Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Quality in Sport

The Role of Physical Activity in Mild Cognitive Impairment
  • Home
  • /
  • The Role of Physical Activity in Mild Cognitive Impairment
  1. Home /
  2. Archives /
  3. Vol. 72 (2026) /
  4. Medical Sciences

The Role of Physical Activity in Mild Cognitive Impairment

Authors

  • Magdalena Iwaszko Jan Biziel University Hospital No. 2 in Bydgoszcz , Poland https://orcid.org/0009-0000-6010-5443
  • Marcelina Skajewska Jan Biziel University Hospital No.2 in Bydgoszcz,Poland https://orcid.org/0009-0009-5029-192X
  • Damian Szymański Independent Public Complex of Health Care Facilities in Lipsko,Poland https://orcid.org/0009-0008-4671-7177
  • Wiktoria Biegała Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń , Poland https://orcid.org/0009-0005-2495-1577
  • Paweł Iwaszko Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń , Poland https://orcid.org/0009-0006-2047-7713
  • Nina Kowalska Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń , Poland https://orcid.org/0009-0006-3703-6797
  • Oliwia Orłowska Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń , Poland https://orcid.org/0009-0007-5012-2259
  • Marta Wesołowska Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń , Poland https://orcid.org/0009-0009-6741-7154
  • Jan Czerwiński Antoni Jurasz University Hospital No. 1 in Bydgoszcz https://orcid.org/0009-0008-0119-2215
  • Wiktoria Czerniawska Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń , Poland https://orcid.org/0009-0001-3721-7604
  • Kamil Gruszka Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń , Poland https://orcid.org/0009-0008-9996-8594

DOI:

https://doi.org/10.12775/QS.2026.72.75315

Keywords

mild cognitive impairment, MCI, physical activity, physical exercise, cognitive functions, older adults

Abstract

Introduction: Mild cognitive impairment (MCI) is a common problem in the older population and is associated with an increased risk of developing dementia. Physical activity is one of the important modifiable lifestyle factors that may support cognitive functioning.
Aim: The aim of this paper was to assess the importance of physical activity in people with MCI, with particular emphasis on neurobiological mechanisms, the effectiveness of different forms of training, and their practical application.
Methods: This paper is a narrative review of the literature. Thirty-five publications were included, including original studies, randomized clinical trials, systematic reviews, meta-analyses, as well as guidelines and expert recommendations.
Results: Available data indicate that regular physical activity may have a beneficial effect on memory, executive functions, and global cognitive functioning in people with MCI. Beneficial effects were observed with aerobic training, resistance training, multicomponent programs, and interventions combining physical activity with cognitive training.
Conclusions: Physical activity is an important component of non-pharmacological management in people with MCI. However, due to the heterogeneity of studies and the limited duration of follow-up, there is still a lack of conclusive evidence that it prevents the progression of MCI to dementia.

References

1. Anderson N. D. (2019). State of the science on mild cognitive impairment (MCI). CNS spectrums, 24(1), 78–87. https://doi.org/10.1017/S1092852918001347

2.Petersen, R. C., Lopez, O., Armstrong, M. J., Getchius, T. S. D., Ganguli, M., Gloss, D., Gronseth, G. S., Marson, D., Pringsheim, T., Day, G. S., Sager, M., Stevens, J., & Rae-Grant, A. (2018). Practice guideline update summary: Mild cognitive impairment [RETIRED]: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology, 90(3), 126–135. https://doi.org/10.1212/WNL.000000000000482

3. Marino, F. R., Lyu, C., Li, Y., Liu, T., Au, R., & Hwang, P. H. (2025). Physical Activity Over the Adult Life Course and Risk of Dementia in the Framingham Heart Study. JAMA network open, 8(11), e2544439. https://doi.org/10.1001/jamanetworkopen.2025.4443

4. Vidyanti, A. N., Rahmawati, F., Rahman, R. H., Prodjohardjono, A., & Gofir, A. (2025). Lifestyle interventions for dementia risk reduction: A review on the role of physical activity and diet in Western and Asian Countries. The journal of prevention of Alzheimer's disease, 12(2), 100028. https://doi.org/10.1016/j.tjpad.2024.100028

