From Acute Injury to Return to Play: A Comprehensive Review of Biomechanical Principles and Current Strategies in the Diagnosis, Treatment, and Rehabilitation of Acute and Chronic Ankle Ligament Injuries in Sporting Populations.
DOI:
https://doi.org/10.12775/QS.2026.53.70042Keywords
ATFL, athletes, chronic ankle instability, return to play, InternalBrace, ankle sprain, ankle injuries, dynamic ultrasonography, PEACE and LOVE protocolAbstract
Background. Lateral ankle sprains (LAS) are the most frequent musculoskeletal injuries in sports medicine, often leading to chronic ankle instability (CAI). Despite their prevalence in disciplines like basketball or soccer, mismanagement remains common, resulting in long-term sensorimotor deficits and joint degeneration. Modern paradigms are currently shifting from traditional immobilization toward proactive functional mobilization and advanced surgical interventions.
Aim. This review synthesizes contemporary clinical evidence and biomechanical principles to establish a standardized management algorithm for athletes with acute and chronic lateral ligamentous lesions.
Material and Methods. A comprehensive analysis of forty peer-reviewed studies published up to early 2025 was conducted. The synthesis prioritizes diagnostic precision, biomechanical strain patterns, and the comparative efficacy of surgical versus functional rehabilitation interventions in competitive sporting populations.
Results. Precise injury grading, ideally performed five days post-injury, increases diagnostic sensitivity to over 90%. High-resolution dynamic ultrasonography offers superior assessment of functional instability compared to static MRI. Implementation of the "PEACE and LOVE" framework results in faster return-to-play timelines than traditional rest. In elite sports, arthroscopic "all-inside" repairs reinforced with InternalBrace augmentation maintain recurrence rates below 5%.
Conclusions. Optimizing athletic recovery requires a multidisciplinary algorithm bridging mechanical healing and functional homeostasis. Precise injury grading, early functional loading, and biologically reinforced repairs are vital for long-term joint integrity and career longevity.
References
1. Chen RP, Wang QH, Li MY, Su XF, Wang DY, Liu XH, Li ZL. Progress in diagnosis and treatment of acute injury to the anterior talofibular ligament. World J Clin Cases. 2023 May 26;11(15):3395-3407. https://doi.org/10.12998/wjcc.v11.i15.3395
2. Aicale R, Maffulli N. Rotational ankle instability: A current concept review. J Orthop Surg (Hong Kong). 2023 May-Aug;31(2):10225536231182347. https://doi.org/10.1177/10225536231182347
3. Fong DT, Chan YY, Mok KM, Yung PS, Chan KM. Understanding acute ankle ligamentous sprain injury in sports. Sports Med Arthrosc Rehabil Ther Technol. 2009 Jul 30;1:14. https://doi.org/10.1186/1758-2555-1-14
4. Maduka GC, Jakusonoka R, Maduka DC, Yusuf N. Conservative Management of Acute Lateral Ligaments of the Ankle Injuries: An Analytical Literature Review. Cureus. 2023 Oct 26;15(10):e47709. https://doi.org/10.7759/cureus.47709
5. Panagiotakis E, Mok KM, Fong DT, Bull AMJ. Biomechanical analysis of ankle ligamentous sprain injury cases from televised basketball games: Understanding when, how and why ligament failure occurs. J Sci Med Sport. 2017 Dec;20(12):1057-1061. https://doi.org/10.1016/j.jsams.2017.05.006
6. Willegger M, Benca E, Hirtler L, Hradecky K, Holinka J, Windhager R, Schuh R. Biomechanical stability of tape augmentation for anterior talofibular ligament (ATFL) repair compared to the native ATFL. Knee Surg Sports Traumatol Arthrosc. 2016 Apr;24(4):1015-21. https://doi.org/10.1007/s00167-016-4048-7
7. Cai Y, Li S, Chen S, Hua Y, Shan J. An Ultrasound Classification of Anterior Talofibular Ligament (ATFL) Injury. Open Orthop J. 2017 Jul 31;11:610-616. https://doi.org/10.2174/1874325001711010610
8. Thès A, Odagiri H, Elkaïm M, Lopes R, Andrieu M, Cordier G, Molinier F, Benoist J, Colin F, Boniface O, Guillo S, Bauer T; French Arthroscopic Society. Arthroscopic classification of chronic anterior talo-fibular ligament lesions in chronic ankle instability. Orthop Traumatol Surg Res. 2018 Dec;104(8S):S207-S211.https://doi.org/10.1016/j.otsr.2018.09.004
9. Mao W, Jin Z, Li W, Zhu Y, Kong W, Wang Y, Qin J. Artroskopowa naprawa więzadła ATFL i CFL metodą all-inside oddzielnie w przewlekłej niestabilności stawu skokowego bocznego w połączeniu z niestabilnością stawu skokowo-piętowego. J Orthop Surg Res. 2025 15 kwietnia; 20(1):380. https://doi.org/10.1186/s13018-025-05780-6
10. Kim JS, Kim MS, Kim DK, Lee SH. Magnetic Resonance Imaging Characteristics of a Lateral Ligament Injury in Acute Ankle Sprains Among Athletes. Orthop J Sports Med. 2023 Nov 9;11(11):23259671231207688. https://doi.org/10.1177/23259671231207688
11. Yoshimoto K, Noguchi M, Tominaga A, Kumaki M, Koseki T, Okazaki K. Comparative effectiveness of combined ATFL and CFL repair versus ATFL-only repair for severe chronic lateral ankle instability. J Exp Orthop. 2025 Jul 13;12(3):e70345. https://doi.org/10.1002/jeo2.70345
12. Hattori S, Alvarez CAD, Canton S, Hogan MV, Onishi K. Ultrasound-Guided Ankle Lateral Ligament Stabilization. Curr Rev Musculoskelet Med. 2019 Dec;12(4):497-508. https://doi.org/10.1007/s12178-019-09592-0
13. Hunt KJ, Griffith R. Open Brostrom for Lateral Ligament Stabilization. Curr Rev Musculoskelet Med. 2020 Dec;13(6):788-796. https://doi.org/10.1007/s12178-020-09679-z
14. Shakked RJ, Karnovsky S, Drakos MC. Operative treatment of lateral ligament instability. Curr Rev Musculoskelet Med. 2017 Mar;10(1):113-121. https://doi.org/10.1007/s12178-017-9391-x
15. Zhu X, Wei F, Li S, Zhang T, Shen P, Fong DT, Song Q. Toe-out landing reduces anterior talofibular ligament strain while maintains calcaneofibular ligament strain in people with chronic ankle instability. J Sport Health Sci. 2025 Dec;14:101035.. https://doi.org/10.1016/j.jshs.2025.101035
16. Manske RC, Wolfe C, Page P, Voight M. Enhancing the Diagnosis of Lateral Ankle Sprains: The Role of MSK Diagnostic Ultrasound in Evaluating ATFL and CFL. Int J Sports Phys Ther. 2024 Feb 1;19(2):245-249.. https://doi.org/10.26603/001c.92232
17. Hertel J, Corbett RO. An Updated Model of Chronic Ankle Instability. J Athl Train. 2019 Jun;54(6):572-588. https://doi.org/10.4085/1062-6050-344-18
18. Biz C, Nicoletti P, Tomasin M, Bragazzi NL, Di Rubbo G, Ruggieri P. Is Kinesio Taping Effective for Sport Performance and Ankle Function of Athletes with Chronic Ankle Instability (CAI)? A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2022 Apr 29;58(5):620. https://doi.org/10.3390/medicina58050620
19. Halabchi F, Hassabi M. Acute ankle sprain in athletes: Clinical aspects and algorithmic approach. World J Orthop. 2020 Dec 18;11(12):534-558. https://doi.org/10.5312/wjo.v11.i12.534
20. D'Hooghe P, Cruz F, Alkhelaifi K. Return to Play After a Lateral Ligament Ankle Sprain. Curr Rev Musculoskelet Med. 2020 Jun;13(3):281-288. https://doi.org/10.1007/s12178-020-09631-1
21. Petersen W, Rembitzki IV, Koppenburg AG, Ellermann A, Liebau C, Brüggemann GP, Best R. Treatment of acute ankle ligament injuries: a systematic review. Arch Orthop Trauma Surg. 2013 Aug;133(8):1129-41. https://doi.org/10.1007/s00402-013-1742-5
22. Picot B, Hardy A, Terrier R, Tassignon B, Lopes R, Fourchet F. Which Functional Tests and Self-Reported Questionnaires Can Help Clinicians Make Valid Return to Sport Decisions in Patients With Chronic Ankle Instability? A Narrative Review and Expert Opinion. Front Sports Act Living. 2022 May 26;4:902886.. https://doi.org/10.3389/fspor.2022.902886
23. van den Bekerom MP, Struijs PA, Blankevoort L, Welling L, van Dijk CN, Kerkhoffs GM. What is the evidence for rest, ice, compression, and elevation therapy in the treatment of ankle sprains in adults? J Athl Train. 2012 Jul-Aug;47(4):435-43.. https://doi.org/10.4085/1062-6050-47.4.14
24. Ghasemi SA, Tallapaneni J, Murray BC, Yin C, Raphael J, Vaupel Z, Grant A, Fortin P. Successful Return to Sport and Daily Activities After Suture Augmentation of Both the Anterior Talofibular Ligament and Calcaneofibular Ligament. Arthrosc Sports Med Rehabil. 2023 Aug 14;5(5):100762. https://doi.org/10.1016/j.asmr.2023.100762
25. Goru P, Talha S, Majeed H. Outcomes and Return to Sports Following the Ankle Lateral Ligament Reconstruction in Professional Athletes: A Systematic Review of the Literature. Indian J Orthop. 2021 Oct 5;56(2):208-215.. https://doi.org/10.1007/s43465-021-00532-0
26. Wang Y, Hinz M, Buchalter WH, Drumm AH, Eren E, Thomas Haytmanek C, Backus JD. Ankle ligament reconstruction-return to sport after injury scale and return to sports after ankle ligament reconstruction or repair-A systematic review. J Exp Orthop. 2024 Jul 2;11(3):e12077. https://doi.org/10.1002/jeo2.12077
27. McGovern RP, Martin RL. Managing ankle ligament sprains and tears: current opinion. Open Access J Sports Med. 2016 Mar 2;7:33-42.. https://doi.org/10.2147/oajsm.s72334
28. Teramoto A, Murahashi Y, Takahashi K, Watanabe K, Yamashita T. Effect of Accelerated Rehabilitation on Early Return to Sport After Arthroscopic Ankle Lateral Ligament Repair. Orthop J Sports Med. 2022 Sep 13;10(9):23259671221121676.. https://doi.org/10.1177/23259671221121676
29. May NR, Driscoll M, Nguyen S, Ferkel RD. Analysis of Return to Play After Modified Broström Lateral Ankle Ligament Reconstruction. Orthop J Sports Med. 2022 Feb 2;10(2):23259671211068541. https://doi.org/10.1177/23259671211068541
30. Bouveau V, Housset V, Chasset F, Bauer T, Hardy A. Return to sports: Rate and time after arthroscopic surgery for chronic lateral ankle instability. Orthop Traumatol Surg Res. 2022 Nov;108(7):103398. https://doi.org/10.1016/j.otsr.2022.103398
31. Dias S, Lewis TL, Alkhalfan Y, Ahluwalia R, Ray R. Current concepts in the surgical management of chronic ankle lateral ligament instability. J Orthop. 2022 Jul 19;33:87-94. https://doi.org/10.1016/j.jor.2022.07.006
32. van Rijn RM, van Os AG, Bernsen RM, Luijsterburg PA, Koes BW, Bierma-Zeinstra SM. What is the clinical course of acute ankle sprains? A systematic literature review. Am J Med. 2008 Apr;121(4):324-331.e6. https://doi.org/10.1016/j.amjmed.2007.11.018
33. Noda Y, Horibe S, Hiramatsu K, Takao R, Fujita K. Quick and simple test to evaluate severity of acute lateral ankle sprain. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2021 May 30;25:30-34. https://doi.org/10.1016/j.asmart.2021.05.003
34. Ashy CC, Rodriguez Materon S, Goodloe JB, Scott DJ. Operative Management of Lateral Ankle Instability: Examination Under Anesthesia, Ankle Arthroscopy and Stabilization Technique. Video J Sports Med. 2024 Jan 30;4(1):26350254231189291. https://doi.org/10.1177/26350254231189291
35. Hou ZC, Miao X, Ao YF, Hu YL, Jiao C, Guo QW, Xie X, Zhao F, Pi YB, Li N, Zhang ZY, Jiang D. Characteristics and predictors of muscle strength deficit in mechanical ankle instability. BMC Musculoskelet Disord. 2020 Nov 10;21(1):730.. https://doi.org/10.1186/s12891-020-03754-9
36. Baltes TPA, Arnáiz J, Geertsema L, Geertsema C, D'Hooghe P, Kerkhoffs GMMJ, Tol JL. Diagnostic value of ultrasonography in acute lateral and syndesmotic ligamentous ankle injuries. Eur Radiol. 2021 Apr;31(4):2610-2620. https://doi.org/10.1007/s00330-020-07305-7
37. Mollon B, Wasserstein D, Murphy GM, White LM, Theodoropoulos J. High Ankle Sprains in Professional Ice Hockey Players: Prognosis and Correlation Between Magnetic Resonance Imaging Patterns of Injury and Return to Play. Orthop J Sports Med. 2019 Sep 27;7(9):2325967119871578.https://doi.org/10.1177/2325967119871578
38. Kilper A, Milani TL, Schütz L, Langenhan R, Reimers N, Lederer AK, Mitschke C. Ankle injury due to supination trauma: Potential factors worsening patient outcome. J Orthop. 2024 Nov 4;59:123-127. https://doi.org/10.1016/j.jor.2024.10.060
39. Fan D, Liu X, Zhang L. Single anchor versus double anchor for arthroscopic anterior talofibular ligament repair: A systematic review and mate-analysis of cohort studies. J Orthop Surg (Hong Kong). 2023 Sep-Dec;31(3):10225536231217914. https://doi.org/10.1177/10225536231217914
40. Zhou YF, Zhang HZ, Zhang ZZ, Jiang C, Chen Z, Zhang CD, Li WP, Shen HY, Song B. Comparison of Function- and Activity-Related Outcomes After Anterior Talofibular Ligament Repair With 1 Versus 2 Suture Anchors. Orthop J Sports Med. 2021 Jul 21;9(7):2325967121991930. https://doi.org/10.1177/2325967121991930
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Copyright (c) 2026 Gabriela Dobosz, Mikołaj Hobot, Zuzanna Przybylska, Aleksandra Purpura, Wiktor Rolski, Paulina Michalska, Bartłomiej Przystaś, Magdalena Grzechowiak, Sebastian Podeszwa

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