Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Quality in Sport

The Impact of Physical Activity on the Clinical Course of Crohn's Disease: Review
  • Home
  • /
  • The Impact of Physical Activity on the Clinical Course of Crohn's Disease: Review
  1. Home /
  2. Archives /
  3. Vol. 46 (2025) /
  4. Medical Sciences

The Impact of Physical Activity on the Clinical Course of Crohn's Disease

Review

Authors

  • Katarzyna Michalak Szpital Morski im. PCK in Gdynia, Powstania Styczniowego 1, 81-519 Gdynia, Poland https://orcid.org/0009-0005-0856-1536
  • Krystian Zukierski Szpital Morski im. PCK in Gdynia, Powstania Styczniowego 1, 81-519 Gdynia, Poland https://orcid.org/0009-0008-1428-5744
  • Michał Mazur Saint Adalbert Hospital in Gdańsk, aleja Jana Pawła II 50, 80-462 Gdańsk, Poland https://orcid.org/0009-0007-8157-5293
  • Katarzyna Żak Saint Adalbert Hospital in Gdańsk, aleja Jana Pawła II 50, 80-462 Gdańsk, Poland https://orcid.org/0009-0006-4036-090X
  • Hubert Jucha Fundacja Zdrowie, Wilhelma Konrada Roentgena 23, 02-781 Warszawa, Poland https://orcid.org/0009-0002-0182-627X
  • Katarzyna Madyniak Medical University of Warsaw, Żwirki I Wigury 61, 02-091 Warszawa, Poland https://orcid.org/0009-0003-6927-3832
  • Aleksandra Pliszka Saint Adalbert Hospital in Gdańsk, aleja Jana Pawła II 50, 80-462 Gdańsk, Poland https://orcid.org/0009-0003-5938-5929
  • Agnieszka Kluz Wolski Hospital, Kasprzaka 17, 01-211 Warszawa, Poland https://orcid.org/0009-0006-7427-5818

DOI:

https://doi.org/10.12775/QS.2025.46.66710

Keywords

Crohn's disease, physical activity, exercise, osteopenia

Abstract

Introduction and Aim: Crohn's Disease (CD) is a chronic inflammatory bowel disease (IBD) characterized by periods of remission and relapse. The influence of lifestyle, particularly physical activity, on the course of IBD is increasingly recognized. This study aims to examine the impact of physical activity on the clinical course of Crohn's disease and the development of associated complications.

 

Methods and Materials: This research will involve a systematic review of the literature published between 2010 and 2025. Relevant studies will be identified by searching electronic databases including PubMed and Google Scholar databases. The search strategy will utilize a combination of keywords related to Crohn's disease, physical activity, exercise, and osteopenia. Studies published in English and Polish that examine the effect of exercise interventions on adult CD patients will be included. Studies evaluating the impact of exercise on disease activity, quality of life, bone mineral density, and other relevant outcomes will be considered. The methodological quality of the included studies will be assessed using appropriate tools. Data extraction and synthesis will be performed following established guidelines for systematic reviews.

 

Results and Conclusion: A comprehensive studies review suggests that physical activity can be a valuable tool in managing Crohn's Disease and preventing complications such as osteopenia. Exercise appears to offer benefits for bone health, mental well-being and overall quality of life of patients with CD. It’s important to note that further research is needed to determine the optimal type, intensity, and duration of exercise for individuals with CD, as well as to identify strategies to promote adherence to exercise programs.

References

1. Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. The Lancet. 2017;390(10114):2769-2778. doi:https://doi.org/10.1016/s0140-6736(17)32448-0

2. Ranjbar R. The Incidence and Prevalence of Crohn’s Disease in Global Scale. SOJ Immunology. 2015;3(2). doi:https://doi.org/10.15226/soji/3/2/00125

3. Economou M, Pappas G. New global map of Crohnʼs disease: Genetic, environmental, and socioeconomic correlations. Inflammatory Bowel Diseases. 2008;14(5):709-720. doi:https://doi.org/10.1002/ibd.20352

4. Peña-Sánchez JN, Osei JA, Marques Santos JD, et al. Increasing Prevalence and Stable Incidence Rates of Inflammatory Bowel Disease Among First Nations: Population-Based Evidence From a Western Canadian Province. Inflammatory Bowel Diseases. 2021;28(4):514-522. doi:https://doi.org/10.1093/ibd/izab096

5. Ranasinghe IR, Hsu R. Crohn Disease. PubMed. Published 2022. https://www.ncbi.nlm.nih.gov/books/NBK436021/#

6. Dolinger M, Torres J, Vermeire S. Crohn’s disease. Lancet (London, England). 2024;403(10432):S0140-6736(23)025862. doi:https://doi.org/10.1016/S0140-6736(23)02586-2

