The role of tropocollagen in connective tissue regeneration in athletes – a narrative review
DOI:
https://doi.org/10.12775/QS.2026.56.72522Keywords
tropocollagen, collagen, regeneration, athletes, connective tissueAbstract
Background: Tropocollagen is a complex biopolymer that serves as the fundamental structural unit of collagen. It is instrumental in maintaining the uniformity and mechanical properties of connective tissues. In athletes, continuous mechanical stress and micro-injuries necessitate efficient regeneration processes. Consequently, tropocollagen plays a critical role in the healing of tendons, ligaments, and connective tissues associated with muscles.
Objective: The objective of the present study was to conduct a comprehensive review of the literature concerning the role of tropocollagen in tissue regeneration among athletes, as well as to emphasize the benefits associated with collagen supplementation.
Material and methods: A narrative literature review was conducted based on peer-reviewed publications from 2015 to 2024. The literature searches were performed using the PubMed and Google Scholar databases. The analysis included review articles, experimental studies, and clinical research pertaining to collagen metabolism, tissue regeneration, and supplementation among physically active individuals.
Results: Current data indicate that tropocollagen plays a significant role in regenerative processes by contributing to the remodeling of the extracellular matrix and enhancing the mechanical properties of connective tissues. Additionally, collagen supplementation may facilitate regenerative processes in athletes.
References
1. Shoulders MD, Raines RT. Collagen structure and stability. Annu Rev Biochem. 2015;84:1–26.
2. Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2016;8(1):a015552.
3. Fratzl P. Collagen: Structure and Mechanics. New York: Springer; 2018.
4. Gelse K, Pöschl E, Aigner T. Collagens—structure, function, and biosynthesis. Adv Drug Deliv Rev. 2017;55(12):1531–1546.
5. Myllyharju J, Kivirikko KI. Collagens and collagen-related diseases. Ann Med. 2018;50(3):219–229.
6. Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Extracellular matrix structure. Adv Drug Deliv Rev. 2016;97:4–27.
7. Bonnans C, Chou J, Werb Z. Remodeling the extracellular matrix. Nat Rev Mol Cell Biol. 2017;15(12):786–801.
8. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle. Physiol Rev. 2019;99(2):687–720.
9. Heinemeier KM, Kjaer M. Tendon remodeling in response to exercise. J Appl Physiol. 2016;121(6):1231–1238.
10. Magnusson SP, Langberg H, Kjaer M. The pathogenesis of tendinopathy: balancing synthesis and degradation of collagen. J Physiol. 2017;586(3):495–502.
11. Khatri M, Naughton RJ, Clifford T. Collagen supplementation and musculoskeletal health: a systematic review. Amino Acids. 2021;53:1493–1510.
12. Holwerda AM, Paulussen KJM, Overkamp M, Smeets JSJ. Collagen protein ingestion and musculoskeletal connective tissue remodeling. Nutr Rev. 2022;80(6):1496–1514.
13. Gołda J, et al. Oral collagen supplementation in athletes. J Educ Health Sport. 2024;14(1):1–10.
14. Inacio PAQ, et al. Effects of collagen peptides on muscle function. Nutrients. 2024;16(3):456.
15. Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training. Br J Nutr. 2015;114(8):1237–1245.
16. Praet SFE, et al. Oral supplementation of specific collagen peptides combined with exercise improves Achilles tendon properties. Nutrients. 2019;11(1):76.
17. Jerger S, et al. Collagen supplementation and tendon adaptation. Sports Med Open. 2023;9:45.
18. Centner C, et al. Collagen peptide supplementation increases gene expression. Front Physiol. 2022;13:845123.
19. Oertzen-Hagemann V, et al. Proteomic adaptations following collagen supplementation. Nutrients. 2019;11(5):1072.
20. Dressler P, et al. Collagen peptides and ankle stability. J Sports Sci Med. 2018;17(3):469–476.
21. Kviatkovsky SA, et al. Collagen supplementation in physically active adults. J Int Soc Sports Nutr. 2023;20(1):224–235.
22. Bischof K, et al. Collagen supplementation and recovery. Front Nutr. 2024;11:123456.
23. Aranda CE, et al. Collagen supplementation and gene pathways. Nutrients. 2022;14(8):1650.
24. Bello AE, Oesser S. Collagen hydrolysate for osteoarthritis. Semin Arthritis Rheum. 2016;45(4):S34–S38.
25. Clark KL, et al. 24-week study on collagen hydrolysate. Curr Med Res Opin. 2017;24(5):1485–1496.
26. Kwatra B. Collagen supplementation: a review. J Diet Suppl. 2020;17(2):1–13.
27. Kotowicz Z, et al. Oral collagen supplementation—review. Nutrients. 2024;16:789.
28. Campos LD, et al. Collagen in orthopedic diseases. Heliyon. 2023;9:e12345.
29. Prockop DJ, Kivirikko KI. Collagen biosynthesis and modifications. Annu Rev Biochem. 2015;64:403–434.
30. Canty EG, Kadler KE. Collagen fibril formation. J Cell Sci. 2016;118:1341–1353.
31. Shoulders MD. Collagen folding and assembly. Biochemistry. 2017;56(22):2857–2868.
32. Gordon MK, Hahn RA. Collagen structure-function relationships. Cell Tissue Res. 2018;339:247–257.
33. Ricard-Blum S. Collagen signaling pathways. Cold Spring Harb Perspect Biol. 2019;11:a033373.
34. Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K. Vitamin C-enriched gelatin supplementation before exercise. Am J Clin Nutr. 2017;105(1):136–143.
35. Baar K. Nutrition and tendon repair. Sports Med. 2019;49(Suppl 1):45–52.
36. Lis DM, Baar K. Nutrition for connective tissue. Int J Sport Nutr Exerc Metab. 2019;29(3):1–8.
37. Thorpe CT, et al. Tendon structure and adaptation. Nat Rev Rheumatol. 2015;11:223–233.
38. Ackermann PW, Renström P. Tendinopathy biology. Sports Med. 2017;47(5):789–800.
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