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Quality in Sport

Exploring Rhodiola rosea: A Comprehensive Review of Its Adaptogenic Effects and Medical Relevance
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Exploring Rhodiola rosea: A Comprehensive Review of Its Adaptogenic Effects and Medical Relevance

Authors

  • Marta Głąbień Medical University of Lodz https://orcid.org/0009-0003-8910-7647
  • Aleksandra Rajewska Medical University of Łódź https://orcid.org/0009-0005-5898-5804
  • Anna Kuśnierz Provincial Multidisciplinary Center of Oncology and Traumatology named after M. Copernicus University in Łódź https://orcid.org/0009-0005-2983-4986
  • Karolina Kusiak Central Clinical Hospital of the Medical University of Lodz https://orcid.org/0009-0008-0667-8097
  • Daria Aleksandrowicz Norbert Barlicki Memorial Teaching Hospital No. 1 of the Medical University of Łódź https://orcid.org/0009-0004-5249-6092
  • Olga Wieczorek Norbert Barlicki Memorial Teaching Hospital No. 1 of the Medical University of Łódź https://orcid.org/0009-0002-1973-6547
  • Zofia Jakubczak Central Clinical Hospital of Medical University of Lodz https://orcid.org/0009-0002-8166-330X
  • Maria Weronika Zimniak Independent Public Health Care Facility of the Ministry of Internal Affairs and Administration https://orcid.org/0009-0005-6048-7791
  • Patryk Śliwiak K. Jonscher Hospital https://orcid.org/0009-0000-7484-8045
  • Aneta Kondratowicz K. Jonscher Hospital https://orcid.org/0009-0002-6548-2525

DOI:

https://doi.org/10.12775/QS.2024.29.55631

Keywords

rhodiola rosea, adaptogen, diabetes, cardiovascular diseases, neurological disease

Abstract

Introduction

Rhodiola rosea L. is an adaptogen with an international reach, widely used in modern medicine. Scientific studies indicate that extracts obtained from Rhodiola rosea L. have a beneficial effect on various pathological conditions, including circulatory system diseases, neurological disorders and metabolic ailments. The wide range of applications of these compounds, combined with potentially low toxicity, makes Rhodiola rosea L. a promising candidate for integration in therapies supporting the treatment of diseases affecting various body systems. The aim of this review is to analyze contemporary research on the potential properties of Rhodiola rosea L., as well as to establish the foundation for further research and development of preparations based on this plant.

 

Materials and Methods

The review was conducted by searching PubMed and other scientific databases focusing on currently available publications. The literature available in the PubMed database was reviewed using the following keywords: “rhodiola rosea”, “adaptogen”, "cardiovascular diseases”, “neurological diseases”, “diabetes”. The analysis of 45 articles published between 1998-2023 was used to write the paper.

References

Stace, C. A. (2010). New Flora of the British Isles (Third ed.). Cambridge, U.K.: Cambridge University Press. ISBN 9780521707725

Li Y, Pham V, Bui M, et al. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Rep. 2017;3(6):384-395. doi:10.1007/s40495-017-0106-1

Moran, Reid V, in Flora of North America. volume 8. pages 164-167

A. Panossian, G. Wikman, J. Sarris, Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy,Phytomedicine,Volume 17, Issue 7,2010,Pages 481-493, ISSN 0944-7113,https://doi.org/10.1016/j.phymed.2010.02.002.

Evstavieva L.; Todorova M.; Antonova D.; Staneva J. (2010). "Chemical composition of the essential oils of Rhodiola rosea L. of three different origins". Pharmacogn Mag. 6 (24): 256–258. doi:10.4103/0973-1296.71782

Brown, Richard & Gerbarg, Patricia & Ramazanov, Zakir. (2002). Rhodiola rosea: A Phytomedicinal Overview. Herbal Gram. 56.

Panossian, A.; Wikman, G.; Sarris, J. Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine 2010, 17, 481–493.

Lian-ying Liao i inni, A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide, „Chinese Medicine”, 13, 2018

Sophia E. Gerontakos i inni, A Critical Review to Identify the Domains Used to Measure the Effect and Outcome of Adaptogenic Herbal Medicines, „The Yale Journal of Biology and Medicine”, 93, 2020

Xu W, Larbi A. Immunity and Inflammation: From Jekyll to Hyde. Exp Gerontol. 2018;107:98-101. doi:10.1016/j.exger.2017.11.018

Coors A, Brosch M, Kahl E, et al. Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating. J Ethnopharmacol. 2019;235:320-328. doi:10.1016/j.jep.2019.02.031

Jin M, Wang C, Xu Y, et al. Pharmacological effects of salidroside on central nervous system diseases. Biomed Pharmacother. 2022;156:113746. doi:10.1016/j.biopha.2022.113746

Tao H, Wu X, Cao J, et al. Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study. Med Res Rev. 2019;39(5):1779-1850. doi:10.1002/med.21564

Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res. 2007;21(1):37-43. doi:10.1002/ptr.2013

Carlini EA. Plants and the central nervous system. Pharmacol Biochem Behav. 2003;75(3):501-512. doi:10.1016/s0091-3057(03)00112-6

Nabavi SF, Braidy N, Orhan IE, Badiee A, Daglia M, Nabavi SM. Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy. Phytother Res. 2016;30(4):532-539. doi:10.1002/ptr.5569

Zhou, Z.D., Yi, L.X., Wang, D.Q. et al. Role of dopamine in the pathophysiology of Parkinson’s disease. Transl Neurodegener 12, 44 (2023). https://doi.org/10.1186/s40035-023-00378-6

Bernatoniene J, Jakstas V, Kopustinskiene DM. Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases. Int J Mol Sci. 2023;24(15):12293. Published 2023 Jul 31. doi:10.3390/ijms241512293

Zhao HB, Ma H, Ha XQ, et al. Salidroside induces rat mesenchymal stem cells to differentiate into dopaminergic neurons. Cell Biol Int. 2014;38(4):462-471. doi:10.1002/cbin.10217

Panza i inni, A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease, „Nat Rev Neurol”, 2019

Tiraboschi P, Hansen LA, Thal LJ, Corey-Bloom J. The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology. 2004;62(11):1984-1989. doi:10.1212/01.wnl.0000129697.01779.0a

Liao ZL, Su H, Tan YF, et al. Salidroside protects PC-12 cells against amyloid β-induced apoptosis by activation of the ERK1/2 and AKT signaling pathways. Int J Mol Med. 2019;43(4):1769-1777. doi:10.3892/ijmm.2019.4088

Nabavi SF, Braidy N, Orhan IE, Badiee A, Daglia M, Nabavi SM. Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy. Phytother Res. 2016;30(4):532-539. doi:10.1002/ptr.5569

van Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann K. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009;122(2):397-401. doi:10.1016/j.jep.2009.01.007

Rother KI. Diabetes treatment--bridging the divide. N Engl J Med. 2007;356(15):1499-1501. doi:10.1056/NEJMp078030

Bai XL, Deng XL, Wu GJ, Li WJ, Jin S. Rhodiola and salidroside in the treatment of metabolic disorders. Mini Rev Med Chem. 2019;19(19):1611-1626. doi:10.2174/1389557519666190903115424

Zhao CC, Wu XY, Yi H, Chen R, Fan G. The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular and Metabolic Diseases: An Updated Review. Chem Biodivers. 2021;18(7):e2100033. doi:10.1002/cbdv.202100033

Jafari M, Juanson Arabit JG, Courville R, et al. The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model. Sci Rep. 2022;12(1):10581. Published 2022 Jun 22. doi:10.1038/s41598-022-14241-7

Niu CS, Chen LJ, Niu HS. Antihyperglycemic action of rhodiola-aqeous extract in type1-like diabetic rats. BMC Complement Altern Med. 2014;14:20. Published 2014 Jan 13. doi:10.1186/1472-6882-14-20

Yuan S, Liu J, Sun Z, et al. Effects of Self-Made Prescription Compound Rhodiola on the Ultrastructure of Podocytes in Rats with Type 2 Diabetic Nephropathy [retracted in: Emerg Med Int. 2024 Jan 24;2024:9875324. doi: 10.1155/2024/9875324]. Emerg Med Int. 2022;2022:3417557. Published 2022 Jun 22. doi:10.1155/2022/3417557

Zhao D, Sun X, Lv S, et al. Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway. Int J Mol Med. 2019;43(6):2279-2290. doi:10.3892/ijmm.2019.4153

Wang ZS, Gao F, Lu FE. Effect of ethanol extract of Rhodiola rosea on the early nephropathy in type 2 diabetic rats. J Huazhong Univ Sci Technolog Med Sci. 2013;33(3):375-378. doi:10.1007/s11596-013-1127-6

Dehghan, M., Mente, A., Zhang, X., Swaminathan, S., Li, W., Mohan, V., Iqbal, R., Kumar, R., Wentzel-Viljoen, E., Rosengren, A., Amma, L. I., Avezum, A., Chifamba, J., Diaz, R., Khatib, R., Lear, S., Lopez-Jaramillo, P., Liu, X., Gupta, R., Mohammadifard, N., … Prospective Urban Rural Epidemiology (PURE) study investigators (2017). Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. Lancet (London, England), 390(10107), 2050–2062. https://doi.org/10.1016/S0140-6736(17)32252-3

