The Correlation between depression and obesity in children and adolescents
DOI:
https://doi.org/10.12775/QS.2026.57.72496Keywords
depression, children, adolescents, physical activity, obesity, mental health, overweight, prevention, lifestyle, dietary habits, childhood, mental illnessAbstract
BACKGROUND. Obesity and depression are both major problems of health in almost whole world. Moreover, it is predicted that population of patients of mentioned diseases are going to growth. While these conditions are becoming bigger problem, it is important to mark their impact on childen. Results of illnesses in childhood are associated with many longlasting complications.
AIM. The aim of this review was to evaluate the bidirectional relationship of depression and obesity in children and adolescents and to underline their influence on health and proper development. Moreover authors were aiming to highlight the importance of physical activity and appropriate diet in the prevention and treatment of mentioned diseases.
MATERIAL AND METHODS. A narrative review of the available literature was conducted. PubMed and Google Scholar databases were used for the research. The following keywords were searched: „depression“, „children“, „obesity“, „anxiety“, „adolescent“, „biological mechanisms“, „depressive episode“, „lifestyle“.
RESULTS. There are many common factors occuring in pathophysiology of obesity and depression. It is important to underscore that patients require treatment involving both illnesses and they should not be treated separately. Parents play a crucial role during treatment and they have to teach their children healthy habits. Healthy lifestyle is essential in treating these conditions.
CONCLUSIONS. Prevention should be the main focus for medical professionals treating obesity and depression. It is important to observe and react in early stages of mentioned conditions. Studies also show the important role of parents and lifestyle education and their impact on development of illnesses.
References
1. Kerr JA, Patton GC, Cini KI, Abate YH, Abbas N, Abd Al Magied AHA, et al. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. The Lancet. 2025;405(10481):785-812.
2. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry. 2022;9(2):137-50.
3. Goodwin RD, Dierker LC, Wu M, Galea S, Hoven CW, Weinberger AH. Trends in U.S. Depression Prevalence From 2015 to 2020: The Widening Treatment Gap. Am J Prev Med. 2022;63(5):726-33.
4. Zhao L, Lou Y, Tao Y, Wang H, Xu N. Global, regional and national burden of depressive disorders in adolescents and young adults, 1990-2021: systematic analysis of the global burden of disease study 2021. Front Public Health. 2025;13:1599602.
5. Kieling C, Baker-Henningham H, Belfer M, Conti G, Ertem I, Omigbodun O, et al. Child and adolescent mental health worldwide: evidence for action. Lancet. 2011;378(9801):1515-25.
6. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627-42.
7. Ali A, Al-Ani O, Al-Ani F. Children's behaviour and childhood obesity. Pediatr Endocrinol Diabetes Metab. 2024;30(3):148-58.
8. Zhao W, Mo L, Pang Y. Hypertension in adolescents: The role of obesity and family history. J Clin Hypertens (Greenwich). 2021;23(12):2065-70.
9. Elizondo-Montemayor L, Hernández-Escobar C, Lara-Torre E, Nieblas B, Gómez-Carmona M. Gynecologic and Obstetric Consequences of Obesity in Adolescent Girls. J Pediatr Adolesc Gynecol. 2017;30(2):156-68.
10. Sarwer DB, Polonsky HM. The Psychosocial Burden of Obesity. Endocrinol Metab Clin North Am. 2016;45(3):677-88.
11. Herrman H, Patel V, Kieling C, Berk M, Buchweitz C, Cuijpers P, et al. Time for united action on depression: a Lancet-World Psychiatric Association Commission. Lancet. 2022;399(10328):957-1022.
12. Gilman SE, Sucha E, Kingsbury M, Horton NJ, Murphy JM, Colman I. Depression and mortality in a longitudinal study: 1952-2011. Cmaj. 2017;189(42):E1304-e10.
