Exercise as a Component of Enhanced Recovery After Surgery (ERAS): A Narrative Review
DOI:
https://doi.org/10.12775/QS.2026.54.70521Keywords
Enhanced Recovery After Surgery (ERAS);, prehabilitation, early mobilization, exercise therapy, perioperative care, physical activity, postoperative recovery, surgical outcomes, functional capacity, rehabilitationAbstract
Background. Enhanced Recovery After Surgery (ERAS) protocols represent a multimodal, evidence-based approach aimed at reducing surgical stress, minimizing complications, and accelerating postoperative recovery. While ERAS pathways have demonstrated significant improvements in perioperative outcomes, the role of exercise—encompassing both prehabilitation and early postoperative mobilization—remains insufficiently standardized and inconsistently implemented despite growing evidence supporting its clinical benefits.
Aim. The aim of this narrative review was to evaluate the role of exercise as a component of ERAS protocols, with particular emphasis on prehabilitation and early postoperative mobilization, and to identify current limitations and propose a structured framework for integrating physical activity into perioperative care.
Material and methods. A narrative literature review was conducted using PubMed, Scopus, and Web of Science databases. The search strategy included keywords such as “ERAS”, “prehabilitation”, “exercise”, “physical activity”, and “early mobilization”. Eligible studies included randomized controlled trials, systematic reviews, meta-analyses, and observational studies related to perioperative exercise. The selected literature was analyzed qualitatively to identify key mechanisms, clinical outcomes, and implementation barriers.
Results. Exercise interventions were shown to improve functional capacity, enhance metabolic resilience, and reduce postoperative complications. Prehabilitation was associated with increased cardiorespiratory fitness and improved tolerance to surgical stress, particularly in high-risk and oncological patients. Early postoperative mobilization contributed to improved pulmonary function, reduced thromboembolic risk, and faster recovery of functional independence. However, significant variability was observed in exercise protocols, including differences in timing, intensity, and implementation, highlighting a lack of standardization within ERAS pathways. Key barriers included patient-related factors, organizational constraints, and limited integration of exercise into clinical practice.
Conclusions. Exercise represents a critical yet underutilized component of ERAS protocols. Its structured integration, including prehabilitation and early mobilization, has the potential to significantly improve perioperative outcomes and recovery. The development of standardized, evidence-based exercise protocols and enhanced interdisciplinary collaboration are essential to optimize implementation and maximize clinical benefits.
References
Barberan-Garcia, A., Ubré, M., Roca, J., Lacy, A. M., Burgos, F., Risco, R., Momblán, D., Balust, J., Blanco, I., & Martínez-Pallí, G. (2018). Personalised prehabilitation in high-risk patients undergoing elective major abdominal surgery: a randomized blinded controlled trial. LWW. https://doi.org/10.1097/SLA.0000000000002293
Boden, I., Skinner, E. H., Browning, L., Reeve, J., Anderson, L., Hill, C., Robertson, I. K., Story, D., & Denehy, L. (2018). Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial. Bmj, 360. https://doi.org/10.1136/bmj.j5916
Booth, F. W., Gordon, S. E., Carlson, C. J., & Hamilton, M. T. (2000). Waging war on modern chronic diseases: primary prevention through exercise biology. Journal of Applied Physiology. https://doi.org/10.1152/jappl.2000.88.2.774
Carli, F. (2020). Prehabilitation for the anesthesiologist. Anesthesiology, 133(3), 645–652.
de Almeida, E., de Almeida, J., Landoni, G., Galas, F., Fukushima, J. T., Fominskiy, E., De Brito, C. M. M., Cavichio, L. B. L., de Almeida, L. A. A., & Ribeiro-Jr, U. (2017). Early mobilization programme improves functional capacity after major abdominal cancer surgery: a randomized controlled trial. BJA: British Journal of Anaesthesia, 119(5), 900–907. https://doi.org/10.1093/bja/aex250
Desborough, J. P. (2000). The stress response to trauma and surgery. British Journal of Anaesthesia, 85(1), 109–117. https://doi.org/10.1093/bja/85.1.109
Fearon, K. C. H., Ljungqvist, O., Von Meyenfeldt, M., Revhaug, A., Dejong, C. H. C., Lassen, K., Nygren, J., Hausel, J., Soop, M., & Andersen, J. (2005). Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection. Clinical Nutrition, 24(3), 466–477. https://doi.org/10.1016/j.clnu.2005.02.00
Gando, S., Saitoh, D., Ishikura, H., Ueyama, M., Otomo, Y., Oda, S., Kushimoto, S., Tanjoh, K., Mayumi, T., & Ikeda, T. (2013). A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. Critical Care, 17(6), R297. https://doi.org/10.1186/cc13163
Geerts, W. H., Bergqvist, D., Pineo, G. F., Heit, J. A., Samama, C. M., Lassen, M. R., & Colwell, C. W. (2008). Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 133(6), 381S-453S. https://doi.org/10.1378/chest.08-0656
Gillis, C., Hasil, L., Keane, C., Brassard, D., Kiernan, F., Bellafronte, N. T., Culos-Reed, S. N., Gramlich, L., Ljungqvist, O., & Fenton, T. R. (2025). A multimodal prehabilitation class for Enhanced Recovery After Surgery: a pragmatic randomised type 1 hybrid effectiveness-implementation trial. British Journal of Anaesthesia. https://doi.org/10.1016/j.bja.2025.03.001
Gillis, C., Li, C., Lee, L., Awasthi, R., Augustin, B., Gamsa, A., Liberman, A., Stein, B., Charlebois, P., & Feldman, L. S. (2014). Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology, 121(5), 937–947. https://doi.org/10.1097/ALN.0000000000000393
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011). The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Reviews Immunology, 11(9), 607–615. https://doi.org/10.1038/nri3041
Gould, M. K., Garcia, D. A., Wren, S. M., Karanicolas, P. J., Arcelus, J. I., Heit, J. A., & Samama, C. M. (2012). Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 141(2), e227S-e277S. https://doi.org/10.1378/chest.11-2297
Hoogeboom, T. J., Oosting, E., Vriezekolk, J. E., Veenhof, C., Siemonsma, P. C., De Bie, R. A., Van den Ende, C. H. M., & Van Meeteren, N. L. U. (2012). Therapeutic validity and effectiveness of preoperative exercise on functional recovery after joint replacement: a systematic review and meta-analysis. PloS One, 7(5), e38031. https://doi.org/10.1371/journal.pone.0038031
Hughes, M. J., McNally, S., & Wigmore, S. J. (2014). Enhanced recovery following liver surgery: a systematic review and meta-analysis. HPB, 16(8), 699–706. https://doi.org/10.1111/hpb.12245
Huisman, M. G., Veronese, G., Audisio, R. A., Ugolini, G., Montroni, I., De Bock, G. H., Van Leeuwen, B. L., Vigano, A., Gilbert, L., & Spiliotis, J. (2016). Poor nutritional status is associated with other geriatric domain impairments and adverse postoperative outcomes in onco-geriatric surgical patients–a multicentre cohort study. European Journal of Surgical Oncology (EJSO), 42(7), 1009–1017. https://doi.org/10.1016/j.ejso.2016.03.005
Kehlet, H. (2011). Fast-track surgery—an update on physiological care principles to enhance recovery. Langenbeck’s Archives of Surgery, 396(5), 585–590. https://doi.org/10.1007/s00423-011-0790-y
Kehlet, H., & Wilmore, D. W. (2008). Evidence-based surgical care and the evolution of fast-track surgery. Annals of Surgery, 248(2), 189–198. https://doi.org/10.1097/SLA.0b013e31817f2c1a
Ljungqvist, O. (2009). Modulating postoperative insulin resistance by preoperative carbohydrate loading. Best Practice & Research Clinical Anaesthesiology, 23(4), 401–409. https://doi.org/10.1016/j.bpa.2009.08.004
Ljungqvist, O., Scott, M., & Fearon, K. C. (2017). Enhanced recovery after surgery: a review. JAMA Surgery, 152(3), 292–298. https://doi.org/10.1001/jamasurg.2016.4952
Low, J. H. S. (2013). Cardiopulmonary exercise testing and survival after major surgery. British Journal of Anaesthesia, 110(3), 484. https://doi.org/10.1093/bja/aes592
Makary, M. A., Segev, D. L., Pronovost, P. J., Syin, D., Bandeen-Roche, K., Patel, P., Takenaga, R., Devgan, L., Holzmueller, C. G., & Tian, J. (2010). Frailty as a predictor of surgical outcomes in older patients. Journal of the American College of Surgeons, 210(6), 901–908. https://doi.org/10.1016/j.jamcollsurg.2010.01.028
Minnella, E. M., Awasthi, R., Loiselle, S.-E., Agnihotram, R. V, Ferri, L. E., & Carli, F. (2018). Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery: a randomized clinical trial. JAMA Surgery, 153(12), 1081–1089. https://doi.org/10.1001/jamasurg.2018.1645
Minnella, E. M., Bousquet-Dion, G., Awasthi, R., Scheede-Bergdahl, C., & Carli, F. (2017). Multimodal prehabilitation improves functional capacity before and after colorectal surgery for cancer: a five-year research experience. Acta Oncologica, 56(2), 295–300. https://doi.org/10.1080/0284186X.2016.1268268
Moran, J., Guinan, E., McCormick, P., Larkin, J., Mockler, D., Hussey, J., Moriarty, J., & Wilson, F. (2016). The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: a systematic review and meta-analysis. Surgery, 160(5), 1189–1201. https://doi.org/10.1016/j.surg.2016.05.014
Pedersen, B. K., & Saltin, B. (2015). Exercise as medicine–evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian Journal of Medicine & Science in Sports, 25, 1–72. https://doi.org/10.1111/sms.125
Powell, R., Scott, N. W., Manyande, A., Bruce, J., Vögele, C., Byrne‐Davis, L. M. T., Unsworth, M., & Johnston, M. (2016). Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia. Cochrane Database of Systematic Reviews, (5). https://doi.org/10.1002/14651858.CD008646.pub2
Thorell, A., MacCormick, A. D., Awad, S., Reynolds, N., Roulin, D., Demartines, N., Vignaud, M., Alvarez, A., Singh, P. M., & Lobo, D. N. (2016). Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World Journal of Surgery, 40(9), 2065–2083. https://doi.org/10.1007/s00268-016-3492-3
Vather, R., Trivedi, S., & Bissett, I. (2013). Defining postoperative ileus: results of a systematic review and global survey. Journal of Gastrointestinal Surgery, 17(5), 962–972. https://doi.org/10.1007/s11605-013-2148-y
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Klaudia Kasperska, Kamil Arciszewski, Paweł Stenzel, Karolina Niewola, Jakub Szumiło, Dominika Walczak, Karolina Orda, Natalia Hariasz, Mariana Markiv, Michał Słowik

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 15
Number of citations: 0