The Role of Prehabilitation on Functional Outcomes After Radical Prostatectomy: A Scoping Review
DOI:
https://doi.org/10.12775/QS.2026.50.68112Keywords
Prehabilitation, Radical Prostatectomy, Urinary Incontinence, Sarcopenia, Prostate CancerAbstract
Background
Radical prostatectomy is a primary treatment for localized prostate cancer but often results in urinary incontinence and erectile dysfunction, significantly impacting patient quality of life. Prehabilitation, defined as the optimization of physical capacity before surgery—aims to increase physiological reserve to buffer the functional decline caused by surgical trauma.
Aim
The primary objective of this scoping review is to comprehensively evaluate the efficacy of various prehabilitation modalities on functional outcomes following radical prostatectomy. Specifically, this report assesses the impact of preoperative Pelvic Floor Muscle Training, High-Intensity Interval Training, resistance exercise, and multimodal lifestyle interventions on the recovery of urinary continence, erectile function, and cardiorespiratory fitness.
Material and Methods
A review of RCTs, prospective cohorts, and meta-analyses published through 2025 was conducted. The synthesis included diverse interventions and measured outcomes using validated tools like the EPIC and IIEF scales, as well as objective pad tests.
Results
Preoperative PFMT with biofeedback significantly speeds early urinary recovery. However, long-term results match standard postoperative care, indicating a "bolus effect" that accelerates initial progress without altering the final anatomical plateau. Systemic prehabilitation via HIIT and resistance training was found to significantly improve cardiorespiratory fitness and muscular strength, leading to a substantial reduction in post-operative complications, though the direct translation to urological function remains heterogeneous.
Conclusions
Prehabilitation is a safe and effective strategy to enhance early functional recovery. While it cannot fully overcome severe anatomical deficits, it provides a crucial buffer that speeds the return to continence. Evidence strongly supports integrating multimodal prehabilitation into standard urological care.
References
Bishop, C., Rodriguez-Cairoli, F., Hagens, A., Bermudez, M. A., Kerrebroeck, P. V., & Collen, S. (2025). Prevalence, Socioeconomic, and Environmental Costs of Urinary Incontinence in the European Union. European urology, 88(2), 157–166. https://doi.org/10.1016/j.eururo.2025.05.025
Kajmakovic, B. M., Petrovic, M., Bulat, P. R., Bumbasirevic, U., Milojevic, B., Nikic, P., Janicic, A., Durutovic, O., Cegar, B., Hadzibegovic, A., Ratkovic, S., & Dzamic, Z. M. (2024). Impact of Intraoperative Prognostic Factors on Urinary Continence Recovery Following Open and Laparoscopic Radical Prostatectomy. Medicina, 60(11), 1824. https://doi.org/10.3390/medicina60111824
Wolin, K. Y., Luly, J., Sutcliffe, S., Andriole, G. L., & Kibel, A. S. (2010). Risk of urinary incontinence following prostatectomy: the role of physical activity and obesity. The Journal of urology, 183(2), 629–633. https://doi.org/10.1016/j.juro.2009.09.082
Milios, J. E., Ackland, T. R., & Green, D. J. (2020). Pelvic Floor Muscle Training and Erectile Dysfunction in Radical Prostatectomy: A Randomized Controlled Trial Investigating a Non-Invasive Addition to Penile Rehabilitation. Sexual medicine, 8(3), 414–421. https://doi.org/10.1016/j.esxm.2020.03.005
Kannady, C., & Clavell-Hernández, J. (2020). Orgasm-associated urinary incontinence (climacturia) following radical prostatectomy: a review of pathophysiology and current treatment options. Asian journal of andrology, 22(6), 549–554. https://doi.org/10.4103/aja.aja_145_19
Clifford, K., Woodfield, J. C., Tait, W., Campbell, H. A., & Baldi, J. C. (2023). Association of Preoperative High-Intensity Interval Training With Cardiorespiratory Fitness and Postoperative Outcomes Among Adults Undergoing Major Surgery: A Systematic Review and Meta-Analysis. JAMA network open, 6(6), e2320527. https://doi.org/10.1001/jamanetworkopen.2023.20527
Aguila-Gimeno, O., Jareño-Vicens, A., & Recasens, C. T. (2025). Pelvic floor rehabilitation before radical prostatectomy: a systematic review. BMC urology, 25(1), 224. https://doi.org/10.1186/s12894-025-01932-2
Zhou, L., Chen, Y., Yuan, X., Zeng, L., Zhu, J., & Zheng, J. (2023). Preoperative pelvic floor muscle exercise for continence after radical prostatectomy: a systematic review and meta-analysis. Frontiers in public health, 11, 1186067. https://doi.org/10.3389/fpubh.2023.1186067
