Prenatal and perinatal risk factors for atopic dermatitis in offspring - a literature review
DOI:
https://doi.org/10.12775/QS.2026.59.72770Keywords
Atopic dermatitis, Child, Pregnancy, Risk factorsAbstract
Background: Atopic dermatitis (AD) is a chronic, inflammatory skin disease that significantly impacts quality of life. This condition most commonly affects children, occurring in 10-20% of the pediatric population. The pathophysiology of the disease is complex and characterized by the interaction of genetic factors, immune dysregulation, and environmental factors. The influence of prenatal and perinatal risk factors on the potential AD occurrence in offspring is crucial.
Aim: Assess the influence of prenatal and perinatal risk factors on the likelihood of AD occurrence in offspring, with particular emphasis on non-modifiable and modifiable risk factors, and the role of eliminating modifiable risk factors early in disease prevention.
Material and methods: A literature review was conducted using PubMed and Google Scholar. Original articles and reviews were analyzed. The studies included a pediatric population.
Result: Numerous proven prenatal and perinatal factors play a role in the development of AD in offspring. These can be divided into biological, environmental, behavioral, and clinical factors. A different classification takes into account modifiable and non-modifiable determinants.
Conclusions: Identifying modifiable risk factors that influence the risk of developing AD in offspring enables preventive measures to be taken, thereby reducing or eliminating them, and ultimately reducing the risk of the disease in offspring. Further research is needed to identify additional risk factors that can increase parents' awareness of prenatal and perinatal risk factors for AD in their offspring.
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Copyright (c) 2026 Aleksandra Purska, Natalia Pawelec, Jaśmina Podkościelna, Urszula Załuska, Kamila Ryszkowska, Kinga Krzyżowska, Jagienka Perzyńska, Weronika Bagińska, Natalia Kasterka
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