Key Differences Between GOLD 2026 and Current Polish Guidelines in the Diagnosis and Treatment of COPD
DOI:
https://doi.org/10.12775/QS.2026.53.70222Keywords
COPD, GOLD 2026, COPD diagnosis, COPD treatment, exacerbations, biologic therapy, biologic drugsAbstract
Chronic obstructive lung disease is recurrently one of the most common causes of morbidity and death in the world, it takes third place among death causes. The dynamic development of medical knowledge provides regular input into recommendations for the diagnosis and treatment of this disease. The goal of this thesis was comparison of most up-to-date GOLD 2026 recommendations with most current recommendations for diagnosis and treatment of COPD in force in Poland and pointing out the differences in both documents. The analysis shows that basic rules of diagnostics and primary treatment are in common and are based on assessment of the symptoms, risk of exacerbations and spirometry results. The differences come from novelty approach to COPD classification according to GOLD 2026 recommendations and availability of new treatments of exacerbations. Areas like disease monitoring, patient education or effectiveness of therapy are very similar and could be easily implemented into Polish clinical practice. The main difference remains the use of new biological therapy in treating COPD. Implementation of those new solutions could be difficult in Polish medical care due to financial reasons. Availability of these drugs is also a important factor.
References
[1] Mohsen N, et al. Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025;406(10513):1811-1872. PMID:41092928 PMCID:PMC12535836 DOI:10.1016/S0140-6736(25)01917-8
https://doi.org/10.1016/S0140-6736(25)01917-8
[2] Safiri S, Carson-Chahhoud K, Noori M, Nejadghaderi SA, Sullman MJM, Ahmadian-Heris J, et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med. 2022;10(5):447-458. PMID:35202650 DOI:10.1016/S2213-2600(21)00511-7
https://doi.org/10.1016/S2213-2600(21)00511-7
[3] Tran HM, Tsai FJ, Lee YL, Chang JH, Chang LT, Chang TY, et al. The impact of air pollution on respiratory diseases in an era of climate change: a review of the current evidence. Sci Total Environ. 2023;898:166340. PMID:37591374 DOI:10.1016/j.scitotenv.2023.166340
https://doi.org/10.1016/j.scitotenv.2023.166340
[4] Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2026 report.
[5] Boers E, Allen A, Barrett M, Benjafield AV, Rice MB, Wedzicha JA, et al. Forecasting the global economic and health burden of COPD from 2025 through 2050. Chest. 2025;168(4):880-889. PMID:40254152 DOI:10.1016/j.chest.2025.03.029
https://doi.org/10.1016/j.chest.2025.03.029
[6] Forey BA, Thornton AJ, Lee PN. Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema. BMC Pulm Med. 2011;11:36. PMID:21682805 DOI:10.1186/1471-2466-11-36
https://doi.org/10.1186/1471-2466-11-36
[7] Guo P, Li R, Piao TH, Wang CL, Wu XL, Cai HY. Pathological mechanism and targeted drugs of COPD. Int J Chron Obstruct Pulmon Dis. 2022;17:1565-1575. PMID:35855746 DOI:10.2147/COPD.S366126
https://doi.org/10.2147/COPD.S366126
[8] Zhang H, et al. Immunological mechanisms involved in chronic obstructive pulmonary disease. Front Immunol. 2024;15:1404615. PMID:38812354 DOI:10.3389/fimmu.2024.1404615
https://doi.org/10.3389/fimmu.2024.1404615
[9] Wagner PD. Ventilation-perfusion inequality and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008;5(2):154-159. PMID:18250205 DOI:10.1513/pats.200708-124ET
https://doi.org/10.1513/pats.200708-124ET
[10] Briones Claudett KH, Briones Claudett MH, Chung Sang Wong M, et al. Hypercapnia in COPD: causes, consequences, and therapy. Respir Care. 2019;64(10):1283-1295. PMID:31484725 DOI:10.4187/respcare.06919
https://doi.org/10.4187/respcare.06919
[11] Kerkhof M, et al. Exacerbation history and blood eosinophil count prior to diagnosis of COPD and risk of subsequent exacerbations. Respir Res. 2020;21:1-10. PMID:33143763 DOI:10.1186/s12931-020-01397-7
https://doi.org/10.1186/s12931-020-01397-7
[12]Sadatsafavi M, McCormack J, Petkau J, Lynd LD, Lee TY, Sin DD. Should the number of acute exacerbations in the previous year be used to guide treatments in COPD? Eur Respir J. 2021 Feb;57(2):2002122. PMID: 32855228 doi:10.1183/13993003.02122-2020.
