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Quality in Sport

Relevance of Medicinal Leeches in plastic and reconstructive surgery - a literature review
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Relevance of Medicinal Leeches in plastic and reconstructive surgery - a literature review

Authors

  • Joanna Słuchocka University of Warmia and Mazury in Olsztyn https://orcid.org/0009-0000-8143-2451
  • Tymon Lewalski University of Warmia and Mazury in Olsztyn https://orcid.org/0009-0007-5345-2077
  • Martyna Florczyk RCKiK in Olsztyn https://orcid.org/0009-0000-6385-110X
  • Lidia Płuciennik Medical University of Łódź https://orcid.org/0009-0007-5860-9213
  • Oskar Lewalski University of Warmia and Mazury in Olsztyn https://orcid.org/0009-0000-0914-0219
  • Klaudia Jeruć Provincial Specialist Children’s Hospital in Olsztyn named after Prof. Dr. Stanisław Popowski https://orcid.org/0009-0000-8107-7736

DOI:

https://doi.org/10.12775/QS.2026.53.70037

Keywords

hirudo medicinalis, medicinal leech therapy, hirudotherapy, hirudin, reconstructive surgery, sports medicine

Abstract

Background. Medicinal leeches, once emblematic of pre-modern bloodletting practices, have re-emerged as valuable therapeutic tools in contemporary medicine that is now an FDA-approved treatment [1]. Primarily utilized in reconstructive microsurgery, orthopedics, and trauma management, leech therapy (hirudotherapy) provides unique physiological benefits that are difficult to replicate with pharmacological agents alone [2].

Aim. This article reviews the biochemical mechanisms of the components of leech saliva, treatment protocol, safety considerations and administration techniques of the leeches with their current applications in modern healthcare and emphasis on their relevance in plastic and reconstructive surgery

Methods. This paper was based on scientific articles and case reports selected from databases such as PubMed and Google Scholar.

Results. The literature considers medicinal leeches an effective therapeutic tool most famously utilized in plastic and reconstructive surgery [5]. They are currently classified as a medical device that is safe and well tolerated by patients [1,5].

Conclusions. Medical leeches may seem primeval, but a deeper dive into the benefits of their usage in the particular purposes shows that they are still a relevant form of therapy. They may be underestimated but their biochemical actions on hemostasis, inflammation, microcirculation, and pain perception which work synergistically are truly impressive. In many cases leeches are successfully used when conventional medicine is just not enough [2,6].

References

1. U.S. Food and Drug Administration. 510(k) Summary: Medicinal Leech (Hirudo medicinalis). Silver Spring (MD): FDA; 2004. no doi

2. Whitaker IS, Izadi D, Oliver DW, Monteath G, Butler PE. Hirudo Medicinalis and the plastic surgeon. Br J Plast Surg. 2004;57(4):348-353. https://doi.org/10.1016/j.bjps.2003.12.016

3. Whitaker IS, Rao J, Izadi D, Butler PE. Historical Article: Hirudo medicinalis: ancient origins of, and trends in the use of medicinal leeches throughout history. Br J Oral Maxillofac Surg. 2004;42(2):133-137. https://doi.org/10.1016/S0266-4356(03)00242-0

4. Mumcuoglu KY. Recommendations for the use of leeches in reconstructive plastic surgery. Evid Based Complement Alternat Med. 2014;2014:205929. https://doi.org/10.1155/2014/205929

5. Baskova IP, Kostrjukova ES, Vlasova MA, et al. Proteins and peptides of the salivary gland secretion of medicinal leeches Hirudo verbana, H. medicinalis, and H. orientalis. Biochemistry (Mosc). 2008;73(3):315-320. https://doi.org/10.1134/s0006297908030127

6. Deckmyn H, Stassen JM, Vreys I, Van Houtte E, Sawyer RT, Vermylen J. Calin from Hirudo medicinalis, an inhibitor of platelet adhesion to collagen, prevents platelet-rich thrombosis in hamsters. Blood. 1995;85(3):712-719. https://doi.org/10.1182/blood.V85.3.712.bloodjournal853712

7. Adams SL. The medicinal leech. A page from the annelids of internal medicine. Ann Intern Med. 1988;109(5):399-405. doi:10.7326/0003-4819-109-5-399 https://doi.org/10.7326/0003-4819-109-5-399

8. Markwardt F. Hirudin as alternative anticoagulant--a historical review. Semin Thromb Hemost. 2002;28(5):405-414. doi:10.1055/s-2002-35292 https://doi.org/10.1055/s-2002-35292

9. Greinacher A, Lubenow N, Eichler P. Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia. Circulation. 2003;108(17):2062-2065. https://doi.org/10.1161/01.CIR.0000096056.37269.14

10. Abdualkader, Abdualrahman & Ghawi, Abbas Mohammad & Alaama, Mohamed & Awang, Mohamed & Merzouk, Ahmed. (2013). Leech Therapeutic Applications. Indian journal of pharmaceutical sciences. 75. 127-137. https://doi.org/10.1038/s41598-023-32459-x

11. Sig AK, Guney M, Uskudar Guclu A, Ozmen E. Medicinal leech therapy-an overall perspective. Integr Med Res. 2017;6(4):337-343. https://doi.org/10.1016/j.imr.2017.08.001

12. Andereya S, Stanzel S, Maus U, et al. Assessment of leech therapy for knee osteoarthritis: a randomized study. Acta Orthop. 2008;79(2):235-243. https://doi.org/10.1080/17453670710015030

13. Abdualkader AM, Ghawi AM, Alaama M, Awang M, Merzouk A. Leech therapeutic applications. Indian J Pharm Sci. 2013;75(2):127-137. https://doi.org/10.4103/0250-474X.115456

14. Knobloch K, Gohritz A, Busch K, Spies M, Vogt PM. Hirudo medicinalis-Anwendungen in der plastischen und rekonstruktiven Mikrochirurgie--eine Literaturübersicht [Hirudo medicinalis-leech applications in plastic and reconstructive microsurgery--a literature review]. Handchir Mikrochir Plast Chir. 2007;39(2):103-107. https://doi.org/10.1055/s-2007-965138

15. Sartor C, Limouzin-Perotti F, Legré R, et al. Nosocomial Infections with Aeromonas hydrophila from Leeches. Clin Infect Dis. 2002;35(1):E1-E5. https://doi.org/10.1086/340711

16. Lineaweaver WC, Hill MK, Buncke GM, et al. Aeromonas hydrophila infections following use of medicinal leeches in replantation and flap surgery. Ann Plast Surg. 1992;29(3):238-244. https://doi.org/10.1097/00000637-199209000-00008

17. Munro R, Jones CP, Sawyer RT. Calin--a platelet adhesion inhibitor from the saliva of the medicinal leech. Blood Coagul Fibrinolysis. 1991;2(1):179-184. doi:10.1097/00001721-199102000-00027 https://doi.org/10.1097/00001721-199102000-00027

18. Babenko VV, Podgorny OV, Manuvera VA, et al. Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches. BMC Genomics. 2020;21(1):331. Published 2020 Apr 29. https://doi.org/10.1186/s12864-020-6748-0

19. Uygur F, Sever C, Yüksel F, et al. Microsurgery and medicinal leeches: applications and outcomes. Microsurgery. 2011;31(4):281–287. https://doi.org/10.1002/micr.20860

20. Abdualkader AM, et al. Review of sport-related soft tissue applications of leech therapy. Clin J Sport Med.2014;24(5):401–406. https://doi.org/10.4103/0250-474X.115456

21. Whitlock MR, O'Hare PM, Sanders R, Morrow NC. The medicinal leech and its use in plastic surgery: a possible cause for infection. Br J Plast Surg. 1983;36(2):240-244. https://doi.org/10.1016/0007-1226(83)90100-5

22. Eldor A, Orevi M, Rigbi M. The role of the leech in medical therapeutics. Blood Rev. 1996;10(4):201-209. https://doi.org/10.1016/s0268-960x(96)90000-4

23. Wilmer A, Slater K, Yip J, Carr N, Grant J. The role of leech water sampling in choice of prophylactic antibiotics in medical leech therapy. Microsurgery. 2013;33(4):301-304. https://doi.org/10.1002/micr.22087

24. Rao J, Janis JE, et al. Int J Surg review of leeches as adjunct therapy. Int J Surg. 2010;8(8):639–644. https://doi.org/10.1097/GOX.0000000000002555

25. Michalsen A, Klotz S, Lüdtke R, Moebus S, Spahn G, Dobos GJ. Effectiveness of leech therapy in osteoarthritis of the knee: a randomized, controlled trial. Ann Intern Med. 2003;139(9):724-730. https://doi.org/10.7326/0003-4819-139-9-200311040-00006

26. Vaesken C, Besnier P, Bernardeau C, et al. Improvement of patient care through hirudotherapy and the management of leeches from their reception to their disposal in France. Eur J Hosp Pharm. 2023;30(e1):e61-e65. https://doi.org/10.1136/ejhpharm-2021-003100

27. Mamelak AJ, Jackson A, Nizamani R, et al. Leech therapy in cutaneous surgery and disease. J Drugs Dermatol. 2010;9(3):252-257. no doi PMID: 20232587.

28. Cherniack EP. Bugs as drugs, Part 1: Insects: the "new" alternative medicine for the 21st century?. Altern Med Rev. 2010;15(2):124-135. no doi PMID: 20806997.

29. Singh AP. Review of medicinal leech therapy. Complement Ther Clin Pract. 2010;16(4):213–215. https://doi.org/10.1016/j.ctcp.2009.11.005

30. Sawyer, Roy. (1986). Roy T Sawyer, 1986. Leech Biology and Behaviour. Oxford University Press. no doi

31. Whitaker IS, Oboumarzouk O, Rozen WM, et al. The efficacy of medicinal leeches in plastic and reconstructive surgery: a systematic review of 277 reported clinical cases. Microsurgery. 2012;32(3):240-250. https://doi.org/10.1002/micr.20971

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Published

2026-03-28

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1.
SŁUCHOCKA, Joanna, LEWALSKI, Tymon, FLORCZYK, Martyna, PŁUCIENNIK, Lidia, LEWALSKI, Oskar and JERUĆ, Klaudia. Relevance of Medicinal Leeches in plastic and reconstructive surgery - a literature review. Quality in Sport. Online. 28 March 2026. Vol. 53, p. 70037. [Accessed 10 April 2026]. DOI 10.12775/QS.2026.53.70037.
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Copyright (c) 2026 Joanna Słuchocka, Tymon Lewalski, Martyna Florczyk, Lidia Płuciennik, Oskar Lewalski, Klaudia Jeruć

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