The Role of Vitamin D3 Supplementation in the Prevention of Hypertension in Adolescents Athletes: A Review
DOI:
https://doi.org/10.12775/QS.2026.59.72791Keywords
vitamin D, athletes, arterial hypertension, endothelium, oxidative stress, supplemantationAbstract
Background. Vitamin D is mainly known for its role in bone health and maintaining proper calcium balance, especially in athletes. In recent years, however, more attention has been paid to its influence on the cardiovascular system. Even though vitamin D deficiency is common among physically active people, its effect on the heart and blood vessels during intense exercise is still often underestimated in sports medicine.
Aim. The aim of this study was to assess how vitamin D deficiency affects the cardiovascular system in athletes, with particular focus on endothelial function, the renin-angiotensin-aldosterone (RAA) system, and blood pressure regulation.
Material and methods. A literature review was carried out using scientific databases such as PubMed and Google Scholar. Current research papers, clinical studies, and review articles concerning 25(OH)D levels, cardiovascular stress during exercise, and vascular health in athletes were analyzed and compared.
Results. The analyzed studies showed that maintaining adequate vitamin D levels is important for proper endothelial function and nitric oxide production, as well as for limiting excessive activation of the RAA system. Vitamin D deficiency may impair vasodilation and increase vascular resistance during exercise, which puts additional strain on the cardiovascular system. As a result, it may contribute to the development of exercise-induced and chronic arterial hypertension, reducing some of the protective cardiovascular effects normally associated with regular physical activity.
Conclusions. The reviewed findings support the hypothesis that individualized vitamin D3 supplementation can improve endothelial function and provide additional cardiovascular protection in athletes, particularly in terms of blood pressure control. Regular monitoring of 25(OH)D levels and properly adjusted supplementation should therefore become an important part of modern sports cardiology practice.
References
Al Mheid, I., Patel, R., Murrow, J., Morris, A., Rahman, A., Fike, L., Kavtaradze, N., Uphoff, I., Hooper, C., Tangpricha, V., Alexander, R. W., Brigham, K., & Quyyumi, A. A. (2011). Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol, 58(2), 186-192. https://doi.org/10.1016/j.jacc.2011.02.051
Andrukhova, O., Slavic, S., Zeitz, U., Riesen, S. C., Heppelmann, M. S., Ambrisko, T. D., Markovic, M., Kuebler, W. M., & Erben, R. G. (2014). Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol, 28(1), 53-64. https://doi.org/10.1210/me.2013-1252
Angeline, M. E., Gee, A. O., Shindle, M., Warren, R. F., & Rodeo, S. A. (2013). The effects of vitamin D deficiency in athletes. Am J Sports Med, 41(2), 461-464. https://doi.org/10.1177/0363546513475787
Berge, H. M., Isern, C. B., & Berge, E. (2015). Blood pressure and hypertension in athletes: a systematic review. Br J Sports Med, 49(11), 716-723. https://doi.org/10.1136/bjsports-2014-093976
Beveridge, L. A., Struthers, A. D., Khan, F., Jorde, R., Scragg, R., Macdonald, H. M., Alvarez, J. A., Boxer, R. S., Dalbeni, A., Gepner, A. D., Isbel, N. M., Larsen, T., Nagpal, J., Petchey, W. G., Stricker, H., Strobel, F., Tangpricha, V., Toxqui, L., Vaquero, M. P.,…Witham, M. D. (2015). Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data. JAMA Intern Med, 175(5), 745-754. https://doi.org/10.1001/jamainternmed.2015.0237
Close, G. L., Leckey, J., Patterson, M., Bradley, W., Owens, D. J., Fraser, W. D., & Morton, J. P. (2013). The effects of vitamin D(3) supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose-response study. Br J Sports Med, 47(11), 692-696. https://doi.org/10.1136/bjsports-2012-091735
de la Puente Yagüe, M., Collado Yurrita, L., Ciudad Cabañas, M. J., & Cuadrado Cenzual, M. A. (2020). Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. Nutrients, 12(2). https://doi.org/10.3390/nu12020579
Farrokhyar, F., Tabasinejad, R., Dao, D., Peterson, D., Ayeni, O. R., Hadioonzadeh, R., & Bhandari, M. (2015). Prevalence of vitamin D inadequacy in athletes: a systematic-review and meta-analysis. Sports Med, 45(3), 365-378. https://doi.org/10.1007/s40279-014-0267-6
Forman, J. P., Giovannucci, E., Holmes, M. D., Bischoff-Ferrari, H. A., Tworoger, S. S., Willett, W. C., & Curhan, G. C. (2007). Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension, 49(5), 1063-1069. https://doi.org/10.1161/hypertensionaha.107.087288
Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 96(7), 1911-1930. https://doi.org/10.1210/jc.2011-0385
Jablonski, K. L., Chonchol, M., Pierce, G. L., Walker, A. E., & Seals, D. R. (2011). 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension, 57(1), 63-69. https://doi.org/10.1161/hypertensionaha.110.160929
Judd, S. E., & Tangpricha, V. (2009). Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci, 338(1), 40-44. https://doi.org/10.1097/MAJ.0b013e3181aaee91
Lanteri, P., Lombardi, G., Colombini, A., & Banfi, G. (2013). Vitamin D in exercise: physiologic and analytical concerns. Clin Chim Acta, 415, 45-53. https://doi.org/10.1016/j.cca.2012.09.004
Larson-Meyer, D. E., & Willis, K. S. (2010). Vitamin D and athletes. Curr Sports Med Rep, 9(4), 220-226. https://doi.org/10.1249/JSR.0b013e3181e7dd45
Li, Y. C., Kong, J., Wei, M., Chen, Z. F., Liu, S. Q., & Cao, L. P. (2002). 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest, 110(2), 229-238. https://doi.org/10.1172/jci15219
Li, Y. C., Qiao, G., Uskokovic, M., Xiang, W., Zheng, W., & Kong, J. (2004). Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol, 89-90(1-5), 387-392. https://doi.org/10.1016/j.jsbmb.2004.03.004
Manson, J. E., Cook, N. R., Lee, I. M., Christen, W., Bassuk, S. S., Mora, S., Gibson, H., Gordon, D., Copeland, T., D'Agostino, D., Friedenberg, G., Ridge, C., Bubes, V., Giovannucci, E. L., Willett, W. C., & Buring, J. E. (2019). Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med, 380(1), 33-44. https://doi.org/10.1056/NEJMoa1809944
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., Meeusen, R., van Loon, L. J. C., Shirreffs, S. M., Spriet, L. L., Stuart, M., Vernec, A., Currell, K., Ali, V. M., Budgett, R. G.,…Engebretsen, L. (2018). IOC consensus statement: dietary supplements and the high-performance athlete. Br J Sports Med, 52(7), 439-455. https://doi.org/10.1136/bjsports-2018-099027
Norman, A. W. (2008). From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr, 88(2), 491s-499s. https://doi.org/10.1093/ajcn/88.2.491S
Ogan, D., & Pritchett, K. (2013). Vitamin D and the athlete: risks, recommendations, and benefits. Nutrients, 5(6), 1856-1868. https://doi.org/10.3390/nu5061856
Owens, D. J., Allison, R., & Close, G. L. (2018). Vitamin D and the Athlete: Current Perspectives and New Challenges. Sports Med, 48(Suppl 1), 3-16. https://doi.org/10.1007/s40279-017-0841-9
Piotr, G., & Andrzej, S. (2026). Interna Szczeklika. Medycyna Praktyczna.
Renke, G., Starling-Soares, B., Baesso, T., Petronio, R., Aguiar, D., & Paes, R. (2023). Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress. Nutrients, 15(3). https://doi.org/10.3390/nu15030769
Scragg, R., Stewart, A. W., Waayer, D., Lawes, C. M. M., Toop, L., Sluyter, J., Murphy, J., Khaw, K. T., & Camargo, C. A., Jr. (2017). Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study : A Randomized Clinical Trial. JAMA Cardiol, 2(6), 608-616. https://doi.org/10.1001/jamacardio.2017.0175
Shuler, F. D., Wingate, M. K., Moore, G. H., & Giangarra, C. (2012). Sports health benefits of vitamin d. Sports Health, 4(6), 496-501. https://doi.org/10.1177/1941738112461621
Tarcin, O., Yavuz, D. G., Ozben, B., Telli, A., Ogunc, A. V., Yuksel, M., Toprak, A., Yazici, D., Sancak, S., Deyneli, O., & Akalin, S. (2009). Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab, 94(10), 4023-4030. https://doi.org/10.1210/jc.2008-1212
Tomaschitz, A., Pilz, S., Ritz, E., Grammer, T., Drechsler, C., Boehm, B. O., & März, W. (2010). Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Clin Chim Acta, 411(17-18), 1354-1360. https://doi.org/10.1016/j.cca.2010.05.037
Vimaleswaran, K. S., Cavadino, A., Berry, D. J., Jorde, R., Dieffenbach, A. K., Lu, C., Alves, A. C., Heerspink, H. J., Tikkanen, E., Eriksson, J., Wong, A., Mangino, M., Jablonski, K. A., Nolte, I. M., Houston, D. K., Ahluwalia, T. S., van der Most, P. J., Pasko, D., Zgaga, L.,…Hyppönen, E. (2014). Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol, 2(9), 719-729. https://doi.org/10.1016/s2213-8587(14)70113-5
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J. M., Capodanno, D., Cosyns, B., Crawford, C., Davos, C. H., Desormais, I., Di Angelantonio, E., Franco, O. H., Halvorsen, S., Hobbs, F. D. R., Hollander, M.,…Williams, B. (2022). [2021 ESC Guidelines on cardiovascular disease prevention in clinical practice]. G Ital Cardiol (Rome), 23(6 Suppl 1), e3-e115. https://doi.org/10.1714/3808.37926 (Linee guida ESC 2021 per la prevenzione delle malattie cardiovascolari nella pratica clinica elaborate dalla Task Force per la prevenzione delle malattie cardiovascolari nella pratica clinica costituita da rappresentanti della Società Europea di Cardiologia e di 12 società medico-scientifiche con il contributo straordinario dell’Associazione Europea di Cardiologia Preventiva (EAPC).)
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Copyright (c) 2026 Marta Armula, Claire Bongage, Arkadiusz Piechowiak, Filip Napieraj, Bartosz Przemysław Herc, Małgorzata Tesla, Anna Agnieszka Gąska, Marta Gutkowska, Joanna Jabłońska, Joanna Wasik

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