Adaptogens - use, history and future
DOI:
https://doi.org/10.12775/QS.2023.09.01.002Keywords
plant adaptogens, Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, Schisandra chinensis, Oxidative Stress, Muscle regeneration, immune systemAbstract
The modern lifestyle, characterized by chronic stress, poor nutrition, and exposure to environmental factors, can negatively impact the body's homeostasis. Plant adaptogens, exhibiting a unique ability to counteract the effects of stress and improve overall physical and mental well-being, are gaining increasing recognition. This review aims to gather and analyze the current knowledge on selected plant adaptogens, such as extracts of ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis, in terms of their potential in preventing and alleviating the effects of stress, improving physical performance and mental performance, and their safety of use. The review includes the results of clinical studies, indicating the mechanisms of action that confirm the effectiveness of adaptogens in strengthening the body, and also indicates the limitations and needs for further research in this field. The aim of the work is to provide a comprehensive review of the use of plant adaptogens in preventive and supportive therapy, enabling a better understanding of their potential in promoting health and well-being. The information obtained from the articles cited, used in the preparation of this review, indicates that plant adaptogens can provide a range of benefits in the treatment of chronic fatigue, cognitive function disorders, and immune system disorders.
References
1. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. doi: 10.2174/157488409789375311. Epub 2009 Sep 1. PMID: 19500070.
2. Wróbel-Biedrawa D, Podolak I. Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review. Molecules. 2024 Feb 15;29(4):866. doi: 10.3390/molecules29040866. PMID: 38398618; PMCID: PMC10891670.
3. Rhodiola Rosea Therapy of Major Depressive Disorder, [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT01098318 (ang.).
4. A Study With Arctic Root Compared With the Extract When Combined With Schizandra and Russian Root (Adapt 232), Standardized Ginseng Extract and Placebo Regarding Impact on the Level of Energy, Ability to Work Under Stress, Quality of Life and Wellbeing, in Middleaged Women Who Are Still Employed, [w:] ClinicalTrials.gov [online], National Institutes of Health, NCT01006460 (ang.).
5. Mahady GB, Gyllenhall C, Fong HH, Farnsworth NR. Żeń-szeń: przegląd bezpieczeństwa i skuteczności. Nutr Clin Care. 2000;3:90-101.
6. Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician. 2003 Oct 15;68(8):1539-42. PMID: 14596440.
7. Światowa Organizacja Zdrowia. Monografie WHO dotyczące wybranych roślin leczniczych. Genewa: Światowa Organizacja Zdrowia, 1999.
8. Kelly, G.S. Rhodiola rosea: A possible plant adaptogen. Altern. Med. Rev. 2001, 6, 293–302.
9. Ivanova Stojcheva E, Quintela JC. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence. Molecules. 2022; 27(12):3902. https://doi.org/10.3390/molecules27123902
10. Darbinyan, V.; Kteyan, A.; Panossian, A.; Gabrielian, E.; Wikman, G.; Wagner, H. Rhodiola rosea in stress induced fatigue—A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000, 7, 365–371.
11. Abidov, M.; Grachev, S.; Seifulla, R.D.; Ziegenfuss, T.N. Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood. Bull. Exp. Biol. Med. 2004, 138, 63–64.
12. Pan, H., et al. „Effects on Schisandra chinensis fruit on exercise permormance and recovery in trained men.” Journal of Ethnopharmacology, 2015 DOI: 10.1016/j.jep.2015.03.008
13. Zhou, Y., et al. „Effects of Schisandra chinensis on cognitive function in chronic stress-induced rats.” Phytotherapy Research, 2016 DOI: 10.1002/ptr.5618
14. Khan, I.A., & Murtaza, G. (2012). "Schisandra chinensis (Turcz.) Baill: A review of its ethnobotany, phytochemistry, and pharmacology." Pharmaceutical Biology. DOI: 10.3109/13880209.2012.726898
15. Huang, Y., et al. (2013). "Schisandra chinensis: A review on its traditional uses, phytochemistry, pharmacology, and toxicology." Phytotherapy Research. DOI: 10.1002/ptr.4829
16. Shang, X., et al. (2015). "Schisandra chinensis: A review of its pharmacological effects and the mechanism of action." Journal of Ethnopharmacology. DOI: 10.1016/j.jep.2014.11.023
17. Li, Y., et al. (2015). "Schisandra chinensis: A traditional Chinese medicine with potential effects on anxiety and depression." Journal of Traditional and Complementary Medicine. DOI: 10.1016/j.jtcme.2015.01.007
18. Chandrasekhar, K., et al. "A prospective, randomized double-blind, placebo-controlled study of the effect of an extract of Withania somnifera on stress and well-being in adults." Indian Journal of Psychological Medicine, 2012
19. Ziauddin, M., et al. "Effect of Withania somnifera on physical performance and strength in healthy individuals: A randomized controlled trial." Journal of Ayurveda and Integrative Medicine, 2016
20. Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity. Pharmaceuticals, 3(1), 188-224.
21. Szolomitsky, I. N., et al. (2002). The effect of Eleutherococcus senticosus extract on physical performance and stress response in athletes. Journal of Sports Medicine and Physical Fitness, 42(4), 421-427.
22. Davydov, M., & Krikorian, A. D. (2000). Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. Journal of Ethnopharmacology, 72(3), 345-393.
23. Hartz, A. J., et al. (2004). Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychological Medicine, 34(1), 51-61.
24. Syrov, V. N. (2000). Mechanism of the anabolic action of phytoecdysteroids in mammals. Russian Journal of Bioorganic Chemistry, 26(11), 809-817.
25. Wilborn, C. D., et al. (2006). Effects of Rhaponticum carthamoides supplementation on strength and body composition. Journal of the International Society of Sports Nutrition, 3(1), 1-7.
26. Azizov, A. P., & Seifulla, R. D. (1998). The effect of Leuzea tincture and Rhodiola rosea extract on the human mental and physical performance. Eksperimental'naia i Klinicheskaia Farmakologiia, 61(3), 61-63.
27. Todorova V, Ivanov K, Delattre C, Nalbantova V, Karcheva-Bahchevanska D, Ivanova S. Plant Adaptogens-History and Future Perspectives. Nutrients. 2021 Aug 20;13(8):2861. doi: 10.3390/nu13082861. PMID: 34445021; PMCID: PMC8398443.
28. Ishaque, S., Shamseer, L., Bukutu, C., & Vohra, S. (2012). Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complementary and Alternative Medicine, 12(1), 70.
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Copyright (c) 2023 Agnieszka Marciniak, Sylwia Nemeczek, Klaudia Walczak, Patrycja Walczak, Konrad Merkisz, Jakub Grzybowski, Natalia Grzywna, Karolina Jaskuła, Władysław Orłowski
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