Screening of Candidate Gene of Diabetes Mellitus Type 1 in Dogs by Bioinformatics Translational Study
Keywords
bioinformatics, diabetes mellitus, genetic markers, pet animal, translational researchAbstract
National Center for Biotechnology Information (NCBI) is an extensively impacted genetic database for big data analysis for bioinformatics studies in all organisms. At the same time, Human-Mouse: Disease Connection (HMDC) is a complete database for mutated gene information in many human and mouse disease models. Diabetes mellitus (DM) type 1 is a common and deadly degenerative disease in dogs, so looking for candidate genes for type 1 DM)genetic markers in dogs is essential. This study aimed to search for candidate genetic markers of DM type 1 in dogs by comparing human and mouse model databases through bioinformatics studies. This study used the HMDC database to find candidate genes of type 1 DM genetic markers with endocrine system disease limitations, then continued to check the accession number and similarity of nucleotide identity from each genetic marker, comparing dogs, humans, and mice. The results identified as many as seven candidate genes for DM type 1 genetic markers in dogs out of 16 candidate genes for DM type 1 humans and mice models. This study concluded that utilizing NCBI and HMDC tools could find the candidate genes for DM type 1 genetic markers in dogs. The findings contribute to molecular diagnostic demand in veterinary medicine, especially for dogs' DM disease.
References
Rererences
1. Mallappallil M, Sabu J, Gruessner A, Salifu M. A review of big data and medical research. SAGE Open Med. 2020;8:2050312120934839.
2. Eppig JT, Blake JA, Bult CJ, Kadin JA, Richardson JE, The Mouse Genome Database Group. The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease. Nucleic Acids Research. 2015 Jan 28;43(D1):D726–36.
3. Heeley AM, O’Neill DG, Davison LJ, Church DB, Corless EK, Brodbelt DC. Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival. Canine Genet Epidemiol. 2020 Dec;7(1):6.
4. Pantoja BTDS, Carvalho RC, Miglino MA, Carreira ACO. The Canine Pancreatic Extracellular Matrix in Diabetes Mellitus and Pancreatitis: Its Essential Role and Therapeutic Perspective. Animals. 2023 Feb 15;13(4):684.
5. Moshref M, Tangey B, Gilor C, Papas KK, Williamson P, Loomba-Albrecht L, et al. Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches. Stem Cells Translational Medicine. 2019 May 1;8(5):450–5.
6. Niessen S, Hazuchova K, Powney S, Guitian J, Niessen A, Pion P, et al. The Big Pet Diabetes Survey: Perceived Frequency and Triggers for Euthanasia. Veterinary Sciences. 2017 May 14;4(4):27.
7. Short AD, Catchpole B, Kennedy LJ, Barnes A, Fretwell N, Jones C, et al. Analysis of Candidate Susceptibility Genes in Canine Diabetes. Journal of Heredity. 2007 Jul 1;98(5):518–25.
8. Elbasan O, Bayram F, Yazan CD, Apaydın T, Dashdamirova S, Polat H, et al. Angiotensin-Converting Enzyme (ACE) level, but not ACE gene polymorphism, is associated with prognosis of COVID-19 infection: Implications for diabetes and hypertension. PLoS One. 2023;18(7):e0288338.
9. Rahimi Z. ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy. J Nephropathol. 2012 Oct 1;1(3):143–51.
10. Abdel Ghafar MT, Elshora OA, Allam AA, Mashaal RG, Hamous SAA, Abd El-Khalik SR, et al. Autoimmune Regulator Gene Polymorphisms and the Risk of Primary Immune Thrombocytopenic Purpura: A Case-Control Study. IJMS. 2023 Mar 5;24(5):5007.
11. Suh J, Choi HS, Kwon A, Chae HW, Lee JS, Kim HS. A novel compound heterozygous mutation of the AIRE gene in a patient with autoimmune polyendocrine syndrome type 1. Ann Pediatr Endocrinol Metab. 2019 Dec 31;24(4):248–52.
12. Popoviciu MS, Kaka N, Sethi Y, Patel N, Chopra H, Cavalu S. Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine. JPM. 2023 Feb 26;13(3):422.
13. Turunen JA, Wessman M, Forsblom C, Kilpikari R, Parkkonen M, Pöntynen N, et al. Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients. Immunogenetics. 2006 Jun;58(5–6):331–8.
14. Hayashida H, Matsumoto A, Nanri H, Nishida Y, Takagi Y, Hara M. ALDH2 rs671 variant allele is associated with higher energy intake in middle-aged and elderly Japanese who routinely consume alcohol. Environ Health Prev Med. 2023;28(0):29–29.
15. Zhang J, Xiao Y, Hu J, Liu S, Zhou Z, Xie L. Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications. Front Immunol. 2022 Oct 6;13:999108.
16. Pelkonen R, Nikkilä EA, Kekki M. Metabolism of glycerol in diabetes mellitus. Diabetologia. 1967 Mar;3(1):1–8.
17. Cheng G, Zheng L. Regulation of the apolipoprotein M signaling pathway: a review. J Recept Signal Transduct Res. 2022 Jun;42(3):285–92.
18. Amor AJ, Castelblanco E, Hernández M, Gimenez M, Granado-Casas M, Blanco J, et al. Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles. Cardiovasc Diabetol. 2020 Dec;19(1):126.
19. Gómez Hernández G, Morell M, Alarcón-Riquelme ME. The Role of BANK1 in B Cell Signaling and Disease. Cells. 2021 May 12;10(5):1184.
20. Zouidi F, Stayoussef M, Bouzid D, Fourati H, Abida O, João C, et al. Association of BANK1 and cytokine gene polymorphisms with type 1 diabetes in Tunisia. Gene. 2014 Feb;536(2):296–301.
21. Yu J, Zhao H, Zhang Y, Liu YC, Yao L, Li X, et al. Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability. FEBS Letters. 2014 May 2;588(9):1509–14.
22. Qingjun L, Zhou H, Langdon W, Zhang J. E3 ubiquitin ligase Cbl-b in innate and adaptive immunity. Cell Cycle. 2014 Jun 15;13(12):1875–84.
23. Marques RE, Guabiraba R, Russo RC, Teixeira MM. Targeting CCL5 in inflammation. Expert Opin Ther Targets. 2013 Dec;17(12):1439–60.
24. Hughes CE, Nibbs RJB. A guide to chemokines and their receptors. FEBS J. 2018 Aug;285(16):2944–71
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