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Quality in Sport

The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications: The importance of stem cells in diabetology
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The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications

The importance of stem cells in diabetology

Authors

  • Monika Kamińska Provincial Hospital in Kielce, 45 Grunwaldzka Street, 25-736 Kielce, Poland https://orcid.org/0000-0003-4968-9219
  • Maria Jasiewicz Medical Center in Łańcut, 5 Paderewskiego Street, 37-100 Łańcut, Poland https://orcid.org/0009-0008-0718-2528
  • Magdalena Miernik-Skrzypczak Lower Silesian Center for Oncology, Pulmonology, and Hematology, 12 Hirszfeld Square, 53-413 Wrocław, Poland https://orcid.org/0009-0004-0987-1686
  • Aleksandra Spyra Silesian Centre for Heart Diseases, 9 Marii Curie Skłodowskiej Street, 41-800 Zabrze, Poland https://orcid.org/0009-0007-2288-6411
  • Marta Malicka University Hospital in Wrocław, 213 Borowska Street, 50-556 Wrocław, Poland https://orcid.org/0009-0009-1955-6512
  • Natalia Dąbrowska Military Institute of Medicine - National Research Institute: Warsaw, 128 Szaserów Street, 04-141 Warszawa, Poland https://orcid.org/0009-0009-7170-0614
  • Aleksandra Kozioł University Hospital in Wrocław, 213 Borowska Street, 50-556 Wrocław, Poland https://orcid.org/0009-0008-8692-0647
  • Katarzyna Moczyróg The Sergeant Grzegorz Załoga Hospital of the Ministry of the Interior and Administration, ul. Wita Stwosza 39-41, 40-042 Katowice, Poland https://orcid.org/0009-0002-3353-2444

DOI:

https://doi.org/10.12775/QS.2025.37.57420

Keywords

stem cells, diabetes mellitus type 1, diabetes mellitus type 2, diabetic retinopathy, wound

Abstract

Introduction and Purpose. Diabetes, characterized by hyperglycemia due to impaired insulin production or action, leads to significant complications like diabetic retinopathy (DR) and diabetic foot syndrome (DFS). Current treatments manage symptoms but do not fully address disease progression. Stem cells, with their regenerative potential and immunomodulatory properties, represent a promising avenue for treating diabetes and its complications. This study explores the use of stem cell therapy in managing type 1 and type 2 diabetes, DR, and DFS.

Material and Method. The study reviewed existing literature on the application of stem cells in diabetes treatment. More than 30 articles addressing these issues were analyzed. They were found using the PubMed search engine, and the time frame of these publications covered the last 20 years.

Results. Stem cells demonstrated significant potential in diabetes management. For type 1 diabetes, MSCs reduced inflammation, preserved pancreatic islet function, and decreased insulin requirements without major adverse effects. Pluripotent stem cells showed promise in islet transplantation, achieving stable glycemic control in clinical trials. In type 2 diabetes, stem cell therapy improved insulin sensitivity and reduced insulin dependency, with evidence of β-cell regeneration. Complications like diabetic foot ulcers and retinopathy also responded positively to stem cell treatments. MSCs improved wound healing by enhancing tissue regeneration and reducing inflammation, while retinal therapies showed promise in slowing disease progression and repairing damaged vasculature.

Conclusions. Stem cell therapies offer a promising approach for diabetes and its complications, particularly for regenerative applications in DR and DFS. While initial results are encouraging, further large-scale studies are needed to optimize protocols, assess long-term safety, and establish standardized clinical applications.

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Published

2025-01-14

How to Cite

1.
KAMIŃSKA, Monika, JASIEWICZ, Maria, MIERNIK-SKRZYPCZAK, Magdalena, SPYRA, Aleksandra, MALICKA, Marta, DĄBROWSKA, Natalia, KOZIOŁ, Aleksandra and MOCZYRÓG, Katarzyna. The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications: The importance of stem cells in diabetology. Quality in Sport. Online. 14 January 2025. Vol. 37, p. 57420. [Accessed 5 July 2025]. DOI 10.12775/QS.2025.37.57420.
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Vol. 37 (2025)

Section

Medical Sciences

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Copyright (c) 2025 Monika Kamińska, Maria Jasiewicz, Magdalena Miernik-Skrzypczak, Aleksandra Spyra, Marta Malicka, Natalia Dąbrowska, Aleksandra Kozioł, Katarzyna Moczyróg

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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