5. Veronese, N., Soysal, P., Demurtas, J., Solmi, M., Bruyère, O., Christodoulou, N., Ramalho, R., Fusar-Poli, P., Lappas, A. S., Pinto, D., Frederiksen, K. S., Corbi, G. M., Karpenko, O., Georges, J., Durães, J., Schlögl, M., Yilmaz, O., Sieber, C., Shenkin, S. D., Smith, L., … endorsed by the European Academy of Neurology (2023). Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline. European geriatric medicine, 14(5), 925–952. https://doi.org/10.1007/s41999-023-00858-y

6. Jack, C. R., Jr, Hu, M., Wiste, H. J., Knopman, D. S., Vemuri, P., Graff-Radford, J., Lowe, V. J., Vassilaki, M., Cogswell, P. M., Schwarz, C. G., Algeciras-Schimnich, A., Petersen, R. C., & Therneau, T. M. (2025). Lifetime and 10-year absolute risk of cognitive impairment in relation to amyloid PET severity: a retrospective, longitudinal cohort study. The Lancet. Neurology, 24(12), 1016–1025. https://doi.org/10.1016/S1474-4422(25)00350-3

7. Khalil M. H. (2025). Walking and Hippocampal Formation Volume Changes: A Systematic Review. Brain sciences, 15(1), 52. https://doi.org/10.3390/brainsci15010052

8. Gieroba, B. (2019). Effect of physical activity on mental health and cognitive functions. Med Og Nauk Zdr., 25(3), 153–161. https://doi.org/10.26444/monz/112259

9. Ungvari, Z., Fazekas-Pongor, V., Csiszar, A. et al. The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms. GeroScience 45, 3211–3239 (2023). https://doi.org/10.1007/s11357-023-00873-8

10. López-Ortiz, S., Pinto-Fraga, J., Valenzuela, P. L., Martín-Hernández, J., Seisdedos, M. M., García-López, O., Toschi, N., Di Giuliano, F., Garaci, F., Mercuri, N. B., Nisticò, R., Emanuele, E., Lista, S., Lucia, A., & Santos-Lozano, A. (2021). Physical Exercise and Alzheimer's Disease: Effects on Pathophysiological Molecular Pathways of the Disease. International journal of molecular sciences, 22(6), 2897. https://doi.org/10.3390/ijms22062897

11. Mansoor, M., Ibrahim, A., Hamide, A., Tran, T., Candreva, E., & Baltaji, J. (2025). Exercise-Induced Neuroplasticity: Adaptive Mechanisms and Preventive Potential in Neurodegenerative Disorders. Physiologia, 5(2), 13. https://doi.org/10.3390/physiologia5020013

12. Zhou, B., Wang, Z., Zhu, L., Huang, G., Li, B., Chen, C., Huang, J., Ma, F., & Liu, T. C. (2022). Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis. Frontiers in aging neuroscience, 14, 981002. https://doi.org/10.3389/fnagi.2022.981002

13. Di Liegro, C. M., Schiera, G., Proia, P., & Di Liegro, I. (2019). Physical Activity and Brain Health. Genes, 10(9), 720. https://doi.org/10.3390/genes10090720

14. Camandola, S., & Mattson, M. P. (2017). Brain metabolism in health, aging, and neurodegeneration. The EMBO journal, 36(11), 1474–1492. https://doi.org/10.15252/embj.201695810

15. Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017). Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nature reviews. Neuroscience, 18(7), 419–434. https://doi.org/10.1038/nrn.2017.48

16. He, X. F., Liu, D. X., Zhang, Q., Liang, F. Y., Dai, G. Y., Zeng, J. S., Pei, Z., Xu, G. Q., & Lan, Y. (2017). Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice. Frontiers in molecular neuroscience, 10, 144. https://doi.org/10.3389/fnmol.2017.00144

17. Izquierdo, M., Merchant, R. A., Morley, J. E., Anker, S. D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E. L., Cesari, M., Chen, L. K., de Souto Barreto, P., Duque, G., Ferrucci, L., Fielding, R. A., García-Hermoso, A., Gutiérrez-Robledo, L. M., Harridge, S. D. R., Kirk, B., Kritchevsky, S., … Fiatarone Singh, M. (2021). International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. The journal of nutrition, health & aging, 25(7), 824–853. https://doi.org/10.1007/s12603-021-1665-8

18. Bull, F. C., Al-Ansari, S. S., Biddle, S., Borodulin, K., Buman, M. P., Cardon, G., Carty, C., Chaput, J. P., Chastin, S., Chou, R., Dempsey, P. C., DiPietro, L., Ekelund, U., Firth, J., Friedenreich, C. M., Garcia, L., Gichu, M., Jago, R., Katzmarzyk, P. T., Lambert, E., … Willumsen, J. F. (2020). World Health Organization 2020 guidelines on physical activity and sedentary behaviour. British journal of sports medicine, 54(24), 1451–1462. https://doi.org/10.1136/bjsports-2020-102955

19. De la Rosa, A., Olaso-Gonzalez, G., Arc-Chagnaud, C., Millan, F., Salvador-Pascual, A., García-Lucerga, C., Blasco-Lafarga, C., Garcia-Dominguez, E., Carretero, A., Correas, A. G., Viña, J., & Gomez-Cabrera, M. C. (2020). Physical exercise in the prevention and treatment of Alzheimer's disease. Journal of sport and health science, 9(5), 394–404. https://doi.org/10.1016/j.jshs.2020.01.004

20. Yoon M. S. (2017). mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass. Frontiers in physiology, 8, 788. https://doi.org/10.3389/fphys.2017.00788

21. Grgic, J., Garofolini, A., Orazem, J., Sabol, F., Schoenfeld, B. J., & Pedisic, Z. (2020). Effects of Resistance Training on Muscle Size and Strength in Very Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Sports medicine (Auckland, N.Z.), 50(11), 1983–1999. https://doi.org/10.1007/s40279-020-01331-7

22. Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019). Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association. Journal of strength and conditioning research, 33(8), 2019–2052. https://doi.org/10.1519/JSC.000000000000323

23. Shojaa, M., von Stengel, S., Kohl, M., Schoene, D., & Kemmler, W. (2020). Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 31(8), 1427–1444. https://doi.org/10.1007/s00198-020-05441-w

24. Ben Ezzdine, L., Dhahbi, W., Dergaa, I., Ceylan, H. İ., Guelmami, N., Ben Saad, H., Chamari, K., Stefanica, V., & El Omri, A. (2025). Physical activity and neuroplasticity in neurodegenerative disorders: a comprehensive review of exercise interventions, cognitive training, and AI applications. Frontiers in neuroscience, 19, 1502417. https://doi.org/10.3389/fnins.2025.1502417

25. Gallou-Guyot, M., Mandigout, S., Bherer, L., & Perrochon, A. (2020). Effects of exergames and cognitive-motor dual-task training on cognitive, physical and dual-task functions in cognitively healthy older adults: An overview. Ageing research reviews, 63, 101135. https://doi.org/10.1016/j.arr.2020.101135

26. Nuzum, H., Stickel, A., Corona, M., Zeller, M., Melrose, R. J., & Wilkins, S. S. (2020). Potential Benefits of Physical Activity in MCI and Dementia. Behavioural neurology, 2020, 7807856. https://doi.org/10.1155/2020/7807856

27. Cui, K., Yu, W., Zhang, J., & Zheng, B. (2026). Exercise modalities in mild cognitive impairment: a systematic review and network meta-analysis of comparative effectiveness. Frontiers in aging neuroscience, 18, 1888709. https://doi.org/10.3389/fnagi.2026.1888709

28. Ribeiro, I. C., Teixeira, C. V. L., de Resende, T. J. R., de Campos, B. M., Silva, G. B., Uchida, M. C., Magalhães, T. N. C., Pimentel-Silva, L. R., Aventurato, Í. K., Gonçalves, B. C., da Silva, M. C. R., Rizzi, L., Fernandes, G. B. P., Fernandes, P. T., Cendes, F., & Balthazar, M. L. F. (2025). Resistance training protects the hippocampus and precuneus against atrophy and benefits white matter integrity in older adults with mild cognitive impairment. GeroScience, 47(3), 5267–5286. https://doi.org/10.1007/s11357-024-01483-8

29. Yi, Q., Liu, Z., Zhong, F., Selvanayagam, V. S., & Cheong, J. P. G. (2024). Cognitive and physical impact of combined exercise and cognitive intervention in older adults with mild cognitive impairment: A systematic review and meta-analysis. PloS one, 19(10), e0308466. https://doi.org/10.1371/journal.pone.0308466

30. Castellote-Caballero, Y., Carcelén Fraile, M. D. C., Aibar-Almazán, A., Afanador-Restrepo, D. F., & González-Martín, A. M. (2024). Effect of combined physical-cognitive training on the functional and cognitive capacity of older people with mild cognitive impairment: a randomized controlled trial. BMC medicine, 22(1), 281. https://doi.org/10.1186/s12916-024-03469-x

31. Dieckelmann, M., González-González, A. I., Banzer, W., Berghold, A., Jeitler, K., Pantel, J., Pregartner, G., Schall, A., Tesky, V. A., & Siebenhofer, A. (2023). Effectiveness of exercise interventions to improve long-term outcomes in people living with mild cognitive impairment: a systematic review and meta-analysis. Scientific reports, 13(1), 18074. https://doi.org/10.1038/s41598-023-44771-7

32. Brasure, M., Desai, P., Davila, H., Nelson, V. A., Calvert, C., Jutkowitz, E., Butler, M., Fink, H. A., Ratner, E., Hemmy, L. S., McCarten, J. R., Barclay, T. R., & Kane, R. L. (2018). Physical Activity Interventions in Preventing Cognitive Decline and Alzheimer-Type Dementia: A Systematic Review. Annals of internal medicine, 168(1), 30–38. https://doi.org/10.7326/M17-1528

33. Liu, C., Lu, L., & Wei, W. (2026). Research advances in exercise management for frail older adults. Frontiers in public health, 14, 1763583. https://doi.org/10.3389/fpubh.2026.1763583

34. Decaix, T., Bonnin, C., Götze, K., François, V., Petit, C., Rivière, C., Greffard, S., Cognat, E., Hugon, J., Paquet, C., Sindzingre, L., & Lilamand, M. (2025). Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review. The Journal of frailty & aging, 14(5), 100069. https://doi.org/10.1016/j.tjfa.2025.100069

35. Bracco, L., Pinto-Carral, A., Hillaert, L., & Mourey, F. (2023). Tango-therapy vs physical exercise in older people with dementia; a randomized controlled trial. BMC geriatrics, 23(1), 693. https://doi.org/10.1186/s12877-023-04342-x

Quality in Sport

Downloads

  • PDF

Published

2026-09-16

How to Cite

1.
IWASZKO, Magdalena, SKAJEWSKA, Marcelina, SZYMAŃSKI, Damian, BIEGAŁA , Wiktoria, IWASZKO, Paweł, KOWALSKA, Nina, ORŁOWSKA, Oliwia, WESOŁOWSKA, Marta, CZERWIŃSKI, Jan, CZERNIAWSKA, Wiktoria and GRUSZKA, Kamil. The Role of Physical Activity in Mild Cognitive Impairment. Quality in Sport. Online. 16 September 2026. Vol. 72, p. 75315. [Accessed 17 September 2026]. DOI 10.12775/QS.2026.72.75315.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 72 (2026)

Section

Medical Sciences

License

Copyright (c) 2026 Magdalena Iwaszko, Marcelina Skajewska, Damian Szymański, Wiktoria Biegała , Paweł Iwaszko, Nina Kowalska, Oliwia Orłowska, Marta Wesołowska, Jan Czerwiński, Wiktoria Czerniawska, Kamil Gruszka

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Stats

Number of views and downloads: 2
Number of citations: 0

Search

Search

Browse

  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

mild cognitive impairment, MCI, physical activity, physical exercise, cognitive functions, older adults
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop