The Role of Creatine in Enhancing Bone Health Among Postmenopausal Women

Abstract

Given the high popularity of creatine as a dietary supplement, its pleiotropic
effects, and its well-established safety profile, it is worth considering as an adjunct
therapy for osteoporosis—a condition that predominantly affects postmenopausal
women due to hormonal changes, particularly a decline in estrogen levels—and has
become a silent epidemic of the 21st century. Creatine may indirectly enhance muscle
mass and strength, leading to increased mechanical stress on bones, and some studies
suggest that creatine might also directly influence osteoblast activity and bone
metabolism, potentially promoting bone formation. These direct and indirect
mechanisms may improve bone health in at-risk women, reducing the risk of falls and
fractures and ultimately contributing to a better quality of life. This research explores
the effects of creatine on bone remodeling, metabolic activity, resistance training
performance, and its potential anti-inflammatory properties in the context of skeletal
health maintenance. It also examines appropriate creatine dosing in older adults—which
typically does not require a loading phase—and evaluates the safety of creatine use in
aging women.