Synergistic Effects of Collagen Peptides and Vitamin C Supplementation in Tendinopathy Rehabilitation: A Critical Review
DOI:
https://doi.org/10.12775/QS.2026.59.72790Keywords
Collagen, Vitamin C, tendinopathy, nutrient timing, mechanotransductionAbstract
Background: Tendinopathies present significant treatment challenges due to the slow healing and low metabolic activity of tendons. While mechanical loading remains the primary intervention, patients progress frequently plateaus.
Objective: To critically evaluate the efficacy and optimal timing of hydrolyzed collagen and Vitamin C supplementation in conjunction with mechanical loading during tendinopathy rehabilitation.
Methods: Laboratory studies, pharmacokinetic research, and clinical trials were systematically reviewed to assess the impact of these supplements on tendon structure and function.
Results: Ascorbic acid is essential for collagen synthesis and tissue repair, with timing proving critical. Administration of 15-30 g of hydrolyzed collagen and 40-50 mg of Vitamin C one hour prior to exercise yields superior outcomes compared to placebo. This protocol results in a doubling of PINP levels, increased tendon stiffness, and greater improvements in clinical scores (VISA-A) relative to standard care or general nutrition, thereby enhancing collagen production and recovery.
Conclusion: Collagen and Vitamin C supplementation is most effective when administered exactly 60 minutes prior to exercise, facilitating tendon healing and strengthening.
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Copyright (c) 2026 Alicja Rogozińska , Wiktor Beśka, Michał Kalisiak, Michał Kasznicki, Małgorzata Czechowska, Natalia Micek, Jakub Łącki, Emilia Skrzypek, Mikołaj Kamela, Karol Jackowiak
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