Rhodiola rosea as a Medicinal Adaptogen: A Review of Its Antidepressant, Anti-Stress, and Performance-Enhancing Effects
DOI:
https://doi.org/10.12775/QS.2025.46.66551Keywords
Rhodiola rosea, adaptogen, depression, stress, anxiety, physical activity, salidroside, rosavin, cognitive functionAbstract
Background: Rhodiola rosea L. is a traditional medicinal plant recognized for its adaptogenic properties, particularly in enhancing the body’s resistance to physical, chemical, and biological stress. Its pharmacological activity has been attributed mainly to phenylpropanoids such as rosavin and salidroside, which influence stress adaptation mechanisms and central neurotransmission.
Aim: The review of the pharmacological action, bioactive compounds, and therapeutic applications of Rhodiola rosea, with a particular focus on its potential role in supporting physical and mental performance under stress-related conditions.
Methodology: A review was conducted using PubMed and Google Scholar. Studies investigating the chemical composition, mechanisms of action, and effects of Rhodiola rosea on stress, fatigue, cognitive function, and homeostasis were analyzed and synthesized.
Results: Rhodiola rosea has demonstrated benefits in reducing fatigue, improving cognitive function, enhancing physical performance, and stabilizing mood. It also possesses a favorable safety profile, with minimal adverse effects.
Conclusions: Rhodiola rosea represents a well-tolerated and biologically active adaptogen with promising applications in managing stress-related fatigue and enhancing resilience to physical and psychological challenges. Further controlled clinical trials are warranted to define its efficacy, optima dosage, and mechanisms of action more precisely.
References
1. Panossian A, Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals (Basel). 2010, 3(1), 188–224. https://doi.org/10.3390/ph3010188
2. Panossian AG, Efferth T, Shikov AN, et al. Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases. Med Res Rev. 2021;41(1):630-703. https://doi.org/10.1002/med.21743
3. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017;1401(1):49-64. https://doi.org/10.1111/nyas.13399
4. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. https://doi.org/10.2174/157488409789375311
5. Kennedy DO, Scholey AB. The psychopharmacology of European herbs with cognition-enhancing properties. Curr Pharm Des. 2006;12(35):4613-4623. https://doi.org/10.2174/138161206779010387
6. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. 2009;16(6-7):617-622. https://doi.org/10.1016/j.phymed.2008.12.003
7. Szopa A, Ekiert R, Ekiert H. Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies. Phytochem Rev. 2017;16(2):195-218. https://doi.org/10.1007/s11101-016-9470-4
8. Zeng J, Tan M, Peng X, Luo Q. (2011). Standardization and Quality Control of Herbal Extracts and Products. Traditional Herbal Medicine Research Methods. 2011. https://doi.org/10.1002/9780470921340.ch9
9. Tóth-Mészáros A, Garmaa G, Hegyi P, Bánvölgyi A, Fenyves B, Fehérvári P, Harnos A, Gergő D, Nguyen Do To U, Csupor D. The effect of adaptogenic plants on stress: A systematic review and meta-analysis. Journal of Functional Foods. 2023;108,105695. https://doi.org/10.1016/j.jff.2023.105695
10. Bernatoniene J, Jakstas V, Kopustinskiene DM. Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases. Int J Mol Sci. 2023;24(15):12293. https://doi.org/10.3390/ijms241512293
11. Ivanova Stojcheva E, Quintela JC. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence. Molecules. 2022;27(12):3902. https://doi.org/10.3390/molecules27123902
12. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493. https://doi.org/10.1016/j.phymed.2010.02.002
13. Chiang HM, Chen HC, Wu CS, Wu PY, Wen KC. Rhodiola plants: Chemistry and biological activity. J Food Drug Anal. 2015;23(3):359-369. https://doi.org/10.1016/j.jfda.2015.04.007