https://doi.org/10.1183/13993003.02122-2020
[13] Maltais F, Bjermer L, Kerwin EM, et al. Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised trial. Respir Res. 2019;20(1):238. PMID:31769397 DOI:10.1186/s12931-019-1187-6
https://doi.org/10.1186/s12931-019-1187-6
[14] Yappalparvi A, Balaraman AK, Padmapriya G, Gaidhane S, Kaur I, Lal M, et al. Safety and efficacy of ensifentrine in COPD: a systematic review and meta analysis. Respir Med. 2025;236:107863. PMID:39557208 DOI:10.1016/j.rmed.2024.107863
https://doi.org/10.1016/j.rmed.2024.107863
[15] Pascoe S, Barnes N, Brusselle G, Compton C, Criner GJ, Dransfield MT, et al. Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial. Lancet Respir Med. 2019 Sep;7(9):745-756. PMID: 31281061. doi:10.1016/S2213-2600(19)30190-0.
https://doi.org/10.1016/S2213-2600(19)30190-0
[16] Martinez FJ, Calverley PMA, Goehring U M, Brose M, Fabbri LMF, Rabe KF, et al. Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet. 2015 Mar 7;385(9971):857 866. PMID: 25684586. doi: /10.1016/S0140-6736(14)62410-7.
https://doi.org/10.1016/S0140-6736(14)62410-7
[17] Rabe KF, Calverley PMA, Martinez FJ, Fabbri LM. Effect of roflumilast in patients with severe COPD and a history of hospitalisation. Eur Respir J. 2017 Jul 5;50(1):1700158. PMID: 28679611. DOI: 10.1183/13993003.00158 2017.
https://doi.org/10.1183/13993003.00158 2017
[18] Czajkowska Malinowska M, Mastalerz Migas A, Kania A, Ledwoch J. Wytyczne konsultanta krajowego w dziedzinie chorób płuc oraz konsultanta krajowego w dziedzinie medycyny rodzinnej dotyczące diagnostyki i leczenia przewlekłej obturacyjnej choroby płuc w POZ w ramach opieki koordynowanej. Lekarz POZ. 2025;11(2):73 86. PMID:— DOI:—
[19] Pływaczewski R, Bednarek M, Jonczak L, Zieliński J. Prevalence of COPD in Warsaw population. Pneumonol Alergol Pol.2003;71(7-8):329-335. PMID:15052966
[20] Białas AJ, Barczyk A, Damps-Konstańska I, et al. Recommendations Following Hospitalization for Acute Exacerbation of COPD—A Consensus Statement of the Polish Respiratory Society. Adv Respir Med. 2026;94(1):4. DOI:10.3390/arm94010004
https://doi.org/10.3390/arm94010004
[21] Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JAD, Criner GJ, et al. Azithromycin for prevention of exacerbations of COPD. N Engl J Med. 2011 Aug 25;365(8):689 698. PMID: 21864166. doi: 10.1056/NEJMoa1104623
https://doi.org/10.1056/NEJMoa1104623
[22] Agache I, et al. Advances in inflammatory mechanisms and biologic therapies in COPD. J Allergy Clin Immunol. 2024. PMID:38560463 DOI:10.1016/j.jaci.2024.03.012
https://doi.org/10.1016/j.jaci.2024.03.012
[23] FDA. Ohtuvayre (ensifentrine) inhalation suspension approval for COPD. 2024. https://antonhealth.com/fda-approves-inhaled-tx-for-copd-ohtuvayre/
[24] European Medicines Agency. Community register of medicinal products for human use. 2017.
https://ec.europa.eu/health/documents/community-register/2017/20170216137188/anx_137188_pl.pdf
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Jakub Franaszek, Knieszko Fahim, Nadia Herchi, Martyna Jabrzyk, Patrycja Jarczyńska, Wojciech Kijowski, Mateusz Klusek, Karolina Michalak, Maciej Przybył

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 18
Number of citations: 0