The Impact of Aerobic Training Programs on Cognitive Functions in Older Adults Based on Intervention Studies: a Narrative Review
DOI:
https://doi.org/10.12775/QS.2026.63.73473Keywords
aerobic training, physical activity, cognitive function, older adults, aging, episodic memory, executive functionsAbstract
Background: In the face of progressive population aging, the decline in cognitive functioning among older adults represents a critical challenge for healthcare systems. Within the paradigm of successful aging, physical activity plays a pivotal role.
Aim: This review aims to evaluate the impact of structured aerobic training programs on global and domain-specific cognitive functions in older adults, based on recent interventional evidence.
Methods: A narrative literature review was conducted by searching the PubMed, Scopus, Web of Science, and Cochrane Library databases. The search was restricted to randomized controlled trials (RCTs) published in English between 2021 and 2026. Studies evaluating cohorts aged 60 years or older, utilizing an aerobic exercise intervention lasting for at least 4-6 weeks, and employing validated neuropsychological assessment tools were eligible for analysis.
Results: Synthesis of the included trials demonstrated that short- and medium-term aerobic training programs (ranging from 6 to 20 weeks, performed 3-5 times per week) induce statistically significant improvements in global cognitive performance, as evidenced by elevated MMSE and MoCA scores. Conversely, in long-term interventions (spanning 1 to 5 years), endurance exercise effectively decelerated the trajectory of normative physiological cognitive decline. Regarding specific cognitive domains, regular moderate-intensity training yielded the most pronounced benefits in memory, executive functions, and information processing speed. This neuroprotective outcome is mediated by a synergistic combination of vascular, neurobiological, and psychological mechanisms.
Conclusions: Aerobic training represents a safe, well-tolerated, and highly effective non-pharmacological intervention that preserves and enhances cognitive health in the geriatric population, demonstrating substantial utility in both mitigating acute age-related deficits and preventing long-term neurodegeneration.
References
1. Halloway S, Wilbur J, Schoeny ME, Arfanakis K. Effects of Endurance-Focused Physical Activity Interventions on Brain Health: A Systematic Review. Biol Res Nurs. 2017;19(1):53-64. https://doi.org/10.1177/1099800416660758
2. Zhao Y, Li Y, Wang L, et al. Physical Activity and Cognition in Sedentary Older Adults: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2022;87(3):957-968. https://doi.org/10.3233/JAD-220073
3. Murman DL. The Impact of Age on Cognition. Semin Hear. 2015;36(3):111-121. https://doi.org/10.1055/s-0035-1555115
4. Dipietro L, Campbell WW, Buchner DM, et al. Physical Activity, Injurious Falls, and Physical Function in Aging: An Umbrella Review. Med Sci Sports Exerc. 2019;51(6):1303-1313. https://doi.org/10.1249/MSS.0000000000001942
5. Bigarella LG, Ballotin VR, Mazurkiewicz LF, Ballardin AC, Rech DL, Bigarella RL, Selistre LDS. Exercise for depression and depressive symptoms in older adults: an umbrella review of systematic reviews and Meta-analyses. Aging Ment Health. 2022 Aug;26(8):1503-1513. https://doi.org/10.1080/13607863.2021.1951660
6. Makhfudli M, Tonapa S, Has E, Chong M, Efendi F. Efficacy of Mind-body Exercise to Reduce Sleep Disturbance and Depression Among Older Adults: A Systematic Review and Meta-analysis. Asian Nursing Research, 2024;18:408-419. https://doi.org/10.1016/j.anr.2024.08.002
7. World Health Organization. WHO Guidelines on Physical Activity and Sedentary Behaviour. Geneva, Switzerland: World Health Organization; 2020.
8. Petersen R, Kokmen E, Waring S, Smith G, Ivnik R, Tangelos E. Aging, Memory, and Mild Cognitive Impairment. International Psychogeriatrics. 1997;9(1):65-69. https://doi.org/10.1017/S1041610297004717
9. Jia X, Wang Z, Huang F, et al. A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study. BMC Psychiatry. 2021;21(1):485. Published 2021 Oct 4. https://doi.org/10.1186/s12888-021-03495-6
10. Kistler-Fischbacher M, Gohar G, de Godoi Rezende Costa Molino C, et al. Cognitive function in generally healthy adults age 70 years and older in the 5-country DO-HEALTH study: MMSE and MoCA scores by sex, education, and country. Aging Clin Exp Res. 2025;37(1):88. Published 2025 Mar 17. https://doi.org/10.1007/s40520-025-02946-4
11. Ashendorf L, Jefferson AL, O'Connor MK, Chaisson C, Green RC, Stern RA. Trail Making Test errors in normal aging, mild cognitive impairment, and dementia. Arch Clin Neuropsychol. 2008;23(2):129-137. https://doi.org/10.1016/j.acn.2007.11.005
12. Lee SC, Chien TH, Chu CP, Lee Y, Chiu EC. Practice effect and test-retest reliability of the Wechsler Memory Scale-Fourth Edition in people with dementia. BMC Geriatr. 2023;23(1):209. Published 2023 Apr 1. https://doi.org/10.1186/s12877-023-03913-2
13. Salthouse TA. Contributions of the Individual Differences Approach to Cognitive Aging. J Gerontol B Psychol Sci Soc Sci. 2017;72(1):7-15. https://doi.org/10.1093/geronb/gbw069
