Exercise Dose, Timing and Supervision: Strategies for Gestational Diabetes Mellitus Prevention and Treatment: A Narrative Review
DOI:
https://doi.org/10.12775/QS.2026.69.74457Keywords
physical activity, gestational diabetes mellitus, pregnancy, prevention, exercise intervention, dose–response, maternal outcomes, neonatal outcomesAbstract
Aim. To synthesize evidence on the role of physical activity (PA) in preventing and managing gestational diabetes mellitus (GDM), covering physiology, observational data, trials, implementation barriers, and gaps.
Materials and methods. Narrative review of studies on preconception and pregnancy PA for GDM prevention and on PA interventions for treatment/control. Outcomes: incident GDM, fasting/postprandial glucose, insulin use, gestational weight gain, hypertensive disorders, delivery mode, neonatal outcomes (LGA, macrosomia, hypoglycemia), and longer‑term offspring data. Dose–response and subgroup analyses by timing, intensity, supervision, and maternal BMI.
Results. Preconception and early‑pregnancy PA are linked to lower GDM risk Protective estimates span ~21–46% overall. Dose–response: ≥15–21 MET h/week preconception; in pregnancy, 10/20/50 MET h/week ≈6/11/15% lower risk. Early, supervised light–moderate programs yield the largest prevention effects; one RCT reported up to 90% risk reduction at 150–180 min/week. A single moderate bout lowers postprandial glucose for 1–2 h; repeated aerobic/resistance training with dietary counseling improves fasting/postprandial glucose and may reduce insulin needs. Intensified lifestyle care reduces gestational weight gain and LGA. Evidence for hypertensive disorders, cesarean delivery, and long‑term outcomes is mixed. PA levels are low (MVPA ~11–14 min/day); barriers are clinical, symptomatic, cultural.
Conclusions. Promote PA before and early in pregnancy (≥15–21 MET h/week preconception; up to ~50 MET h/week in the first trimester when feasible). Early, supervised light–moderate programs and regular aerobic or resistance exercise plus dietary counseling are effective. More RCTs should refine optimal modality, dose, timing, supervision, and long‑term outcomes.
References
1. Mijatovic-Vukas J, Capling L, Cheng S, Stamatakis E, Louie J, Cheung NW, et al. Associations of Diet and Physical Activity with Risk for Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Nutrients. 30 maja 2018;10(6):698. doi:10.3390/nu10060698 PubMed PMID: 29849003; PubMed Central PMCID: PMC6024719.
2. Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. grudnia 2020;54(24):1451–62. doi:10.1136/bjsports-2020-102955 PubMed PMID: 33239350; PubMed Central PMCID: PMC7719906.
3. GASCOIGNE EL, WEBSTER CM, WEST HONART A, WANG P, SMITH-RYAN A, MANUCK TA. Physical activity and pregnancy outcomes: An expert review. Am J Obstet Gynecol MFM. stycznia 2023;5(1):100758. doi:10.1016/j.ajogmf.2022.100758 PubMed PMID: 36174931; PubMed Central PMCID: PMC9772147.
4. Warburton DER, Bredin SSD. Health benefits of physical activity: a systematic review of current systematic reviews. Curr Opin Cardiol. września 2017;32(5):541. doi:10.1097/HCO.0000000000000437
5. Sweeting A, Wong J, Murphy HR, Ross GP. A Clinical Update on Gestational Diabetes Mellitus. Endocr Rev. 26 września 2022;43(5):763–93. doi:10.1210/endrev/bnac003 PubMed PMID: 35041752; PubMed Central PMCID: PMC9512153.
6. Paulo MS, Abdo NM, Bettencourt-Silva R, Al-Rifai RH. Gestational Diabetes Mellitus in Europe: A Systematic Review and Meta-Analysis of Prevalence Studies. Front Endocrinol. 9 grudnia 2021;12:691033. doi:10.3389/fendo.2021.691033 PubMed PMID: 34956073; PubMed Central PMCID: PMC8698118.
7. Li X, Yang Q, Lu L, Zhang X, He L, Lin R, et al. Pilot study on exercise-induced placental transcriptomic changes and oxidative stress reduction in gestational diabetes mellitus. Sci Rep. 29 grudnia 2025;15:44821. doi:10.1038/s41598-025-28642-x PubMed PMID: 41462441; PubMed Central PMCID: PMC12749014.
8. Bauer ST, Cate JJM, Whitsel AI, Combs CA. Society for Maternal-Fetal Medicine Special Statement: Quality metric on the rate of postpartum diabetes screening after pregnancies with gestational diabetes mellitus. Am J Obstet Gynecol. 1 kwietnia 2023;228(4):B2–9. doi:10.1016/j.ajog.2022.12.315 PubMed PMID: 36584961.
9. Pu J, Zhao B, Wang EJ, Nimbal V, Osmundson S, Kunz L, et al. Racial/Ethnic Differences in Gestational Diabetes Prevalence and Contribution of Common Risk Factors. Paediatr Perinat Epidemiol. września 2015;29(5):436–43. doi:10.1111/ppe.12209 PubMed PMID: 26201385; PubMed Central PMCID: PMC6519933.
10. Wu S, Jin J, Hu KL, Wu Y, Zhang D. Prevention of Gestational Diabetes Mellitus and Gestational Weight Gain Restriction in Overweight/Obese Pregnant Women: A Systematic Review and Network Meta-Analysis. Nutrients. stycznia 2022;14(12):2383. doi:10.3390/nu14122383
11. Luo Y, Meng X, Cui L, Wang S. Circadian Regulation of Lipid Metabolism during Pregnancy. Int J Mol Sci. stycznia 2024;25(21):11491. doi:10.3390/ijms252111491
12. Zhou X, Zhang H, Wei L, Wang Z, Zhu S, Yu J, et al. Oxidative stress, mitochondrial dysfunction, and ferroptosis in the placenta of gestational diabetes mellitus. J Mol Med Berl Ger. 2026;104(1):8. doi:10.1007/s00109-025-02629-7 PubMed PMID: 41410733; PubMed Central PMCID: PMC12714824.
13. Stern C, Schwarz S, Moser G, Cvitic S, Jantscher-Krenn E, Gauster M, et al. Placental Endocrine Activity: Adaptation and Disruption of Maternal Glucose Metabolism in Pregnancy and the Influence of Fetal Sex. Int J Mol Sci. 24 listopada 2021;22(23):12722. doi:10.3390/ijms222312722
14. Sweeting A, Wong J, Murphy HR, Ross GP. A Clinical Update on Gestational Diabetes Mellitus. Endocr Rev. 26 września 2022;43(5):763–93. doi:10.1210/endrev/bnac003
15. Lu M, Sferruzzi-Perri AN. Placental mitochondrial function in response to gestational exposures. Placenta. stycznia 2021;104:124–37. doi:10.1016/j.placenta.2020.11.012
16. Zaugg J, Lopez-Tello J, Musial B, Vaughan OR, Fowden AL, Albrecht C, et al. Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations. Cell Mol Life Sci. 25 marca 2024;81(1):151. doi:10.1007/s00018-024-05192-5
17. Pan X, Jin X, Wang J, Hu Q, Dai B. Placenta inflammation is closely associated with gestational diabetes mellitus. Am J Transl Res. 15 maja 2021;13(5):4068–79. PubMed PMID: 34149999; PubMed Central PMCID: PMC8205654.
18. Zgutka K, Tkacz M, Tomasiak P, Piotrowska K, Ustianowski P, Pawlik A, et al. Gestational Diabetes Mellitus-Induced Inflammation in the Placenta via IL-1β and Toll-like Receptor Pathways. Int J Mol Sci. stycznia 2024;25(21):11409. doi:10.3390/ijms252111409
19. Garlanda C, Dinarello CA, Mantovani A. The Interleukin-1 Family: Back to the Future. Immunity. 12 grudnia 2013;39(6):1003–18. doi:10.1016/j.immuni.2013.11.010 PubMed PMID: 24332029.
20. Weber A, Wasiliew P, Kracht M. Interleukin-1 (IL-1) Pathway. Sci Signal. 19 stycznia 2010;3(105):cm1–cm1. doi:10.1126/scisignal.3105cm1
21. Qi Z, He J, Zhang Y, Shao Y, Ding S. Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats. Free Radic Biol Med. 1 kwietnia 2011;50(7):794–800. doi:10.1016/j.freeradbiomed.2010.12.022 PubMed PMID: 21185935.
22. Hardy DB, Mu X, Marchiori KS, Mottola MF. Exercise in Pregnancy Increases Placental Angiogenin without Changes in Oxidative or Endoplasmic Reticulum Stress. Med Sci Sports Exerc. września 2021;53(9):1846. doi:10.1249/MSS.0000000000002647
23. Xie W, Zhang L, Cheng J, Wang Y, Kang H, Gao Y. Physical activity during pregnancy and the risk of gestational diabetes mellitus: a systematic review and dose–response meta-analysis. BMC Public Health. 23 lutego 2024;24:594. doi:10.1186/s12889-024-18131-7 PubMed PMID: 38395913; PubMed Central PMCID: PMC10893683.
24. Martínez-Vizcaíno V, Sanabria-Martínez G, Fernández-Rodríguez R, Cavero-Redondo I, Pascual-Morena C, Álvarez-Bueno C, et al. Exercise during pregnancy for preventing gestational diabetes mellitus and hypertensive disorders: An umbrella review of randomised controlled trials and an updated meta-analysis. BJOG Int J Obstet Gynaecol. lutego 2023;130(3):264–75. doi:10.1111/1471-0528.17304 PubMed PMID: 36156844; PubMed Central PMCID: PMC10092296.
25. Cordero Y, Mottola MF, Vargas J, Blanco M, Barakat R. Exercise Is Associated with a Reduction in Gestational Diabetes Mellitus. Med Sci Sports Exerc. lipca 2015;47(7):1328–33. doi:10.1249/MSS.0000000000000547 PubMed PMID: 25333246.
26. Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, et al. Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care. 11 października 2016;39(11):2065–79. doi:10.2337/dc16-1728
27. Rasmussen L, Poulsen CW, Kampmann U, Smedegaard SB, Ovesen PG, Fuglsang J. Diet and Healthy Lifestyle in the Management of Gestational Diabetes Mellitus. Nutrients. 6 października 2020;12(10):3050. doi:10.3390/nu12103050 PubMed PMID: 33036170; PubMed Central PMCID: PMC7599681.
28. Andersen MB, Ovesen PG, Daugaard M, Ostenfeld EB, Fuglsang J. Cycling reduces blood glucose excursions after an oral glucose tolerance test in pregnant women: a randomized crossover trial. Appl Physiol Nutr Metab Physiol Appl Nutr Metab. listopada 2020;45(11):1247–52. doi:10.1139/apnm-2020-0020 PubMed PMID: 32442384.
29. García-Patterson A, Martín E, Ubeda J, María MA, de Leiva A, Corcoy R. Evaluation of Light Exercise in the Treatment of Gestational Diabetes. Diabetes Care. 1 listopada 2001;24(11):2006–7. doi:10.2337/diacare.24.11.2006
30. Huifen Z, Yaping X, Meijing Z, Huibin H, Chunhong L, Fengfeng H, et al. Effects of moderate-intensity resistance exercise on blood glucose and pregnancy outcome in patients with gestational diabetes mellitus: A randomized controlled trial. J Diabetes Complications. 1 maja 2022;36(5):108186. doi:10.1016/j.jdiacomp.2022.108186
31. Martis R, Crowther CA, Shepherd E, Alsweiler J, Downie MR, Brown J. Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews - Martis, R - 2018 | Cochrane Library [Internet]. [cytowane 9 kwietnia 2026]. Dostępne na: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012327.pub2/full
32. Laredo-Aguilera JA, Gallardo-Bravo M, Rabanales-Sotos JA, Cobo-Cuenca AI, Carmona-Torres JM. Physical Activity Programs during Pregnancy Are Effective for the Control of Gestational Diabetes Mellitus. Int J Environ Res Public Health. 24 sierpnia 2020;17(17):6151. doi:10.3390/ijerph17176151 PubMed PMID: 32847106; PubMed Central PMCID: PMC7503359.
33. Brown J, Alwan NA, West J, Brown S, McKinlay CJ, Farrar D, et al. Lifestyle interventions for the treatment of women with gestational diabetes. Cochrane Database Syst Rev. 4 maja 2017;2017(5):CD011970. doi:10.1002/14651858.CD011970.pub2 PubMed PMID: 28472859; PubMed Central PMCID: PMC6481373.
34. Nawaz H, Adams ML, Katz DL. Physician-patient interactions regarding diet, exercise, and smoking. Prev Med. grudnia 2000;31(6):652–7. doi:10.1006/pmed.2000.0760 PubMed PMID: 11133331.
35. Alexander SC, Cox ME, Boling Turer CL, Lyna P, Østbye T, Tulsky JA, et al. Do the five A’s work when physicians counsel about weight loss? Fam Med. marca 2011;43(3):179–84. PubMed PMID: 21380950; PubMed Central PMCID: PMC3367376.
36. Serdula MK, Khan LK, Dietz WH. Weight loss counseling revisited. JAMA. 9 kwietnia 2003;289(14):1747–50. doi:10.1001/jama.289.14.1747 PubMed PMID: 12684339.
37. Physical Activity and Exercise During Pregnancy and the Postpartum Period: ACOG Committee Opinion, Number 804. Obstet Gynecol. kwietnia 2020;135(4):e178. doi:10.1097/AOG.0000000000003772
38. McMurray RG, Mottola MF, Wolfe LA, Artal R, Millar L, Pivarnik JM. Recent advances in understanding maternal and fetal responses to exercise. Med Sci Sports Exerc. grudnia 1993;25(12):1305–21. PubMed PMID: 8107536.
39. Persinger R, Foster C, Gibson M, Fater DCW, Porcari JP. Consistency of the talk test for exercise prescription. Med Sci Sports Exerc. września 2004;36(9):1632–6. PubMed PMID: 15354048.
40. Soultanakis HN, Artal R, Wiswell RA. Prolonged exercise in pregnancy: glucose homeostasis, ventilatory and cardiovascular responses. Semin Perinatol. sierpnia 1996;20(4):315–27. doi:10.1016/s0146-0005(96)80024-3 PubMed PMID: 8888457.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Szymon Marciszuk, Justyna Jankowska, Marlena Radzka, Klaudia Forystek, Paweł Budzik, Julia Bezak, Agata Kaczmarzyk, Jonatan Rataj

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 109
Number of citations: 0