Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Quality in Sport

Unlocking Better Sleep and Stress Relief: The Power of Ashwagandha (Withania somnifera) Supplementation – A Literature Review
  • Home
  • /
  • Unlocking Better Sleep and Stress Relief: The Power of Ashwagandha (Withania somnifera) Supplementation – A Literature Review
  1. Home /
  2. Archives /
  3. Vol. 26 (2024) /
  4. Medical Sciences

Unlocking Better Sleep and Stress Relief: The Power of Ashwagandha (Withania somnifera) Supplementation – A Literature Review

Authors

  • Wojciech Krzysztof Grabowski Municipal Hospital in Zabrze https://orcid.org/0009-0006-9238-1411
  • Karolina Anna Karoń Municipal Hospital in Zabrze https://orcid.org/0009-0005-0356-8907
  • Łukasz Mikołaj Karoń Department of Pathology and Molecular Diagnostics, Medical University of Silesia in Katowice https://orcid.org/0009-0009-5083-8307
  • Anna Ewa Zygmunt Department of Pathology and Molecular Diagnostics, Medical University of Silesia in Katowice https://orcid.org/0009-0002-5849-6347
  • Grzegorz Drapała Wojewodzki Szpital Zespolony w Kielcach https://orcid.org/0009-0008-1492-1544
  • Emilia Pedrycz Wojewodzki Szpital Zespolony w Kielcach https://orcid.org/0009-0006-2751-2227
  • Daria Katarzyna Pedrycz Department of Family Medicine, Medical University of Białystok https://orcid.org/0009-0001-4988-5992

DOI:

https://doi.org/10.12775/QS.2024.26.54904

Keywords

ashwaghanda, sleep quality, stress reduction, adaptogen, cortisol modulation, neurotransmitter regulation

Abstract

Ashwagandha (Withania somnifera) is known for its adaptogenic properties, helping the body manage stress from various sources. This review, based on 23 studies, evaluates Ashwagandha's effectiveness in enhancing sleep quality and reducing stress. The herb's bioactive compounds modulate stress responses and neurotransmitter systems, contributing to improved mental and physical resilience. The studies consistently show that Ashwagandha supplementation (250 to 600 mg daily for 4 to 12 weeks) significantly improves sleep quality, latency, and efficiency. These effects are largely due to the modulation of the hypothalamic-pituitary-adrenal (HPA) axis, cortisol reduction, and enhancement of GABAergic and serotonergic pathways. Ashwagandha also extends total sleep time in various populations, including healthy adults and the elderly. In addition to enhancing sleep, Ashwagandha reduces stress by lowering cortisol levels and modulating neurotransmitter systems. Numerous studies highlight its role in alleviating anxiety and improving mental well-being. However, some studies report gastrointestinal issues and potential interactions with medications, necessitating caution and consultation with healthcare providers. This review synthesizes current research, identifies trends, and highlights gaps in the literature, contributing to a better understanding of Ashwagandha's role in modern health practices. Given the challenges of sleep disorders and stress-related conditions, Ashwagandha shows promise as a natural remedy, particularly for those with anxiety or chronic stress. Future research should focus on understanding the underlying mechanisms, ensuring long-term safety, and standardizing supplement quality to strengthen its therapeutic applications.

References

Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., & Dey, A. (2021). Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & Pharmacotherapy, 143, 112175. https://doi.org/10.1016/j.biopha.2021.112175

Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus. https://doi.org/10.7759/cureus.6466

Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468–1495. https://doi.org/10.2174/1570159x19666210712151556

Cheah, K. L., Norhayati, M. N., Yaacob, L. H., & Rahman, R. A. (2021). Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS ONE, 16(9), e0257843. https://doi.org/10.1371/journal.pone.0257843

Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus. https://doi.org/10.7759/cureus.5797

Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine, 98(37), e17186. https://doi.org/10.1097/md.0000000000017186

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized Double-Blind, Placebo-Controlled study of safety and efficacy of a High-Concentration Full-Spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262. https://doi.org/10.4103/0253-7176.106022

Bonilla, D. A., Moreno, Y., Gho, C., Petro, J. L., Odriozola-Martínez, A., & Kreider, R. B. (2021b). Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of Functional Morphology and Kinesiology, 6(1), 20. https://doi.org/10.3390/jfmk6010020

Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, Double-Blind, Placebo-Controlled study. Evidence-based Complementary and Alternative Medicine, 2021, 1–10. https://doi.org/10.1155/2021/8254344

Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023). Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057

Borrás, S., Martínez-Solís, I., & Ríos, J. L. (2021). Medicinal Plants for insomnia Related to Anxiety: An updated review. Planta Medica, 87(10/11), 738–753. https://doi.org/10.1055/a-1510-9826

Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: a prospective, randomized, double-blind, placebo-controlled study. Cureus. https://doi.org/10.7759/cureus.7083

Maloh, J., Chakkalakal, M., Sulaiman, F., Burney, W., Chambers, C., & Sivamani, R. (2022). Combining topical and oral botanicals for skin redness, pigmentation, sleep, and mood: a randomized controlled study. Journal of Clinical Medicine, 11(22), 6690. https://doi.org/10.3390/jcm11226690

Deshpande, A., Irani, N., & Balakrishnan, R. (2018). Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep. Medicine, 97(26), e11299. https://doi.org/10.1097/md.0000000000011299

Pérez-Piñero, S., Muñoz-Carrillo, J. C., Echepare-Taberna, J., Muñoz-Cámara, M., Herrera-Fernández, C., Ávila-Gandía, V., Ladreda, M. H. F., Martínez, J. M., & López-Román, F. J. (2024). Effectiveness of Enriched Milk with Ashwagandha Extract and Tryptophan for Improving Subjective Sleep Quality in Adults with Sleep Problems: A Randomized Double-Blind Controlled Trial. Clocks & Sleep, 6(3), 417–432. https://doi.org/10.3390/clockssleep6030028

Ajgaonkar, A., Jain, M., & Debnath, K. (2022). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus. https://doi.org/10.7759/cureus.30787

Atul, U., Charu, B. & Umesh, S. (2020). Efficacy of Brimhana Nasya and Ashwagandha (Withania somnifera (L.) Dunal) root powder in primary insomnia in elderly male: A randomized open-label clinical study. AYU (an International Quarterly Journal of Research in Ayurveda), 41(3), 159. https://doi.org/10.4103/ayu.ayu_177_19

Langade, D., Thakare, V., Kanchi, S., & Kelgane, S. (2021). Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. Journal of ethnopharmacology, 264, 113276. https://doi.org/10.1016/j.jep.2020.113276

O’Connor, J., Lindsay, K., Baker, C., Kirby, J., Hutchins, A., & Harris, M. (2022). The impact of ashwagandha on stress, sleep quality, and food cravings in college students: Quantitative analysis of a Double-Blind randomized Control trial. Journal of Medicinal Food, 25(12), 1086–1094. https://doi.org/10.1089/jmf.2022.0040

Dimpfel, W., Schombert, L., Keplinger-Dimpfel, I. K., & Panossian, A. (2020). Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study. Pharmaceuticals, 13(3), 45. https://doi.org/10.3390/ph13030045

Pérez-Piñero, S., Muñoz-Carrillo, J. C., Echepare-Taberna, J., Luque-Rubia, A. J., Rivero, J. E. M., Muñoz-Cámara, M., Silvente, M. J. D., Merlos, E. V., Ávila-Gandía, V., Caturla, N., Navarro, P., Cabrera, M., & López-Román, F. J. (2024). Dietary supplementation with plant extracts for amelioration of persistent myofascial discomfort in the cervical and back regions: a randomized double-blind controlled study. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1403108

Evans, C., & Kalman, D. (2024). Addressing GI health through the bidirectional modulation of the Gut-Brain axis with herbal extracts: A Narrative review. Cureus. https://doi.org/10.7759/cureus.66698

Fatima, K., Malik, J., Muskan, F., Raza, G., Waseem, A., Shahid, H., Jaffery, S. F., Khan, U., Zaheer, M. K., Shaikh, Y., & Rashid, A. M. (2024). Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta‐analysis. Human Psychopharmacology Clinical and Experimental. https://doi.org/10.1002/hup.2911

Downloads

  • PDF

Published

2024-10-17

How to Cite

1.
GRABOWSKI, Wojciech Krzysztof, KAROŃ, Karolina Anna, KAROŃ, Łukasz Mikołaj, ZYGMUNT, Anna Ewa, DRAPAŁA, Grzegorz, PEDRYCZ, Emilia and PEDRYCZ, Daria Katarzyna. Unlocking Better Sleep and Stress Relief: The Power of Ashwagandha (Withania somnifera) Supplementation – A Literature Review. Quality in Sport. Online. 17 October 2024. Vol. 26, p. 54904. [Accessed 28 June 2025]. DOI 10.12775/QS.2024.26.54904.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 26 (2024)

Section

Medical Sciences

License

Copyright (c) 2024 Wojciech Krzysztof Grabowski, Karolina Anna Karoń, Łukasz Mikołaj Karoń, Anna Ewa Zygmunt, Grzegorz Drapała, Emilia Pedrycz, Daria Katarzyna Pedrycz

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Stats

Number of views and downloads: 752
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

ashwaghanda, sleep quality, stress reduction, adaptogen, cortisol modulation, neurotransmitter regulation
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop