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Medical and Biological Sciences

Enterobacteriaceae strains with reduced susceptibility to carbapenems
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Enterobacteriaceae strains with reduced susceptibility to carbapenems

Authors

  • Izabela Witkowska Department of Microbiology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
  • Alicja Sękowska Department of Microbiology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
  • Eugenia Gospodarek Department of Microbiology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland

DOI:

https://doi.org/10.12775/MBS.2015.008

Keywords

Enterobacteriaceae, carbepenem-resistant Enterobacteriaceae, reduced susceptibility to carbapenems

Abstract

The aim of the study was to estimate the prevalence of Enterobacteriaceae with reduced susceptibility to carbapenems. Forty-five strains of Enterobacteriaceae with reduced susceptibility to carbapenems were investigated. The strains were cultured from patients treated at the Dr Antoni Jurasz University Hospital no.1 in Bydgoszcz. Identification of the strains was carried out based on the results of biochemical reactions performed in identification cards GN (bioMérieux). Susceptibility testing to carbapenems and determining Minimal Inhibitory Concentration (MIC) was carried out using E - test (bioMérieux) (for ertapenem and imipenem), and agar dilution method for meropenem. The analysed strains were isolated from: urine – 13 strains (28.9%), blood and bronchoalveolar lavage - six strains from each (13.3% ), 5 – wound swabs (11.2%) and other clinical materials – 15 (33.3%). 53.3% of the strains were identified as Klebsiella pneumoniae. 93.4% of the isolates were susceptible to meropenem. Only 4.5% of the analysed strains were susceptible to ertapenem. None of the analyzed strains produced carbapenemases.

References

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Schechner W., Kotlovsky T., Tarabeia J., Predictors of rectal carriage of carbapenem-resistant Enterobacteriaceae (CRE) among patients with known CRE carriage at their next hospital encounter, Infect Contr Hosp Epidemiol., 2011, 32:497-503.

Lee G.C., Lawson K.A., Burgess D.S., Clinical epidemiology of carbapenem-resistant Enterobacteriaceae in community hospitals: a case-case-control study, Ann Pharmacother., 2013, 47:1115-1121.

European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. 2011, Version 1.3, Available from: www.korld.edu.pl/pdf/eucast/EUCAST_breakpoints_1-3popr.pdf.

Żabicka D., Baraniak A., Gniadkowski M., Wykrywanie karbapenemaz – zalecenia 2013, Available from: www.korld.edu.pl/pdf/Wykrywanie karbapenemaz - zalecenia 2013.pdf.

Nordmann P., Dortet L., Poirel L., Carbapenem resistance in Enterobacteriaceae: here is the storm!, Trends Mol Med., 2012, 18:263-272.

Medical and Biological Sciences

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Published

2015-06-05

How to Cite

1.
WITKOWSKA, Izabela, SĘKOWSKA, Alicja and GOSPODAREK, Eugenia. Enterobacteriaceae strains with reduced susceptibility to carbapenems. Medical and Biological Sciences. Online. 5 June 2015. Vol. 29, no. 1, pp. 51-54. [Accessed 7 July 2025]. DOI 10.12775/MBS.2015.008.
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Issue

Vol. 29 No. 1 (2015)

Section

ORIGINAL ARTICLES

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