Sodium nitrate affects myocardium in pregnant rats and their pups
DOI:
https://doi.org/10.12775/EQ.2018.029Keywords
sodium nitrite, hypoxia, myocardium, rats, microscopyAbstract
The problem of pollution with nitrates and nitrites of the natural environment is very relevant nowadays. The purpose of this research was to study the morphological features of the myocardium in pregnant rats and their newborn pups exposed to chronic hemic hypoxia induced by sodium nitrite. The changes in the contractile apparatus of cardiomyocytes were atrophy and lysis of myofibrils which were most pronounced at the periphery of the cardiomyocytes, near the capillaries. A similar condition of the microcirculatory vessels accompanies absolutely all types of cardiomyopathies, regardless of the genesis of the disease. Cell-stromal relationships on the background of chronic myocardial ischemia cause destructive processes of myocardial remodeling. The final morphological outcome of prolonged hypoxic heart damage can be focal dystrophy of the myocardium, which leads to the development of chronic heart failure and the appearance of life-threatening arrhythmias.References
Acker T. & Acker H., 2010, Cellular oxygen sensing need in CNS function: physiological and pathological implications. J. Exp. Biol. 2007: 3171-3188.
Bacon R., 1997, Nitrate preserved sausage meat causes an unusual food poisoning incident. Commun. Dis. Rep. CDR Rev. 7(7): 45-47.
Craun G.F., Greathouse D.G. & Gunderson D.H., 1981, Methaemoglobin levels in young children consuming high nitrate well water in the United States. Int. J. Epidemiol. 10: 309-317.
Council Directive 86/609/EEC, 1986, On the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. http://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:31986L0609 [Accessed 19.12.2016].
Feelisch M. & Noack E., 1987, Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. Eur. J. Pharmacol. 142: 465-469.
Ger J., Kao H., Shih T.S. & Deng J.F., 1996, Fatal toxic methemoglobinemia due to occupational exposure to methyl nitrite. Clin. Med. J. 57: 578.
Gupta S.K., Gupta R.C., Seth AK., Gupta A.B., Bassin, J.K. & Gupta A., 2000, Methemoglobinaemia in areas with high nitrate concentration in drinking water. Nat. Med. J. India 13(2): 58-61.
Feron V.J., Arts J.H., Kuper C.F., Slootweg P.J. & Woutersen R.A., 2001, Health risks associated with inhaled nasal toxicants. Crit. Rev. Toxicol. 31: 313-347.
Kloner R.A., Arimie R.B., Kay G.L., Cannom D., Matthews R., Bhandari A., Shook T., Pollick C. & Burstein S., 2001, Evidence for stunned myocardium in humans: a 2001 update. Coron. Artery Dis. 12(5): 349-356.
Kloner R.A. & Jennings R.B., 2001, Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. Circulation 104(24): 2981-2989.
Knobeloch L., Salna B., Hogan A., Postle J. & Anderson H., 2000, Blue babies and nitrate-contaminated well water. Environ Health Perspect 108: 675-678.
Lodovici M., Casalini C., Briani C. & Dolara P., 1997, Oxidative liver DNA damage in rats treated with pesticide mixtures. Toxicology 117: 55-60.
Nakagawa D., Ohshima Y., Takusagawa M., Ikota N., Takahashi Y., Shimizu S. & Ozawa T., 2001, Functional Modification of Cytochrome C by Peroxynitrite in an Electron Transfer Reaction. Chem. Pharm. Bull. 12(12): 1547-1554.
Patterson A.J. & Zhang L., 2010, Hypoxia and fetal heart development. Curr. Mol. Med. 10(7): 653–666.
Riobo N.A., Clementi E., Melani M., Boveris A., Cadenas E., Moncada S. & Poderoso J.J., 2001, Nitric Oxide Inhibits Mitochondrial NADH: Ubiquinon Reductase Activity through Peroxynitrite Formation. Biochem. J. 359: 139-145.
Simanonok J.P., 1996, Non-ishemic hypoxia of the arterial wall is primary cause of atherosclerosis. Med. Hypoteses 46 (2): 155-161.
Yamashita Т., Ando Y., Sacashita N., Hirayama K., Tanaka Y., Tashima K., Uchino M. & Ando M., 1997, Role of nitric oxide in the cerebellar degeneration during methylmercury intoxication. Biochim. Biophys. Acta 1334(2-3): 303-311.
Yanvareva I.N., Baranova Т.I., Kovalenko R.I. & Mitrofanova A.V., 2006, Evolutionary determined adaptation to hypoxia and human health. VIII World Congress Int. Society for Adaptive Medicine, Moscow, Russia: 17-18.
Yerucham I., Shiosberg A., Hanji V., Bellaiche M., Marcus M. & Liberboim M., 1997, Nitrate toxicosis in beef and dairy cattle herds due to contamination of drinking water and whey. Vet. Hum. Toxicol. 39 (5): 296-298.
Zadnipryany I.V., Tretiakova O.S., Sataieva T.P. & Zukow W., 2017, Experimental review of cobalt induced cardiomyopathy. Russian Open Medical Journal 6(1): 1-4.
Downloads
Published
How to Cite
Issue
Section
Stats
Number of views and downloads: 680
Number of citations: 1
