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Quality in Sport

The impact of bicycling on PSA levels: a narrative review
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The impact of bicycling on PSA levels: a narrative review

Authors

  • Krzysztof Peszuk District Medical Center in Grójec https://orcid.org/0009-0006-6381-904X
  • Iga Woźniakowska Bielański Hospital named after blessed Father Jerzy Popiełuszko, Warsaw, Poland https://orcid.org/0009-0000-6123-0692
  • Maja Zambrzycka Regional Hospital in Łomża, Poland https://orcid.org/0009-0000-7685-0835
  • Aleksandra Misarko Bielański Hospital named after blessed Father Jerzy Popiełuszko, Warsaw, Poland https://orcid.org/0009-0004-8818-2634
  • Monika Jedwabnik District Medical Center in Grójec, Piotra Skargi 10, 05-600 Grójec, Poland https://orcid.org/0009-0004-7471-9955
  • Stanisław Ścigała Bielański Hospital named after blessed Father Jerzy Popiełuszko, Warsaw, Poland https://orcid.org/0009-0001-0909-6796
  • Weronika Lech Szpital im. Ojca Rafala z Proszowic w Proszowicach https://orcid.org/0009-0002-5306-174X
  • Adrianna Dobrosielska National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland https://orcid.org/0009-0007-4563-8808
  • Hoang Viet Krajewski Anna Gostynska Wolski Hospital, 01-211 Warsaw, Poland https://orcid.org/0009-0007-1683-3698
  • Bartosz Olszewski Nowodworskie Centrum Medyczne ul. Miodowa 2, Nowy Dwór Mazowiecki https://orcid.org/0009-0009-4998-0525

DOI:

https://doi.org/10.12775/QS.2026.55.70931

Keywords

PSA, prostate-specific antigen, cycling, bicycling, physical activity, exercise, prostate

Abstract

Background: Cycling is a widely popular form of physical activity that may influence serum prostate-specific antigen (PSA) levels, a key biomarker used in the detection and monitoring of prostate diseases. However, it remains unclear whether cycling has an effect on PSA concentrations.

Aim: The aim of this review was to evaluate the effect of cycling on serum PSA levels and to identify factors that may influence changes in PSA after exercise.

Material and methods: A narrative review of PubMed literature focused on the effects of cycling on PSA levels in adult men.

Results: The findings were heterogeneous. Several studies reported small and transient increases in PSA levels, particularly when blood samples were collected immediately after prolonged or intensive cycling. In contrast, other studies found no significant changes in PSA concentrations. Factors such as timing of blood sampling, exercise intensity, and participant characteristics were identified as key determinants of PSA variability.

Conclusions: Cycling does not appear to have a consistent or clinically significant effect on PSA levels. However, transient increases may occur under specific conditions. PSA results should therefore be interpreted with caution in individuals who have recently engaged in physical activity. Further research with standardized protocols is needed to clarify this relationship.

References

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2. Tchetgen MB, Oesterling JE. The effect of prostatitis, urinary retention, ejaculation, and ambulation on the serum prostate-specific antigen concentration. Urol Clin North Am. 1997 May;24(2):283-291. doi: 10.1016/s0094-0143(05)70374-8. PMID: 9126225.

3. McAleer JK, Gerson LW, McMahon D, Geller L. Effect of digital rectal examination (and ejaculation) on serum prostate-specific antigen after twenty-four hours. A randomized, prospective study. Urology. 1993 Feb;41(2):111-2. doi: 10.1016/0090-4295(93)90158-7. PMID: 7684542.

4. Oremek GM, Seiffert UB. Physical activity releases prostate-specific antigen (PSA) from the prostate gland into blood and increases serum PSA concentrations. Clin Chem. 1996 May 1;42(5):691–5. doi:10.1093/clinchem/42.5.691

5. Mejak SL, Bayliss J, Hanks SD. Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over. Steyerberg EW, editor. PLoS ONE. 2013 Feb 13;8(2):e56030. doi:10.1371/journal.pone.0056030

6. Crawford, E. D., 3rd, Mackenzie, S. H., Safford, H. R., & Capriola, M. (1996). The effect of bicycle riding on serum prostate specific antigen levels. The Journal of urology, 156(1), 103–105. https://doi.org/10.1016/s0022-5347(01)65954-8

7. Lunacek A, Tischler M, Mrstik C, Hebenstreit D, Oeser R, Bektic J, et al. Effects of cycling and rowing on serum concentrations of prostate-specific antigen: A randomized study of 101 male subjects. The Prostate. 2022 May;82(7):804–8. doi:10.1002/pros.24322 PubMed PMID: 35192201.

8. Heger Z, Gumulec J, Ondrak A, Skoda J, Zitka Z, Cernei N, et al. Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer. Int J Mol Sci. 2016 Mar 17;17(3):377. doi:10.3390/ijms17030377 PubMed PMID: 26999116; PubMed Central PMCID: PMC4813236.

9. Saka T, Sofikerim M, Demirtas A, Kulaksizoglu S, Caniklioglu M, Karacagil M. Rigorous bicycling does not increase serum levels of total and free prostate-specific antigen (PSA), the free/total PSA ratio, gonadotropin levels, or uroflowmetric parameters. Urology. 2009 Dec;74(6):1325–30. doi:10.1016/j.urology.2009.07.1219 PubMed PMID: 19781750.

10. Herrmann M, Scharhag J, Sand-Hill M, Kindermann W, Herrmann W. Long-distance mountain biking does not disturb the measurement of total, free or complexed prostate-specific antigen in healthy men. Clin Chem Lab Med. 2004 Mar;42(3):347–9. doi:10.1515/CCLM.2004.061 PubMed PMID: 15080570.

11. Jiandani D, Randhawa A, Brown RE, Hamilton R, Matthew AG, Kuk JL, et al. The effect of bicycling on PSA levels: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2015 Sep;18(3):208–12. doi:10.1038/pcan.2015.16

12. Kindermann W, Lehmann V, Herrmann M, Loch T. [Influencing of the PSA concentration in serum by physical exercise (especially bicycle riding)]. Urol Ausg A. 2011 Feb;50(2):188–96. doi:10.1007/s00120-010-2489-z PubMed PMID: 21246346.

13. Luboldt HJ, Peck KD, Oberpenning F, Schmid HP, Semjonow A. Bicycle riding has no important impact on total and free prostate-specific antigen serum levels in older men. Urology. 2003 Jun;61(6):1177–80. doi:10.1016/s0090-4295(03)00007-4 PubMed PMID: 12809893.

14. Lippi G, Corgnati A, Salvagno G, Schena F, Franchini M, Guidi G. Total and free PSA serum concentrations are not influenced by extensive physical exercise and bicycle riding. Int J Sports Med. 2005;26(1):79–81. doi:10.1055/s-2004-830450 PubMed PMID: 15643540.

Quality in Sport

Published

2026-05-11

How to Cite

1.
PESZUK, Krzysztof, WOŹNIAKOWSKA , Iga, ZAMBRZYCKA, Maja, MISARKO, Aleksandra, JEDWABNIK, Monika, ŚCIGAŁA, Stanisław, LECH, Weronika, DOBROSIELSKA, Adrianna, KRAJEWSKI, Hoang Viet and OLSZEWSKI, Bartosz. The impact of bicycling on PSA levels: a narrative review. Quality in Sport. Online. 11 May 2026. Vol. 55, p. 70931. [Accessed 13 May 2026]. DOI 10.12775/QS.2026.55.70931.
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Vol. 55 (2026)

Section

Medical Sciences

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Copyright (c) 2026 Krzysztof Peszuk, Iga Woźniakowska , Maja Zambrzycka, Aleksandra Misarko, Monika Jedwabnik, Stanisław Ścigała, Weronika Lech, Adrianna Dobrosielska, Hoang Viet Krajewski, Bartosz Olszewski

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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