Unlocking Better Sleep and Stress Relief: The Power of Ashwagandha (Withania somnifera) Supplementation – A Literature Review
DOI:
https://doi.org/10.12775/QS.2024.26.54904Keywords
ashwaghanda, sleep quality, stress reduction, adaptogen, cortisol modulation, neurotransmitter regulationAbstract
Ashwagandha (Withania somnifera) is known for its adaptogenic properties, helping the body manage stress from various sources. This review, based on 23 studies, evaluates Ashwagandha's effectiveness in enhancing sleep quality and reducing stress. The herb's bioactive compounds modulate stress responses and neurotransmitter systems, contributing to improved mental and physical resilience. The studies consistently show that Ashwagandha supplementation (250 to 600 mg daily for 4 to 12 weeks) significantly improves sleep quality, latency, and efficiency. These effects are largely due to the modulation of the hypothalamic-pituitary-adrenal (HPA) axis, cortisol reduction, and enhancement of GABAergic and serotonergic pathways. Ashwagandha also extends total sleep time in various populations, including healthy adults and the elderly. In addition to enhancing sleep, Ashwagandha reduces stress by lowering cortisol levels and modulating neurotransmitter systems. Numerous studies highlight its role in alleviating anxiety and improving mental well-being. However, some studies report gastrointestinal issues and potential interactions with medications, necessitating caution and consultation with healthcare providers. This review synthesizes current research, identifies trends, and highlights gaps in the literature, contributing to a better understanding of Ashwagandha's role in modern health practices. Given the challenges of sleep disorders and stress-related conditions, Ashwagandha shows promise as a natural remedy, particularly for those with anxiety or chronic stress. Future research should focus on understanding the underlying mechanisms, ensuring long-term safety, and standardizing supplement quality to strengthen its therapeutic applications.
References
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., & Dey, A. (2021). Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & Pharmacotherapy, 143, 112175. https://doi.org/10.1016/j.biopha.2021.112175
Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus. https://doi.org/10.7759/cureus.6466
Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468–1495. https://doi.org/10.2174/1570159x19666210712151556
Cheah, K. L., Norhayati, M. N., Yaacob, L. H., & Rahman, R. A. (2021). Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS ONE, 16(9), e0257843. https://doi.org/10.1371/journal.pone.0257843
Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus. https://doi.org/10.7759/cureus.5797
Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine, 98(37), e17186. https://doi.org/10.1097/md.0000000000017186
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized Double-Blind, Placebo-Controlled study of safety and efficacy of a High-Concentration Full-Spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262. https://doi.org/10.4103/0253-7176.106022
Bonilla, D. A., Moreno, Y., Gho, C., Petro, J. L., Odriozola-Martínez, A., & Kreider, R. B. (2021b). Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of Functional Morphology and Kinesiology, 6(1), 20. https://doi.org/10.3390/jfmk6010020
Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, Double-Blind, Placebo-Controlled study. Evidence-based Complementary and Alternative Medicine, 2021, 1–10. https://doi.org/10.1155/2021/8254344
Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023). Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
Borrás, S., Martínez-Solís, I., & Ríos, J. L. (2021). Medicinal Plants for insomnia Related to Anxiety: An updated review. Planta Medica, 87(10/11), 738–753. https://doi.org/10.1055/a-1510-9826
Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: a prospective, randomized, double-blind, placebo-controlled study. Cureus. https://doi.org/10.7759/cureus.7083
Maloh, J., Chakkalakal, M., Sulaiman, F., Burney, W., Chambers, C., & Sivamani, R. (2022). Combining topical and oral botanicals for skin redness, pigmentation, sleep, and mood: a randomized controlled study. Journal of Clinical Medicine, 11(22), 6690. https://doi.org/10.3390/jcm11226690
Deshpande, A., Irani, N., & Balakrishnan, R. (2018). Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep. Medicine, 97(26), e11299. https://doi.org/10.1097/md.0000000000011299
Pérez-Piñero, S., Muñoz-Carrillo, J. C., Echepare-Taberna, J., Muñoz-Cámara, M., Herrera-Fernández, C., Ávila-Gandía, V., Ladreda, M. H. F., Martínez, J. M., & López-Román, F. J. (2024). Effectiveness of Enriched Milk with Ashwagandha Extract and Tryptophan for Improving Subjective Sleep Quality in Adults with Sleep Problems: A Randomized Double-Blind Controlled Trial. Clocks & Sleep, 6(3), 417–432. https://doi.org/10.3390/clockssleep6030028
Ajgaonkar, A., Jain, M., & Debnath, K. (2022). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus. https://doi.org/10.7759/cureus.30787
Atul, U., Charu, B. & Umesh, S. (2020). Efficacy of Brimhana Nasya and Ashwagandha (Withania somnifera (L.) Dunal) root powder in primary insomnia in elderly male: A randomized open-label clinical study. AYU (an International Quarterly Journal of Research in Ayurveda), 41(3), 159. https://doi.org/10.4103/ayu.ayu_177_19
Langade, D., Thakare, V., Kanchi, S., & Kelgane, S. (2021). Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. Journal of ethnopharmacology, 264, 113276. https://doi.org/10.1016/j.jep.2020.113276
O’Connor, J., Lindsay, K., Baker, C., Kirby, J., Hutchins, A., & Harris, M. (2022). The impact of ashwagandha on stress, sleep quality, and food cravings in college students: Quantitative analysis of a Double-Blind randomized Control trial. Journal of Medicinal Food, 25(12), 1086–1094. https://doi.org/10.1089/jmf.2022.0040
Dimpfel, W., Schombert, L., Keplinger-Dimpfel, I. K., & Panossian, A. (2020). Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study. Pharmaceuticals, 13(3), 45. https://doi.org/10.3390/ph13030045
Pérez-Piñero, S., Muñoz-Carrillo, J. C., Echepare-Taberna, J., Luque-Rubia, A. J., Rivero, J. E. M., Muñoz-Cámara, M., Silvente, M. J. D., Merlos, E. V., Ávila-Gandía, V., Caturla, N., Navarro, P., Cabrera, M., & López-Román, F. J. (2024). Dietary supplementation with plant extracts for amelioration of persistent myofascial discomfort in the cervical and back regions: a randomized double-blind controlled study. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1403108
Evans, C., & Kalman, D. (2024). Addressing GI health through the bidirectional modulation of the Gut-Brain axis with herbal extracts: A Narrative review. Cureus. https://doi.org/10.7759/cureus.66698
Fatima, K., Malik, J., Muskan, F., Raza, G., Waseem, A., Shahid, H., Jaffery, S. F., Khan, U., Zaheer, M. K., Shaikh, Y., & Rashid, A. M. (2024). Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta‐analysis. Human Psychopharmacology Clinical and Experimental. https://doi.org/10.1002/hup.2911
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Copyright (c) 2024 Wojciech Krzysztof Grabowski, Karolina Anna Karoń, Łukasz Mikołaj Karoń, Anna Ewa Zygmunt, Grzegorz Drapała, Emilia Pedrycz, Daria Katarzyna Pedrycz
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