (EIS) of purulent-septic origin in the period of stabilization of secondary toxic autoagression.

Methods. Indicators of kidney volume receptor function have been studied in patients of the following groups. The first group (І, control) consisted of 31 patients with systemic inflammatory response syndrome (SIRS). The second group (ІІ) consisted of 22 patients with EIS who were treated according to Surviving Sepsis Campaign 2016 (standard therapy) [9]. The third group (ІІ) consisited of 24 patients with EIS, who received sorbilact in addition to standard therapy. The fourth group (IV) included 21 patients with SEI who received standard therapy as well as Sorbilact and L-arginine. Sorbilact infusion to patients of III and IV groups was performed at a rate of 6-7 ml/kg body weight, intravenously dripping at a rate of 7-8 ml/min. After the end of infusion of sorbilact, patients of IV group were infused with 4.2% solution of L-arginine (“Tivortin” intravenous drip according to the instructions). Data was obtained and results gathered on the application of drugs in the period of stabilization of secondary toxic autoagresion (fourth day of drugs’ application).

Findings. In the period of stabilization there is a restoration of the volume-regulatory function of the kidneys under standard therapy of endotoxicosis of purulent-septic genesis. The use of sorbilact with standard therapy activates the volume-regulatory function of the kidneys (in terms of sodium clearance by 31%, p <0,05) in the period of stabilization of toxic autoaggression. The combination of sorbilact with L-arginine increases the activity of sodium clearance by 12% (p <0,05) induced by sorbilact.

Conclusions. The investigated features of basic adjuvant therapy with L-arginine and sorbilact can be recommended for use in order to restore the volume-regulatory function of the kidneys in cases of endotoxicosis of purulent-septic genesis.

References

Prescott HC, Angus DC. [Enhancing Recovery From Sepsis: A Review]. JAMA, 2017; 319 (1): 62–75.

Kamenova K, Gluhcheva Y, Vladov I, Stoykova S & Ivanova J. [Ameliorative effect of the anticancer agent salinomycin on cadmium-induced hepatotoxicity and renal dysfunction in mice]. Environmental Science and Pollution Research, 2017; 1–12.

Hato T, Zollman A, Plotkin Z, El-Achkar TM, Maier BF, Pay SL et al. [Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney]. Journal of the American Society of Nephrology, 2018; 29(1): 104–117.

Zarbock A, John S, Jörres A, & Kindgen-Milles D. [Neue KDIGO-Leitlinien zur akuten Nierenschädigung]. Anaesthesist, 2014; 63(7): 578–588.

Nichitaĭlo ME. [Application of Sorbilact in the treatment and prophylaxis of postoperative intestinal paresis after reconstructive operations on the biliary ducts] Klinichna khirurhiia, 2011; 6: 30–31.

Senbel AM, Omar AG, Abdel-Moneim LM, Mohamed HF & Daabees TT. [Evaluation of l-arginine on kidney function and vascular reactivity following ischemic injury in rats: protective effects and potential interactions]. Pharmacological Reports, 2014; 66(6): 976–983.

Konovchuk VM, Andruschak AV & Maksimchuk NO. Pat. 112508 Ukrayina, MPK G01N 33/48. Sposib otsinki perebigu endogennoyi intoksikatsiyi [Pat. 112508 Ukrayina, MPK G01N 33/48. Method of evaluation of the course of endogenous intoxication] Patent UA, no. u201604697, 2016; 1-2. (in Ukrainian)

Johnson RJ., Feehally J & Floege J. [Comprehensive Clinical Nephrology E-Book]. Elsevier Health Sciences, 2014; 113–125.

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 / A. Rhodes, L.E. Evans, W. Alhazzani [et al.] // Intensive care medicine. – 2017. – Т. 43, № 3. – С. 304-377.

Pedagogy and Psychology of Sport

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Published

2018-01-31

How to Cite

1.
MAKSYMCHUK, N. O. and KONOVCHUK, V. M. Features of sorbilact-L-arginine-combined action on the kidneys’ volumoregulatory function of patients with purulent-septic complications. Pedagogy and Psychology of Sport. Online. 31 January 2018. Vol. 4, no. 1, pp. 31-36. [Accessed 1 July 2025]. DOI 10.12775/PPS.2018.003.
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