Matcha versus Coffee: Comparative Effects on Cognitive Performance, Stress Response and Cardiometabolic Health in Physically Active Individuals – A Narrative Review
DOI:
https://doi.org/10.12775/QS.2026.76.75354Keywords
matcha, coffee, L-theanine, catechins, epigallocatechin gallate (EGCG), cognitive performance, stress response, cardiometabolic health, exercise performance, physically active individualsAbstract
Background. Matcha and coffee are widely consumed sources of caffeine and other bioactive compounds. Caffeine-mediated effects are well established, but the distinct phytochemical profiles of these beverages contribute to different physiological responses. Direct comparisons between matcha and coffee remain limited.
Aim. We aim to compare the effects of matcha and coffee on cognitive performance, stress response, and cardiometabolic health, with emphasis on their practical relevance for physically active individuals and their potential applications before, during, and after exercise.
Material and methods. This narrative review analyzed recent publications identified through manual searches in PubMed, Scopus, and Google Scholar.
Results. Both beverages provide caffeine and may improve alertness, attention, and exercise performance, with coffee currently supported by larger evidence base for acute ergogenic effects. Matcha produce a more balanced state of alertness and may be advantageous for sustained attention under conditions of psychological and subjective arousal. Matcha-derived catechins may influence blood pressure, glucose metabolism, lipid metabolism, inflammation, and oxidative stress. Coffee consumption has been associated with favorable or neutral long-term cardiometabolic outcomes.
Conclusions. Matcha and coffee should not be viewed as competing beverages, but sources of distinct combinations of bioactive compounds with potentially complementary functional profiles. Coffee has the strongest evidence for rapid caffeine-mediated stimulation and acute exercise performance, whereas matcha is relevant to sustained cognitive engagement and regular exposure to tea-derived polyphenols.
References
Almeida, B. A., Morales, A. P., Ribeiro, J. R. C., Sampaio-Jorge, F., Ribeiro, Y. G., Barth, T., & Ribeiro, B. G. (2024). Impact of Caffeine Intake Strategies on Heart Rate Variability duringPost-Exercise Recovery: A Systematic Review and Meta-Analysis. Current Cardiology Reviews, 20(3), e140324227991. https://doi.org/10.2174/011573403X289842240307114736
Aust, F., & Stahl, C. (2020). The enhancing effect of 200 mg caffeine on mnemonic discrimination is at best small. Memory, 28(7), 858–869. https://doi.org/10.1080/09658211.2020.1781899
Baba, Y., Inagaki, S., Nakagawa, S., Kobayashi, M., Kaneko, T., & Takihara, T. (2021). Effects of Daily Matcha and Caffeine Intake on Mild Acute Psychological Stress-Related Cognitive Function in Middle-Aged and Older Adults: A Randomized Placebo-Controlled Study. Nutrients, 13(5), 1700. https://doi.org/10.3390/nu13051700
Baba, Y., Kaneko, T., & Takihara, T. (2021). Matcha consumption maintains attentional function following a mild acute psychological stress without affecting a feeling of fatigue: A randomized placebo-controlled study in young adults. Nutrition Research, 88, 44–52. https://doi.org/10.1016/j.nutres.2020.12.024
Baba, Y., Takihara, T., & Okamura, N. (2023). Theanine maintains sleep quality in healthy young women by suppressing the increase in caffeine-induced wakefulness after sleep onset. Food & Function, 14(15), 7109–7116. https://doi.org/10.1039/d3fo01247f
Baba, Y., Takihara, T., & Okamura, N. (2024). Matcha Does Not Affect Electroencephalography during Sleep but May Enhance Mental Well-Being: A Randomized Placebo-Controlled Clinical Trial. Nutrients, 16(17), 2907. https://doi.org/10.3390/nu16172907
