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Quality in Sport

Impact of physical activity on physical function and quality of life after liver transplantation
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  • Impact of physical activity on physical function and quality of life after liver transplantation
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Impact of physical activity on physical function and quality of life after liver transplantation

Authors

  • Jakub Wirkijowski https://orcid.org/0009-0007-9882-9341
  • Wiktoria Niegowska Independent Public Clinical Hospital of Prof. W. Orlowski, Czerniakowska 231, 00-401, Warsaw, Poland https://orcid.org/0009-0001-9843-8048
  • Wiktoria Gajek-Flanczewska Central Clinical Hospital, Banacha 1A, 02-097 Warsaw, Poland https://orcid.org/0009-0004-8875-433X
  • Sebastian Flanczewski Central Clinical Hospital, Banacha 1A, 02-097 Warsaw, Poland https://orcid.org/0009-0006-8461-2806
  • Agata Wiklińska Praski Hospital of the Transfiguration of the Lord, al. "Solidarności" 67, 03-401 Warsaw, Poland https://orcid.org/0009-0008-8758-5860
  • Martyna Śliwińska Military Institute of Medicine – National Research Institute, Szaserów 128, 04-141 Warsaw, Poland https://orcid.org/0009-0008-2757-5660
  • Katarzyna Wójtowicz Central Clinical Hospital, Banacha 1A, 02-097 Warsaw, Poland https://orcid.org/0009-0009-3914-7804
  • Agata Walczak National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507, Warsaw, Poland https://orcid.org/0009-0004-7023-634X
  • Aleksandra Jaroń Praski Hospital of the Transfiguration of the Lord, al. "Solidarności" 67, 03-401 Warsaw, Poland https://orcid.org/0009-0003-7877-5308
  • Karolina Piątkowska Health Care Complex of the District Hospital in Sochaczew, Batalionów Chłopskich 3/7 96-500 Sochaczew, Poland https://orcid.org/0009-0000-6750-7517

DOI:

https://doi.org/10.12775/QS.2024.31.55180

Keywords

liver transplantation, physical activity, physical performance, quality of life, frailty, sarcopenia

Abstract

Introduction and aim of the study: Liver-related diseases are very common in our society, and as a result, the number of people requiring liver transplantation is likewise increasing. In our research, we intended to analyze the topic of increasing survival rates and improving comfort along with the quality of life while waiting for a transplant, as well as in the postoperative period. We determined that we would investigate the impact of physical activity on risk factors that increase hospitalizations after surgery and decrease quality of life. We summarized the effect and type of exercise on sarcopenia, frailty, and their direct relation to the pre- and post-operative period of liver transplantation. In addition, we analyzed possible obstacles and difficulties arising from the implementation of physical activity in liver transplant recipients.

Materials and methods: The authors conducted an extensive review of articles available in PubMed, Google Scholar, UpToDate, Science Direct, and Cochrane databases. The keywords liver transplantation, physical activity, quality of life, sarcopenia, and frailty were the basis of the review. Studies published between 2001 and 2024 were included in the review.

Results: The vast majority of the studies emphasized the positive effects of exercise, particularly aerobic and resistance training, on improving the clinical conditions and well-being of liver transplant patients. The papers with inconsistent results nevertheless underscored the need to delve further into this topic. Thus, the overall evidence supports the inclusion of physical exercise in post-transplant care as a key strategy for improving health and quality of life.

Conclusion: Regular physical activity is beneficial for clinical outcomes and patients’ quality of life after liver transplantation.

References

Mahmud N. Selection for Liver Transplantation: Indications and Evaluation. Curr Hepatol Rep. 2020;19(3):203-12.

Fox AN, Brown RS, Jr. Is the patient a candidate for liver transplantation? Clin Liver Dis. 2012;16(2):435-48.

Hamoir C, Horsmans Y, Stärkel P, Dahlqvist G, Negrin Dastis S, Lanthier N. Risk of hepatocellular carcinoma and fibrosis evolution in hepatitis C patients with severe fibrosis or cirrhosis treated with direct acting antiviral agents. Acta Gastroenterol Belg. 2021;84(1):25-32.

Roerecke M, Vafaei A, Hasan OSM, Chrystoja BR, Cruz M, Lee R, et al. Alcohol Consumption and Risk of Liver Cirrhosis: A Systematic Review and Meta-Analysis. Am J Gastroenterol. 2019;114(10):1574-86.

Sangro P, de la Torre Aláez M, Sangro B, D'Avola D. Metabolic dysfunction-associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment. J Physiol Biochem. 2023;79(4):869-79.

Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011;377(9765):557-67.

