Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Quality in Sport

Functional Supplements for Managing Exercise-Induced Gastrointestinal Distress: A Focused Review for Athletes
  • Home
  • /
  • Functional Supplements for Managing Exercise-Induced Gastrointestinal Distress: A Focused Review for Athletes
  1. Home /
  2. Archives /
  3. Vol. 45 (2025) /
  4. Medical Sciences

Functional Supplements for Managing Exercise-Induced Gastrointestinal Distress: A Focused Review for Athletes

Authors

  • Jakub Bazarewicz Autonomous Public Health Maintenance Organisation Jędrzej Śniadecki Voivodship Polyclinical Hospital in Białystok M. C. Skłodowskiej 26, 15-950 Białystok, Poland https://orcid.org/0009-0006-6137-4366
  • Grzegorz Adaśko Autonomous Public Health Maintenance Organisation Jędrzej Śniadecki Voivodship Polyclinical Hospital in Białystok https://orcid.org/0009-0004-6426-8636
  • Michał Świda Uniwersytecki Szpital Kliniczny w Białymstoku https://orcid.org/0009-0003-6101-7324
  • Cezary Kubuj Międzyleski Szpital Specjalistyczny w Warszawie https://orcid.org/0009-0006-1578-8541
  • Urszula Mazur Pomeranian Hospitals LLC: Polish Red Cross Maritime Hospital https://orcid.org/0009-0006-1645-3479
  • Paulina Ogonowska St. Vincent’s de Paul Hospital https://orcid.org/0009-0001-3766-9985
  • Daniel Dmowski Autonomous Public Health Maintenance Organisation Jędrzej Śniadecki Voivodship Polyclinical Hospital in Białystok https://orcid.org/0009-0004-2399-1342
  • Anna Michalska Autonomous Public Health Maintenance Organisation J. Śniadecki Voivodship Polyclinical Hospital in Białystok M. Curie-Skłodowskiej 26, 15-950 Białystok https://orcid.org/0009-0008-1806-7699
  • Julia Waszak Pomeranian Hospitals LLC:Polish Red Cross Maritime Hospital https://orcid.org/0009-0001-8725-7049
  • Marcin Siwik 10. Military Clinical Hospital with Polyclinic in Bydgoszcz https://orcid.org/0000-0002-3815-0819

DOI:

https://doi.org/10.12775/QS.2025.45.66517

Keywords

Exercise-Induced Gastrointestinal Distress, Supplements, Ginger, Athletes, Probiotics

Abstract

Introduction: Exercise-induced gastrointestinal (GI) distress is common among endurance and high-intensity athletes. Symptoms such as nausea, cramps, and diarrhea can impair performance and recovery. Functional supplements with anti-inflammatory and gut-supportive properties are being explored as complementary strategies.

Objective: This review evaluates six functional supplements—probiotics, ginger, curcumin, berberine, black currant, and bovine colostrum—for their potential to reduce exercise-induced GI symptoms.

Methods: Recent studies (2017–2025) were identified via PubMed and Scopus, prioritizing human trials in athletic or exercise settings. Clinical models such as IBS and heat stress were also considered where athlete-specific data were lacking.

Results: Probiotics and bovine colostrum show the most consistent benefits for gut integrity and immune modulation. Ginger and curcumin offer anti-inflammatory and antioxidant support, while black currant and berberine show promise despite limited direct sports data. Effects vary by dose, strain, and supplementation duration.

Conclusions: Functional supplements may aid in managing GI distress in athletes. However, standardized protocols and athlete-specific trials are needed. Personalized approaches based on symptom profiles and training cycles may optimize efficacy.

References

1. Karhu, E., Forsgård, R.A., Alanko, L. et al. Exercise and gastrointestinal symptoms: running-induced changes in intestinal permeability and markers of gastrointestinal function in asymptomatic and symptomatic runners. Eur J Appl Physiol. 2017;117(12):2519–2526. https://doi.org/10.1007/s00421-017-3739-1

2. McKenna ZJ, Fennel ZJ, Berkemeier QN, et al. Exercise in hypobaric hypoxia increases markers of intestinal injury and symptoms of gastrointestinal distress. Exp Physiol. 2022;107(3):326–36. https://doi.org/10.1113/EP090266

3. Henningsen K, Mika A, Alcock R, et al. The increase in core body temperature in response to exertional-heat stress can predict exercise-induced gastrointestinal syndrome. Temperature (Austin). 2023;11(1):72–91. https://doi.org/10.1080/23328940.2023.2213625