Benjamim, C. J. R., Kliszczewicz, B., Garner, D. M., Cavalcante, T. C. F., da Silva, A. A. M., Santana, M. D. R., & Valenti, V. E. (2020). Is Caffeine Recommended Before Exercise? A Systematic Review To Investigate Its Impact On Cardiac Autonomic Control Via Heart Rate And Its Variability. Journal of the American College of Nutrition, 39(6), 563–573. https://doi.org/10.1080/07315724.2019.1705201
Bonita, J., Mandarano, M., Shuta, D., & Vinson, J. (2007). Coffee and cardiovascular disease: In vitro, cellular, animal, and human studies. Pharmacological Research, 55(3), 187–198. https://doi.org/10.1016/j.phrs.2007.01.006
Borota, D., Murray, E., Keceli, G., Chang, A., Watabe, J. M., Ly, M., Toscano, J. P., & Yassa, M. A. (2014). Post-study caffeine administration enhances memory consolidation in humans. Nature Neuroscience, 17(2), 201–203. https://doi.org/10.1038/nn.3623
Borrelli, R. C., Visconti, A., Mennella, C., Anese, M., & Fogliano, V. (2002). Chemical characterization and antioxidant properties of coffee melanoidins. Journal of Agricultural and Food Chemistry, 50(22), 6527–6533. https://doi.org/10.1021/jf025686o
Cai, Z.-Y., Li, X.-M., Liang, J.-P., Xiang, L.-P., Wang, K.-R., Shi, Y.-L., Yang, R., Shi, M., Ye, J.-H., Lu, J.-L., Zheng, X.-Q., & Liang, Y.-R. (2018). Bioavailability of Tea Catechins and Its Improvement. Molecules, 23(9), 2346. https://doi.org/10.3390/molecules23092346
Camfield, D. A., Stough, C., Farrimond, J., & Scholey, A. B. (2014). Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: A systematic review and meta-analysis. Nutrition Reviews, 72(8), 507–522. https://doi.org/10.1111/nure.12120
Caprioli, G., Cortese, M., Maggi, F., Minnetti, C., Odello, L., Sagratini, G., & Vittori, S. (2014). Quantification of caffeine, trigonelline and nicotinic acid in espresso coffee: The influence of espresso machines and coffee cultivars. International Journal of Food Sciences and Nutrition, 65(4), 465–469. https://doi.org/10.3109/09637486.2013.873890
Casal, S., Oliveira, M. B., Alves, M. R., & Ferreira, M. A. (2000). Discriminate analysis of roasted coffee varieties for trigonelline, nicotinic acid, and caffeine content. Journal of Agricultural and Food Chemistry, 48(8), 3420–3424. https://doi.org/10.1021/jf990702b
Chen, X., Ye, K., Xu, Y., Zhao, Y., & Zhao, D. (2022). Effect of Shading on the Morphological, Physiological, and Biochemical Characteristics as Well as the Transcriptome of Matcha Green Tea. International Journal of Molecular Sciences, 23(22), 14169. https://doi.org/10.3390/ijms232214169
Choi, S., & Je, Y. (2024). Coffee consumption and C-reactive protein levels: A systematic review and meta-analysis. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 34(11), 2425–2439. https://doi.org/10.1016/j.numecd.2024.06.024
Clark, I., & Landolt, H. P. (2017). Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Medicine Reviews, 31, 70–78. https://doi.org/10.1016/j.smrv.2016.01.006
Dassanayake, T. L., Kahathuduwa, C. N., & Weerasinghe, V. S. (2022). L-theanine improves neurophysiological measures of attention in a dose-dependent manner: A double-blind, placebo-controlled, crossover study. Nutritional Neuroscience, 25(4), 698–708. https://doi.org/10.1080/1028415X.2020.1804098
Delgado-Andrade, C., & Morales, F. J. (2005). Unraveling the contribution of melanoidins to the antioxidant activity of coffee brews. Journal of Agricultural and Food Chemistry, 53(5), 1403–1407. https://doi.org/10.1021/jf048500p
Dludla, P. V., Cirilli, I., Marcheggiani, F., Silvestri, S., Orlando, P., Muvhulawa, N., Moetlediwa, M. T., Nkambule, B. B., Mazibuko-Mbeje, S. E., Hlengwa, N., Hanser, S., Ndwandwe, D., Marnewick, J. L., Basson, A. K., & Tiano, L. (2023). Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease. Molecules, 28(18), 6440. https://doi.org/10.3390/molecules28186440
Drake, C., Roehrs, T., Shambroom, J., & Roth, T. (2013). Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 9(11), 1195–1200. https://doi.org/10.5664/jcsm.3170
Du, Y., Lv, Y., Zha, W., Hong, X., & Luo, Q. (2020). Effect of coffee consumption on dyslipidemia: A meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 30(12), 2159–2170. https://doi.org/10.1016/j.numecd.2020.08.017
Duncan, M. J., Stanley, M., Parkhouse, N., Cook, K., & Smith, M. (2013). Acute caffeine ingestion enhances strength performance and reduces perceived exertion and muscle pain perception during resistance exercise. European Journal of Sport Science, 13(4), 392–399. https://doi.org/10.1080/17461391.2011.635811
Einöther, S. J. L., & Giesbrecht, T. (2013). Caffeine as an attention enhancer: Reviewing existing assumptions. Psychopharmacology, 225(2), 251–274. https://doi.org/10.1007/s00213-012-2917-4
Einöther, S. J. L., Martens, V. E. G., Rycroft, J. A., & De Bruin, E. A. (2010). L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite, 54(2), 406–409. https://doi.org/10.1016/j.appet.2010.01.003
Evans, M., McDonald, A. C., Xiong, L., Crowley, D. C., & Guthrie, N. (2021). A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population. Neurology and Therapy, 10(2), 1061–1078. https://doi.org/10.1007/s40120-021-00284-x
Foxe, J. J., Morie, K. P., Laud, P. J., Rowson, M. J., de Bruin, E. A., & Kelly, S. P. (2012). Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology, 62(7), 2320–2327. https://doi.org/10.1016/j.neuropharm.2012.01.020
Fredholm, B. B. (1995). Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacology & Toxicology, 76(2), 93–101. https://doi.org/10.1111/j.1600-0773.1995.tb00111.x
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews, 51(1), 83–133.
Gardiner, C., Weakley, J., Burke, L. M., Roach, G. D., Sargent, C., Maniar, N., Townshend, A., & Halson, S. L. (2023). The effect of caffeine on subsequent sleep: A systematic review and meta-analysis. Sleep Medicine Reviews, 69, 101764. https://doi.org/10.1016/j.smrv.2023.101764
Gholami, F., Antonio, J., Iranpour, M., Curtis, J., & Pereira, F. (2024). Does green tea catechin enhance weight-loss effect of exercise training in overweight and obese individuals? A systematic review and meta-analysis of randomized trials. Journal of the International Society of Sports Nutrition, 21(1), 2411029. https://doi.org/10.1080/15502783.2024.2411029
Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 13(6), 283–290. https://doi.org/10.1179/147683010X12611460764840
Gomez-Ramirez, M., Kelly, S. P., Montesi, J. L., & Foxe, J. J. (2009). The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topography, 22(1), 44–51. https://doi.org/10.1007/s10548-008-0068-z
Grgic, J., Grgic, I., Pickering, C., Schoenfeld, B. J., Bishop, D. J., & Pedisic, Z. (2020). Wake up and smell the coffee: Caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. British Journal of Sports Medicine, 54(11), 681–688. https://doi.org/10.1136/bjsports-2018-100278
Gross, G., Jaccaud, E., & Huggett, A. C. (1997). Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 35(6), 547–554. https://doi.org/10.1016/s0278-6915(96)00123-8
Grosso, G., Godos, J., Galvano, F., & Giovannucci, E. L. (2017). Coffee, Caffeine, and Health Outcomes: An Umbrella Review. Annual Review of Nutrition, 37, 131–156. https://doi.org/10.1146/annurev-nutr-071816-064941
Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: Caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4
Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological Psychology, 77(2), 113–122. https://doi.org/10.1016/j.biopsycho.2007.09.008
Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. https://doi.org/10.3390/nu11102362
Higgins, S., Straight, C. R., & Lewis, R. D. (2016). The Effects of Preexercise Caffeinated Coffee Ingestion on Endurance Performance: An Evidence-Based Review. International Journal of Sport Nutrition and Exercise Metabolism, 26(3), 221–239. https://doi.org/10.1123/ijsnem.2015-0147