14. Ganzera M, Yayla Y, Khan IA. Analysis of the marker compounds of Rhodiola rosea L. (golden root) by reversed phase high performance liquid chromatography. Chem Pharm Bull (Tokyo). 2001;49(4):465-467. https://doi.org/10.1248/cpb.49.465
15. Elameen A, Kosman VM, Thomsen M, Pozharitskaya ON, Shikov AN. Variability of Major Phenyletanes and Phenylpropanoids in 16-Year-Old Rhodiola rosea L. Clones in Norway. Molecules. 2020;25(15):3463. https://doi.org/10.3390/molecules25153463
16. Panossian A, Hambardzumyan M, Hovhanissyan A, Wikman G. The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol. Drug Target Insights. 2007;2:39-54. https://doi.org/10.1177/117739280700200011
17. Ivanova Stojcheva E, Quintela JC. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence. Molecules. 2022;27(12):3902. https://doi.org/10.3390/molecules27123902
18. Lee Y, Jung JC, Jang S, et al. Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea. Evid Based Complement Alternat Med. 2013;2013:514049. https://doi.org/10.1155/2013/514049
19. Xu W, Yang T, Zhang J, Li H, Guo M. Rhodiola rosea: a review in the context of PPPM approach. EPMA J. 2024;15(2):233-259. https://doi.org/10.1007/s13167-024-00367-3
20. Pu WL, Zhang MY, Bai RY, et al. Anti-inflammatory effects of Rhodiola rosea L.: A review. Biomed Pharmacother. 2020;121:109552. https://doi.org/10.1016/j.biopha.2019.109552
21. Zhang N, Nao J, Dong X. Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies. J Agric Food Chem. 2023;71(46):17597-17614. https://doi.org/10.1021/acs.jafc.3c06672
22. Zhuang W, Yue L, Dang X, et al. Rosenroot (Rhodiola): Potential Applications in Aging-related Diseases. Aging Dis. 2019;10(1):134-146. https://doi.org/10.14336/AD.2018.0511
23. Wang H, Li Q, Sun S, Chen S. Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer's Disease. Cell Mol Neurobiol. 2020;40(7):1133-1142. https://doi.org/10.1007/s10571-020-00801-w
24. Gerbarg PL, Brown RP. Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator. Phytomedicine. 2016;23(7):763-769. https://doi.org/10.1016/j.phymed.2015.11.013
25. Calcabrini C, De Bellis R, Mancini U, et al. Rhodiola rosea ability to enrich cellular antioxidant defences of cultured human keratinocytes. Arch Dermatol Res. 2010;302(3):191-200. https://doi.org/10.1007/s00403-009-0985-z
26. Chen Y, Tang M, Yuan S, et al. Rhodiola rosea: A Therapeutic Candidate on Cardiovascular Diseases. Oxid Med Cell Longev. 2022;2022:1348795. https://doi.org/10.1155/2022/1348795
27. Leung SB, Zhang H, Lau CW, Huang Y, Lin Z. Salidroside improves homocysteine-induced endothelial dysfunction by reducing oxidative stress. Evid Based Complement Alternat Med. 2013;2013:679635. https://doi.org/10.1155/2013/679635
28. Zhou Q, Han X, Li R, et al. Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function. Phytomedicine. 2018;51:171-180. https://doi.org/10.1016/j.phymed.2018.10.002
29. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells. Front Neurosci. 2012;6:6. https://doi.org/10.3389/fnins.2012.00006
30. Dimpfel W, Schombert L, Panossian AG. Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory. Front Pharmacol. 2018;9:425. https://doi.org/10.3389/fphar.2018.00425
31. Yang Z, Huang X, Lai W, et al. Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. Eur J Med Chem. 2021;209:112935. https://doi.org/10.1016/j.ejmech.2020.112935
32. Dinel AL, Guinobert I, Lucas C, et al. Reduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract. Food Sci Nutr. 2019;7(11):3827-3841. https://doi.org/10.1002/fsn3.1249
33. Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75(2):105-112. https://doi.org/10.1055/s-0028-1088346
34. Burns J. Common herbs for stress: The science and strategy of a botanical medicine approach to self-care. J Interprof Educ Pract. 2023;30:100592. https://doi.org/10.1016/j.xjep.2022.100592
35. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression [published correction appears in Nord J Psychiatry. 2007;61(6):503]. Nord J Psychiatry. 2007;61(5):343-348. https://doi.org/10.1080/08039480701643290
36. Mao JJ, Xie SX, Zee J, et al. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine. 2015;22(3):394-399. https://doi.org/10.1016/j.phymed.2015.01.010
37. Gao L, Wu C, Liao Y, Wang J. Antidepressants effects of Rhodiola capsule combined with sertraline for major depressive disorder: A randomized double-blind placebo-controlled clinical trial. J Affect Disord. 2020;265:99-103. https://doi.org/10.1016/j.jad.2020.01.065
38. Mao JJ, Li QS, Soeller I, Xie SX, Amsterdam JD. Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial. J Clin Trials. 2014;4:170. https://doi.org/10.4172/2167-0870.1000170
39. Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. World J Biol Psychiatry. 2022;23(6):424-455. https://doi.org/10.1080/15622975.2021.2013041
40. Amsterdam JD, Panossian AG. Rhodiola rosea L. as a putative botanical antidepressant. Phytomedicine. 2016;23(7):770-783. https://doi.org/10.1016/j.phymed.2016.02.009
41. Ishaque S, Shamseer L, Bukutu C, Vohra S. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med. 2012;12:70. https://doi.org/10.1186/1472-6882-12-70
42. Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. 2015;29(12):1934-1939. https://doi.org/10.1002/ptr.5486
43. Li Y, Pham V, Bui M, et al. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Rep. 2017;3(6):384-395. https://doi.org/10.1007/s40495-017-0106-1
44. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. 2008;14(2):175-180. https://doi.org/10.1089/acm.2007.7117
45. Lu Y, Deng B, Xu L, Liu H, Song Y, Lin F. Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review [published correction appears in Front Nutr. 2022 Jun 20;9:928909. https://doi.org/10.3389/fnut.2022.856287
46. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000;7(2):85-89. https://doi.org/10.1016/S0944-7113(00)80078-1
47. Tinsley GM, Jagim AR, Potter GDM, Garner D, Galpin AJ. Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature. Br J Nutr. 2024;131(3):461-473. https://doi.org/10.1017/S0007114523001988
48. Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011;21(12):841-860. https://doi.org/10.1016/j.euroneuro.2011.04.002
49. Ma GP, Zheng Q, Xu MB, et al. Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Front Pharmacol. 2018;9:1415. https://doi.org/10.3389/fphar.2018.01415
50. Li T, Zhang W, Kang X, et al. Salidroside protects dopaminergic neurons by regulating the mitochondrial MEF2D-ND6 pathway in the MPTP/MPP+ -induced model of Parkinson's disease. J Neurochem. 2020;153(2):276-289. https://doi.org/10.1111/jnc.14868
51. Chen Y, Tang M, Yuan S, et al. Rhodiola rosea: A Therapeutic Candidate on Cardiovascular Diseases. Oxid Med Cell Longev. 2022;2022:1348795. https://doi.org/10.1155/2022/1348795
52. Drafi F, Bauerova K, Chrastina M, et al. Rhodiola rosea L. Extract, a Known Adaptogen, Evaluated in Experimental Arthritis. Molecules. 2023;28(13):5053. https://doi.org/10.3390/molecules28135053
53. Zhong ZF, Han J, Zhang JZ, et al. Neuroprotective Effects of Salidroside on Cerebral Ischemia/Reperfusion-Induced Behavioral Impairment Involves the Dopaminergic System. Front Pharmacol. 2019;10:1433. https://doi.org/10.3389/fphar.2019.01433
54. Li X, Chen W, Xu Y, et al. Quality Evaluation of Randomized Controlled Trials of Rhodiola Species: A Systematic Review. Evid Based Complement Alternat Med. 2021;2021:9989546. https://doi.org/10.1155/2021/9989546
55. Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011;18(4):235-244. https://doi.org/10.1016/j.phymed.2010.08.014
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Copyright (c) 2025 Karolina Kutnik, Gabriela Sikora, Martyna Woźniak, Karolina Koguc, Karolina Kusibab, Michał Czechowski, Gabriela Skórska, Marcela Słomianny, Karolina Kolada, Małgorzata Sajda
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