Effects of bovine colostrum supplementation on athletic performance – literature review
DOI:
https://doi.org/10.12775/QS.2026.64.73627Keywords
bovine colostrum, immunity, immunology, 'supplementation', athlete, sport performanceAbstract
Background: Colostrum is the first milk produced by mammals after birth and contains numerous bioactive compounds, including immunoglobulins, growth factors, lactoferrin, cytokines, and antimicrobial peptides. Bovine colostrum is widely used as a dietary supplement and has been associated with immunomodulatory, anti-inflammatory, antimicrobial, and regenerative properties. In sports nutrition, it has been investigated for its potential role in supporting immune function, post-exercise recovery, gastrointestinal barrier integrity, and adaptation to exercise-induced stress. However, its effects on athletic performance and mechanisms of action remain debated.
Aim: This review evaluates evidence on the effects of bovine colostrum supplementation on performance, recovery, gastrointestinal integrity, and selected immune parameters in athletes and physically active individuals.
Material and methods: A narrative review of randomized controlled trials, experimental studies, systematic reviews, and meta-analyses was conducted using PubMed, Scopus, and Web of Science.
Results: Current evidence suggests modest and context-dependent benefits, mainly for mucosal immunity, intestinal barrier function, inflammatory responses, and post-exercise recovery. Some studies reported favorable effects on salivary secretory IgA, intestinal permeability or injury markers, and selected biochemical indicators. However, direct effects on strength, endurance, body composition, and sport-specific performance remain inconsistent.
Conclusions: Bovine colostrum may be considered a supportive nutritional strategy for selected athletes exposed to intensive training, endurance exercise, or immune and gastrointestinal stress. Further randomized controlled trials are needed to define optimal dose, duration, timing, and target populations.
References
1. El-Loly MM. Colostrum ingredients, its nutritional and health benefits - an overview. Clin Nutr Open Sci. 2022 Aug 1;44:126–43. doi:10.1016/j.nutos.2022.07.001
2. Bagwe S, Tharappel LJP, Kaur G, Buttar HS. Bovine colostrum: an emerging nutraceutical. J Complement Integr Med. 2015 Sep;12(3):175–85. doi:10.1515/jcim-2014-0039 PubMed PMID: 25781716.
3. Arslan A, Kaplan M, Duman H, Bayraktar A, Ertürk M, Henrick BM, et al. Bovine Colostrum and Its Potential for Human Health and Nutrition. Front Nutr. 2021 Jun 21;8:651721. doi:10.3389/fnut.2021.651721 PubMed PMID: 34235166; PubMed Central PMCID: PMC8255475.
4. Dzik S, Miciński B, Aitzhanova I, Miciński J, Pogorzelska J, Beisenov A, et al. Properties of bovine colostrum and the possibilities of use. Pol Ann Med. 2017 Aug 1;24(2):295–9. doi:10.1016/j.poamed.2017.03.004
5. Silva EG dos SO, Rangel AH do N, Mürmam L, Bezerra MF, Oliveira JPF de. Bovine colostrum: benefits of its use in human food. Food Sci Technol. 2019;39:355–62. doi:https://doi.org/10.1590/fst.14619
6. Michalska M, Winiarek K, Wardyn W, Tokarczyk E, Ziemińska D, Guzowski C, et al. Colostrum: The Golden Elixir of Health – Unveiling Its Multifaceted Benefits in Modern Medicine. Qual Sport. 2024 Nov 15;32:56082–56082. doi:10.12775/QS.2024.32.56082
7. Ghosh S, Iacucci M. Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease. Nutrients. 2021 Nov;13(11):3798. doi:10.3390/nu13113798
8. Dziewiecka H, Buttar HS, Kasperska A, Ostapiuk-Karolczuk J, Domagalska M, Cichoń J, et al. A Systematic Review of the Influence of Bovine Colostrum Supplementation on Leaky Gut Syndrome in Athletes: Diagnostic Biomarkers and Future Directions. Nutrients. 2022 Jun 17;14(12):2512. doi:10.3390/nu14122512 PubMed PMID: 35745242; PubMed Central PMCID: PMC9227274.
9. Chandwe K, Kelly P. Colostrum Therapy for Human Gastrointestinal Health and Disease. Nutrients. 2021 Jun 7;13(6):1956. doi:10.3390/nu13061956 PubMed PMID: 34200282; PubMed Central PMCID: PMC8228205.
10. Saad K, Abo-Elela MGM, El-Baseer KAA, Ahmed AE, Ahmad FA, Tawfeek MSK, et al. Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children. Medicine (Baltimore). 2016 Sep;95(37):e4560. doi:10.1097/MD.0000000000004560 PubMed PMID: 27631207; PubMed Central PMCID: PMC5402550.
11. Jones AW, Thatcher R, Davison G. Effects of acute bovine colostrum supplementation on immune responses to prolonged cycling: a randomised crossover trial. Eur J Nutr. 2026;65(4):153. doi:10.1007/s00394-026-04016-5 PubMed PMID: 42249952; PubMed Central PMCID: PMC13242472.
12. Playford RJ, Weiser MJ. Bovine Colostrum: Its Constituents and Uses. Nutrients. 2021 Jan 18;13(1):265. doi:10.3390/nu13010265 PubMed PMID: 33477653; PubMed Central PMCID: PMC7831509.
13. Kshirsagar AY, Vekariya MA, Gupta V, Pednekar AS, Mahna A, Patankar R, et al. A comparative study of colostrum dressing versus conventional dressing in deep wounds. J Clin Diagn Res JCDR. 2015 Apr;9(4):PC01-04. doi:10.7860/JCDR/2015/12004.5739 PubMed PMID: 26023589; PubMed Central PMCID: PMC4437104.
14. Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am. 2013 Feb;60(1):49–74. doi:10.1016/j.pcl.2012.10.002 PubMed PMID: 23178060; PubMed Central PMCID: PMC3586783.
15. Rio-Aige K, Azagra-Boronat I, Castell M, Selma-Royo M, Collado MC, Rodríguez-Lagunas MJ, et al. The Breast Milk Immunoglobulinome. Nutrients. 2021 May 26;13(6):1810. doi:10.3390/nu13061810 PubMed PMID: 34073540; PubMed Central PMCID: PMC8230140.
16. McGrath BA, Fox PF, McSweeney PLH, Kelly AL. Composition and properties of bovine colostrum: a review. Dairy Sci Technol. 2016 Mar 1;96(2):133–58. doi:10.1007/s13594-015-0258-x
17. Costa A, Franzoi M, Visentin G, Goi A, De Marchi M, Penasa M. The concentrations of immunoglobulins in bovine colostrum determined by the gold standard method are genetically correlated with their near-infrared prediction. Genet Sel Evol GSE. 2021 Nov 10;53(1):87. doi:10.1186/s12711-021-00681-8 PubMed PMID: 34758741; PubMed Central PMCID: PMC8579186.
18. Ge H, Zhu W, Zhang J, Wang Z, Shi H, Sun J, et al. Human milk microbiota and oligosaccharides in colostrum and mature milk: comparison and correlation. Front Nutr. 2024 Dec 12;11. doi:10.3389/fnut.2024.1512700
19. Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a Natural Immune Modulator. Curr Pharm Des. 2009;15(17):1956–73. doi:10.2174/138161209788453202 PubMed PMID: 19519436; PubMed Central PMCID: PMC2915836.
20. Guliński P, Gago V. The influence of selected factors on the yield and quality of colostrum produced by Polish Holstein-Friesian cows. Acta Sci Pol Zootech. 2019 May 23;18(1):11–8.
21. Godden SM, Lombard JE, Woolums AR. Colostrum Management for Dairy Calves. Vet Clin North Am Food Anim Pract. 2019 Nov;35(3):535–56. doi:10.1016/j.cvfa.2019.07.005 PubMed PMID: 31590901; PubMed Central PMCID: PMC7125574.
22. Kaplan M, Arslan A, Duman H, Karyelioğlu M, Baydemir B, Günar BB, et al. Production of Bovine Colostrum for Human Consumption to Improve Health. Front Pharmacol. 2022 Jan 3;12:796824. doi:10.3389/fphar.2021.796824 PubMed PMID: 35046820; PubMed Central PMCID: PMC8762312.
23. Główka N, Woźniewicz M. Potential use of Colostrum Bovinum supplementation in athletes – A review. Acta Sci Pol Technol Aliment. 2019 Jun 30;18(2):115–23. doi:10.17306/J.AFS.2019.0654
24. Gleeson M, Walsh NP, British Association of Sport and Exercise Sciences. The BASES expert statement on exercise, immunity, and infection. J Sports Sci. 2012;30(3):321–4. doi:10.1080/02640414.2011.627371 PubMed PMID: 22132765.
25. Nieman DC, Wentz LM. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019 May;8(3):201–17. doi:10.1016/j.jshs.2018.09.009 PubMed PMID: 31193280; PubMed Central PMCID: PMC6523821.
26. Walsh NP, Gleeson M, Shephard RJ, Gleeson M, Woods JA, Bishop NC, et al. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev. 2011;17:6–63. PubMed PMID: 21446352.
27. Durkalec-Michalski K, Główka N, Podgórski T, Woźniewicz M, Nowaczyk PM. The effect of 12-week high-dose Colostrum Bovinum supplementation on immunological, hematological and biochemical markers in endurance athletes: a randomized crossover placebo-controlled study. Front Immunol. 2024 Oct 21;15. doi:10.3389/fimmu.2024.1425785
28. Nieman DC. Exercise, upper respiratory tract infection, and the immune system. Med Sci Sports Exerc. 1994 Feb;26(2):128–39. doi:10.1249/00005768-199402000-00002 PubMed PMID: 8164529.
29. Główka N, Durkalec-Michalski K, Woźniewicz M. Immunological Outcomes of Bovine Colostrum Supplementation in Trained and Physically Active People: A Systematic Review and Meta-Analysis. Nutrients. 2020 Apr 8;12(4):1023. doi:10.3390/nu12041023 PubMed PMID: 32276466; PubMed Central PMCID: PMC7231218.
30. Gleeson M, Williams C. Intense exercise training and immune function. Nestle Nutr Inst Workshop Ser. 2013;76:39–50. doi:10.1159/000350254 PubMed PMID: 23899753.
31. Costa RJS, Snipe RMJ, Kitic CM, Gibson PR. Systematic review: exercise-induced gastrointestinal syndrome—implications for health and intestinal disease. Aliment Pharmacol Ther. 2017;46(3):246–65. doi:10.1111/apt.14157
32. Jones AW, March DS, Thatcher R, Diment B, Walsh NP, Davison G. The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial. Eur J Nutr. 2019 Feb 1;58(1):335–44. doi:10.1007/s00394-017-1597-6
33. Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol-Gastrointest Liver Physiol. 2011 Mar;300(3):G477–84. doi:10.1152/ajpgi.00281.2010
34. Ulfman LH, Leusen JHW, Savelkoul HFJ, Warner JO, van Neerven RJJ. Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection. Front Nutr. 2018 Jun 22;5. doi:10.3389/fnut.2018.00052
35. Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001 Mar;17(3):243–7. doi:10.1016/s0899-9007(00)00552-9 PubMed PMID: 11312068.
36. Brinkworth GD, Buckley JD, Slavotinek JP, Kurmis AP. Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men. Eur J Appl Physiol. 2004 Jan;91(1):53–60. doi:10.1007/s00421-003-0944-x PubMed PMID: 14504943.
37. Kotsis Y, Mikellidi A, Aresti C, Persia E, Sotiropoulos A, Panagiotakos DB, et al. A low-dose, 6-week bovine colostrum supplementation maintains performance and attenuates inflammatory indices following a Loughborough Intermittent Shuttle Test in soccer players. Eur J Nutr. 2018 Apr;57(3):1181–95. doi:10.1007/s00394-017-1401-7 PubMed PMID: 28285432; PubMed Central PMCID: PMC5861165.
38. Cieślicka M, Stankiewicz B, Muszkieta R, Tafil-Klawe M, Klawe J, Skarpańska-Stejnborn A, et al. Long-Term Bovine Colostrum Supplementation in Football Players. Nutrients. 2023 Nov 14;15(22):4779. doi:10.3390/nu15224779 PubMed PMID: 38004173; PubMed Central PMCID: PMC10675434.
39. Cieślicka M, Ostapiuk-Karolczuk J, Buttar HS, Dziewiecka H, Kasperska A, Skarpańska-Stejnborn A. Effects of Long-Term Supplementation of Bovine Colostrum on Iron Homeostasis, Oxidative Stress, and Inflammation in Female Athletes: A Placebo-Controlled Clinical Trial. Nutrients. 2022 Dec 30;15(1):186. doi:10.3390/nu15010186 PubMed PMID: 36615842; PubMed Central PMCID: PMC9824210.
40. March DS, Jones AW, Thatcher R, Davison G. The effect of bovine colostrum supplementation on intestinal injury and circulating intestinal bacterial DNA following exercise in the heat. Eur J Nutr. 2019 Jun;58(4):1441–51. doi:10.1007/s00394-018-1670-9 PubMed PMID: 29574607; PubMed Central PMCID: PMC6561991.
41. McKenna Z, Berkemeier Q, Naylor A, Kleint A, Gorini F, Ng J, et al. Bovine colostrum supplementation does not affect plasma I-FABP concentrations following exercise in a hot and humid environment. Eur J Appl Physiol. 2017 Dec 1;117(12):2561–7. doi:10.1007/s00421-017-3743-5
42. Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. Am J Clin Nutr. 2016 Aug;104(2):526–36. doi:10.3945/ajcn.116.134403 PubMed PMID: 27357095.
43. Davison G, Jones AW, Marchbank T, Playford RJ. Oral bovine colostrum supplementation does not increase circulating insulin-like growth factor-1 concentration in healthy adults: results from short- and long-term administration studies. Eur J Nutr. 2020 Jun;59(4):1473–9. doi:10.1007/s00394-019-02004-6 PubMed PMID: 31123862; PubMed Central PMCID: PMC7230051.
44. Skarpańska-Stejnborn A, Cieślicka M, Dziewiecka H, Kujawski S, Marcinkiewicz A, Trzeciak J, et al. Effects of Long-Term Supplementation of Bovine Colostrum on the Immune System in Young Female Basketball Players. Randomized Trial. Nutrients. 2020 Dec 30;13(1):118. doi:10.3390/nu13010118 PubMed PMID: 33396972; PubMed Central PMCID: PMC7823942.
45. Durkalec-Michalski K, Główka N, Podgórski T, Szymocha M, Przybylik B, Wochna K, et al. Does Colostrum Bovinum Supplementation Affect Swimming Performance in Endurance-Trained Males? A Randomized Placebo-Controlled Crossover Study. Nutrients. 2024 Sep 22;16(18):3204. doi:10.3390/nu16183204 PubMed PMID: 39339805; PubMed Central PMCID: PMC11435245.
46. Durkalec-Michalski K, Główka N, Podgórski T, Wochna K, Woźniewicz M, Nowaczyk PM. Twelve-Week Colostrum Bovinum Supplementation Supports Aerobic Capacity but has No Effect on Body Composition in Endurance-Trained Males: A Randomized Placebo-Controlled Crossover Study. Eur J Sport Sci. 2025;25(5):e12288. doi:10.1002/ejsc.12288
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Copyright (c) 2026 Gabriela Świetlicka, Maria Pietrzak, Paulina Pietraś, Aneta Chawryło, Marcela Łupina-Romaniuk, Dominika Piecuch, Michał Stolarczyk, Julia Kołodziejczyk, Karolina Oleksińska, Karolina Pracoń
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