Holgado, D., Sanabria, D., Perales, J. C., & Vadillo, M. A. (2020). Mental Fatigue Might Be Not So Bad for Exercise Performance After All: A Systematic Review and Bias-Sensitive Meta-Analysis. Journal of Cognition, 3(1), 38. https://doi.org/10.5334/joc.126
Hoppe, J. M., Björkstrand, J., Vegelius, J., Klevebrant, L., Gingnell, M., & Frick, A. (2025). Acute effects of 150 mg caffeine on subjective, physiological, and behavioral components of anxiety in panic disorder and healthy controls—A randomized placebo-controlled crossover trial. Journal of Psychopharmacology, 39(8), 836–846. https://doi.org/10.1177/02698811251344692
Hu, G. L., Wang, X., Zhang, L., & Qiu, M. H. (2019). The sources and mechanisms of bioactive ingredients in coffee. Food & Function, 10(6), 3113–3126. https://doi.org/10.1039/c9fo00288j
Hursel, R., Viechtbauer, W., & Westerterp-Plantenga, M. S. (2009). The effects of green tea on weight loss and weight maintenance: A meta-analysis. International Journal of Obesity, 33(9), 956–961. https://doi.org/10.1038/ijo.2009.135
Irwin, C., Khalesi, S., Desbrow, B., & McCartney, D. (2020). Effects of acute caffeine consumption following sleep loss on cognitive, physical, occupational and driving performance: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 108, 877–888. https://doi.org/10.1016/j.neubiorev.2019.12.008
Kaplan, G. B., Greenblatt, D. J., Ehrenberg, B. L., Goddard, J. E., Cotreau, M. M., Harmatz, J. S., & Shader, R. I. (1997). Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. Journal of Clinical Pharmacology, 37(8), 693–703. https://doi.org/10.1002/j.1552-4604.1997.tb04356.x
Kelly, S. P., Gomez-Ramirez, M., Montesi, J. L., & Foxe, J. J. (2008). L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. The Journal of Nutrition, 138(8), 1572S-1577S. https://doi.org/10.1093/jn/138.8.1572S
Khalesi, S., Sun, J., Buys, N., Jamshidi, A., Nikbakht-Nasrabadi, E., & Khosravi-Boroujeni, H. (2014). Green tea catechins and blood pressure: A systematic review and meta-analysis of randomised controlled trials. European Journal of Nutrition, 53(6), 1299–1311. https://doi.org/10.1007/s00394-014-0720-1
Khan, N., & Mukhtar, H. (2007). Tea polyphenols for health promotion. Life Sciences, 81(7), 519–533. https://doi.org/10.1016/j.lfs.2007.06.011
Kim, A., Chiu, A., Barone, M. K., Avino, D., Wang, F., Coleman, C. I., & Phung, O. J. (2011). Green tea catechins decrease total and low-density lipoprotein cholesterol: A systematic review and meta-analysis. Journal of the American Dietetic Association, 111(11), 1720–1729. https://doi.org/10.1016/j.jada.2011.08.009
Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39–45. https://doi.org/10.1016/j.biopsycho.2006.06.006
Kløve, K., & Petersen, A. (2025). A systematic review and meta-analysis of the acute effect of caffeine on attention. Psychopharmacology, 242(9), 1909–1930. https://doi.org/10.1007/s00213-025-06775-1
Kochman, J., Jakubczyk, K., Antoniewicz, J., Mruk, H., & Janda, K. (2020). Health Benefits and Chemical Composition of Matcha Green Tea: A Review. Molecules, 26(1), 85. https://doi.org/10.3390/molecules26010085
Koenig, J., Jarczok, M. N., Kuhn, W., Morsch, K., Schäfer, A., Hillecke, T. K., & Thayer, J. F. (2013). Impact of Caffeine on Heart Rate Variability: A Systematic Review. Journal of Caffeine Research, 3(1), 22–37. https://doi.org/10.1089/jcr.2013.0009
Liang, Y., Dai, X., Cao, Y., Wang, X., Lu, J., Xie, L., Liu, K., & Li, X. (2023). The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms. Biochimie, 206, 93–104. https://doi.org/10.1016/j.biochi.2022.10.009
Liu, C., Wang, L., Zhang, C., Hu, Z., Tang, J., Xue, J., & Lu, W. (2024). Caffeine intake and anxiety: A meta-analysis. Frontiers in Psychology, 15, 1270246. https://doi.org/10.3389/fpsyg.2024.1270246
