Ergogenic Properties of Caffeine in the Diet of Athletes
DOI:
https://doi.org/10.12775/QS.2026.51.68631Keywords
caffeine, athletes, ergogenic aids, supplementation, dietAbstract
Caffeine is one of the most widely consumed and extensively studied ergogenic aids in both amateur and professional sports. Its prevalence spans athletes across a range of disciplines. While some athletes regard caffeine as beneficial for athletic performance, others incorporate it into their daily routine. In competitive sports, where every detail of preparation can be essential, caffeine supplementation is frequently employed to enhance physical performance, cognitive function, and training capacity.
This review summarizes current scientific evidence regarding the pharmacokinetics, mechanisms, effects, and safety of caffeine use in athletic populations. Biochemically, caffeine is a naturally occurring methylxanthine with rapid absorption, high bioavailability, and predictable hepatic cytochrome P450 1A2 mediated metabolism.
Its ergogenic effects are attributed to non-selective antagonism of central adenosine receptors, which increases nervous system excitability, reduces perception of effort and pain, and enhances neuromuscular, cognitive, and psychomotor functions. Evidence-based recommendations indicate that low to moderate doses of caffeine, administered before or during exercise, are effective for most athletes, while smaller repeated doses are advantageous during prolonged events requiring sustained performance.
Caffeine is generally considered safe within recommended limits; however, individual variability in dietary habits, genetic factors, and sensitivity necessitates personalized supplementation strategies.
Overall, caffeine is a safe and effective ergogenic aid when used appropriately, with optimal outcomes achieved through individualized protocols tailored to specific sports and competition contexts.
References
1. Valiño-Marques A, Lamas A, Miranda JM, Cepeda A, Regal P. Nutritional Ergogenic Aids in Cycling: A Systematic Review. Nutrients. 2024;16(11):1768. doi:10.3390/nu16111768
2. Vicente-Salar N, Fuster-Muñoz E, Martínez-Rodríguez A. Nutritional Ergogenic Aids in Combat Sports: A Systematic Review and Meta-Analysis. Nutrients. 2022;14(13):2588. doi:10.3390/nu14132588
3. López-Torres O, Rodríguez-Longobardo C, Capel-Escoriza R, Fernández-Elías VE. Ergogenic Aids to Improve Physical Performance in Female Athletes: A Systematic Review with Meta-Analysis. Nutrients. 2022;15(1):81. doi:10.3390/nu15010081
4. Antonio J, Pereira F, Curtis J, Rojas J, Evans C. The Top 5 Can’t-Miss Sport Supplements. Nutrients. 2024;16(19):3247. doi:10.3390/nu16193247
5. Mabrey G, Koozehchian MS, Newton AT, Naderi A, Forbes SC, Haddad M. The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024;16(6):766. doi:10.3390/nu16060766
6. Bonilla DA, Boullosa D, Del Coso J. Advances in Nutrition, Dietary Supplements and Ergogenic Aids for Athletic Performance: Trends and Future Prospects. Nutrients. 2023;15(10):2246. doi:10.3390/nu15102246
7. Rodak K, Kokot I, Kratz EM. Caffeine as a Factor Influencing the Functioning of the Human Body—Friend or Foe? Nutrients. 2021;13(9):3088. doi:10.3390/nu13093088
8. Song X, Singh M, Lee KE, Vinayagam R, Kang SG. Caffeine: A Multifunctional Efficacious Molecule with Diverse Health Implications and Emerging Delivery Systems. Int J Mol Sci. 2024;25(22):12003. doi:10.3390/ijms252212003
9. Ősz BE, Jîtcă G, Ștefănescu RE, Pușcaș A, Tero-Vescan A, Vari CE. Caffeine and Its Antioxidant Properties—It Is All about Dose and Source. Int J Mol Sci. 2022;23(21):13074. doi:10.3390/ijms232113074
10. Yan A, Rosa AL, Chhablani PP, Chhablani J. Caffeine and Vision: Effects on the Eye. Turk J Ophthalmol. 54(5):291-300. doi:10.4274/tjo.galenos.2024.43895
11. Pickering C, Kiely J. Are the Current Guidelines on Caffeine Use in Sport Optimal for Everyone? Inter-individual Variation in Caffeine Ergogenicity, and a Move Towards Personalised Sports Nutrition. Sports Med Auckl Nz. 2018;48(1):7-16. doi:10.1007/s40279-017-0776-1
12. Sökmen B, Armstrong LE, Kraemer WJ, et al. Caffeine Use in Sports: Considerations for the Athlete. J Strength Cond Res. 2008;22(3):978. doi:10.1519/JSC.0b013e3181660cec
13. Triki-Fendri S, Sánchez-Diz P, Rey-González D, et al. Genetic structure of the Kuwaiti population revealed by paternal lineages. Am J Hum Biol. 2016;28(2):203-212. doi:10.1002/ajhb.22773
14. Goldstein ER, Ziegenfuss T, Kalman D, et al. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr. 2010;7(1):5. doi:10.1186/1550-2783-7-5
15. Ganio MS, Klau JF, Casa DJ, Armstrong LE, Maresh CM. Effect of Caffeine on Sport-Specific Endurance Performance: A Systematic Review. J Strength Cond Res. 2009;23(1):315. doi:10.1519/JSC.0b013e31818b979a
16. Nerlich AG, Bachmeier BE, Schleicher E, Rohrbach H, Paesold G, Boos N. Immunomorphological Analysis of RAGE Receptor Expression and NF-κB Activation in Tissue Samples from Normal and Degenerated Intervertebral Discs of Various Ages. Ann N Y Acad Sci. 2007;1096(1):239-248. doi:10.1196/annals.1397.090
17. Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Med Auckl NZ. 2014;44 Suppl 2(Suppl 2):S175-184. doi:10.1007/s40279-014-0257-8
18. Grgic J, Mikulic P. Caffeine ingestion acutely enhances muscular strength and power but not muscular endurance in resistance-trained men. Eur J Sport Sci. 2017;17(8):1029-1036. doi:10.1080/17461391.2017.1330362
19. Grgic J. Effects of Caffeine on Resistance Exercise: A Review of Recent Research. Sports Med. 2021;51(11):2281-2298. doi:10.1007/s40279-021-01521-x
20. Kamimori GH, Karyekar CS, Otterstetter R, et al. The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm. 2002;234(1):159-167. doi:10.1016/S0378-5173(01)00958-9
21. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab Physiol Appl Nutr Metab. 2008;33(6):1319-1334. doi:10.1139/H08-130
22. Desbrow B, Biddulph C, Devlin B, Grant GD, Anoopkumar-Dukie S, Leveritt MD. The effects of different doses of caffeine on endurance cycling time trial performance. J Sports Sci. 2012;30(2):115-120. doi:10.1080/02640414.2011.632431
23. Guest N, Corey P, Vescovi J, El-Sohemy A. Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes. Med Sci Sports Exerc. 2018;50(8):1570. doi:10.1249/MSS.0000000000001596
24. Clark I, Landolt HP. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev. 2017;31:70-78. doi:10.1016/j.smrv.2016.01.006
25. O’Callaghan F, Muurlink O, Reid N. Effects of caffeine on sleep quality and daytime functioning. Risk Manag Healthc Policy. 2018;11:263-271. doi:10.2147/RMHP.S156404
26. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the safety of caffeine. EFSA J. 2015;13(5):4102. doi:10.2903/j.efsa.2015.4102
27. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51(1):83-133.
28. James JE, Rogers PJ. Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation. Psychopharmacology (Berl). 2005;182(1):1-8. doi:10.1007/s00213-005-0084-6
29. Graham TE, Spriet LL. Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. J Appl Physiol Bethesda Md 1985. 1995;78(3):867-874. doi:10.1152/jappl.1995.78.3.867
30. Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl). 2004;176(1):1-29. doi:10.1007/s00213-004-2000-x
31. Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB. Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circulation. 2014;129(6):643-659. doi:10.1161/CIRCULATIONAHA.113.005925
32. Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024. doi:10.1136/bmj.j5024
33. Monitoring Program. World Anti Doping Agency. Accessed January 22, 2026. https://www.wada-ama.org/en/resources/monitoring-program
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Aleksandra Fałczyńska, Weronika Szkudlarek, Kinga Woźniak, Maciej Bieniek, Sandra Dachowska, Jan Haraj, Marcin Sobkowiak, Maria Namysł, Simon Matczak

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 5
Number of citations: 0