13. Lu B, Lin L, Su X. Global burden of depression or depressive symptoms in children and adolescents: A systematic review and meta-analysis. J Affect Disord. 2024;354:553-62.
14. Thapar A, Collishaw S, Pine DS, Thapar AK. Depression in adolescence. Lancet. 2012;379(9820):1056-67.
15. Iyer V, Azhar Y, Aslam SP. Depression in Children. StatPearls. Treasure Island (FL): StatPearls Publishing
Copyright © 2026, StatPearls Publishing LLC.; 2026.
16. Hazell P. Depression in children. Bmj. 2002;325(7358):229-30.
17. Wang Y, Qin C, Chen H, Liang W, Liu M, Liu J. Global, regional, and national burden of major depressive disorders in adults aged 60 years and older from 1990 to 2021, with projections of prevalence to 2050: Analyses from the Global Burden of Disease Study 2021. J Affect Disord. 2025;374:486-94.
18. Zhou J, Song Y, Ying J, Zhang C, Wu J, Shan S, et al. Effects of lifestyle interventions on mental health in children and adolescents with overweight or obesity: a systematic review and meta-analysis. EClinicalMedicine. 2025;81:103121.
19. Cui J, Sun X, Li X, Ke M, Sun J, Yasmeen N, et al. Association Between Different Indicators of Obesity and Depression in Adults in Qingdao, China: A Cross-Sectional Study. Front Endocrinol (Lausanne). 2018;9:549.
20. Goodman E, Whitaker RC. A prospective study of the role of depression in the development and persistence of adolescent obesity. Pediatrics. 2002;110(3):497-504.
21. Blundell E, De Stavola BL, Kellock MD, Kelly Y, Lewis G, McMunn A, et al. Longitudinal pathways between childhood BMI, body dissatisfaction, and adolescent depression: an observational study using the UK Millenium Cohort Study. Lancet Psychiatry. 2024;11(1):47-55.
22. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220-9.
23. Rao WW, Zong QQ, Zhang JW, An FR, Jackson T, Ungvari GS, et al. Obesity increases the risk of depression in children and adolescents: Results from a systematic review and meta-analysis. J Affect Disord. 2020;267:78-85.
24. Biehl A, Hovengen R, Grøholt EK, Hjelmesæth J, Strand BH, Meyer HE. Parental marital status and childhood overweight and obesity in Norway: a nationally representative cross-sectional study. BMJ Open. 2014;4(6):e004502.
25. D'Onofrio B, Emery R. Parental divorce or separation and children's mental health. World Psychiatry. 2019;18(1):100-1.
26. Midei AJ, Matthews KA. Interpersonal violence in childhood as a risk factor for obesity: a systematic review of the literature and proposed pathways. Obes Rev. 2011;12(5):e159-72.
27. Wang R, Zhu B, Yu X, Tan W, Shi Q. Childhood violence exposure and anxiety and depression of children and adolescents. J Affect Disord. 2025;369:608-14.
28. Jiang J, Rosenqvist U, Wang H, Greiner T, Ma Y, Toschke AM. Risk factors for overweight in 2- to 6-year-old children in Beijing, China. Int J Pediatr Obes. 2006;1(2):103-8.
29. Ngan HTD, Tuyen LD, Phu PV, Nambiar S. Childhood overweight and obesity amongst primary school children in Hai Phong City, Vietnam. Asia Pac J Clin Nutr. 2018;27(2):399-405.
30. Gunnlaugsson G, Whitehead TA, Baboudóttir FN, Baldé A, Jandi Z, Boiro H, Einarsdóttir J. Use of Digital Technology among Adolescents Attending Schools in Bissau, Guinea-Bissau. Int J Environ Res Public Health. 2020;17(23).
31. P S, Vellapandian C. Hypothalamic-Pituitary-Adrenal (HPA) Axis: Unveiling the Potential Mechanisms Involved in Stress-Induced Alzheimer's Disease and Depression. Cureus. 2024;16(8):e67595.