Liu, K., Zhou, R., Wang, B., Chen, K., Shi, L.-Y., Zhu, J.-D., & Mi, M.-T. (2013). Effect of green tea on glucose control and insulin sensitivity: A meta-analysis of 17 randomized controlled trials. The American Journal of Clinical Nutrition, 98(2), 340–348. https://doi.org/10.3945/ajcn.112.052746
Lorenzo Calvo, J., Fei, X., Domínguez, R., & Pareja-Galeano, H. (2021). Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis. Nutrients, 13(3), 868. https://doi.org/10.3390/nu13030868
Lovallo, W. R., Farag, N. H., Vincent, A. S., Thomas, T. L., & Wilson, M. F. (2006). Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacology, Biochemistry, and Behavior, 83(3), 441–447. https://doi.org/10.1016/j.pbb.2006.03.005
Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020). Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions. Comprehensive Reviews in Food Science and Food Safety, 19(6), 3130–3158. https://doi.org/10.1111/1541-4337.12620
Mancini, E., Beglinger, C., Drewe, J., Zanchi, D., Lang, U. E., & Borgwardt, S. (2017). Green tea effects on cognition, mood and human brain function: A systematic review. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 34, 26–37. https://doi.org/10.1016/j.phymed.2017.07.008
Martini, D., Del Bo’, C., Tassotti, M., Riso, P., Del Rio, D., Brighenti, F., & Porrini, M. (2016). Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies. Molecules, 21(8), 979. https://doi.org/10.3390/molecules21080979
Martins, G. L., Aparecido, J. M., Marquezi, M. L., Frientes, C. S., Miedes, L. R., Fornel, M. S., Fernandes, T., & Lancha, A. H. (2026). Dose-Response Effect of Oral Caffeine Use on Aerobic Exercise Performance: A Systematic Review and Meta-Analysis. Nutrients, 18(12), 1989. https://doi.org/10.3390/nu18121989
McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016). A review of caffeine’s effects on cognitive, physical and occupational performance. Neuroscience and Biobehavioral Reviews, 71, 294–312. https://doi.org/10.1016/j.neubiorev.2016.09.001
Moeenfard, M., & Alves, A. (2020). New trends in coffee diterpenes research from technological to health aspects. Food Research International, 134, 109207. https://doi.org/10.1016/j.foodres.2020.109207
Moon, S.-M., Joo, M.-J., Lee, Y.-S., & Kim, M.-G. (2021). Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis. Nutrients, 13(11), 3976. https://doi.org/10.3390/nu13113976
Moreira, A. S. P., Nunes, F. M., Domingues, M. R., & Coimbra, M. A. (2012). Coffee melanoidins: Structures, mechanisms of formation and potential health impacts. Food & Function, 3(9), 903–915. https://doi.org/10.1039/c2fo30048f
Nawarathna, G. S., Ariyasinghe, D. I., & Dassanayake, T. L. (2025). High-dose L-theanine-caffeine combination improves neurobehavioural and neurophysiological measures of selective attention in acutely sleep-deprived young adults: A double-blind, placebo-controlled crossover study. The British Journal of Nutrition, 134(3), 195–204. https://doi.org/10.1017/S0007114525104169
Nguyen, V., Taine, E. G., Meng, D., Cui, T., & Tan, W. (2024). Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials. Nutrients, 16(7), 924. https://doi.org/10.3390/nu16070924
Noordzij, M., Uiterwaal, C. S. P. M., Arends, L. R., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M. (2005). Blood pressure response to chronic intake of coffee and caffeine: A meta-analysis of randomized controlled trials. Journal of Hypertension, 23(5), 921–928. https://doi.org/10.1097/01.hjh.0000166828.94699.1d
Ong, K. W., Hsu, A., & Tan, B. K. H. (2012). Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: A contributor to the beneficial effects of coffee on diabetes. PloS One, 7(3), e32718. https://doi.org/10.1371/journal.pone.0032718
Ong, K. W., Hsu, A., & Tan, B. K. H. (2013). Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochemical Pharmacology, 85(9), 1341–1351. https://doi.org/10.1016/j.bcp.2013.02.008
