The role of the ketogenic diet in the treatment and prevention of diseases: A literature review
DOI:
https://doi.org/10.12775/QS.2024.34.55222Keywords
ketogenic diet, cardiovascular, weight loss, cancer, DiabetesAbstract
In recent years the ketogenic diet (KD) has become more and more popular. This diet is used not only to reduce weight but also there are an increasingly amount of new researches with multiple possitives effects in some diseases, such as prevention in cardiovascular conditions, diabetes mellitus, obstructive sleep apnea syndrome, some types of cancers and psoriasis. This paper offers an overview of these various medical conditions in which ketogenic diet can be used. Furthermore we describe the mechanism and potential efficacy of the KD. The PubMed and Google Scholar databases were searched.
References
https://ncez.pzh.gov.pl/choroba-a-dieta/dieta-ketogenna/
Paoli, A. Ketogenic diet for obesity: Friend or foe? Int. J. Environ. Res. Public Health 2014, 11, 2092–2107.
James W. Wheless, M.D. : History of the ketogenic diet, Pediatric Neurology, St. Jude Children's Research Hospital, 777 Washington Avenue, Ste. P-335, Memphis, TN 38105, USA https://doi.org/10.1111/j.1528-1167.2008.01821.x
Geyelin HR. (1921) Fasting as a method for treating epilepsy. Med Rec 99: 1037–1039.
Wilder RM. (1921) The effect on ketonemia on the course of epilepsy. Mayo Clin Bull 2: 307.
Woodyatt RT. (1921) Objects and method of diet adjustment in diabetics. Arch Intern Med 28: 125–141.
Atkins RC., Dr. Atkins’ Diet Revolution; the High Calorie Way to Stay Thin Forever. D. McKay Co; 1972. [Accessed December 14, 2021.
Daniela D. Weber, Sepideh Aminzadeh-Gohari, Julia Tulipan, Luca Catalano, René G. Feichtinger, Barbara Kofler* Ketogenic diet in the treatment of cancer e Where do we stand?
Peterman MG. The ketogenic diet in epi- lepsy. JAMA. 1925;84(26):1979-1983
Kossoff, E.H., Zupec-Kania, B.A., Auvin, S., Ballaban-Gil, K.R., Christina Bergqvist, A.G., Blackford, R., et al., 2018. Optimal clinical management of children receiving dietary therapies for epilepsy: updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open 3:175e192.
Sills MA, Forsythe WI, Haidukewych D, MacDonald A, Robinson M. The medium- chain triglyceride diet and intractable epilepsy. Arch Disease Child. 1986;61(12): 1169-1172.
Shah, N.D., Limketkai, B.N., 2017. The use of medium-chain triglycerides in gastrointestinal disorders. Practical Gastroenterology 41:20e28.
Huttenlocher, P.R., Wilbourn, A.J., Signore, J.M., 1971. Medium-chain tri- glycerides as a therapy for intractable childhood epilepsy. Neurology 21: 1097e1103.
Page, K.A., Williamson, A., Yu, N.Y., McNay, E.C., Dzuira, J., McCrimmon, R.J., et al., 2009. Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes 58:1237e1244.
Kossoff, E.H., Dorward, J.L., 2008. The modified Atkins diet. Epilepsia 49: 37e41
Auvin, S., 2012. Should we routinely use modified Atkins diet instead of regular ketogenic diet to treat children with epilepsy? Seizure European Journal of Epilepsy 21:237e240.
Pfeifer HH, Thiele EA. Low-glycemic- index treatment: A liberalized ketogenic diet for treatment of intractable epilepsy. Neurology. 2005;65(11):1810-1812
Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N. Lancet. Endometrial cancer. 2022 Apr 9;399(10333):1412-1428. doi: 10.1016/S0140-6736(22)00323-3.
Bueno, N.B.; de Melo, I.S.; de Oliveira, S.L.; da Rocha Ataide, T. Very-low-carbohydrate ketogenic diet v. Low-fat diet for long-term weight loss: A meta-analysis of randomised controlled trials. Br. J. Nutr. 2013, 110, 1178–1187.
Mansoor N, Vinknes KJ, Veierod MB, Retterstol K. Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials. Br J Nutr. 2016;115(3):466–479. doi: 10.1017/S0007114515004699.
Atkins RC., Dr. Atkins’ Diet Revolution; the High Calorie Way to Stay Thin Forever. D. McKay Co; 1972.