Lanthier N, Vanuytsel T. Metabolic dysfunction-associated fatty liver disease: a new clearer nomenclature with positive diagnostic criteria. Acta Gastroenterol Belg. 2020;83(4):513-5.

Stine JG, Long MT, Corey KE, Sallis RE, Allen AM, Armstrong MJ, et al. Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the American College of Sports Medicine. Med Sci Sports Exerc. 2023;55(9):1717-26.

Gitto S, Golfieri L, Mannelli N, Tamè MR, Lopez I, Ceccato R, et al. Quality of life in liver transplant recipients during the Corona virus disease 19 pandemic: A multicentre study. Liver Int. 2022;42(7):1618-28.

Loschi TM, Baccan M, Della Guardia B, Martins PN, Boteon A, Boteon YL. Exercise training as an intervention for frailty in cirrhotic patients on the liver transplant waiting list: A systematic review. World J Hepatol. 2023;15(10):1153-63.

OPTN/SRTR 2022 Annual Data Report: Liver [Internet]. The Scientific Registry of Transplant Recipients 2022. Available from: https://srtr.transplant.hrsa.gov/annual_reports/2022/Liver.aspx.

Eurotransplant Statistics Report Library [Internet]. 2023. Available from: https://statistics.eurotransplant.org/.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412-23.

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31.

Tandon P, Mourtzakis M, Low G, Zenith L, Ney M, Carbonneau M, et al. Comparing the Variability Between Measurements for Sarcopenia Using Magnetic Resonance Imaging and Computed Tomography Imaging. Am J Transplant. 2016;16(9):2766-7.

Praktiknjo M, Book M, Luetkens J, Pohlmann A, Meyer C, Thomas D, et al. Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis. Hepatology. 2018;67(3):1014-26.

Lindqvist C, Brismar TB, Majeed A, Wahlin S. Assessment of muscle mass depletion in chronic liver disease: Dual-energy x-ray absorptiometry compared with computed tomography. Nutrition. 2019;61:93-8.

Sinclair M, Hoermann R, Peterson A, Testro A, Angus PW, Hey P, et al. Use of Dual X-ray Absorptiometry in men with advanced cirrhosis to predict sarcopenia-associated mortality risk. Liver Int. 2019;39(6):1089-97.

Lai JC, Tandon P, Bernal W, Tapper EB, Ekong U, Dasarathy S, et al. Malnutrition, Frailty, and Sarcopenia in Patients With Cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology. 2021;74(3):1611-44.

Abate M, Di Iorio A, Di Renzo D, Paganelli R, Saggini R, Abate G. Frailty in the elderly: the physical dimension. Eura Medicophys. 2007;43(3):407-15.

Goffaux A, Delorme A, Dahlqvist G, Lanthier N. Improving the prognosis before and after liver transplantation: Is muscle a game changer? World J Gastroenterol. 2022;28(40):5807-17.

Lim M, Kim JM, Yang J, Kwon J, Kim KD, Jeong ES, et al. Upper thigh skeletal muscle index predicts outcomes in liver transplant recipients. Ann Surg Treat Res. 2023;105(4):219-27.

Trovato FM, Artru F. Nutritional optimization in liver transplant patients: from the pre-transplant setting to post-transplant outcome. Acta Gastroenterol Belg. 2023;86(2):335-42.

Miarka M, Gibiński K, Janik MK, Główczyńska R, Zając K, Pacho R, et al. Sarcopenia-The Impact on Physical Capacity of Liver Transplant Patients. Life (Basel). 2021;11(8).

De Smet S, O'Donoghue K, Lormans M, Monbaliu D, Pengel L. Does Exercise Training Improve Physical Fitness and Health in Adult Liver Transplant Recipients? A Systematic Review and Meta-analysis. Transplantation. 2023;107(1):e11-e26.

Dhillon RJ, Hasni S. Pathogenesis and Management of Sarcopenia. Clin Geriatr Med. 2017;33(1):17-26.

Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008;9(7):629-35.

Tandon P, Montano-Loza AJ, Lai JC, Dasarathy S, Merli M. Sarcopenia and frailty in decompensated cirrhosis. J Hepatol. 2021;75 Suppl 1(Suppl 1):S147-s62.

Ramsey KA, Rojer AGM, D'Andrea L, Otten RHJ, Heymans MW, Trappenburg MC, et al. The association of objectively measured physical activity and sedentary behavior with skeletal muscle strength and muscle power in older adults: A systematic review and meta-analysis. Ageing Res Rev. 2021;67:101266.

Lu L, Mao L, Feng Y, Ainsworth BE, Liu Y, Chen N. Effects of different exercise training modes on muscle strength and physical performance in older people with sarcopenia: a systematic review and meta-analysis. BMC Geriatr. 2021;21(1):708.

Gonzalez A, Valero-Breton M, Huerta-Salgado C, Achiardi O, Simon F, Cabello-Verrugio C. Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis. Eur J Transl Myol. 2021;31(1).

Mohan R, Kalra A. Nutrition, frailty assessment, and interventions for the liver transplant candidate. Clin Liver Dis (Hoboken). 2023;22(1):23-8.

Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54(6):991-1001.

Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal. 2001;1:323-36.

Cron DC, Friedman JF, Winder GS, Thelen AE, Derck JE, Fakhoury JW, et al. Depression and Frailty in Patients With End-Stage Liver Disease Referred for Transplant Evaluation. Am J Transplant. 2016;16(6):1805-11.

Tandon P, Tangri N, Thomas L, Zenith L, Shaikh T, Carbonneau M, et al. A Rapid Bedside Screen to Predict Unplanned Hospitalization and Death in Outpatients With Cirrhosis: A Prospective Evaluation of the Clinical Frailty Scale. Am J Gastroenterol. 2016;111(12):1759-67.

Tandon P, Zanetto A, Piano S, Heimbach JK, Dasarathy S. Liver transplantation in the patient with physical frailty. J Hepatol. 2023;78(6):1105-17.

Francisco UoS. Functional Assessment in Liver Transplantation: University of San Francisco [Liver Frailty Index]. Available from: https://liverfrailtyindex.ucsf.edu/.

Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, et al. Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology. 2017;66(2):564-74.

Jutras G, Lai JC. The Liver Frailty Index: a model for establishing organ-specific frailty metrics across all solid organ transplantation. Curr Opin Organ Transplant. 2024;29(4):266-70.

Lai JC, Shui AM, Duarte-Rojo A, Rahimi RS, Ganger DR, Verna EC, et al. Association of Frailty With Health-Related Quality of Life in Liver Transplant Recipients. JAMA Surg. 2023;158(2):130-8.

Dunn MA, Rogal SS, Duarte-Rojo A, Lai JC. Physical Function, Physical Activity, and Quality of Life After Liver Transplantation. Liver Transpl. 2020;26(5):702-8.

Gitto S, Golfieri L, Gabrielli F, Falcini M, Sofi F, Tamè MR, et al. Physical activity in liver transplant recipients: a large multicenter study. Intern Emerg Med. 2024;19(2):343-52.

Choo YJ, Cho CW, Chang MC. Effects of supervised exercise on aerobic capacity and quality of life in patients with chronic liver disease and patients who underwent liver transplantation: a systematic review and meta-analysis. Int J Rehabil Res. 2022;45(1):1-11.

Lin FP, Visina JM, Bloomer PM, Dunn MA, Josbeno DA, Zhang X, et al. Prehabilitation-Driven Changes in Frailty Metrics Predict Mortality in Patients With Advanced Liver Disease. Am J Gastroenterol. 2021;116(10):2105-17.

Janaudis-Ferreira T, Tansey CM, Mathur S, Blydt-Hansen T, Lamoureaux J, Räkel A, et al. The effects of exercise training in adult solid organ transplant recipients: A systematic review and meta-analysis. Transpl Int. 2021;34(5):801-24.

Cappelle M, Masschelein E, Vos R, Van Remoortel H, Smets S, Vanbekbergen J, et al. High-Intensity Training for 6 Months Safely, but Only Temporarily, Improves Exercise Capacity in Selected Solid Organ Transplant Recipients. Transplant Proc. 2021;53(6):1836-45.

Minich A, Arisar FAQ, Shaikh NS, Herman L, Azhie A, Orchanian-Cheff A, et al. Predictors of patient survival following liver transplant in non-alcoholic steatohepatitis: A systematic review and meta-analysis. EClinicalMedicine. 2022;50:101534.

Kanwal F, Dulai GS, Spiegel BM, Yee HF, Gralnek IM. A comparison of liver transplantation outcomes in the pre- vs. post-MELD eras. Aliment Pharmacol Ther. 2005;21(2):169-77.

Peng Y, Qi X, Guo X. Child-Pugh Versus MELD Score for the Assessment of Prognosis in Liver Cirrhosis: A Systematic Review and Meta-Analysis of Observational Studies. Medicine (Baltimore). 2016;95(8):e2877.

Reichelt S, Pratschke J, Engelmann C, Neumann UP, Lurje G, Czigany Z. Body composition and the skeletal muscle compartment in liver transplantation: Turning challenges into opportunities. Am J Transplant. 2022;22(8):1943-57.