Orrje, E., Fristedt, R., Rosqvist, F., Landberg, R., & Iggman, D. (2025). Cafestol and kahweol concentrations in workplace machine coffee compared with conventional brewing methods. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 35(8), 103933. https://doi.org/10.1016/j.numecd.2025.103933
Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience, 11(4), 193–198. https://doi.org/10.1179/147683008X301513
Paiva, C., Beserra, B., Reis, C., Dorea, J. G., Da Costa, T., & Amato, A. A. (2019). Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review. Critical Reviews in Food Science and Nutrition, 59(4), 652–663. https://doi.org/10.1080/10408398.2017.1386159
Pané-Farré, C. A., Alius, M. G., Modeß, C., Methling, K., Blumenthal, T., & Hamm, A. O. (2015). Anxiety sensitivity and expectation of arousal differentially affect the respiratory response to caffeine. Psychopharmacology, 232(11), 1931–1939. https://doi.org/10.1007/s00213-014-3828-3
Park, S.-K., Jung, I.-C., Lee, W. K., Lee, Y. S., Park, H. K., Go, H. J., Kim, K., Lim, N. K., Hong, J. T., Ly, S. Y., & Rho, S. S. (2011). A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: A double-blind placebo-controlled study. Journal of Medicinal Food, 14(4), 334–343. https://doi.org/10.1089/jmf.2009.1374
Payne, E. R., Aceves-Martins, M., Dubost, J., Greyling, A., & de Roos, B. (2025). Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrition Reviews, 83(10), 1873–1891. https://doi.org/10.1093/nutrit/nuaf054
Pedersen, D. J., Lessard, S. J., Coffey, V. G., Churchley, E. G., Wootton, A. M., Ng, T., Watt, M. J., & Hawley, J. A. (2008). High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. Journal of Applied Physiology, 105(1), 7–13. https://doi.org/10.1152/japplphysiol.01121.2007
Peng, X., Zhou, R., Wang, B., Yu, X., Yang, X., Liu, K., & Mi, M. (2014). Effect of green tea consumption on blood pressure: A meta-analysis of 13 randomized controlled trials. Scientific Reports, 4(1), 6251. https://doi.org/10.1038/srep06251
Perrone, D., Farah, A., & Donangelo, C. M. (2012). Influence of coffee roasting on the incorporation of phenolic compounds into melanoidins and their relationship with antioxidant activity of the brew. Journal of Agricultural and Food Chemistry, 60(17), 4265–4275. https://doi.org/10.1021/jf205388x
Phuah, Y. Q., Chang, S. K., Ng, W. J., Lam, M. Q., & Ee, K. Y. (2023). A review on matcha: Chemical composition, health benefits, with insights on its quality control by applying chemometrics and multi-omics. Food Research International, 170, 113007. https://doi.org/10.1016/j.foodres.2023.113007
Phung, O. J., Baker, W. L., Matthews, L. J., Lanosa, M., Thorne, A., & Coleman, C. I. (2010). Effect of green tea catechins with or without caffeine on anthropometric measures: A systematic review and meta-analysis. The American Journal of Clinical Nutrition, 91(1), 73–81. https://doi.org/10.3945/ajcn.2009.28157
Poole, R., Kennedy, O. J., Roderick, P., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2017). Coffee consumption and health: Umbrella review of meta-analyses of multiple health outcomes. BMJ, 359, j5024. https://doi.org/10.1136/bmj.j5024
Porto, A. A., Benjamim, C. J. R., Gonzaga, L. A., Luciano De Almeida, M., Bueno Júnior, C. R., Garner, D. M., & Valenti, V. E. (2022). Caffeine intake and its influences on heart rate variability recovery in healthy active adults after exercise: A systematic review and meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, 32(5), 1071–1082. https://doi.org/10.1016/j.numecd.2022.01.015
Post, S. M., de Wit, E. C., & Princen, H. M. (1997). Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(11), 3064–3070. https://doi.org/10.1161/01.atv.17.11.3064
Reis, C. E. G., Dórea, J. G., & da Costa, T. H. M. (2019). Effects of coffee consumption on glucose metabolism: A systematic review of clinical trials. Journal of Traditional and Complementary Medicine, 9(3), 184–191. https://doi.org/10.1016/j.jtcme.2018.01.001
