DEXMEDETOMIDINE TOXIC INFLUENCE ON ANMAL ORGANISMS BY PROLONGED APPLICATION ON THE RESEARCH EXAMPLE ON WHITE MICE

Abstract

This study investigated the effects of dexmedetomidine on bodily functions in animals by prolonged use. The studies were carried out on laboratory mice, which were divided into 2 groups: the first (test) one was administered administered orally by the Dexmedetomidine drug at a 0.01 ml dose, the second (control) one did not introduce any drugs. During the experiment, control over both groups’ mice’s coordination of movements, metabolic parameters were carried out, and the bodyweight was measured. Vital signs monitoring was carried out in 3 stages: 1) before drug administration; 2) 15 minutes after administration; and 3) after awakening, respectively. Results revealed that in 2-3 days, the frequency of respiratory movements began to increase by 19,1%, the awakening began to increase, and the general condition (refusal to eat, inactivity) changed for the worse. There was a 11% decrease in the test group on the last day after the next body weight measurement, while in the control group, on the contrary, the weight increased by almost 5%, and also at autopsy, changes were found in the tissues of the lungs and liver. The research aimed to identify the toxic effects of drugs in the category of α2-adrenergic receptor agonists, and at the moment it is possible to talk about some toxic effects of this group, but research needs to continue.