Hidden in the Chest: Myocardial Bridging and Cardiovascular Response to Exercise
DOI:
https://doi.org/10.12775/QS.2026.52.69553Keywords
myocardial bridging, myocardial ischemia, systolic compression, coronary artery diseaseAbstract
Myocardial bridging (MB) of the coronary arteries has long been considered a benign anatomical variant with no significant clinical relevance. However, the development of modern imaging and functional diagnostic methods indicates that its impact on myocardial perfusion may become apparent under conditions of increased hemodynamic load, especially during physical exertion. In the context of sports science, this issue is particularly important, as even subtle coronary flow disturbances can modulate the heart's response to training load and affect exercise tolerance.The aim of this study was to present the current state of knowledge on the anatomy, pathophysiology, clinical picture, diagnosis, and therapeutic management of myocardial bridges, with particular emphasis on their functional significance under conditions of stress typical of physical activity. The article is a narrative review of the literature based on a critical analysis of anatomical, observational, and imaging studies, as well as works devoted to functional assessment and treatment strategies.
Available data indicate that MBs are a common structure, but heterogeneous in terms of morphology and hemodynamic significance. Although they remain asymptomatic in most people, in selected cases they may be associated with myocardial ischemia, arrhythmias, and reduced exercise tolerance. Myocardial bridges require individualized clinical and functional assessment, and their presence should not be automatically considered insignificant, especially in the context of exercise capacity assessment.
References
[1] Saminathan S, Selvaraj V. A cadaveric study of the myocardial bridges. J. Evolution Med. Dent. Sci. 2019;8(02):133-136, DOI: 10.14260/jemds/2019/29
[2] Möhlenkamp, S., Hort, W., Ge, J., & Erbel, R. (2002). Update on myocardial bridging. Circulation, 106(20), 2616–2622. https://doi.org/10.1161/01.cir.0000038420.14867.7a
[3] Lee, M. S., & Chen, C. H. (2015). Myocardial Bridging: An Up-to-Date Review. The Journal of invasive cardiology, 27(11), 521–528.
[4] Corban, M. T., Hung, O. Y., Eshtehardi, P., Rasoul-Arzrumly, E., McDaniel, M., Mekonnen, G., Timmins, L. H., Lutz, J., Guyton, R. A., & Samady, H. (2014). Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies. Journal of the American College of Cardiology, 63(22), 2346–2355. https://doi.org/10.1016/j.jacc.2014.01.049
[5] Tarantini, G., Migliore, F., Cademartiri, F., Fraccaro, C., & Iliceto, S. (2016). Left Anterior Descending Artery Myocardial Bridging: A Clinical Approach. Journal of the American College of Cardiology, 68(25), 2887–2899. https://doi.org/10.1016/j.jacc.2016.09.973
[6] Masuda, T., Ishikawa, Y., Akasaka, Y., Itoh, K., Kiguchi, H., & Ishii, T. (2001). The effect of myocardial bridging of the coronary artery on vasoactive agents and atherosclerosis localization. The Journal of pathology, 193(3), 408–414. https://doi.org/10.1002/1096-9896(2000)9999:9999<::AID-PATH792>3.0.CO;2-R
[7] Alegria, J. R., Herrmann, J., Holmes, D. R., Jr, Lerman, A., & Rihal, C. S. (2005). Myocardial bridging. European heart journal, 26(12), 1159–1168. https://doi.org/10.1093/eurheartj/ehi203
[8] Angelini, P., Uribe, C., & Raghuram, A. (2025). Coronary Myocardial Bridge Updates: Anatomy, Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment Options. Texas Heart Institute journal, 52(1), e238300. https://doi.org/10.14503/THIJ-23-8300
[9] Hostiuc, S., Negoi, I., Rusu, M. C., & Hostiuc, M. (2018). Myocardial Bridging: A Meta-Analysis of Prevalence. Journal of forensic sciences, 63(4), 1176–1185. https://doi.org/10.1111/1556-4029.13665
[10] Zeina, A. R., Odeh, M., Blinder, J., Rosenschein, U., & Barmeir, E. (2007). Myocardial bridge: evaluation on MDCT. AJR. American journal of roentgenology, 188(4), 1069–1073. https://doi.org/10.2214/AJR.06.0714
[11] Kim SY, Lee YS, Lee JB, et al. Evaluation of myocardial bridge with multidetector computed tomography. Circ J. 2010;74(1):137-141. https://doi.org/10.1253/circj.CJ-09-0407
[12] Ge, J., Erbel, R., Rupprecht, H. J., Koch, L., Kearney, P., Görge, G., Haude, M., & Meyer, J. (1994). Comparison of intravascular ultrasound and angiography in the assessment of myocardial bridging. Circulation, 89(4), 1725–1732. https://doi.org/10.1161/01.cir.89.4.1725
[13] Ishikawa, Y., Kawawa, Y., Kohda, E., Shimada, K., & Ishii, T. (2011). Significance of the anatomical properties of a myocardial bridge in coronary heart disease. Circulation journal : official journal of the Japanese Circulation Society, 75(7), 1559–1566. https://doi.org/10.1253/circj.cj-10-1278
[14] Taqueti, V. R., & Di Carli, M. F. (2018). Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 72(21), 2625–2641. https://doi.org/10.1016/j.jacc.2018.09.042
[15] Javadzadegan, A., Moshfegh, A., Qian, Y., Kritharides, L., & Yong, A. S. C. (2019). Myocardial bridging and endothelial dysfunction - Computational fluid dynamics study. Journal of biomechanics, 85, 92–100. https://doi.org/10.1016/j.jbiomech.2019.01.021
[16] Sara, J. D. S., Corban, M. T., Prasad, M., Prasad, A., Gulati, R., Lerman, L. O., & Lerman, A. (2020). Prevalence of myocardial bridging associated with coronary endothelial dysfunction in patients with chest pain and non-obstructive coronary artery disease. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 15(14), 1262–1268. https://doi.org/10.4244/EIJ-D-18-00920
[17] Morales AR, Romanelli R, Boucek RJ. The mural left anterior descending coronary artery, strenuous exercise and sudden death. Circulation. 1980;62(2):230-237. https://doi.org/10.1161/01.CIR.62.2.230
[18] Bourassa, M. G., Butnaru, A., Lespérance, J., & Tardif, J. C. (2003). Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies. Journal of the American College of Cardiology, 41(3), 351–359. https://doi.org/10.1016/s0735-1097(02)02768-7
[19] Gaibazzi, N., Rigo, F., & Reverberi, C. (2011). Severe coronary tortuosity or myocardial bridging in patients with chest pain, normal coronary arteries, and reversible myocardial perfusion defects. The American journal of cardiology, 108(7), 973–978. https://doi.org/10.1016/j.amjcard.2011.05.030
[20] Roul G, Sens P, Germain P, Bareiss P. Myocardial bridging as a cause of acute transient left heart dysfunction. Chest. 1999;116(2):574-580. doi:10.1378/chest.116.2.574
[21] Gowda, R. M., Khan, I. A., Ansari, A. W., & Cohen, R. A. (2003). Acute ST segment elevation myocardial infarction from myocardial bridging of left anterior descending coronary artery. International journal of cardiology, 90(1), 117–118. https://doi.org/10.1016/s0167-5273(02)00518-1
[22] Berry, J. F., von Mering, G. O., Schmalfuss, C., Hill, J. A., & Kerensky, R. A. (2002). Systolic compression of the left anterior descending coronary artery: a case series, review of the literature, and therapeutic options including stenting. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 56(1), 58–63. https://doi.org/10.1002/ccd.10151
[23] Tio, R. A., Van Gelder, I. C., Boonstra, P. W., & Crijns, H. J. (1997). Myocardial bridging in a survivor of sudden cardiac near-death: role of intracoronary doppler flow measurements and angiography during dobutamine stress in the clinical evaluation. Heart (British Cardiac Society), 77(3), 280–282. https://doi.org/10.1136/hrt.77.3.280
[24] Hongo, Y., Tada, H., Ito, K., Yasumura, Y., Miyatake, K., & Yamagishi, M. (1999). Augmentation of vessel squeezing at coronary-myocardial bridge by nitroglycerin: study by quantitative coronary angiography and intravascular ultrasound. American heart journal, 138(2 Pt 1), 345–350. https://doi.org/10.1016/s0002-8703(99)70123-7
[25] Bil J. Fizjologia mostków mięśniowych. Kardiologia Inwazyjna. 2016;11(1):12–15. doi:10.5603/ki.47153.
[26] Kersemans, M., Van Heuverswyn, F., De Pauw, M., Gheeraert, P., Taeymans, Y., & Drieghe, B. (2009). Hemodynamic effect of myocardial bridging. Circulation. Cardiovascular interventions, 2(4), 361–362. https://doi.org/10.1161/CIRCINTERVENTIONS.109.855395
[27] Escaned, J., Cortés, J., Flores, A., Goicolea, J., Alfonso, F., Hernández, R., Fernández-Ortiz, A., Sabaté, M., Bañuelos, C., & Macaya, C. (2003). Importance of diastolic fractional flow reserve and dobutamine challenge in physiologic assessment of myocardial bridging. Journal of the American College of Cardiology, 42(2), 226–233. https://doi.org/10.1016/s0735-1097(03)00588-6
[28] Kim, P. J., Hur, G., Kim, S. Y., Namgung, J., Hong, S. W., Kim, Y. H., & Lee, W. R. (2009). Frequency of myocardial bridges and dynamic compression of epicardial coronary arteries: a comparison between computed tomography and invasive coronary angiography. Circulation, 119(10), 1408–1416. https://doi.org/10.1161/CIRCULATIONAHA.108.788901
[29] Gawor, R., Kuśmierek, J., Płachcińska, A., Bieńkiewicz, M., Drożdż, J., Piotrowski, G., & Chiżyński, K. (2011). Myocardial perfusion GSPECT imaging in patients with myocardial bridging. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 18(6), 1059–1065. https://doi.org/10.1007/s12350-011-9406-8
[30] Ho, Y. L., Wu, C. C., Yen, R. F., Hung, S. R., Chen, M. F., & Huang, P. J. (2001). Comparison of ischemic patterns in myocardial bridge and syndrome X: evaluation by dobutamine stress echocardiography and stress thallium-201 SPECT. Journal of the Formosan Medical Association = Taiwan yi zhi, 100(2), 83–88.
[31] Rezayat P, Hassan D, Amirreza S, Susan H. Myocardial bridge. Surgical outcome and midterm follow up. Saudi Med J. 2006;27(10):1530-1533.
[32] Bockeria, L. A., Sukhanov, S. G., Orekhova, E. N., Shatakhyan, M. P., Korotayev, D. A., & Sternik, L. (2013). Results of coronary artery bypass grafting in myocardial bridging of left anterior descending artery. Journal of cardiac surgery, 28(3), 218–221. https://doi.org/10.1111/jocs.12101
[33] Attaran, S., Moscarelli, M., Athanasiou, T., & Anderson, J. (2013). Is coronary artery bypass grafting an acceptable alternative to myotomy for the treatment of myocardial bridging?. Interactive cardiovascular and thoracic surgery, 16(3), 347–349. https://doi.org/10.1093/icvts/ivs459
[34] Wu, Q. Y., & Xu, Z. H. (2007). Surgical treatment of myocardial bridging: report of 31 cases. Chinese medical journal, 120(19), 1689–1693.
[35] Ernst, A., Bulum, J., Šeparović Hanževački, J., Lovrić Benčić, M., & Strozzi, M. (2013). Five-year angiographic and clinical follow-up of patients with drug-eluting stent implantation for symptomatic myocardial bridging in absence of coronary atherosclerotic disease. The Journal of invasive cardiology, 25(11), 586–592.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Dominik Kret, Wiktoria Szlachta, Daria Twardowska, Wiktoria Tłoczek, Wiktoria Śliwa

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 86
Number of citations: 0