Ren, Y., Wang, C., Xu, J., & Wang, S. (2019). Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. International Journal of Molecular Sciences, 20(17), 4238. https://doi.org/10.3390/ijms20174238
Ricketts, M.-L., Boekschoten, M. V., Kreeft, A. J., Hooiveld, G. J. E. J., Moen, C. J. A., Müller, M., Frants, R. R., Kasanmoentalib, S., Post, S. M., Princen, H. M. G., Porter, J. G., Katan, M. B., Hofker, M. H., & Moore, D. D. (2007). The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Molecular Endocrinology, 21(7), 1603–1616. https://doi.org/10.1210/me.2007-0133
Rojano-Ortega, D. (2021). Regular, but not acute, green tea supplementation increases total antioxidant status and reduces exercise-induced oxidative stress: A systematic review. Nutrition Research, 94, 34–43. https://doi.org/10.1016/j.nutres.2021.08.004
Rustan, A. C., Halvorsen, B., Huggett, A. C., Ranheim, T., & Drevon, C. A. (1997). Effect of coffee lipids (cafestol and kahweol) on regulation of cholesterol metabolism in HepG2 cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(10), 2140–2149. https://doi.org/10.1161/01.atv.17.10.2140
Serban, C., Sahebkar, A., Antal, D., Ursoniu, S., & Banach, M. (2015). Effects of supplementation with green tea catechins on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials. Nutrition, 31(9), 1061–1071. https://doi.org/10.1016/j.nut.2015.02.004
Sherman, S. M., Buckley, T. P., Baena, E., & Ryan, L. (2016). Caffeine Enhances Memory Performance in Young Adults during Their Non-optimal Time of Day. Frontiers in Psychology, 7, 1764. https://doi.org/10.3389/fpsyg.2016.01764
Southward, K., Rutherfurd-Markwick, K. J., & Ali, A. (2018). The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis. Sports Medicine, 48(8), 1913–1928. https://doi.org/10.1007/s40279-018-0939-8
Steffen, M., Kuhle, C., Hensrud, D., Erwin, P. J., & Murad, M. H. (2012). The effect of coffee consumption on blood pressure and the development of hypertension: A systematic review and meta-analysis. Journal of Hypertension, 30(12), 2245–2254. https://doi.org/10.1097/HJH.0b013e3283588d73
Sugita, M., Kapoor, M. P., Nishimura, A., & Okubo, T. (2016). Influence of green tea catechins on oxidative stress metabolites at rest and during exercise in healthy humans. Nutrition, 32(3), 321–331. https://doi.org/10.1016/j.nut.2015.09.005
Tabrizi, R., Saneei, P., Lankarani, K. B., Akbari, M., Kolahdooz, F., Esmaillzadeh, A., Nadi-Ravandi, S., Mazoochi, M., & Asemi, Z. (2019). The effects of caffeine intake on weight loss: A systematic review and dos-response meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 59(16), 2688–2696. https://doi.org/10.1080/10408398.2018.1507996
Tuncer, S. Y., Ozdenk, S., Yildirim, U. C., Erkan, D., Sari, C., Gundem, M. C., Sar, H., Yilmaz, B., Karakulak, I., & Akca, F. (2025). Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: A randomized, double-blind, placebo-controlled crossover study. Frontiers in Nutrition, 12, 1751673. https://doi.org/10.3389/fnut.2025.1751673
Unno, K., Sumiyoshi, A., Konishi, T., Hayashi, M., Taguchi, K., Muguruma, Y., Inoue, K., Iguchi, K., Nonaka, H., Kawashima, R., Hasegawa-Ishii, S., Shimada, A., & Nakamura, Y. (2020). Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses. Nutrients, 12(1), 174. https://doi.org/10.3390/nu12010174
Urgert, R., & Katan, M. B. (1997). The cholesterol-raising factor from coffee beans. Annual Review of Nutrition, 17, 305–324. https://doi.org/10.1146/annurev.nutr.17.1.305
van Cruchten, S. T. J., de Haan, L. H. J., Mulder, P. P. J., Kunne, C., Boekschoten, M. V., Katan, M. B., Aarts, J. M. M. J. G., & Witkamp, R. F. (2010). The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol. The Journal of Nutritional Biochemistry, 21(8), 757–763. https://doi.org/10.1016/j.jnutbio.2009.05.001
Wang, L., Pan, X., Jiang, L., Chu, Y., Gao, S., Jiang, X., Zhang, Y., Chen, Y., Luo, S., & Peng, C. (2022). The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review. Frontiers in Nutrition, 9, 943911. https://doi.org/10.3389/fnut.2022.943911
