The Role of Physical Activity in Parkinson’s Disease: Neuroprotective Mechanisms and Clinical Implications
DOI:
https://doi.org/10.12775/QS.2026.58.72622Keywords
Parkinson’s disease, physical activity, exercise therapy, neuroprotection, neuroplasticity, motor symptoms, quality of lifeAbstract
Background: Parkinson’s disease is a progressive neurodegenerative disorder associated with motor and non-motor symptoms. Physical activity is increasingly recognized as a supportive intervention with potential neuroprotective and therapeutic benefits.
Aim: This review aimed to summarize the potential neuroprotective mechanisms and clinical benefits of physical activity in Parkinson’s disease.
Results: Physical activity may improve motor function, gait, balance, physical capacity, selected non-motor symptoms, functional independence, and quality of life. These effects may be linked to neuroplasticity, mitochondrial function, reduced oxidative stress and neuroinflammation, and modulation of dopaminergic pathways.
Conclusions: Physical activity should be considered an integral part of Parkinson’s disease management. Although its symptomatic and functional benefits are well supported, further studies are needed to confirm its long-term neuroprotective and disease-modifying effects.
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