Pedersen, M. B., Saxton, J. M., Villumsen, B. R., Birch, S., Nielsen, A. H., & Jensen, J. B. (2025). Home based prehabilitation in prostate cancer patients undergoing nerve sparing robot assisted radical prostatectomy - The TelePrehabTrial. European journal of oncology nursing : the official journal of European Oncology Nursing Society, 77, 102903. https://doi.org/10.1016/j.ejon.2025.102903
Gerlegiz, E. N. A., Akbayrak, T., Gürşen, C., Yazici, M. S., Bolat, N. M., Akdoğan, B., Nakip, G., & Özgül, S. (2025). Lifestyle recommendations and pelvic floor muscle training with Knack maneuver for post-prostatectomy urinary incontinence: a randomized controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 33(2), 132. https://doi.org/10.1007/s00520-025-09197-z
Fonseca, J., Moraes-Fontes, M. F., Sousa, I., Oliveira, F., Froes, G., Gaivão, A., Palmas, A., Rebola, J., Muresan, C., Santos, T., Dias, D., Varandas, M., Lopez-Beltran, A., Ribeiro, R., & Fraga, A. (2024). Membranous urethral length is the single independent predictor of urinary continence recovery at 12 months following Retzius-sparing robot-assisted radical prostatectomy. Journal of robotic surgery, 18(1), 230. https://doi.org/10.1007/s11701-024-01986-8
Brea-Gómez, B., Pazo-Palacios, R., Pérez-Gisbert, L., Valenza, M. C., & Torres-Sánchez, I. (2025). Pelvic Floor Muscle Training with Preoperative Biofeedback in Patients with Postprostatectomy Incontinence: A Systematic Review and Meta-analysis of Randomised Clinical Trials. European urology focus, 11(5), 767–781. https://doi.org/10.1016/j.euf.2025.04.004
Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., Smith, K., Williams, J. P., Phillips, B. E., & Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial. Prostate cancer and prostatic diseases, 23(4), 696–704. https://doi.org/10.1038/s41391-020-0219-1
Woodfield, J. C., Clifford, K., Wilson, G. A., Munro, F., & Baldi, J. C. (2022). Short-term high-intensity interval training improves fitness before surgery: A randomized clinical trial. Scandinavian journal of medicine & science in sports, 32(5), 856–865. https://doi.org/10.1111/sms.14130
Singh, F., Newton, R. U., Taaffe, D. R., Lopez, P., Thavaseelan, J., Brown, M., Ooi, E., Nosaka, K., Hayne, D., & Galvão, D. A. (2023). Prehabilitative versus rehabilitative exercise in prostate cancer patients undergoing prostatectomy. Journal of cancer research and clinical oncology, 149(18), 16563–16573. https://doi.org/10.1007/s00432-023-05409-3
Jones, L. W., Hornsby, W. E., Freedland, S. J., Lane, A., West, M. J., Moul, J. W., Ferrandino, M. N., Allen, J. D., Kenjale, A. A., Thomas, S. M., Herndon, J. E., 2nd, Koontz, B. F., Chan, J. M., Khouri, M. G., Douglas, P. S., & Eves, N. D. (2014). Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer. European urology, 65(5), 852–855. https://doi.org/10.1016/j.eururo.2013.11.009
Hamilton-Reeves, J. M., Johnson, C. N., Hand, L. K., Bechtel, M. D., Robertson, H. L., Michel, C., Metcalf, M., Chalise, P., Mahan, N. J., Mirza, M., Lee, E. K., Sullivan, D. K., Klemp, J. R., Befort, C. A., Parker, W. P., Gibbs, H. D., Demark-Wahnefried, W., & Thrasher, J. B. (2021). Feasibility of a Weight Management Program Tailored for Overweight Men with Localized Prostate Cancer - A Pilot Study. Nutrition and cancer, 73(11-12), 2671–2686. https://doi.org/10.1080/01635581.2020.1856890
Ashton, R. E., Aning, J. J., Tew, G. A., Robson, W. A., & Saxton, J. M. (2021). Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(8), 4595–4605. https://doi.org/10.1007/s00520-021-06002-5
Mac Curtain, B. M., Sugrue, D. D., Qian, W., O'Callaghan, M., & Davis, N. F. (2024). Membranous urethral length and urinary incontinence following robot-assisted radical prostatectomy: a systematic review and meta-analysis. BJU international, 133(6), 646–655. https://doi.org/10.1111/bju.16170
Angerer, M., Salomon, G., Beyersdorff, D., Fisch, M., Graefen, M., & Rosenbaum, C. M. (2021). Impact of Sarcopenia on Functional and Oncological Outcomes After Radical Prostatectomy. Frontiers in surgery, 7, 620714. https://doi.org/10.3389/fsurg.2020.620714
Hill, B., Grubic, N., Williamson, M., Phelan, D. M., Baggish, A. L., Dorian, P., Drezner, J. A., & Johri, A. M. (2023). Does cardiovascular preparticipation screening cause psychological distress in athletes? A systematic review. British journal of sports medicine, 57(3), 172–178. https://doi.org/10.1136/bjsports-2022-105918
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Copyright (c) 2026 Andrii Bilyk, Natalia Bruska, Przemysław Kołodziej, Patryk Hebda, Roman Cemaga, Mikołaj Franciszek Patalong, Ewa Szplit, Mieszko Czapliński, Wiktoria Michnowska, Paweł Pustuła

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