14. Visser D, Wattel EM, Gerrits KHL, et al. Effectiveness and characteristics of physical fitness training on aerobic fitness in vulnerable older adults: an umbrella review of systematic reviews. BMJ Open. 2022;12(5):e058056. https://doi.org/10.1136/bmjopen-2021-058056
15. Izquierdo M, Merchant RA, Morley JE, et al. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021;25(7):824-853. https://doi.org/10.1007/s12603-021-1665-8
16. Xu Q, Fan Y, Zhu J, Wang X. The effect of different exercise on physical fitness, cognition, and mental health in healthy older adults. Heliyon. 2024;10(16):e36510. Published 2024 Aug 16. https://doi.org/10.1016/j.heliyon.2024.e36510
17. Mundada PH, Dadgal RM. Comparison of Dual Task Training Versus Aerobics Training in Improving Cognition in Healthy Elderly Population. Cureus. 2022;14(9):e29027. https://doi.org/10.7759/cureus.29027
18. Xu C, Wang Y, Tang C, Chen H, Cui L, Yu X, Wang F. Enhancing cognitive and emotional well-being in older adults through aerobic, strength, or balance training: insights from a randomized controlled trial. Acta Psychologica. 2025;257:105068. https://doi.org/10.1016/j.actpsy.2025.105068
19. Bakken J, Brissach DE, Ingeström EML, et al. Effects of 5-Year Exercise Training on Cognition in Older Adults: 10-Years Follow-Up from the Generation 100 Study. Sports Med Open. 2025;11(1):153. https://doi.org/10.1186/s40798-025-00956-0
20. Tomoto T, Verma A, Kostroske K, et al. One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults. J Cereb Blood Flow Metab. 2023;43(3):404-418. https://doi.org/10.1177/0271678X221133861
21. Najar J, Östling S, Gudmundsson P, Sundh V, Johansson L, Kern S, Guo X, Hällström T, Skoog I. Cognitive and physical activity and dementia. A 44-year longitudinal population study of women. Neurology. 2019;92 (12):1322-1330. https://doi.org/10.1212/WNL.0000000000007021
22. Boa Sorte Silva N, Barha C, Erickson K, Kramer A, Liu-Ambrose T. Physical exercise, cognition, and brain health in aging. Trends in Neurosciences. 2024;47(6):402-417. https://doi.org/10.1016/j.tins.2024.04.004
23. Han H, Zhang J, Zhang F, Li F, Wu Z. Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis. Front Aging Neurosci. 2025;17:1510773. https://doi.org/10.3389/fnagi.2025.1510773
24. Rodriguez-Rodríguez S, Canet-Vintró M, Wee SO, et al. Cognitive Enhancement Strategies for Older Adults: An Evaluation of Different Training Modalities to Improve Executive Function-A Systematic Review and Meta-Analysis. J Clin Med. 2024;13(5):1301. https://doi.org/10.3390/jcm13051301
25. Zhang J, Ye W, Li W, Zhang F, Wu Z. Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis. Experimental Gerontology. 2025;206:112768. https://doi.org/10.1016/j.exger.2025.112768
26. Rieker JA, Reales JM, Muiños M, Ballesteros S. The Effects of Combined Cognitive-Physical Interventions on Cognitive Functioning in Healthy Older Adults: A Systematic Review and Multilevel Meta-Analysis. Front Hum Neurosci. 2022;16:838968. https://doi.org/10.3389/fnhum.2022.838968
27. Yong L, Liu L, Ding T, et al. Evidence of Effect of Aerobic Exercise on Cognitive Intervention in Older Adults With Mild Cognitive Impairment. Front Psychiatry. 2021;12:713671. https://doi.org/10.3389/fpsyt.2021.713671
28. Venegas-Sanabria LC, Cavero-Redondo I, Martínez-Vizcaino V, Cano-Gutierrez CA, Álvarez-Bueno C. Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis. BMC Geriatr. 2022;22(1):617. https://doi.org/10.1186/s12877-022-03302-1
29. Blondell SJ, Hammersley-Mather R, Veerman JL. Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies. BMC Public Health. 2014;14:510. https://doi.org/10.1186/1471-2458-14-510
30. Sáez de Asteasu M, Martínez-Velilla N, Zambom-Ferraresi F, Casas-Herrero A, Izquierdo M. Role of physical exercise on cognitive function in healthy older adults: A systematic review of randomized clinical trials. Ageing Research Reviews. 2017;37:117-134. https://doi.org/10.1016/j.arr.2017.05.007
31. van Uffelen JG, Chin A, Paw MJ, Hopman-Rock M, van Mechelen W. The effects of exercise on cognition in older adults with and without cognitive decline: a systematic review. Clin J Sport Med. 2008;18(6):486-500. https://doi.org/10.1097/JSM.0b013e3181845f0b
32. Kim H, Lee D, Lee Y. The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor (BDNF) in Individuals with Mild Cognitive Impairment: a Systematic Review and Meta-Analysis of a Randomized Controlled Trials. Physical Therapy Rehabilitation Science. 2022;11:304-10. https://doi.org/10.14474/ptrs.2022.11.3.304
33. Gholami F, Mesrabadi J, Iranpour M, Donyaei S. Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials. Experimental Gerontology. 2025;199:112658. https://doi.org/10.1016/j.exger.2024.112658
34. Quigley A, MacKay-Lyons M, Eskes G. Effects of Exercise on Cognitive Performance in Older Adults: A Narrative Review of the Evidence, Possible Biological Mechanisms, and Recommendations for Exercise Prescription. J Aging Res. 2020;2020:1407896. https://doi.org/10.1155/2020/1407896
35. Saraei T, Schrenk S, Puta C, et al. Physical Activity and BrainAGE: Exploring the Impact on Brain Health and Plasticity in Older Adults. Hum Brain Mapp. 2025;46(15):e70378. https://doi.org/10.1002/hbm.70378
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Kamila Klimek-Ociepka, Maria Kusibab, Gabriela Augustynowicz, Dawid Stępień

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 50
Number of citations: 0