Wang, X., Tian, J., Jiang, J., Li, L., Ying, X., Tian, H., & Nie, M. (2014). Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: A systematic review and meta-analysis of randomised controlled trials. Journal of Human Nutrition and Dietetics: The Official Journal of the British Dietetic Association, 27(5), 501–512. https://doi.org/10.1111/jhn.12181
Wang, Y., Wang, B., Du, F., Su, X., Sun, G., Zhou, G., Bian, X., & Liu, N. (2015). Epigallocatechin-3-Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF-κB and Nrf2/HO-1 Signalling Pathway Regulation. Basic & Clinical Pharmacology & Toxicology, 117(3), 164–172. https://doi.org/10.1111/bcpt.12383
Wang, Z., Qiu, B., Gao, J., & Del Coso, J. (2022). Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis. Nutrients, 15(1), 148. https://doi.org/10.3390/nu15010148
White, D. J., de Klerk, S., Woods, W., Gondalia, S., Noonan, C., & Scholey, A. B. (2016). Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients, 8(1), 53. https://doi.org/10.3390/nu8010053
Williams, J. L., Everett, J. M., D’Cunha, N. M., Sergi, D., Georgousopoulou, E. N., Keegan, R. J., McKune, A. J., Mellor, D. D., Anstice, N., & Naumovski, N. (2020). The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: A Systematic Review. Plant Foods for Human Nutrition, 75(1), 12–23. https://doi.org/10.1007/s11130-019-00771-5
Xu, R., Yang, K., Ding, J., & Chen, G. (2020). Effect of green tea supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Medicine, 99(6), e19047. https://doi.org/10.1097/MD.0000000000019047
Xu, R., Yang, K., Li, S., Dai, M., & Chen, G. (2020). Effect of green tea consumption on blood lipids: A systematic review and meta-analysis of randomized controlled trials. Nutrition Journal, 19(1), 48. https://doi.org/10.1186/s12937-020-00557-5
Yang, C. S., Sang, S., Lambert, J. D., & Lee, M.-J. (2008). Bioavailability issues in studying the health effects of plant polyphenolic compounds. Molecular Nutrition & Food Research, 52 Suppl 1, S139-151. https://doi.org/10.1002/mnfr.200700234
Yu, J., Song, P., Perry, R., Penfold, C., & Cooper, A. R. (2017). The Effectiveness of Green Tea or Green Tea Extract on Insulin Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A Meta-Analysis. Diabetes & Metabolism Journal, 41(4), 251–262. https://doi.org/10.4093/dmj.2017.41.4.251
Zhang, H., Zhang, H., Troise, A. D., & Fogliano, V. (2019). Melanoidins from Coffee, Cocoa, and Bread Are Able to Scavenge α-Dicarbonyl Compounds under Simulated Physiological Conditions. Journal of Agricultural and Food Chemistry, 67(39), 10921–10929. https://doi.org/10.1021/acs.jafc.9b03744
Zhang, S., Mao, B., Cui, S., Zhang, Q., Zhao, J., Tang, X., & Chen, W. (2024). Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate. Critical Reviews in Food Science and Nutrition, 64(19), 6546–6566. https://doi.org/10.1080/10408398.2023.2170972
Zhang, Y., & Zhang, D.-Z. (2018). Is coffee consumption associated with a lower level of serum C-reactive protein? A meta-analysis of observational studies. International Journal of Food Sciences and Nutrition, 69(8), 985–994. https://doi.org/10.1080/09637486.2018.1433640
Zheng, X.-X., Xu, Y.-L., Li, S.-H., Liu, X.-X., Hui, R., & Huang, X.-H. (2011). Green tea intake lowers fasting serum total and LDL cholesterol in adults: A meta-analysis of 14 randomized controlled trials. The American Journal of Clinical Nutrition, 94(2), 601–610. https://doi.org/10.3945/ajcn.110.010926
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Copyright (c) 2026 Aleksandra Wojtera, Szymon Bojanowski, Marcelina Skajewska, Magdalena Iwaszko, Wojciech Ziębka, Damian Szymański, Aleksandra Anna Miciak, Karolina Kaczmarz-Chojnacka, Karina Barbara Kaszowska, Wiktor Rybicki, Nina Urantówka

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