The Role of Physical Activity in Mild Cognitive Impairment
DOI:
https://doi.org/10.12775/QS.2026.72.75315Keywords
mild cognitive impairment, MCI, physical activity, physical exercise, cognitive functions, older adultsAbstract
Introduction: Mild cognitive impairment (MCI) is a common problem in the older population and is associated with an increased risk of developing dementia. Physical activity is one of the important modifiable lifestyle factors that may support cognitive functioning.
Aim: The aim of this paper was to assess the importance of physical activity in people with MCI, with particular emphasis on neurobiological mechanisms, the effectiveness of different forms of training, and their practical application.
Methods: This paper is a narrative review of the literature. Thirty-five publications were included, including original studies, randomized clinical trials, systematic reviews, meta-analyses, as well as guidelines and expert recommendations.
Results: Available data indicate that regular physical activity may have a beneficial effect on memory, executive functions, and global cognitive functioning in people with MCI. Beneficial effects were observed with aerobic training, resistance training, multicomponent programs, and interventions combining physical activity with cognitive training.
Conclusions: Physical activity is an important component of non-pharmacological management in people with MCI. However, due to the heterogeneity of studies and the limited duration of follow-up, there is still a lack of conclusive evidence that it prevents the progression of MCI to dementia.
References
1. Anderson N. D. (2019). State of the science on mild cognitive impairment (MCI). CNS spectrums, 24(1), 78–87. https://doi.org/10.1017/S1092852918001347
2.Petersen, R. C., Lopez, O., Armstrong, M. J., Getchius, T. S. D., Ganguli, M., Gloss, D., Gronseth, G. S., Marson, D., Pringsheim, T., Day, G. S., Sager, M., Stevens, J., & Rae-Grant, A. (2018). Practice guideline update summary: Mild cognitive impairment [RETIRED]: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology, 90(3), 126–135. https://doi.org/10.1212/WNL.000000000000482
3. Marino, F. R., Lyu, C., Li, Y., Liu, T., Au, R., & Hwang, P. H. (2025). Physical Activity Over the Adult Life Course and Risk of Dementia in the Framingham Heart Study. JAMA network open, 8(11), e2544439. https://doi.org/10.1001/jamanetworkopen.2025.4443
4. Vidyanti, A. N., Rahmawati, F., Rahman, R. H., Prodjohardjono, A., & Gofir, A. (2025). Lifestyle interventions for dementia risk reduction: A review on the role of physical activity and diet in Western and Asian Countries. The journal of prevention of Alzheimer's disease, 12(2), 100028. https://doi.org/10.1016/j.tjpad.2024.100028
5. Veronese, N., Soysal, P., Demurtas, J., Solmi, M., Bruyère, O., Christodoulou, N., Ramalho, R., Fusar-Poli, P., Lappas, A. S., Pinto, D., Frederiksen, K. S., Corbi, G. M., Karpenko, O., Georges, J., Durães, J., Schlögl, M., Yilmaz, O., Sieber, C., Shenkin, S. D., Smith, L., … endorsed by the European Academy of Neurology (2023). Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline. European geriatric medicine, 14(5), 925–952. https://doi.org/10.1007/s41999-023-00858-y
6. Jack, C. R., Jr, Hu, M., Wiste, H. J., Knopman, D. S., Vemuri, P., Graff-Radford, J., Lowe, V. J., Vassilaki, M., Cogswell, P. M., Schwarz, C. G., Algeciras-Schimnich, A., Petersen, R. C., & Therneau, T. M. (2025). Lifetime and 10-year absolute risk of cognitive impairment in relation to amyloid PET severity: a retrospective, longitudinal cohort study. The Lancet. Neurology, 24(12), 1016–1025. https://doi.org/10.1016/S1474-4422(25)00350-3
7. Khalil M. H. (2025). Walking and Hippocampal Formation Volume Changes: A Systematic Review. Brain sciences, 15(1), 52. https://doi.org/10.3390/brainsci15010052
8. Gieroba, B. (2019). Effect of physical activity on mental health and cognitive functions. Med Og Nauk Zdr., 25(3), 153–161. https://doi.org/10.26444/monz/112259
9. Ungvari, Z., Fazekas-Pongor, V., Csiszar, A. et al. The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms. GeroScience 45, 3211–3239 (2023). https://doi.org/10.1007/s11357-023-00873-8
10. López-Ortiz, S., Pinto-Fraga, J., Valenzuela, P. L., Martín-Hernández, J., Seisdedos, M. M., García-López, O., Toschi, N., Di Giuliano, F., Garaci, F., Mercuri, N. B., Nisticò, R., Emanuele, E., Lista, S., Lucia, A., & Santos-Lozano, A. (2021). Physical Exercise and Alzheimer's Disease: Effects on Pathophysiological Molecular Pathways of the Disease. International journal of molecular sciences, 22(6), 2897. https://doi.org/10.3390/ijms22062897
11. Mansoor, M., Ibrahim, A., Hamide, A., Tran, T., Candreva, E., & Baltaji, J. (2025). Exercise-Induced Neuroplasticity: Adaptive Mechanisms and Preventive Potential in Neurodegenerative Disorders. Physiologia, 5(2), 13. https://doi.org/10.3390/physiologia5020013
12. Zhou, B., Wang, Z., Zhu, L., Huang, G., Li, B., Chen, C., Huang, J., Ma, F., & Liu, T. C. (2022). Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis. Frontiers in aging neuroscience, 14, 981002. https://doi.org/10.3389/fnagi.2022.981002
13. Di Liegro, C. M., Schiera, G., Proia, P., & Di Liegro, I. (2019). Physical Activity and Brain Health. Genes, 10(9), 720. https://doi.org/10.3390/genes10090720
14. Camandola, S., & Mattson, M. P. (2017). Brain metabolism in health, aging, and neurodegeneration. The EMBO journal, 36(11), 1474–1492. https://doi.org/10.15252/embj.201695810
15. Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017). Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nature reviews. Neuroscience, 18(7), 419–434. https://doi.org/10.1038/nrn.2017.48
16. He, X. F., Liu, D. X., Zhang, Q., Liang, F. Y., Dai, G. Y., Zeng, J. S., Pei, Z., Xu, G. Q., & Lan, Y. (2017). Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice. Frontiers in molecular neuroscience, 10, 144. https://doi.org/10.3389/fnmol.2017.00144
17. Izquierdo, M., Merchant, R. A., Morley, J. E., Anker, S. D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E. L., Cesari, M., Chen, L. K., de Souto Barreto, P., Duque, G., Ferrucci, L., Fielding, R. A., García-Hermoso, A., Gutiérrez-Robledo, L. M., Harridge, S. D. R., Kirk, B., Kritchevsky, S., … Fiatarone Singh, M. (2021). International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. The journal of nutrition, health & aging, 25(7), 824–853. https://doi.org/10.1007/s12603-021-1665-8
18. Bull, F. C., Al-Ansari, S. S., Biddle, S., Borodulin, K., Buman, M. P., Cardon, G., Carty, C., Chaput, J. P., Chastin, S., Chou, R., Dempsey, P. C., DiPietro, L., Ekelund, U., Firth, J., Friedenreich, C. M., Garcia, L., Gichu, M., Jago, R., Katzmarzyk, P. T., Lambert, E., … Willumsen, J. F. (2020). World Health Organization 2020 guidelines on physical activity and sedentary behaviour. British journal of sports medicine, 54(24), 1451–1462. https://doi.org/10.1136/bjsports-2020-102955
19. De la Rosa, A., Olaso-Gonzalez, G., Arc-Chagnaud, C., Millan, F., Salvador-Pascual, A., García-Lucerga, C., Blasco-Lafarga, C., Garcia-Dominguez, E., Carretero, A., Correas, A. G., Viña, J., & Gomez-Cabrera, M. C. (2020). Physical exercise in the prevention and treatment of Alzheimer's disease. Journal of sport and health science, 9(5), 394–404. https://doi.org/10.1016/j.jshs.2020.01.004
20. Yoon M. S. (2017). mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass. Frontiers in physiology, 8, 788. https://doi.org/10.3389/fphys.2017.00788
21. Grgic, J., Garofolini, A., Orazem, J., Sabol, F., Schoenfeld, B. J., & Pedisic, Z. (2020). Effects of Resistance Training on Muscle Size and Strength in Very Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Sports medicine (Auckland, N.Z.), 50(11), 1983–1999. https://doi.org/10.1007/s40279-020-01331-7
22. Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019). Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association. Journal of strength and conditioning research, 33(8), 2019–2052. https://doi.org/10.1519/JSC.000000000000323
23. Shojaa, M., von Stengel, S., Kohl, M., Schoene, D., & Kemmler, W. (2020). Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 31(8), 1427–1444. https://doi.org/10.1007/s00198-020-05441-w
24. Ben Ezzdine, L., Dhahbi, W., Dergaa, I., Ceylan, H. İ., Guelmami, N., Ben Saad, H., Chamari, K., Stefanica, V., & El Omri, A. (2025). Physical activity and neuroplasticity in neurodegenerative disorders: a comprehensive review of exercise interventions, cognitive training, and AI applications. Frontiers in neuroscience, 19, 1502417. https://doi.org/10.3389/fnins.2025.1502417
25. Gallou-Guyot, M., Mandigout, S., Bherer, L., & Perrochon, A. (2020). Effects of exergames and cognitive-motor dual-task training on cognitive, physical and dual-task functions in cognitively healthy older adults: An overview. Ageing research reviews, 63, 101135. https://doi.org/10.1016/j.arr.2020.101135
26. Nuzum, H., Stickel, A., Corona, M., Zeller, M., Melrose, R. J., & Wilkins, S. S. (2020). Potential Benefits of Physical Activity in MCI and Dementia. Behavioural neurology, 2020, 7807856. https://doi.org/10.1155/2020/7807856
27. Cui, K., Yu, W., Zhang, J., & Zheng, B. (2026). Exercise modalities in mild cognitive impairment: a systematic review and network meta-analysis of comparative effectiveness. Frontiers in aging neuroscience, 18, 1888709. https://doi.org/10.3389/fnagi.2026.1888709
28. Ribeiro, I. C., Teixeira, C. V. L., de Resende, T. J. R., de Campos, B. M., Silva, G. B., Uchida, M. C., Magalhães, T. N. C., Pimentel-Silva, L. R., Aventurato, Í. K., Gonçalves, B. C., da Silva, M. C. R., Rizzi, L., Fernandes, G. B. P., Fernandes, P. T., Cendes, F., & Balthazar, M. L. F. (2025). Resistance training protects the hippocampus and precuneus against atrophy and benefits white matter integrity in older adults with mild cognitive impairment. GeroScience, 47(3), 5267–5286. https://doi.org/10.1007/s11357-024-01483-8
29. Yi, Q., Liu, Z., Zhong, F., Selvanayagam, V. S., & Cheong, J. P. G. (2024). Cognitive and physical impact of combined exercise and cognitive intervention in older adults with mild cognitive impairment: A systematic review and meta-analysis. PloS one, 19(10), e0308466. https://doi.org/10.1371/journal.pone.0308466
30. Castellote-Caballero, Y., Carcelén Fraile, M. D. C., Aibar-Almazán, A., Afanador-Restrepo, D. F., & González-Martín, A. M. (2024). Effect of combined physical-cognitive training on the functional and cognitive capacity of older people with mild cognitive impairment: a randomized controlled trial. BMC medicine, 22(1), 281. https://doi.org/10.1186/s12916-024-03469-x
31. Dieckelmann, M., González-González, A. I., Banzer, W., Berghold, A., Jeitler, K., Pantel, J., Pregartner, G., Schall, A., Tesky, V. A., & Siebenhofer, A. (2023). Effectiveness of exercise interventions to improve long-term outcomes in people living with mild cognitive impairment: a systematic review and meta-analysis. Scientific reports, 13(1), 18074. https://doi.org/10.1038/s41598-023-44771-7
32. Brasure, M., Desai, P., Davila, H., Nelson, V. A., Calvert, C., Jutkowitz, E., Butler, M., Fink, H. A., Ratner, E., Hemmy, L. S., McCarten, J. R., Barclay, T. R., & Kane, R. L. (2018). Physical Activity Interventions in Preventing Cognitive Decline and Alzheimer-Type Dementia: A Systematic Review. Annals of internal medicine, 168(1), 30–38. https://doi.org/10.7326/M17-1528
33. Liu, C., Lu, L., & Wei, W. (2026). Research advances in exercise management for frail older adults. Frontiers in public health, 14, 1763583. https://doi.org/10.3389/fpubh.2026.1763583
34. Decaix, T., Bonnin, C., Götze, K., François, V., Petit, C., Rivière, C., Greffard, S., Cognat, E., Hugon, J., Paquet, C., Sindzingre, L., & Lilamand, M. (2025). Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review. The Journal of frailty & aging, 14(5), 100069. https://doi.org/10.1016/j.tjfa.2025.100069
35. Bracco, L., Pinto-Carral, A., Hillaert, L., & Mourey, F. (2023). Tango-therapy vs physical exercise in older people with dementia; a randomized controlled trial. BMC geriatrics, 23(1), 693. https://doi.org/10.1186/s12877-023-04342-x
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Copyright (c) 2026 Magdalena Iwaszko, Marcelina Skajewska, Damian Szymański, Wiktoria Biegała , Paweł Iwaszko, Nina Kowalska, Oliwia Orłowska, Marta Wesołowska, Jan Czerwiński, Wiktoria Czerniawska, Kamil Gruszka

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