4. Young P, Russo I, Gill P, Muir J, Henry R, Davidson Z, Costa RJS. Reliability of pathophysiological markers reflective of exercise-induced gastrointestinal syndrome (EIGS) in response to 2-h high-intensity interval exercise: A comprehensive methodological efficacy exploration. Front Physiol. 2023;14:1126392. https://doi.org/10.3389/fphys.2023.1063335

5. Ribichini, E., Scalese, G., Cesarini, A., Mocci, C., Pallotta, N., Severi, C., & Corazziari, E. S. Exercise-Induced Gastrointestinal Symptoms in Endurance Sports: A Review of Pathophysiology, Symptoms, and Nutritional Management. Dietetics. 2023;2(3):289-307. https://doi.org/10.3390/dietetics2030021

6. Henningsen K, Andersen AM, Nybo L. Exertional heat stress as a key driver of gastrointestinal syndrome in elite endurance athletes. Temperature (Austin). 2023;11(1):1–9. https://doi.org/10.1080/23328940.2023.2213625

7. Shalmon G, Suez J, Shai I. Differential Gut Microbiome Profiles in Long-Distance Endurance Cyclists and Runners. Life (Basel). 2024;14(2):302. https://doi.org/10.3390/life14121703

8. Urwin, C.S., Main, L.C., Mikocka-Walus, A. et al. The Relationship Between Psychological Stress and Anxiety with Gastrointestinal Symptoms Before and During a 56 km Ultramarathon Running Race. Sports Med Open. 2021;7(1):40. https://doi.org/10.1186/s40798-021-00389-5

9. Hoogervorst D, van der Burg N, Versteegen JJ, et al. Gastrointestinal Complaints and Correlations with Self-Reported Macronutrient Intake in Independent Groups of (Ultra)Marathon Runners Competing at Different Distances. Sports (Basel). 2019;7(6):140. Published 2019 Jun 7. https://doi.org/10.3390/sports7060140

10. Crichton M, Marshall S, Isenring E, et al. Effect of a Standardized Ginger Root Powder Regimen on Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial. J Acad Nutr Diet. 2023;123(4):652–662.e3. https://doi.org/10.1016/j.jand.2023.09.003

11. Sforza M, Sidhu M, Okhiria R, et al. Using Ginger Oil to Treat Nausea and Vomiting Following Breast Augmentation Surgery. Plast Aesthet Nurs. 2023;43(4):225-230. https://doi.org/10.1097/PSN.0000000000000534

12. Karizak SZ, Shahnehzad M, Zar A. Impact of ginger supplementation on serum PGE2, COX2, and IL-6 in response to exhaustive exercise in female taekwondo athletes. Comp Exerc Physiol. 2024. https://doi.org/10.1163/17552559-20230041

13. Wang X, Zhang G, Bian Z, et al. An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice. Nat Commun. 2025;16. https://doi.org/10.1038/s41467-025-56624-0

14. Santos J, Deshmukh H, Elmassry MM, et al. Beneficial Effects of Ginger Root Extract on Pain Behaviors, Inflammation, and Mitochondrial Function in the Colon and Different Brain Regions of Male and Female Neuropathic Rats: A Gut–Brain Axis Study. Nutrients. 2024;16. https://doi.org/10.3390/nu16203563

15. Khaerani M, Chaeratunnisa R, Salsabila A, et al. Curcumin-mediated alleviation of dextran-induced leaky gut in Drosophila melanogaster. Narra J. 2024;4. http://doi.org/10.52225/narra.v4i1.743

16. Vasile PRD, Martinez-López P, Massip-Salcedo M, Esquius L. Evaluation of curcumin intake in reducing exercise-induced muscle damage in athletes: a systematic review. J Int Soc Sports Nutr. 2024;21. https://doi.org/10.1080/15502783.2024.2434217

17. Han X, Luo R, Qi S, et al. “Dual sensitive supramolecular curcumin nanoparticles” in “advanced yeast particles” mediate macrophage reprogramming, ROS scavenging and inflammation resolution for ulcerative colitis treatment. J Nanobiotechnol. 2023;21. https://doi.org/10.1186/s12951-023-01976-2

18. Clayton DJ, Burbeary R, Parker C, et al. Combined Turmeric, Vitamin C, and Vitamin D Ready-to-Drink Supplements Reduce Upper Respiratory Illness Symptoms and Gastrointestinal Discomfort in Elite Male Football Players. Nutrients. 2024;16. https://doi.org/10.3390/nu16020243

19. He Y, Yuan X, Zuo H, Sun Y, Feng A. Berberine exerts a protective effect on gut-vascular barrier via the modulation of the Wnt/β-catenin signaling pathway during sepsis. Cell Physiol Biochem. 2018;49:1342–1351. https://doi.org/10.1159/000493412

20. Feng A, Su S, Li C, et al. Berberine decreases S100B generation to regulate gut vascular barrier permeability in mice with burn injury. Pharm Biol. 2023;62:53–61. https://doi.org/10.1080/13880209.2023.2291679

21. Wang Y, Zhang Z, Du M, et al. Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model. Front Immunol. 2024;15. https://doi.org/10.3389/fimmu.2024.1460127

22. Dehau T, Cherlet M, Croubels S, Van Immerseel F, Goossens E. A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens. mSystems. 2023;8. https://doi.org/10.1128/msystems.01239-22

23. Łagowska K, Bajerska J, Kamiński S, Del Bo’ C. Effects of Probiotics Supplementation on Gastrointestinal Symptoms in Athletes: A Systematic Review of Randomized Controlled Trials. Nutrients. 2022;14. https://doi.org/10.3390/nu14132645

24. Di Dio M, Calella P, Cerullo G, et al. ffects of Probiotics Supplementation on Risk and Severity of Infections in Athletes: A Systematic Review. Int J Environ Res Public Health. 2022;19. https://doi.org/10.3390/ijerph191811534

25. Schmitz L, Ferrari N, Schwiertz A, et al. Impact of endurance exercise and probiotic supplementation on the intestinal microbiota: a cross-over pilot study. Pilot Feasibility Stud. 2019;5. https://doi.org/10.1186/s40814-019-0459-9

26. McDermott, C.E., Vincent, H.K., Mathews, A.E. et al.Impact of probiotic supplementation on exercise endurance among non-elite athletes: study protocol for a randomized, placebo-controlled, double-blind, clinical trial. Trials. 2022;23. https://doi.org/10.1186/s13063-022-06552-x

27. Pugh J. Gastrointestinal function, damage and symptoms during exercise and the potential therapeutic role of probiotic supplementation. [dissertation]. Liverpool: John Moores University; 2019.

28. Zhang Y, Diao R, Zhang L. Effects of Probiotics Supplementation on the Performance and Metabolic Health of Overtraining Athletes. J Food Nutr Res. 2022. https://doi.org/10.12691/jfnr-10-8-4

29. Hurst R, Lyall K, Roberts JM, et al. Consumption of an Anthocyanin-Rich Extract Made From New Zealand Blackcurrants Prior to Exercise May Assist Recovery From Oxidative Stress and Maintains Circulating Neutrophil Function: A Pilot Study. Front Nutr. 2019;6. https://doi.org/10.3389/fnut.2019.00073

30. Hurst R, Lyall K, Wells RW, et al. Daily Consumption of an Anthocyanin-Rich Extract Made From New Zealand Blackcurrants for 5 Weeks Supports Exercise Recovery Through the Management of Oxidative Stress and Inflammation: A Randomized Placebo Controlled Pilot Study. Front Nutr. 2020;7. https://doi.org/10.3389/fnut.2020.00016

31. Tu P, Chi L, Bian X, et al. A Black Raspberry-Rich Diet Protects From Dextran Sulfate Sodium-Induced Intestinal Inflammation and Host Metabolic Perturbation in Association With Increased Aryl Hydrocarbon Receptor Ligands in the Gut Microbiota of Mice. Front Nutr. 2022;9. https://doi.org/10.3389/fnut.2022.842298

32. Ruszkowska J, Drygas W, Kwaśniewska M. he Influence of Berry-Derived Polyphenol Supplementation on Exercise-Induced Oxidative Stress and Cardiovascular Health in Physically Active Individuals. Antioxidants. 2024;13. https://doi.org/10.3390/antiox13121561

33. Hałasa M, Maciejewska D, Baśkiewicz-Hałasa M, et al. ral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes. Nutrients. 2017;9. https://doi.org/10.3390/nu9040370