7. Balestrieri P, Ribolsi M, Guarino MPL, Emerenziani S, Altomare A, Cicala M. Nutritional Aspects in Inflammatory Bowel Diseases. Nutrients. 2020;12(2):372. doi:https://doi.org/10.3390/nu12020372

8. Valvano M, Capannolo A, Cesaro N, et al. Nutrition, Nutritional Status, Micronutrients Deficiency, and Disease Course of Inflammatory Bowel Disease. Nutrients. 2023;15(17):3824-3824. doi:https://doi.org/10.3390/nu15173824

9. Otake H, Matsumoto S, Mashima H. Long-term clinical and real-world experience with Crohn’s disease treated with anti-tumor necrosis factor-α antibodies. Intestinal Research. Published online March 31, 2022. doi:https://doi.org/10.5217/ir.2021.00139

10. Chan D, Robbins H, Rogers S, Clark S, Poullis A. Inflammatory bowel disease and exercise: results of a Crohn’s and Colitis UK survey. Frontline Gastroenterology. 2014;5(1):44-48. doi:https://doi.org/10.1136/flgastro-2013-100339

11. Roda G, Chien Ng S, Kotze PG, et al. Crohn’s disease. Nature Reviews Disease Primers. 2020;6(1):1-19. doi:https://doi.org/10.1038/s41572-020-0156-2

12. Chen JM, He LW, Yan T, et al. Oral exclusive enteral nutrition induces mucosal and transmural healing in patients with Crohn’s disease. Gastroenterology Report. 2019;7(3):176-184. doi:https://doi.org/10.1093/gastro/goy050

13. Jones K, Naisby J, Baker K, Tew GA. Exercise perceptions and experiences in adults with Crohn’s disease following a combined impact and resistance training programme: A qualitative study. Crohn’s & Colitis 360. Published online March 24, 2023. doi:https://doi.org/10.1093/crocol/otad019

14. Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn’s Disease. The Lancet. 2017;389(10080):1741-1755. doi:https://doi.org/10.1016/s0140-6736(16)31711-1

15. Koutouratsas T, Philippou A, Kolios G, Koutsilieris M, Gazouli M. Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review. World Journal of Gastroenterology. 2021;27(30):5037-5046. doi:https://doi.org/10.3748/wjg.v27.i30.5037

16. Engels M, Cross RK, Long MD. Exercise in patients with inflammatory bowel diseases: current perspectives. Clinical and Experimental Gastroenterology. 2017;11:1-11. doi:https://doi.org/10.2147/CEG.S120816

17. Justyna Wasielica-Berger. Osteoporoza w nieswoistych chorobach zapalnych jelit. Gastroenterologia Kliniczna Postępy i Standardy. 2015;7(3):96-101. Accessed May 1, 2025. https://journals.viamedica.pl/gastroenterologia_kliniczna/article/view/44600/35511

18. Wu F, Huang Y, Hu J, Shao Z. Mendelian randomization study of inflammatory bowel disease and bone mineral density. BMC medicine. 2020;18(1):312. doi:https://doi.org/10.1186/s12916-020-01778-5

19. Bernstein CN. The Incidence of Fracture among Patients with Inflammatory Bowel Disease: A Population-Based Cohort Study. Annals of Internal Medicine. 2000;133(10):795. doi:https://doi.org/10.7326/0003-4819-133-10-200011210-00012

20. Dai Z, Xu W, Ding R, et al. Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis. Frontiers in Public Health. 2023;11. doi:https://doi.org/10.3389/fpubh.2023.1151837

21. Pierote NR, Braz AF, Barros SL, et al. Effect of mineral status and glucocorticoid use on bone mineral density in patients with Crohn’s disease. Nutrition (Burbank, Los Angeles County, Calif). 2018;48:13-17. doi:https://doi.org/10.1016/j.nut.2017.10.016

22. Ward LM, Ma J, Rauch F, et al. Musculoskeletal health in newly diagnosed children with Crohn’s disease. Osteoporosis International. 2017;28(11):3169-3177. doi:https://doi.org/10.1007/s00198-017-4159-0

23. Steell L, Johnston BA, Dewantoro D, et al. Muscle deficits with normal bone microarchitecture and geometry in young adults with well-controlled childhood-onset Crohn’s disease. European journal of gastroenterology & hepatology. 2020;32(12):1497-1506. doi:https://doi.org/10.1097/MEG.0000000000001838

24. Baban YN, Edicheria CM, Joseph J, Kaur P, Mostafa JA. Osteoporosis Complications in Crohn’s Disease Patients: Factors, Pathogenesis, and Treatment Outlines. Cureus. Published online December 21, 2021. doi:https://doi.org/10.7759/cureus.20564

25. Philavong P, Żołądek M, Nowaczyk M, Linke K, Łykowska-Szuber L, Iwona Krela-Kaźmierczak. Osteoporoza posteroidowa w chorobie Leśniowskiego-Crohna — studium przypadku. Gastroenterologia Kliniczna Postępy i Standardy. 2016;8(1):36-41.

