Three dimensional printing techniques and their applications in medicine
DOI:
https://doi.org/10.12775/QS.2026.51.68569Keywords
3D imprinting, medicine, innovations, medicamentsAbstract
The beginnings of 3D printing are estimated to date back to 1984. Since then, the technology has evolved significantly thanks to the development of software and a significant increase in computer power. 3D technology is used in many areas of orthopedic medicine. From the production of bone models, implants and the creation of drugs. Thanks to the development of software and biological materials, it is possible to create personalized patient implants or create much more accurate models than using single MRI or CT images in order to better plan the treatment procedure. Currently, materials made of paper, metal, ceramics and hydroxyapatite are used. Unfortunately, the above technology has a number of disadvantages. Despite continuous development, the costs are often several times higher than when using traditional therapeutic methods. Additionally, the amount of materials that can be used is limited. Perhaps this will change in the future, because the technology itself offers promising possibilities that may allow for much more accurate, personalized treatment and faster recovery of patients.
References
1.Vanessa Marcia Vaz and Lalit Kumar; 3D Printing as a Promising Tool in Personalized Medicine AAPS PharmSciTech. 2021 Jan; 22(1): 49.
2.C. Lee Ventola, Medical Applications for 3D Printing: Current and Projected Uses P T. 2014 Oct; 39(10): 704–711.
3.Philip Tack , Jan Victor , Paul Gemmel , Lieven Annemans ; 3D-printing techniques in a medical setting: a systematic literature review Biomed Eng Online. 2016 Oct 21;15(1):115
4.Yashan Feng , Shijie Zhu , Di Mei , Jiang Li , Jiaxiang Zhang , Shaolong Yang , Shaokang Guan; Application of 3D Printing Technology in Bone Tissue Engineering: A Review Curr Drug Deliv. 2021;18(7):847-861
5.Parastoo Memarian , Elham Pishavar , Federica Zanotti, Martina Trentini, Francesca Camponogara , Elisa Soliani , Paolo Gargiulo, Maurizio Isola, Barbara Zavan ; Active Materials for D Printing in Small Animals: Current Modalities and Future Directions for Orthopedic Applications Int J Mol Sci. 2022 Jan 18;23(3):1045
6.Venkateshwar Reddy Maryada , Praharsha Mulpur , Krishna Kiran Eachempati , Adarsh Annapareddy , Vemaganti Badri Narayana Prasad , A V Gurava Reddy ; Pre-operative planning and templating with 3-D printed models for complex primary and revision total hip arthroplasty J Orthop. 2022 Sep 13:34:240-245
7.Aleksandr Grinčuk , Aleksas Makulavičius , Narūnas Porvaneckas , Sigitas Ryliškis , Igoris Šatkauskas , Valentinas Uvarovas ; The role of 3-dimensional printed models in the management of the distal radius fractures Acta Orthop Traumatol Turc. 2023 Jan;57(1):40-45.
8.Davide Ranaldo , Filippo Zonta , Simone Florian , Jacopo Lazzaro; A facile, semi-automatic protocol for the design and production of 3D printed, anatomical customized orthopedic casts for forearm fractures J Clin Orthop Trauma. 2023 Jun 24:42
9.Yuxuan Zhang , Tao Lin , Haoye Meng , Xueting Wang , Hong Peng , Guangbo Liu , Shuai Wei , Qiang Lu , Yu Wang , Aiyuan Wang , Wenjing Xu , Huiping Shao , Jiang Peng 3D gel-printed porous magnesium scaffold coated with dibasic calcium phosphate dihydrate for bone repair in vivo J Orthop Translat. 2022 Feb 3:33:13-23
10.Abishek Kafle , Eric Luis, Raman Silwal , Houwen Matthew Pan, Pratisthit Lal Shrestha , Anil Kumar Bastola ;3D/4D Printing of Polymers: Fused Deposition Modelling (FDM), Selective Laser Sintering (SLS), and Stereolithography (SLA)
Polymers (Basel). 2021 Sep 15;13(18):3101
11.Binglong Li, Meng Zhang, Qunshan Lu, Baoqing Zhang, Zhuang Miao, Lei Li, Tong Zheng, and Peilai Liu; Application and Development of Modern 3D Printing Technology in the Field of Orthopedics Biomed Res Int. 2022;
12.Ricardo Rodriguez Colon , Vasudev Vivekanand Nayak, Paulo E L Parente, Philipp Leucht, Nick Tovar, Charles C Lin, Kevin Rezzadeh, Jacques H Hacquebord, Paulo G Coelho, Lukasz Witek ; The presence of 3D printing in orthopedics: A clinical and material review J Orthop Res. 2023 Mar;41(3):601-613
13.Lei Zhang, Guojing Yan, Blake N Johnson, Xiaofeng Jia; Three-dimensional (3D) printed scaffold and material selection for bone repair Acta Biomater. 2019 Jan 15:84:16-33.
14.Yu Wen , Sun Xun, Meng Haoye, Sun Baichuan, Chen Peng, Liu Xuejian, Zhang Kaihong, Yang Xuan, Peng Jiang, Lu Shibi; 3D printed porous ceramic scaffolds for bone tissue engineering: a review Biomater Sci 2017 Aug 22;5(9):1690-1698
15.Ai-Min Wu, Jia-Liang Lin, Kenny Yat Hong Kwan, Xiang-Yang Wang , Jie Zhao; 3D-printing techniques in spine surgery: the future prospects and current challenges Expert Rev Med Devices. 2018 Jun;15(6):399-401
16.Nanfang Xu , Feng Wei, Xiaoguang Liu, Liang Jiang, Hong Cai, Zihe Li, Miao Yu, Fengliang Wu, Zhongjun Liu ; Reconstruction of the Upper Cervical Spine Using a Personalized 3D-Printed Vertebral Body in an Adolescent With Ewing Sarcoma Spine (Phila Pa 1976). 2016 Jan;41(1):E50-4
17.Kevin Phan , Alessandro Sgro , Monish M Maharaj , Paul D'Urso , Ralph J Mobbs; Application of a 3D custom printed patient specific spinal implant for C1/2 arthrodesis J Spine Surg. 2016 Dec;2(4):314-318
18.Meng Meng, Jinzuo Wang, Huagui Huang, Xin Liu, Jing Zhang, Zhonghai Li;3D printing metal implants in orthopedic surgery: Methods, applications and future prospects J Orthop Translat. 2023 Sep 1:42:94-112.
19.Bhavuk Garg , Nishank Mehta ; Current status of 3D printing in spine surgery J Clin Orthop Trauma. 2018 Jul-Sep;9(3):218-225
20.Alpaslan Senkoylu, Ismail Daldal , Mehmet Cetinkaya ; 3D printing and spine surgery J Orthop Surg (Hong Kong). 2020 Jan-Apr;28
21.Pengfei Zheng, Qingqiang Yao, Peng Xu, Liming Wang; Application of computer-aided design and 3D-printed navigation template in Locking Compression Pediatric Hip PlateΤΜ placement for pediatric hip disease Int J Comput Assist Radiol Surg. 2017 May;12(5):865-871.
22.Sven Goetstouwers , Dagmar Kempink , Bertram The , Denise Eygendaal , Bart van Oirschot , Christiaan Ja van Bergen ; Three-dimensional printing in paediatric orthopaedic surgery World J Orthop. 2022 Jan 18;13(1):1-10
23.Mitsouras D, et al. Medical 3D printing for the radiologist. Radiographics. 2015;35(7):1965–1988.
24.Rengier F, et al. 3D printing based on imaging data: review of medical applications. Int J Comput Assist Radiol Surg. 2010;5(4):335–341.
25.Javaid M, Haleem A. Current status and applications of additive manufacturing in dentistry. J Oral Biol Craniofac Res. 2019;9(3):179–185.
26.Dawood A, et al. 3D printing in dentistry. Br Dent J. 2015;219(11):521–529.
27.Jamróz W, et al. 3D printing in pharmaceutical and medical applications. Pharm Res. 2018;35:176.
28.Norman J, et al. A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Adv Drug Deliv Rev. 2017;108:39–50.
29.Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014;32(8):773–785.
30.Groll J, et al. Biofabrication: reappraising the definition of an evolving field. Biofabrication. 2016;8(1):013001.
31.Martelli N, et al. Advantages and disadvantages of 3D printing in surgery. J Surg Res. 2016;201(2):328–336.
32.Lim KH, et al. Role of 3D printing in medical education. Med Educ Online. 2016;21:29874.
33.Ventola CL. Medical applications for 3D printing: current and projected uses. P&T. 2014;39(10):704–711.
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