34. Anderson R, Dalziel J, Haggarty N, et al. Short communication: Processed bovine colostrum milk protein concentrate increases epithelial barrier integrity of Caco-2 cell layers. J Dairy Sci. 2019. https://doi.org/10.3168/jds.2019-16951

35. Aidos L, Pallaoro M, Mirra G, et al Intestine Health and Barrier Function in Fattening Rabbits Fed Bovine Colostrum. Vet Sci. 2023;10. https://doi.org/10.3390/vetsci10110657

36. Riva F, Draghi S, Inglesi A, et al. Bovine Colostrum Supplementation in Rabbit Diet Modulates Gene Expression of Cytokines, Gut–Vascular Barrier, and Red-Ox-Related Molecules in the Gut Wall. Animals. 2024;14. https://doi.org/10.3390/ani14050800

37. Dziewiecka H, Buttar H, Kasperska A, et al. A Systematic Review of the Influence of Bovine Colostrum Supplementation on Leaky Gut Syndrome in Athletes: Diagnostic Biomarkers and Future Directions. Nutrients. 2022;14. https://doi.org/10.3390/nu14122512

38. Chantler S, Griffiths A, Matu J, et al. Role of dietary A systematic review: Role of dietary supplements on markers of exercise-associated gut damage and permeability. PLoS One. 2022;17. https://doi.org/10.1371/journal.pone.0266379

39. Durkalec-Michalski K, Główka N, Podgórski T, et al. The effect of 12-week high-dose Colostrum Bovinumsupplementation on immunological, hematological and biochemical markers in endurance athletes: a randomized crossover placebo-controlled study. Front Immunol. 2024;15. https://doi.org/10.3389/fimmu.2024.1425785

40. Hajihashemi P, Haghighatdoost F, Kassaian N, et al. Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials. Dig Dis Sci. 2024. https://doi.org/10.1007/s10620-023-08219-2

41. Wardenaar FC, Mohr AE, Ortega-Santos CP, et al. Explorative Characterization of GI Complaints, General Physical and Mental Wellbeing, and Gut Microbiota in Trained Recreative and Competitive Athletes with or without Self-Reported Gastrointestinal Symptoms Nutrients. 2024;16. https://doi.org/10.3390/nu16111712

42. Wardenaar FC, Schott KD, Mohr A, et al. An Exploratory Study Investigating the Prevalence of Gastrointestinal Symptoms in Collegiate Division I American Football Athletes. Int J Environ Res Public Health. 2023;20. https://doi.org/10.3390/ijerph20156453

43. Nekrasov E, Vita AA, Bradley R, et al. Changes in digestive health and well-being after 14 days of a multi-functional GI primer supplement. Nutrients. 2024;16. https://doi.org/10.3390/nu16183173

44. Erpenbach K, Erpenbach MC, Maier D, et al. A-044 Using ID-Vit Test Systems to Assess the Effect of Vitamin B Supplementation on Fatigue Symptoms in Professional Athletes. Clin Chem. 2023. https://doi.org/10.1093/clinchem/hvad097.042

45. Clevers E, Nordqvist A, Törnblom H, et al. Food-symptom diaries can generate personalized lifestyle advice for managing gastrointestinal symptoms: A pilot study Neurogastroenterol Motil. 2020;32. https://doi.org/10.1111/nmo.13820

Quality in Sport

Downloads

  • PDF

Published

2025-11-12

How to Cite

1.
BAZAREWICZ, Jakub, ADAŚKO, Grzegorz, ŚWIDA, Michał, KUBUJ, Cezary, MAZUR, Urszula, OGONOWSKA, Paulina, DMOWSKI, Daniel, MICHALSKA, Anna, WASZAK, Julia and SIWIK, Marcin. Functional Supplements for Managing Exercise-Induced Gastrointestinal Distress: A Focused Review for Athletes. Quality in Sport. Online. 12 November 2025. Vol. 45, p. 66517. [Accessed 27 December 2025]. DOI 10.12775/QS.2025.45.66517.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 45 (2025)

Section

Medical Sciences

License

Copyright (c) 2025 Jakub Bazarewicz, Grzegorz Adaśko, Michał Świda, Cezary Kubuj, Urszula Mazur, Paulina Ogonowska, Daniel Dmowski, Anna Michalska, Julia Waszak, Marcin Siwik

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Stats

Number of views and downloads: 90
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

Exercise-Induced Gastrointestinal Distress, Supplements, Ginger, Athletes, Probiotics
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop