The Use of Probiotics in Dentistry.
A Review of Current Evidence
DOI:
https://doi.org/10.12775/QS.2026.49.67786Keywords
probiotics, microbiota, oral health, gingivitis, periodontitis, halitosisAbstract
Probiotics, mostly known for their positive effects on gut health, are also increasingly showing beneficial effects in the context of oral health. This review paper discusses the role of probiotics in the prevention and treatment of oral diseases such as dental caries, periodontal disease and halitosis. It emphasizes that the microbial balance in the oral cavity – know as eubiosis – is crucial for the health of teeth and gums. Dysbiosis, the disruption of this balance, promotes the growth of pathogenic bacteria leading to disease. Probiotics work by directly competing with carious bacteria, producing antimicrobial substances and influencing the immune system. Studies have been presented showing the effectiveness of strains such as Lactobacillus rhamnosus, L. reuteri, Weissella cibaria and Streptococcus salivarius in reducing pathogenic bacteria and oral disease symptoms. Regular consumption of fermented diary products can help maintain a healthy oral microbiota. In conclusion, probiotics can provide important support in prevention and treatment of oral diseases, but their effectiveness depends on the type of strain, form of administration and regularity of use.
References
1. Parvez S, Malik KA, Ah Kang S, Kim HY. Probiotics and their fermented food products are beneficial for health. J Appl Microbiol. 2006;100(6):1171-85.
2. Wieërs G, Belkhir L, Enaud R, Leclercq S, Philippart de Foy JM, Dequenne I, de Timary P, Cani PD. How Probiotics Affect the Microbiota. Front Cell Infect Microbiol. 2020 Jan 15; 9:454. doi: 10.3389/fcimb.2019.00454. PMID: 32010640; PMCID: PMC6974441.
3. Lilly, D. M., and Stillwell, R. H. (1965). Probiotics: growth-promoting factors produced by microorganisms. Science 147, 747–748. doi: 10.1126/science.147.3659.747.
4. Guarner, F., I Schaafsma, G. J. (1998). Probiotyki. Int. J. Food Microbiol. 39, 237-238. doi: 10.1016/S0168-1605(97)00136-0
5. Goldenberg, J. Z., Yap, C., Lytvyn, L., Lo, C. K., Beardsley, J., Mertz, D., et al. (2017). Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst. Rev. 12:CD006095. doi: 10.1002/14651858.CD006095.pub4
6. Bonifait L, Chandad F, Grenier D. Probiotics for oral health: myth or reality? J Can Dent Assoc. 2009 Oct;75(8):585-90. PMID: 19840501.
7. Relman, D. A., and Falkow, S. (2001). The meaning and impact of the human genome sequence for microbiology. Trends Microbiol. 9 (5), 206–208. doi: 10.1016/ S0966-842X (01)02041-8
8. Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., and Dewhirst, F. E. (2005). Defining the normal bacterial flora of the oral cavity. J. Clin. Microbiol. 43 (11), 5721–5732. doi: 10.1128/JCM.43.11.5721-5732.2005
9. Bik, E. M., Long, C. D., Armitage, G. C., Loomer, P., Emerson, J., Mongodin, E. F., et al. (2010). Bacterial diversity in the oral cavity of 10 healthy individuals. ISME. J. 4 (8), 962–974. doi: 10.1038/ismej.2010.30
10. Liu, B., Faller, L. L., Klitgord, N., Mazumdar, V., Ghodsi, M., Sommer, D. D., et al. (2012). Deep sequencing of the oral microbiome reveals signatures of periodontal disease. PloS One 7 (6), e37919. doi: 10.1371/journal.pone.0037919
11. Collaborators, G. O. D., Bernabe, E., Marcenes, W., Hernandez, C., Bailey, J., Abreu, L., et al. (2020). Global, regional, and national levels and trends in burden of oral conditions from 1990 to 2017: A systematic analysis for the global burden of disease 2017 study. J. Dental Res. 99 (4), 362–373. doi: 10.1177/0022034520908533
12. Homayouni Rad A, Pourjafar H, Mirzakhani E. A comprehensive review of the application of probiotics and postbiotics in oral health. Front Cell Infect Microbiol. 2023 Mar 8; 13:1120995. doi: 10.3389/fcimb.2023.1120995. PMID: 36968114; PMCID: PMC10031100.
13. Abd, S. T., and Ali, A. F. (2016). The effect of zinc oxide nanoparticles on streptococcus mutans of human saliva (In vitro study). J. Baghdad. Coll. Dentistry. 28 (2), 158–164.
14. Flichy Fernández, A., Alegre Domingo, T., Peñarrocha Oltra, D., and Peñarrocha Diago, M. (2010). Probiotic treatment in the oral cavity: An update. Med Oral Patol Oral Cir Bucal. 15 (5), 677–80.
15. Walker, R., and Buckley, M. (2006). Probiotic microbes: the scientific basis.
16. Dierksen, K. P., Moore, C. J., Inglis, M., Wescombe, P. A., and Tagg, J. R. (2007). The effect of ingestion of milk supplemented with salivaricin a-producing streptococcus salivarius on the bacteriocin-like inhibitory activity of streptococcal populations on the tongue. FEMS Microbiol. Ecol. 59 (3), 584–591. doi: 10.1111/j.1574-6941.2006. 00228.x
17. Gruner, D., Paris, S., and Schwendicke, F. (2016). Probiotics for managing caries and periodontitis: Systematic review and meta-analysis. J. Dentistry. 48, 16–25. doi: 10.1016/j.jdent.2016.03.002
18. Miles, L. (2007). Are probiotics beneficial for health? Nutr. Bull. 32 (1), 2–5. doi: 10.1111/j.1467-3010.2007. 00611.x
19. Meurman, J. H. (2005). Probiotics: do they have a role in oral medicine and dentistry? Eur. J. Oral. Sci. 113 (3), 188–196. doi: 10.1111/j.1600-0722.2005. 00191.x
20. Gomar-Vercher, S., Cabrera-Rubio, R., Mira, A., and Almerich-Silla, J. (2014). Relationship of children’s salivary microbiota with their caries status: a pyrosequencing study. Clin. Oral. Invest. 18 (9), 2087–2094. doi: 10.1007/s00784-014-1200-y
21. Tanner, A., Kressirer, C., Rothmiller, S., Johansson, I., and Chalmers, N. (2018). The caries microbiome: implications for reversing dysbiosis. Adv. Dental Res. 29 (1), 78–85. doi: 10.1177/0022034517736496
22. Chhour, K.-L., Nadkarni, M. A., Byun, R., Martin, F. E., Jacques, N. A., and Hunter, N. (2005). Molecular analysis of microbial diversity in advanced caries. J. Clin. Microbiol. 43 (2), 843–849. doi: 10.1128/JCM.43.2.843-849.2005
23. Khushbu, Y., and Satyam, P. (2016). Dental caries: A review. Asian J. Biomed. Pharm. Sci. 6 (53), 1–7.
24. Gedalia I, Ionat-Bendat D, Ben-Mosheh S, Shapira L. Tooth enamel softening with a cola type drink and rehardening with hard cheese or stimulated saliva in situ. J Oral Rehabil. 1991;18(6):501-6.
25. Jensen ME, Wefel JS. Effects of processed cheese on human plaque pH and demineralization and remineralization. Am J Dent. 1990;3(5):217-23.
26. Haukioja A, Yli-Knuuttila H, Loimaranta V, Kari K, Ouwehand AC, Meurman JH, et al. Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro. Oral Microbiol Immunol. 2006;21(5):326-32.
27. Meurman JH, Antila H, Salminen S. Recovery of Lactobacillus strain GG (ATCC 53103) from saliva of healthy volunteers after consumption of yoghurt prepared with the bacterium. Microbiol Ecol Health Dis. 1994;7(6):295-8.
28. Yli-Knuuttila H, Snäll J, Kari K, Meurman JH. Colonization of Lactobacillus rhamnosus GG in the oral cavity. Oral Microbiol Immunol. 2006;21(2):129-31.
29. Comelli EM, Guggenheim B, Stingele F, Neeser JR. Selection of dairy bacterial strains as probiotics for oral health. Eur J Oral Sci. 2002;110(3):218-24.
30. Kang MS, Chung J, Kim SM, Yang KH, Oh JS. Effect of Weissella cibaria isolates on the formation of Streptococcus mutans biofilm. Caries Res. 2006;40(5):418-25.
31. Meurman JH, Antila H, Korhonen A, Salminen S. Effect of Lactobacillus rhamnosus strain GG (ATCC 53103) on the growth of Streptococcus sobrinus in vitro. Eur J Oral Sci. 1995;103(4):253-8.
32. Petti S, Tarsitani G, Simonetti D’Arca A. Antibacterial activity of yoghurt against viridans streptococci in vitro. Arch Oral Biol. 2008;53(10):985-90. Epub 2008 Jun 9.
33. Nikawa H, Makihira S, Fukushima H, Nishimura H, Ozaki K, Darmawan S, et al. Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci. Int J Food Microbiol. 2004;95(2):219-23.
34. Näse L, Hatakka K, Savilahti E, Saxelin M, Pönkä A, Poussa T, et al. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res. 2001;35(6):412-20.
35. Houle MA, Grenier D. Maladies parodontales: connaissances actuelles. Current concepts in periodontal diseases. Médecine et maladies infectieuses. 2003;33(7):331-40
36. Koll-Klais P, Mändar R, Leibur E, Marcotte H, Hammarström L. Mikelsaar M. Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity. Oral Microbiol Immunol. 2005;20(6):354-61.
37. Sookkhee S, Chulasiri M, Prachyabrued W. Lactic acid bacteria from healthy oral cavity of Thai volunteers: inhibition of oral pathogens. J Appl Microbiol. 2001;90(2):172-9.
38. Krasse P, Carlsson B, Dahl C, Paulsson A, Nilsson A, Sinkiewicz G. Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri. Swed Dent J. 2006;30(2):55-60.
39. Riccia DN, Bizzini F, Perilli MG, Polimeni A, Trinchieri V, Amicosante G, et al. Anti-inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease. Oral Dis. 2007;13(4):376-85.
40. Kang MS, Kim BG, Chung J, Lee HC, Oh JS. Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds. J Clin Periodontol. 2006;33(3):226-32.
41. Kazor CE, Michell PM, Lee AM, Stokes LN, Loesche WJ, Dewhirst FE, et al. Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. J Clin Microbiol. 2003;41(2):558-63.
42. Burton JP, Chilcott CN, Moore CJ, Speiser G, Tagg JR. A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. J Appl Microbiol. 2006;100(4):754-64.
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Copyright (c) 2026 Klaudia Burzykowska, Kamila Gęborys, Katarzyna Trela, Laura Więcko, Aleksander Tuteja, Liwia Olczyk, Rema Mohaissen, Mikolaj Tyla, Patryk Stabrawa, Konrad Krupa
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