26. Harbord M, Annese V, Vavricka SR, et al. The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease. Journal of Crohn’s and Colitis. 2015;10(3):239-254. doi: https://doi.org/10.1093/ecco-jcc/jjv213

27. Bonio K, Chęć M, Borkowska I, eds. Witamina D i jej wpływ na organizm człowieka Vitamin D and it’s effect on the human body. Młodzi Naukowcy. https://www.mlodzinaukowcy.com/dl/dbe528ef5d4c710788892cbc1507a934/#page=34

28. Hoffmann P, Krisam J, Kasperk C, Gauss A. Prevalence, Risk Factors and Course of Osteoporosis in Patients with Crohn’s Disease at a Tertiary Referral Center. Journal of Clinical Medicine. 2019;8(12):2178. doi:https://doi.org/10.3390/jcm8122178

29. Dhaliwal A, Quinlan JI, Overthrow K, et al. Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview. Nutrients. 2021;13(2):656. doi:https://doi.org/10.3390/nu13020656

30. Papadimitriou K. Effect of resistance exercise training on Crohn’s disease patients. Intestinal Research. 2020;19(3). doi:https://doi.org/10.5217/ir.2020.00043

31. Scheffers LE, Vos IK, E.M.W.J. Utens, et al. Physical Training and Healthy Diet Improved Bowel Symptoms, Quality of Life, and Fatigue in Children With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition. 2023;77(2):214-221. doi:https://doi.org/10.1097/mpg.0000000000003816

32. Ilan K, Motro Y, Nemirovsky A, et al. Cognitive behavioral and mindfulness with daily exercise intervention is associated with changes in intestinal microbial taxa and systemic inflammation in patients with Crohn’s disease. Gut microbes. 2024;16(1). doi: https://doi.org/10.1080/19490976.2024.2337269

33. Narula N, Fedorak RN. Exercise and Inflammatory Bowel Disease. Canadian Journal of Gastroenterology. 2008;22(5):497-504. doi: https://doi.org/10.1155/2008/785953

34. Sciberras M, Karmiris K, Nascimento C, et al. Mental Health, Work Presenteeism, and Exercise in Inflammatory Bowel Disease. Journal of Crohn’s & colitis. 2022;16(8):1197-1201. doi:https://doi.org/10.1093/ecco-jcc/jjac037

35. Neasa Mc Gettigan, Allen K, Sedaghat R, Toole AL, Boland K. A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease. International Journal of Colorectal Disease. 2023;38(1). doi:https://doi.org/10.1007/s00384-023-04437-2

36. Lee D, Lewis JD, Shults J, et al. The Association of Diet and Exercise With Body Composition in Pediatric Crohn’s Disease. Inflammatory Bowel Diseases. 2018;24(6):1368-1375. doi:https://doi.org/10.1093/ibd/izy024

37. Neal WN, Jones CD, Pekmezi D, Motl RW. Physical Activity in Adults With Crohn’s Disease: A Scoping Review. Crohn’s & Colitis 360. 2022;4(2). doi:https://doi.org/10.1093/crocol/otac022

38. Janssen I, LeBlanc AG. Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. International Journal of Behavioral Nutrition and Physical Activity. 2010;7(1):40. doi:https://doi.org/10.1186/1479-5868-7-40

Quality in Sport

Downloads

  • PDF

Published

2025-11-26

How to Cite

1.
MICHALAK, Katarzyna, ZUKIERSKI, Krystian, MAZUR, Michał, ŻAK, Katarzyna, JUCHA, Hubert, MADYNIAK, Katarzyna, PLISZKA, Aleksandra and KLUZ, Agnieszka. The Impact of Physical Activity on the Clinical Course of Crohn’s Disease: Review. Quality in Sport. Online. 26 November 2025. Vol. 46, p. 66710. [Accessed 11 December 2025]. DOI 10.12775/QS.2025.46.66710.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 46 (2025)

Section

Medical Sciences

License

Copyright (c) 2025 Katarzyna Michalak, Krystian Zukierski, Michał Mazur, Katarzyna Żak, Hubert Jucha, Katarzyna Madyniak, Aleksandra Pliszka, Agnieszka Kluz

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Stats

Number of views and downloads: 50
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

Crohn's disease, physical activity, exercise, osteopenia
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop