The Relationship Between Low Vitamin D Levels and the Development of Autoimmune Endocrine Diseases
DOI:
https://doi.org/10.12775/QS.2024.20.54027Keywords
vitamin D, diet, nutrition, lifestyle, autoimmune diseases, endocrine diseases, hormonesAbstract
Vitamin D is an essential nutrient that plays an important role in promoting overall health and well-being. Deficiencies of nutrients such as vitamin D are common in patients with autoimmune diseases. The incidence of these conditions is constantly increasing. As a result, patients are exposed to severe symptoms and discomfort in daily functioning. The causes, as well as the symptoms and complications they cause, are diverse, making diagnosis and treatment difficult. Therefore, during the clinical care of patients with AID, possible micronutrient deficiencies should be taken into account and, if observed, they should be treated with controlled supplementation. The aim of this article was to review the literature on the impact of low vitamin D status on the development of autoimmune diseases in the field of endocrinology.
References
Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M, Lips P, Mitchell DM, Murad MH, Powers S, Rao SD, Scragg R, Tayek JA, Valent AM, Walsh JME, McCartney CR. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, 2024, 00, 1–41
https://doi.org/10.1210/clinem/dgae290
Sîrbe C, Rednic S, Grama A, Pop TL. An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases. Int. J. Mol. Sci. 2022, 23, 9784. https://doi.org/10.3390/ ijms23179784
Gallo D, Baci D, Kustrimovic N, Lanzo N, Patera B, Tanda ML, Piantanida E, Mortara L. How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases? Int. J. Mol. Sci.2023,24,4689
https://doi.org/ 10.3390/ijms24054689
Pang B, Li L, Liu X, Cao Z, Pang T, Wang Q, Wei1 J. Association between serum vitamin D level and Graves’ disease: a systematic review and meta-analysis. Pang et al. Nutrition Journal (2024) 23:60
https://doi.org/10.1186/s12937-024-00960-2
Bellan M, Andreoli L, Mele C, Sainaghi PP, Rigamonti C, Piantoni S, De Benedittis C, Aimaretti G, Pirisi M, Marzullo P. Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases. Nutrients 2020, 12, 789
doi:10.3390/nu12030789
Kmieć P, Sworczak K. Korzyści i zagrożenia wynikające z suplementacji witaminą D. Benefits and risks of vitamin D supplementation. Forum Medycyny Rodzinnej 2017, tom 11, nr 1, 38–46
www.journals.viamedica.pl/forum_medycyny_rodzinnej
Dupuis ML, Pagano MT, Pierdominici M, Ortona E. The role of vitamin D in autoimmune diseases: Could sex make the difference?
Biol Sex Differ 2021 Jan 12;12(1):12.
doi: 10.1186/s13293-021-00358-3
Mavar M, Soric T, Bagaric E, Saric A, Matek Saric M. The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans? Nutrients2024,16,1176
https:// doi.org/10.3390/nu16081176
Cutolo M, Gotelli E. The 2023’s Growing Evidence Confirming the Relationship between Vitamin D and Autoimmune Diseases. Nutrients 2023,15,4760. https://doi.org/ 10.3390/nu15224760
Kawakami-Tani T, Fukawa E, Tanaka H, Abe Y, Makino I. Effect of 1 alpha-hydroxyvitamin D3 on serum levels of thyroid hormones in hyperthyroid patients with untreated Graves’ disease.
Metabolism 1997, 46, 1184–1188
DOI: 10.1016/s0026-0495(97)90214-6
Duntas LH, Alexandraki KI. On the Centennial of Vitamin D-Vitamin D, Inflammation, and Autoimmune Thyroiditis: A Web of Links and Implications. Nutrients 2022, 14, 5032
https://doi.org/10.3390/nu14235032
Unal AD, Tarcin O, Parildar H, Cigerli O, Eroglu H, Demirag NG. Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis.
Cent. Eur. J. Immunol. 2014, 39, 493–497
https://doi.org/10.5114/ceji.2014.47735
Kim D. The Role of Vitamin D in Thyroid Diseases.
Int J Mol Sci. 2017 Sep; 18(9): 1949.
doi: 10.3390/ijms18091949
Gorini F, Tonacci A. Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease—A Comprehensive Review.
Nutrients 2024, 16, 1762
https://doi.org/10.3390/ nu16111762
Altieri B, Muscogiuri G, Luigi Barrea L, et al. Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept; Rev Endocr Metab Disord. 2017 Sep;18(3):335-346.
Peterson P, Uibo R, Krohn KJE. Adrenal Autoimmunity: Results and Developments; Trends in Endocrinology & Metabolism; Volume 11, Issue 7, 1 September 2000, Pages 285-290.
Neufeld MN, Blizzard R. (1980) Auto-Immune Polyglandual Syndromes. Pediatric Annals, 9, 154-162. https://doi.org/10.3928/0090-4481-19800401-07
Penna-Martinez M, Meyer G, Wolff AB, et al. Vitamin D status and pathway genes in five European autoimmune Addison's disease cohorts. European Journal of Endocrinology, Volume 184, Issue 3, Mar 2021, Pages 373–381, https://doi.org/10.1530/EJE-20-0956
Bellastella G, Maiorino MI, Petrizzo M, De Bellis A, Capuano A, Esposito K, et al. Vitamin D and autoimmunity: what happens in autoimmune polyendocrine syndromes? J Endocrinol Investig. 2015;38(6):629–33. doi:10.1007/s40618-014-0233-z.
Montoli A, Colussi G, Minetti L. Hypercalcaemia in Addison’s disease: calciotropic hormone profile and bone histology. J Intern Med. 1992;232(6):535–40.
Suliman AM, Freaney R, Smith TP, McBrinn Y, Murray B, McKenna TJ. The impact of different glucocorticoid replacement schedules on bone turnover and insulin sensitivity in patients with adrenal insufficiency. Clin Endocrinol. 2003;59(3):380–7.].
Bellastella G, Maiorino MI, Petrizzo M, De Bellis A, Capuano A, Esposito K, et al. Vitamin D and autoimmunity: what happens in autoimmune polyendocrine syndromes? J Endocrinol Investig. 2015;38(6):629–33. doi:10.1007/s40618-014-0233-z.
Dziechciarz P. Plejotropowe działanie witaminy D– o odsiewaniu ziaren od plew. Kraków: Medycyna Praktyczna.
Lumme J, Morin-Papunen L, Pesonen P, et al. Vitamin D Status in Women with a History of Infertility and Decreased Fecundability: A Population-Based Study; Nutrients 2023, 15(11), 2522; https://doi.org/10.3390/nu15112522
Raperport C, Homburg R. The Source of Polycystic Ovarian Syndrome. Clin. Med. Insights Reprod. Health. 2019;13:1179558119871467. doi: 10.1177/1179558119871467.
Mavar M, Sorić T, et al. The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans?; Nutrients. 2024 Apr; 16(8): 1176.
Ghaseminejad-Raeini A, Ghaderi A, Sharafi A, et al. Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review; Front Immunol. 2023; 14: 950465.
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