Gao, Q., & Shao, M. (2017). Salidroside improve the contractoin and dilatation function of vascular endotheliocyte. Shaanxi Medical Journal, 46(2), 304-306. [Google Scholar]

Leung, S. B., Zhang, H., Lau, C. W., Huang, Y., & Lin, Z. (2013). Salidroside improves homocysteine-induced endothelial dysfunction by reducing oxidative stress. Evidence-based complementary and alternative medicine : eCAM, 2013, 679635. https://doi.org/10.1155/2013/679635

Gupta, V., Lahiri, S. S., Sultana, S., Tulsawani, R. K., & Kumar, R. (2010). Anti-oxidative effect of Rhodiola imbricata root extract in rats during cold, hypoxia and restraint (C-H-R) exposure and post-stress recovery. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(4), 1019–1025. https://doi.org/10.1016/j.fct.2010.01.012

Haunstetter, A., & Izumo, S. (1998). Apoptosis: basic mechanisms and implications for cardiovascular disease. Circulation research, 82(11), 1111–1129. https://doi.org/10.1161/01.res.82.11.1111

Foo, R. S., Mani, K., & Kitsis, R. N. (2005). Death begets failure in the heart. The Journal of clinical investigation, 115(3), 565–571. https://doi.org/10.1172/JCI24569

Zhong, H., Xin, H., Wu, L. X., & Zhu, Y. Z. (2010). Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. Journal of pharmacological sciences, 114(4), 399–408. https://doi.org/10.1254/jphs.10078fp

Zhu, L., Wei, T., Gao, J., Chang, X., He, H., Luo, F., Zhou, R., Ma, C., Liu, Y., & Yan, T. (2015). The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation. Apoptosis : an international journal on programmed cell death, 20(11), 1433–1443. https://doi.org/10.1007/s10495-015-1174-5

Cheng, Y. Z., Chen, L. J., Lee, W. J., Chen, M. F., Jung Lin, H., & Cheng, J. T. (2012). Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats. Journal of ethnopharmacology, 144(2), 234–239. https://doi.org/10.1016/j.jep.2012.08.029

Hsiao, Y. W., Tsai, Y. N., Huang, Y. T., Liu, S. H., Lin, Y. J., Lo, L. W., Hu, Y. F., Chung, F. P., Lin, S. F., Chang, S. L., Higa, S., & Chen, S. A. (2021). Rhodiola crenulata reduces ventricular arrhythmia through mitigating the activation of IL-17 and inhibiting the MAPK signaling pathway. Cardiovascular drugs and therapy, 35(5), 889–900. https://doi.org/10.1007/s10557-020-07072-z

Zhang, B. C., Li, W. M., Guo, R., & Xu, Y. W. (2012). Salidroside decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice. Evidence-based complementary and alternative medicine : eCAM, 2012, 607508. https://doi.org/10.1155/2012/607508

Liu, S. H., Hsiao, Y. W., Chong, E., Singhal, R., Fong, M. C., Tsai, Y. N., Hsu, C. P., Chen, Y. C., Chen, Y. J., Chiou, C. W., Chiang, S. J., Chang, S. L., & Chen, S. A. (2016). Rhodiola Inhibits Atrial Arrhythmogenesis in a Heart Failure Model. Journal of cardiovascular electrophysiology, 27(9), 1093–1101. https://doi.org/10.1111/jce.13026

Lee, W. J., Chung, H. H., Cheng, Y. Z., Lin, H. J., & Cheng, J. T. (2013). Rhodiola-water extract induces β-endorphin secretion to lower blood pressure in spontaneously hypertensive rats. Phytotherapy research : PTR, 27(10), 1543–1547. https://doi.org/10.1002/ptr.4900

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Published

2024-10-26

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GŁĄBIEŃ, Marta, RAJEWSKA, Aleksandra, KUŚNIERZ, Anna, KUSIAK, Karolina, ALEKSANDROWICZ, Daria, WIECZOREK, Olga, JAKUBCZAK, Zofia, ZIMNIAK, Maria Weronika, ŚLIWIAK , Patryk and KONDRATOWICZ, Aneta. Exploring Rhodiola rosea: A Comprehensive Review of Its Adaptogenic Effects and Medical Relevance. Quality in Sport. Online. 26 October 2024. Vol. 29, p. 55631. [Accessed 25 December 2025]. DOI 10.12775/QS.2024.29.55631.
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Vol. 29 (2024)

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Copyright (c) 2024 Marta Głąbień, Aleksandra Rajewska, Anna Kuśnierz, Karolina Kusiak, Daria Aleksandrowicz, Olga Wieczorek, Zofia Jakubczak, Maria Weronika Zimniak, Patryk Śliwiak , Aneta Kondratowicz

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