Ultraviolet-Related Ocular Disease: Tissue-Specific Effects, Outdoor Exposure and Prevention - A Literature Review
DOI:
https://doi.org/10.12775/QS.2026.61.72938Keywords
ultraviolet radiation, UVA, UVB, photokeratitis, pinguecula, pterygium, cataract, age-related macular degeneration, ocular photoprotectionAbstract
Background. Ultraviolet radiation (UVR) is a well-established cause of skin damage, photoaging and cancer but its ocular effects are less consistently addressed in prevention. The cornea, conjunctiva, limbus and crystalline lens are exposed to wavelength-dependent photochemical stress, particularly during outdoor activities and sports.
Aim. To review the pathophysiology, clinical features, epidemiology and prevention of UV-related ocular disease, with emphasis on wavelength-dependent exposure, peripheral light focusing and high-risk settings such as outdoor and sports environments. Key conditions include photokeratitis, pinguecula, pterygium, cortical cataract and age-related macular degeneration.
Material and methods. A literature review of scientific publications on UV-related ocular disease was conducted, focusing on major disorders, mechanisms of damage and ocular photoprotection.
Results. UVA (315–400 nm), UVB (280–315 nm) and UVC (100–280 nm) differ in atmospheric transmission and tissue absorption. UVB is mainly absorbed by the cornea and causes acute epithelial injury, while chronic exposure contributes to conjunctival degeneration, limbal remodeling and lens opacification. Peripheral light focusing increases irradiance at the nasal limbus and lens cortex, consistent with the distribution of pinguecula, pterygium and cortical cataract. Outdoor sports increase cumulative UV exposure.
Conclusions. UV-related ocular disease represents tissue-specific responses to a shared environmental exposure. Prevention is essential in outdoor and sports settings and requires certified UV-filtering eyewear, proper frame design and regular use. Lens tint alone is insufficient.
Keywords: ultraviolet radiation; UVA; UVB; photokeratitis; pinguecula; pterygium; cataract; age-related macular degeneration; ocular photoprotection.
References
1. Behar-Cohen F, Baillet G, de Ayguavives T, Ortega Garcia P, Krutmann J, Peña-García P, Remé C, Wolffsohn JS. Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. Clin Ophthalmol. 2014;8:87-104. https://doi.org/10.2147/OPTH.S46189.
2. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-12248. https://doi.org/10.3390/ijms140612222.
3. Marro M, Moccozet L, Vernez D. Assessing human eye exposure to UV light: a narrative review. Front Public Health. 2022;10:900979. https://doi.org/10.3389/fpubh.2022.900979.
4. Neale RE, Lucas RM, Byrne SN, et al. The effects of exposure to solar radiation on human health. Photochem Photobiol Sci. 2023;22(5):1011-1047. https://doi.org/10.1007/s43630-023-00375-8.
5. Moe MC, Ozmert E, Baudouin C, et al. International Olympic Committee (IOC) consensus paper on sports-related ophthalmology issues in elite sports. BMJ Open Sport Exerc Med. 2023;9(3):e001644. https://doi.org/10.1136/bmjsem-2023-001644.
6. Sui GY, Liu GC, Liu GY, Gao YY, Deng Y, Wang WY, Tong SH, Wang L. Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. Br J Ophthalmol. 2013;97(4):389-394. https://doi.org/10.1136/bjophthalmol-2012-302281.
7. Backes C, Religi A, Moccozet L, Behar-Cohen F, Vuilleumier L, Bulliard JL, et al. Sun exposure to the eyes: predicted UV protection effectiveness of various sunglasses. J Expo Sci Environ Epidemiol. 2019;29(6):753-764. https://doi.org/10.1038/s41370-018-0087-0.
8. Rifai K, Hornauer M, Buechinger R, Schoen R, Barraza-Bernal M, Habtegiorgis S, et al. Efficiency of ocular UV protection by clear lenses. Biomed Opt Express. 2018;9(4):1948-1963. https://doi.org/10.1364/BOE.9.001948.
9. Chan JYY, Chow VWS, Chan CKM, et al. Photokeratitis in outdoor event participants exposed to UV radiation display. JAMA Ophthalmol. 2024;142(6):568-571. https://doi.org/10.1001/jamaophthalmol.2024.1092.
10. Maugeri G, D'Amico AG, Rasa DM, et al. Regulation of UV-B-induced inflammatory mediators by activity-dependent neuroprotective protein-derived peptide in corneal epithelium. Int J Mol Sci. 2023;24(8):6895. https://doi.org/10.3390/ijms24086895.
11. Shahraki T, Arabi A, Feizi S. Pterygium: an update on pathophysiology, clinical features and management. Ther Adv Ophthalmol. 2021;13:25158414211020152. https://doi.org/10.1177/25158414211020152.
12. Tandon R, Vashist P, Gupta N, et al. The association of sun exposure, ultraviolet radiation effects and other risk factors for pterygium in geographically diverse adult rural populations of India: the SURE RISK for pterygium study. PLoS One. 2022;17(7):e0270065. https://doi.org/10.1371/journal.pone.0270065.
13. Van Acker SI, Van den Bogerd B, Haagdorens M, Siozopoulou V, Ni Dhubhghaill S, Pintelon I, Koppen C. Pterygium - the good, the bad and the ugly. Cells. 2021;10(7):1567. https://doi.org/10.3390/cells10071567.
14. Linaburg T, Choi D, Bunya VY, Massaro-Giordano M, Rapuano CJ, Hammersmith KM, Nagra PK, Ayres B, Shtein RM. Systematic review: the effects of pterygium and pingueculum on the ocular surface and efficacy of surgical excision. Cornea. 2021;40(2):258-267. https://doi.org/10.1097/ICO.0000000000002575.
15. Rodriguez NG, de la Puente M, Czepita M, et al. Conjunctival ultraviolet autofluorescence as a biomarker of outdoor exposure in myopia: a systematic review and meta-analysis. Sci Rep. 2024;14:1620. https://doi.org/10.1038/s41598-024-51417-9.
16. Haag R, Sieber N, Hessling M. Cataract development by exposure to ultraviolet and blue visible light in porcine lenses. Medicina (Kaunas). 2021;57(6):535. https://doi.org/10.3390/medicina57060535.
17. MacFarlane ER, Donaldson PJ, Grey AC. UV light and the ocular lens: a review of exposure models and resulting biomolecular changes. Front Ophthalmol. 2024;4:1414483. https://doi.org/10.3389/fopht.2024.1414483.
18. Kulbay M, Simon T, Guo X, et al. Oxidative stress and cataract formation: evaluating the efficacy of antioxidant therapies. Biomolecules. 2024;14(9):1055. https://doi.org/10.3390/biom14091055.
19. Qu Y, Jiang Y, Zhang G, et al. Association of exposure to ultraviolet radiation and warm-season ozone air pollution with incident age-related macular degeneration: a nationwide cohort study in China. Sci Total Environ. 2024;959:177723. https://doi.org/10.1016/j.scitotenv.2024.177723.
20. Iwundu CN, Yin C, Coleman AL, Hansen J, Kwon J, Heck JE. Occupational exposures and age-related cataract: a review. Arch Environ Occup Health. 2024;79(9-10):283-292. https://doi.org/10.1080/19338244.2025.2451907.
21. Modenese A, Chou BR, Adam B, et al. Occupational exposure to solar radiation and the eye: a call to implement health surveillance of outdoor workers. Med Lav. 2023;114(4):e2023032. https://doi.org/10.23749/mdl.v114i4.14657.
22. Buxton LS, Reeder AI, Marsh L, Iosua E, McNoe BM. Erythemal ultraviolet radiation exposure of high school rowers in Aotearoa/New Zealand. J Photochem Photobiol B. 2021;222:112254. https://doi.org/10.1016/j.jphotobiol.2021.112254.
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Copyright (c) 2026 Aleksandra Borowska, Pola Kobryń, Dawid Ocicki, Michał Bojarski, Michał Kwiatkowski, Michał Musielak, Iga Kobryń, Aleksandra Zybert, Igor Nowiński, Jakub Grabowski

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