32. Brown ES, Varghese FP, McEwen BS. Association of depression with medical illness: does cortisol play a role? Biol Psychiatry. 2004;55(1):1-9.
33. Zorena K, Jachimowicz-Duda O, Ślęzak D, Robakowska M, Mrugacz M. Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications. Int J Mol Sci. 2020;21(10).
34. Jow GM, Yang TT, Chen CL. Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J Affect Disord. 2006;90(1):21-7.
35. Suwalska J, Skibińska M, Łojko D, Bogdański P. The assessment of selected factors associated with the co-occurrence of overweight/obesity and symptoms of depression in a group of young women. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2024;19(1):1-8.
36. Cowen PJ, Parry-Billings M, Newsholme EA. Decreased plasma tryptophan levels in major depression. J Affect Disord. 1989;16(1):27-31.
37. Sugimoto H, Oda S, Otsuki T, Hino T, Yoshida T, Shiro Y. Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. Proc Natl Acad Sci U S A. 2006;103(8):2611-6.
38. Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R. The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(3):702-21.
39. Hryhorczuk C, Sharma S, Fulton SE. Metabolic disturbances connecting obesity and depression. Front Neurosci. 2013;7:177.
40. Brazil JF, Gibson I, Dunne D, Hynes LB, Harris A, Bakir M, et al. Improved Quality of Life, Fitness, Mental Health and Cardiovascular Risk Factors with a Publicly Funded Bariatric Lifestyle Intervention for Adults with Severe Obesity: A Prospective Cohort Study. Nutrients. 2021;13(11).
41. Mohseni M, Kuckuck S, Meeusen REH, Jiskoot G, Lengton R, Savas M, et al. Improved Physical and Mental Health After a Combined Lifestyle Intervention with Cognitive Behavioural Therapy for Obesity. Int J Endocrinol Metab. 2023;21(1):e129906.
42. Sarmiento-Riveros A, Aguilar-Cordero MJ, Barahona-Barahona JA, Galindo GE, Carvallo C, Crespo FA, Burgos H. Child and Adolescent Health Programs in Obesity and Depression: A Systematic Review and Meta-Analysis. Nutrients. 2025;17(6).
43. Tamura K, Morrison J, Pikhart H. Children's behavioural problems and its associations with socioeconomic position and early parenting environment: findings from the UK Millennium Cohort Study. Epidemiol Psychiatr Sci. 2020;29:e155.
44. SayuriYamagata A, Brietzke E, Rosenblat JD, Kakar R, McIntyre RS. Medical comorbidity in bipolar disorder: The link with metabolic-inflammatory systems. J Affect Disord. 2017;211:99-106.
45. Shashaj B, Graziani MP, Tozzi AE, Manco M. [Obesity and cardiovascular risk in children]. Recenti Prog Med. 2014;105(12):454-6.
46. Muha J, Campisi SC, Tsujimoto K, Tu E, Agarwal SM, Toulany A, et al. Major Depressive Disorder and Cardiovascular Disease Risk in Children and Adolescents. Acad Pediatr. 2026;26(1):103112.
47. Nigatu YT, Reijneveld SA, de Jonge P, van Rossum E, Bültmann U. The Combined Effects of Obesity, Abdominal Obesity and Major Depression/Anxiety on Health-Related Quality of Life: the LifeLines Cohort Study. PLoS One. 2016;11(2):e0148871.
48. Nelson MC, Story M, Larson NI, Neumark-Sztainer D, Lytle LA. Emerging adulthood and college-aged youth: an overlooked age for weight-related behavior change. Obesity (Silver Spring). 2008;16(10):2205-11.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Olga Błażowska, Amir Naziri, Maria Styczyńska, Julianna Chyl, Łukasz Kowalewski, Weronika Nowak, Oliwia Gutowska, Wiktoria Kostuch, Agata Zimon, Alicja Jurewicz

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 21
Number of citations: 0