McGaugh E, Barthel B A Review of Ketogenic Diet and Lifestyle Mo Med. 2022 Jan-Feb;119(1):84-88
Johnstone, A.M.; Horgan, G.W.; Murison, S.D.; Bremner, D.M.; Lobley, G.E. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. Amer. J. Clin. Nutr. 2008, 87, 44–55.
Sumithran, P.; Prendergast, L.A.; Delbridge, E.; Purcell, K.; Shulkes, A.; Kriketos, A.; Proietto, J. Ketosis and appetite-mediating nutrients and hormones after weight loss. Eur. J. Clin. Nutr. 2013, 67, 759–764.
Fine, E.J.; Feinman, R.D. Thermodynamics of weight loss diets. Nutr. Metab. 2004, 1.
Cahill, G.F., Jr. Fuel metabolism in starvation. Annu. Rev. Nutr. 2006, 26, 1–22.
Feinman, R.D.; Fine, E.J. Nonequilibrium thermodynamics and energy efficiency in weight loss diets. Theor. Biol. Med. Model. 2007, 4.
Sharman MJ, Gomez AL, Kraemer WJ, Volek JS. Very Low-Carbohydrate and Low-Fat Diets Affect Fasting Lipids and Postprandial Lipemia Differently in Overweight Men. J Nutr. 2004;134(4):880–885. doi: 101093/jn/134.4.880.
Zheng Y, Ley SH, Hu FB Global aetiology and epidemiology of type 2 diabetes mellitus and its complications Nat Rev Endocrinol. 2018 Feb;14(2):88-98. doi: 10.1038/nrendo.2017.151. Epub 2017 Dec 8.
Zhou, C.; Wang, M.; Liang, J.; He, G.; Chen, N. Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails. Int. J. Environ. Res. Public Health 2022, 19, 10429. https://doi.org/10.3390/ijerph19161042
Goday, A.; Bellido, D.; Sajoux, I.; Crujeiras, A.B.; Burguera, B.; García-Luna, P.P.; Oleaga, A.; Moreno, B.; Casanueva, F.F. Short-Term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus. Nutr. Diabetes 2016, 6, e230.
Tay, J.; Luscombe-Marsh, N.D.; Thompson, C.H.; Noakes, M.; Buckley, J.D.; Wittert, G.A.; Yancy, W.S., Jr.; Brinkworth, G.D. Comparison of low- and high-carbohydrate diets for type 2 diabetes management: A randomized trial. Am. J. Clin. Nutr. 2015, 102, 780–790
Westman, E.C.; Yancy, W.S., Jr.; Mavropoulos, J.C.; Marquart, M.; McDuffie, J.R. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr. Metab. 2008, 5, 36.
Saslow, L.R.; Kim, S.; Daubenmier, J.J.; Moskowitz, J.T.; Phinney, S.D.; Goldman, V.; Murphy, E.J.; Cox, R.M.; Moran, P.; Hecht, F.M. A randomized pilot trial of a moderate carbohydrate diet compared to a very low carbohydrate diet in overweight or obese individuals with type 2 diabetes mellitus or prediabetes. PLoS ONE 2014, 9, e9102
Saslow, L.R.; Daubenmier, J.J.; Moskowitz, J.T.; Kim, S.; Murphy, E.J.; Phinney, S.D.; Ploutz-Snyder, R.; Goldman, V.; Cox, R.M.; Mason, A.E.; et al. Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutr. Diabetes 2017, 7, 304.
Yancy WS, Foy M, Chalecki AM, Vernon MC, Westman EC. A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutr Metab. 2005;2(1):34. doi: 10.1186/1743-7075-2-34.
Goldenberg JZ, Day A, Brinkworth GD, Sato J, Yamada S, Jönsson T, et al. Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data. BMJ. 2021;372:m4743. doi: 10.1136/bmj.m4743.
Dyńka, D.; Kowalcze, K.; Charuta, A.; Paziewska, A. The Ketogenic Diet and Cardiovascular Diseases. Nutrients 2023, 15, 3368. https://doi.org/10.3390/nu15153368
Gardner, C.D.; Landry, M.J.; Perelman, D.; Petlura, C.; Durand, L.R.; Aronica, L.; Crimarco, A.; Cunanan, K.M.; Chang, A.; Dant, C.C.; et al. Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: The interventional Keto-Med randomized crossover trial. Am. J. Clin. Nutr. 2022, 116, 640–652, Erratum in Am. J. Clin. Nutr. 2022, 116, 1904.
Schiavo, L.; Pierro, R.; Asteria, C.; Calabrese, P.; Di Biasio, A.; Coluzzi, I.; Severino, L.; Giovanelli, A.; Pilone, V.; Silecchia, G. Low-Calorie Ketogenic Diet with Continuous Positive Airway Pressure to Alleviate Severe Obstructive Sleep Apnea Syndrome in Patients with Obesity Scheduled for Bariatric/Metabolic Surgery: A Pilot, Prospective, Randomized Multicenter Comparative Study. Obes. Surg. 2022, 32, 634–642.
Vidić, V.; Ilić, V.; Toskić, L.; Janković, N.; Ugarković, D. Effects of calorie restricted low carbohydrate high fat ketogenic vs. non-ketogenic diet on strength, body-composition, hormonal and lipid profile in trained middle-aged men. Clin. Nutr. 2021, 40, 1495–1502.
Du, Z.; Qin, Y. Dyslipidemia and Cardiovascular Disease: Current Knowledge, Existing Challenges, and New Opportunities for Management Strategies. J. Clin. Med. 2023, 12, 363. https://doi.org/10.3390/jcm12010363
Ravnskov U, Diamond DM, Hama R, Hamazaki T, Hammarskjöld B, Hynes N, Kendrick M, Langsjoen PH, Malhotra A, Mascitelli L, McCully KS, Ogushi Y, Okuyama H, Rosch PJ, Schersten T, Sultan S, Sundberg R. Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review BMJ Open. 2016 Jun 12;6(6):e010401. doi: 10.1136/bmjopen-2015-010401.
Fiordelisi, A.; Iaccarino, G.; Morisco, C.; Coscioni, E.; Sorriento, D. NFkappaB is a Key Player in the Crosstalk between Inflammation Cardiovascular Diseases. Int. J. Mol. Sci. 2019, 20, 1599
Brigant, B.; Metzinger-Le Meuth, V.; Rochette, J.; Metzinger, L. TRIMming down to TRIM37: Relevance to Inflammation, Cardiovascular Disorders, and Cancer in MULIBREY Nanism. Int. J. Mol. Sci. 2018, 20, 67.
Poff, A.; Kesl, S.; Koutnik, A.; Ward, N.; Ari, C.; Deblasi, J.; D’Agostino, D. Characterizing the metabolic effects of exogenous ketone supplementation—An alternative or adjuvant to the ketogenic diet. FASEB J. 2017, 31, 970.7.
Jiang, H.; Wang, L.; Wang, D.; Yan, N.; Li, C.; Wu, M.; Wang, F.; Mi, B.; Chen, F.; Jia, W.; et al. Omega-3 polyunsaturated fatty acid biomarkers and risk of type 2 diabetes, cardiovascular disease, cancer, and mortality. Clin. Nutr. 2022, 41, 1798–1807
Yang, B.; Tseng, P.T.; Hu, X.; Zeng, B.Y.; Chang, J.P.; Liu, Y.; Chu, W.J.; Zhang, S.S.; Zhou, Z.L.; Chu, C.S.; et al. Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials. Prog. Lipid Res. 2022, 88, 101196, Erratum in Prog. Lipid Res. 2022, 101206.
Nasser, S.; Vialichka, V.; Biesiekierska, M.; Balcerczyk, A.; Pirola, L. Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters. World J. Diabetes 2020, 11, 584–595.
Klement, R.J., Schäfer, G., Sweeney, R.A., 2019. A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy: an interim analysis of the KETOCOMP study. Journal of Traditional and Complementary Medicine
Ewa Duchnik, Joanna Kruk, Aleksandra Tuchowska and Mariola Marchlewicz : The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence Nutrients 2023, 15(4), 840; https://doi.org/10.3390/nu15040840
Castaldo, G.; Pagano, I.; Grimaldi, M.; Marino, C.; Molettieri, P.; Santoro, A.; Stillitano, I.; Romano, R.; Montoro, P.; D’Ursi, A.M.; et al. Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study. J. Proteome Res. 2021, 20, 1509–1521.
Barrea, L.; Megna, M.; Cacciapuoti, S.; Frias-Toral, E.; Fabbrocini, G.; Savastano, S.; Colao, A.; Muscogiuri, G. Very low-calorie ketogenic diet (VLCKD) in patients with psoriasis and obesity: An update for dermatologists and nutritionists. Crit. Rev. Food Sci. Nutr. 2022, 62, 398–414.
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Copyright (c) 2024 Dawid Barański, Piotr Węgrzyn, Konstancja Węgrzyn, Agnieszka Góra, Anna Salińska, Marcin Wasilewski, Julia Skwara, Maciej Nowicki, Gustaw Laskowski, Natalia Dąbrowska
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