Exertional Heat Stroke — Recognition and Cooling Protocols: A Narrative Review
DOI:
https://doi.org/10.12775/QS.2026.74.75372Keywords
exertional heat stroke, hyperthermia, recognition, cold-water immersion, cooling rate, core temperature, prehospital careAbstract
Background. Exertional heat stroke (EHS) is the most severe form of exertional heat illness and one of the leading causes of non-traumatic sudden death in athletes, soldiers and outdoor workers. It is defined by central nervous system dysfunction combined with severe hyperthermia, and its outcome depends almost entirely on how quickly the diagnosis is made and body cooling is begun. With rising global temperatures and growing participation in endurance and team sports, timely recognition and correct cooling have become increasingly relevant to clinical practice.
Aim. This narrative review synthesises the current evidence on the recognition of EHS and on cooling protocols, with a focus on medical aspects, and critically compares diagnostic tools and cooling modalities across sporting, military, occupational and community settings.
Material and methods. A thematic narrative synthesis was performed of original studies, systematic reviews, case reports and consensus-based reviews addressing the pathophysiology, recognition, cooling and prevention of EHS.
Results. EHS diagnosis rests on the combination of neurological dysfunction and elevated core temperature; rectal thermometry is the reference standard, whereas peripheral methods are unreliable and frequently unavailable. Rapid whole-body cold-water immersion is the gold-standard treatment; cooling rates above 0.15 °C·min⁻¹ and the principle of "cool first, transport second" are consistently associated with survival without complications, yet these practices remain incompletely implemented. Alternative field methods differ substantially in efficacy.
Conclusions. Recognition and aggressive cooling are the decisive, modifiable determinants of survival in EHS. Persistent gaps in temperature assessment, prehospital protocols and provider knowledge must be closed to reduce preventable morbidity and mortality.
References
1. Périard JD, DeGroot D, Jay O. Exertional heat stroke in sport and the military: epidemiology and mitigation. Exp Physiol. 2022;107(10):1111–21. https://doi.org/10.1113/EP090686
2. Hifumi T, Kondo Y, Shimizu K, Miyake Y. Heat stroke. J Intensive Care. 2018;6:30. https://doi.org/10.1186/s40560-018-0298-4
3. Ogden HB, Child RB, Fallowfield JL, Delves SK, Westwood CS, Layden JD. The gastrointestinal exertional heat stroke paradigm: pathophysiology, assessment, severity, aetiology and nutritional countermeasures. Nutrients. 2020;12(2):537. https://doi.org/10.3390/nu12020537
4. Filep EM, Murata Y, Endres BD, Kim G, Stearns RL, Casa DJ. Exertional heat stroke, modality cooling rate, and survival outcomes: a systematic review. Medicina (Kaunas). 2020;56(11):589. https://doi.org/10.3390/medicina56110589
5. Alawad A, Merghani T, Yousif N, Satti S, Edris A, Hakim A, Fadelelmoula T. Heat stroke dysfunctions: from pathophysiology to prediction. Front Physiol. 2025;16:1700342. https://doi.org/10.3389/fphys.2025.1700342
6. Wang S, Zhang X, Zhang Y, Wu N, Bo L, Wang M. The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury. Front Cell Dev Biol. 2025;13:1569346. https://doi.org/10.3389/fcell.2025.1569346
7. Khan A, Mubeen M. Heat stroke in the era of global warming: a call for urgent action. Ann Glob Health. 2025;91(1):1. https://doi.org/10.5334/aogh.4519
8. Wicher AM, Jainta PJ, Podyma N, Fryszkiewicz PA, Harmansa PK, Kempska I, Zieleziński P, Gwóźdź JZ, Szczygłowski Z, Torbicka A. Long-term neurological sequelae of exertional heat stroke in athletes — a narrative review. Qual Sport. 2026;61:72945. https://doi.org/10.12775/QS.2026.61.72945
9. Savioli G, Zanza C, Longhitano Y, Nardone A, Varesi A, Ceresa IF, Manetti AC, Volonnino G, Maiese A, La Russa R. Heat-related illness in emergency and critical care: recommendations for recognition and management with medico-legal considerations. Biomedicines. 2022;10(10):2542. https://doi.org/10.3390/biomedicines10102542
10. Hirschhorn R, DadeMatthews O, Sefton J. Exertional heat stroke knowledge and management among emergency medical service providers. Int J Environ Res Public Health. 2021;18(9):5016. https://doi.org/10.3390/ijerph18095016
11. Cong S, Zheng G, Liang X, Gui J, Zhang H, Wang J. Pre-hospital cooling in community-acquired heat stroke (CAHS): evidence, challenges, and strategies. Eur J Med Res. 2025;30:472. https://doi.org/10.1186/s40001-025-02628-x
12. Monseau AJ, Hurlburt GA, Balcik BJ, Oppenlander KE, Chill NM, Martin PS. Status of US emergency medical service protocols regarding pre-transfer cooling for exertional heat stroke. Cureus. 2021;13(11):e19505. https://doi.org/10.7759/cureus.19505
13. Nguyen NX, Pham NT, Le HTT, Tran QV, Tran HNT, Vo TKT, Phan PV. Exertional heat stroke with multiorgan dysfunction in a community sports event: case report and one-month follow-up. Int J Emerg Med. 2026;19:5. https://doi.org/10.1186/s12245-025-01071-3
14. Damatto RL, Cezar MDM, dos Santos PP. Control of body temperature during physical exercise. Arq Bras Cardiol. 2019;112(5):543–4. https://doi.org/10.5935/abc.20190081
15. Sekiguchi Y, Benjamin CL, Lee EC, Struder JF, Manning CN, Morrissey MC, Szymanski MR, Stearns RL, Armstrong LE, Casa DJ. Effects of heat acclimation following heat acclimatization on whole body heat exchange in trained endurance athletes. Int J Environ Res Public Health. 2022;19(11):6412. https://doi.org/10.3390/ijerph19116412
16. Litwa E, Dobosiewicz AM, Różański G, Badiuk N. Biological effects of cold and its use in sport. Pedagogy Psychol Sport. 2020;6(2):197–202. https://doi.org/10.12775/PPS.2020.06.02.19
17. Klimek K, Bugla K, Gabryel Ł, Wikarek A, Dołęga J, Grabarczyk M, Kosińska P, Rybak J, Magiera B, Grabarczyk A. Exploring the benefits of cold exposure in health and athletic performance — review of articles. J Educ Health Sport. 2024;55:52–72. https://doi.org/10.12775/JEHS.2024.55.004
18. Sobczyk M, Oleksa P, Wójcik P, Żuraw D, Rogowska M, Słaboń M. Positive and negative aspects of sauna bathing — current knowledge status. J Educ Health Sport. 2021;11(9):497–503. https://doi.org/10.12775/JEHS.2021.11.09.064
19. Kruijt N, van den Bersselaar LR, Hopman MTE, Snoeck MMJ, van Rijswick M, Wiggers TGH, Jungbluth H, Bongers CCWG, Voermans NC. Exertional heat stroke and rhabdomyolysis: a medical record review and patient perspective on management and long-term symptoms. Sports Med Open. 2023;9:33. https://doi.org/10.1186/s40798-023-00570-y
20. Kluz A, Żak K, Jucha H, Mazur M, Pliszka A, Michalak K, Zukierski K, Madyniak K. The impact of ultramarathon running on acute kidney injury risk: a review of current evidence. Qual Sport. 2025;48:66747. https://doi.org/10.12775/QS.2025.48.66747
21. Henderson MJ, Grandou C, Chrismas BCR, Coutts AJ, Impellizzeri FM, Taylor L. Core body temperatures in intermittent sports: a systematic review. Sports Med. 2023;53(11):2147–70. https://doi.org/10.1007/s40279-023-01892-3
22. Donnan K, Williams EL, Stanger N. The effects of heat exposure during intermittent exercise on physical and cognitive performance among team sport athletes. Percept Mot Skills. 2021;128(1):439–66. https://doi.org/10.1177/0031512520966522
23. de Korte JQ, Bongers CCWG, Hopman MTE, Eijsvogels TMH. Exercise performance and thermoregulatory responses of elite athletes exercising in the heat: outcomes of the Thermo Tokyo study. Sports Med. 2021;51(11):2423–36. https://doi.org/10.1007/s40279-021-01530-w
24. Yeargin SW, Dickinson JJ, Emerson DM, Koller J, Torres-McGehee TM, Kerr ZY. Exertional heat illness risk factors and physiological responses of youth football players. J Sport Health Sci. 2021;10(1):91–8. https://doi.org/10.1016/j.jshs.2019.03.002
25. Alkemade P, Daanen HAM, Janssen TWJ, Broad E, Goosey-Tolfrey VL, Ibusuki T, Kneepkens H, Périard JD, Eijsvogels TMH. Heat preparedness and exertional heat illness in Paralympic athletes: a Tokyo 2020 survey. Temperature (Austin). 2023;10(2):264–75. https://doi.org/10.1080/23328940.2022.2147364
26. Verdonk C, Mellier C, Charlot K, Jouvion A, Trousselard M, Sagui E, Malgoyre A, Tardo-Dino PE. Feeling the heat: investigating interoception and motivation as risk factors for exertional heatstroke. Physiol Rep. 2025;13:e70529. https://doi.org/10.14814/phy2.70529
27. Stearns RL, Hosokawa Y, Adams WM, Belval LN, Huggins RA, Jardine JF, Katch RK, Davis RJ, Casa DJ. Incidence of recurrent exertional heat stroke in a warm-weather road race. Medicina (Kaunas). 2020;56(12):720. https://doi.org/10.3390/medicina56120720
28. Rogerson S, Brearley M. Suspected exertional heat stroke: a case study of worker cooling in a hot and humid field environment. Work. 2024;79(4):2103–8. https://doi.org/10.3233/WOR-240060
29. Dolson CM, Harlow ER, Phelan DM, Gabbett TJ, Gaal B, McMellen C, Geletka BJ, Calcei JG, Voos JE, Seshadri DR. Wearable sensor technology to predict core body temperature: a systematic review. Sensors (Basel). 2022;22(19):7639. https://doi.org/10.3390/s22197639
30. Silawarawet K, Kaewchukul P, Saadprai S. Heat stroke warning system prototype for athletes: a pilot study. Sensors (Basel). 2025;25(2):294. https://doi.org/10.3390/s25020294
31. Shimazaki T, Anzai D, Watanabe K, Nakajima A, Fukuda M, Ata S. Heat stroke prevention in hot specific occupational environment enhanced by supervised machine learning with personalized vital signs. Sensors (Basel). 2022;22(1):395. https://doi.org/10.3390/s22010395
32. Brearley M, Walker A. Water immersion for post incident cooling of firefighters; a review of practical fire ground cooling modalities. Extrem Physiol Med. 2015;4:15. https://doi.org/10.1186/s13728-015-0034-9
33. Hosokawa Y, Belval LN, Adams WM, Vandermark LW, Casa DJ. Chemically activated cooling vest's effect on cooling rate following exercise-induced hyperthermia: a randomized counter-balanced crossover study. Medicina (Kaunas). 2020;56(10):539. https://doi.org/10.3390/medicina56100539
34. Gutiérrez-Arroyo J, Rodríguez-Marroyo JA, García-Heras F, Rodríguez-Medina J, Villa-Vicente G, Carballo-Leyenda B. Effectiveness of cooling strategies for emergency personnel: a systematic review and meta-analysis. Sci Rep. 2025;15:29492. https://doi.org/10.1038/s41598-025-15636-y
35. Bouscaren N, Faricier R, Millet GY, Racinais S. Heat acclimatization, cooling strategies, and hydration during an ultra-trail in warm and humid conditions. Nutrients. 2021;13(4):1085. https://doi.org/10.3390/nu13041085
36. Naito T, Ogaki T. Comparison of the effects of cold water and ice ingestion on endurance cycling capacity in the heat. J Sport Health Sci. 2017;6(1):111–7. https://doi.org/10.1016/j.jshs.2015.12.002
37. Naito T, Saito T, Morito A, Yamada S, Shimomasuda M, Nakamura M. Pre-cooling with ingesting a high-carbohydrate ice slurry on thermoregulatory responses and subcutaneous interstitial fluid glucose during heat exposure. J Physiol Anthropol. 2022;41:34. https://doi.org/10.1186/s40101-022-00309-w
38. Katagiri A, Kawai S, Nishiyasu T, Fujii N. Ice slurry mitigates hyperventilation and cerebral hypoperfusion, and may enhance endurance performance in the heat. Med Sci Sports Exerc. 2025;57(7):1488–500. https://doi.org/10.1249/MSS.0000000000003662
39. Ketko I, Druyan A, Yanovich R, Epstein Y, Heled Y. Return to duty/play after exertional heat injury: do we have all the answers? A lesson from two case studies. Disaster Mil Med. 2015;1:18. https://doi.org/10.1186/s40696-015-0010-3
40. Gozhenko A, Zukow W, Gozhenko O, Vitiukov O. Pathophysiological role of thermoregulatory reactions in the development of common cold diseases: paradigmatic shift from pathogen-centric to host-response model: a critical review. Pedagogy Psychol Sport. 2025;24:64946. https://doi.org/10.12775/PPS.2025.24.64946
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