Kalafateli M, Mantzoukis K, Choi Yau Y, Mohammad AO, Arora S, Rodrigues S, et al. Malnutrition and sarcopenia predict post-liver transplantation outcomes independently of the Model for End-stage Liver Disease score. J Cachexia Sarcopenia Muscle. 2017;8(1):113-21.

Tsao YT, Lee WC, Huang CH, Lin IH, Huang YY. A comprehensive investigation of nutritional status and psoas muscle mass in predicting five-year survival in patients with liver transplant. J Formos Med Assoc. 2022;121(7):1317-24.

Spillman LN, Madden AM, Richardson H, Imamura F, Jones D, Nash M, et al. Nutritional Intake after Liver Transplant: Systematic Review and Meta-Analysis. Nutrients. 2023;15(11).

Oikonomou IM, Sinakos E, Antoniadis N, Goulis I, Giouleme O, Anifanti M, et al. Effects of an active lifestyle on the physical frailty of liver transplant candidates. World J Transplant. 2022;12(11):365-77.

Ruck JM, Shui AM, Jefferis AA, Duarte Rojo A, Rahimi RS, Ganger DR, et al. Association of body mass index with post-liver transplant outcomes. Clin Transplant. 2024;38(1):e15205.

Lin FP, Bloomer PM, Grubbs RK, Rockette-Wagner B, Tevar AD, Dunn MA, et al. Low Daily Step Count Is Associated With a High Risk of Hospital Admission and Death in Community-Dwelling Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2022;20(8):1813-20.e2.

Goetze JP, Bruneau BG, Ramos HR, Ogawa T, de Bold MK, de Bold AJ. Cardiac natriuretic peptides. Nat Rev Cardiol. 2020;17(11):698-717.

Onghena L, Berrevoet F, Vanlander A, Van Vlierberghe H, Verhelst X, Hoste E, et al. Illness cognitions and health-related quality of life in liver transplant patients related to length of stay, comorbidities and complications. Qual Life Res. 2022;31(8):2493-504.

Raju S, Mathew JS, S S, Padma UD. Quality of life 5 years following liver transplantation. Indian J Gastroenterol. 2021;40(4):353-60.

Kaplan A, Korenjak M, Brown RS, Jr. Post-liver transplantation patient experience. J Hepatol. 2023;78(6):1234-44.

Getsuwan S, Tanpowpong P, Lertudomphonwanit C, Chuthapisith J, Butsriphum N, Prabpram W, et al. Health-Related Quality of Life in Pediatric Liver Transplant Recipients. Transplant Proc. 2021;53(1):141-7.

Mulder MB, Busschbach JV, van Hoek B, van den Berg AP, Polak WG, Alwayn IPJ, et al. Health-related Quality of Life and Fatigue in Liver Transplant Recipients Receiving Tacrolimus Versus Sirolimus-based Immunosuppression: Results From a Randomized Trial. Transplantation. 2023;107(12):2545-53.

Hager A, Guo Y, Wang Y, Mazurak V, Gilmour SM, Mager DR. Exercise rehabilitation to treat sarcopenia in pediatric transplant populations. Pediatr Transplant. 2023;27(8):e14602.

Hickman IJ, Hannigan AK, Johnston HE, Elvin-Walsh L, Mayr HL, Staudacher HM, et al. Telehealth-delivered, Cardioprotective Diet and Exercise Program for Liver Transplant Recipients: A Randomized Feasibility Study. Transplant Direct. 2021;7(3):e667.

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Published

2024-11-12

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WIRKIJOWSKI, Jakub, NIEGOWSKA, Wiktoria, GAJEK-FLANCZEWSKA, Wiktoria, FLANCZEWSKI, Sebastian, WIKLIŃSKA, Agata, ŚLIWIŃSKA, Martyna, WÓJTOWICZ, Katarzyna, WALCZAK, Agata, JAROŃ, Aleksandra and PIĄTKOWSKA, Karolina. Impact of physical activity on physical function and quality of life after liver transplantation. Quality in Sport. Online. 12 November 2024. Vol. 31, p. 55180. [Accessed 28 June 2025]. DOI 10.12775/QS.2024.31.55180.
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Vol. 31 (2024)

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Copyright (c) 2024 Jakub Wirkijowski, Wiktoria Niegowska, Wiktoria Gajek-Flanczewska, Sebastian Flanczewski, Agata Wiklińska, Martyna Śliwińska, Katarzyna Wójtowicz, Agata Walczak, Aleksandra Jaroń, Karolina Piątkowska

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