Boerhaave Syndrome - A Rare but Serious Esophageal Emergency
DOI:
https://doi.org/10.12775/QS.2025.44.62987Keywords
spontaneous perforation, esophageal perforation, esophageal diseases, Rupture, SpontaneousAbstract
Introduction: Boerhaave syndrome is a rare but serious cause of spontaneous esophageal rupture. It typically occurs after a sudden rise in pressure within the esophagus against a closed glottis, most often following severe vomiting. This full-thickness tear in the esophagus leads to a high risk of death, especially when there is a delay in diagnosis. The syndrome mainly impacts middle-aged men and often shows non-specific symptoms like chest pain, difficulty breathing, and subcutaneous emphysema, which can resemble cardiopulmonary emergencies. Quick identification remains challenging because of its rarity and varied clinical signs.
Aim of the Study: This review aims to provide a comprehensive overview of the syndrome’s definition, pathophysiology, clinical characteristics, diagnostic algorithms, and current therapeutic strategies, emphasizing the pivotal role of early intervention in reducing morbidity and mortality.
Materials and Methods: A literature review was conducted using databases such as Google Scholar and PubMed with search terms including "Boerhaave syndrome”, “spontaneous esophageal rupture”, “gastrointestinal emergencies”, “esophageal trauma”.
Conclusions: Boerhaave syndrome requires quick diagnosis and treatment to prevent death. Computed Tomography (CT) with contrast and esophagography can help detect it early, but only if used immediately. Prompt treatment within 12 to 24 hours and strong teamwork among doctors from different specialties greatly improve the patient’s chances of survival.
References
1. Cristiana Canelas Mendes, Duarte L, João Madeira Lopes. Boerhaave’s Syndrome: An Unusual Geriatric Presentation. Cureus. Published online September 29, 2023. doi:https://doi.org/10.7759/cureus.46212
2. Sdralis E (Ilias) K, Petousis S, Rashid F, Lorenzi B, Charalabopoulos A. Epidemiology, diagnosis, and management of esophageal perforations: systematic review. Diseases of the Esophagus. 2017;30(8):1-6. doi:https://doi.org/10.1093/dote/dox013
3. Tiago Ceriz, Andreia Diegues, João Lagarteira, Rui Terras Alexandre, Andrés Carrascal. Boerhaave’s Syndrome: A Case Report. Curēus. Published online April 5, 2022. doi:https://doi.org/10.7759/cureus.23836
4. Kwiatkowska NM, Kaminska A, Sielewicz M, Kasprzyk M, Piwkowski C. Boerhaave syndrome complicated by subsequent esophageal stenosis and esophageal fistula. Polish Journal of Cardio-Thoracic Surgery. 2023;20(4):274-276. doi:https://doi.org/10.5114/kitp.2023.134167
5. Mertens A, Essing T, Christoph Roderburg, Luedde T, Kandler J, Loosen SH. A Systematic Analysis of Incidence, Therapeutic Strategies, and In-hospital Mortality of Mallory-Weiss Syndrome in Germany. Journal of Clinical Gastroenterology. 2023;58(7):640-649. doi:https://doi.org/10.1097/mcg.0000000000001918
6. Shaqran TM, Engineer R, Abdalla EM, et al. The Management of Esophageal Perforation: A Systematic Review. Cureus. Published online July 2, 2024. doi:https://doi.org/10.7759/cureus.63651
7. Haba Y, Yano S, Akizuki H, Hashimoto T, Naito T, Hashiguchi N. Boerhaave syndrome due to excessive alcohol consumption: two case reports. International Journal of Emergency Medicine. 2020;13(1). doi:https://doi.org/10.1186/s12245-020-00318-5
8. Eremia IA, Anghel CA, Cofaru FA, Nica S. Early Presentation of Boerhaave Syndrome in the Emergency Department: A Case Report and Review of the Literature. Diagnostics (Basel, Switzerland). 2024;14(15):1592. doi:https://doi.org/10.3390/diagnostics14151592
9. Shaheem S, Panikkaveettil H, Shaheem S, Panikkaveettil H. Aetiology, Clinical Manifestations, Diagnosis, and Treatment of Oesophageal Perforation: A Review. Cureus. 2024;16(2). doi:https://doi.org/10.7759/cureus.55041
10. Bakhshi G, Tiwari S, Dutt A, Menon B, Bhagyashree Ochiramani. A Rare but Lethal Emergency: A Case Report on Boerhaave’s Syndrome. Cureus. Published online March 10, 2025. doi:https://doi.org/10.7759/cureus.80377
11. Chen YH, Lin PC, Chen YL, Yiang GT, Wu MY. Point-of-Care Ultrasonography Helped to Rapidly Detect Pneumomediastinum in a Vomiting Female. Medicina. 2023;59(2):394. doi:https://doi.org/10.3390/medicina59020394
12. Horrocks R. Boerhaave syndrome, a rare oesophageal rupture: a case report. British Paramedic Journal. 2021;5(4):49-53. doi:https://doi.org/10.29045/14784726.2021.3.5.4.49
13. Chowdhury D. Mediastinal emphysema in the context of perforated gastric ulcer. World Journal of Clinical Cases. 2024;12(15):2479-2481. doi:https://doi.org/10.12998/wjcc.v12.i15.2479
14. Mahant SS, Ajay Lanjewar. A Case Report of Conservatively Managed Boerhaave Syndrome. Curēus. Published online February
29, 2024. doi:https://doi.org/10.7759/cureus.55225
15. Ioannidis O, Malliora A, Panagiotis Christidis, et al. Tratamiento conservador del síndrome de Boerhaave en un octogenario complicado con estenosis esofágica distal tardía y tratado con éxito mediante colocación de stent. Cirugía y Cirujanos. 2021;89(91). doi:https://doi.org/10.24875/ciru.20000882
16. Wang J, Wang D, Chen J. Diagnostic challenge and surgical management of Boerhaave’s syndrome: a case series . Journal of medical case reports. 2021;15(1). doi:https://doi.org/10.1186/s13256-021-03080-1
17. Ribeiro R, Cardoso P, Santos F. A Conservative and Multidisciplinary Approach to Boerhaave Syndrome: A Case Report. Cureus. Published online May 3, 2024. doi:https://doi.org/10.7759/cureus.59602
18. Albion Totsi, Konstantinos Fortounis, Stamatia Michailidou, Nikolaos Balasas, Papavasiliou C. Early Diagnosis and Surgical Management of Boerhaave Syndrome: A Case Report. Cureus. Published online October 24, 2023. doi:https://doi.org/10.7759/cureus.47596
19. Suraj Surendran, Victor C, Yacob M, et al. Clinical profile and treatment outcomes of Boerhaave’s syndrome: A 13-year experience from an upper gastrointestinal surgical unit. PubMed. 2023;39(3):177-189. doi:https://doi.org/10.47717/turkjsurg.2023.5830
20. Hanajima T, Kataoka Y, Masuda T, Asari Y. Usefulness of lavage and drainage using video-assisted thoracoscopic surgery for Boerhaave’s syndrome: a retrospective analysis. Journal of Thoracic Disease. 2021;13(6):3420-3425. doi:https://doi.org/10.21037/jtd-20-2445
21. Aiolfi A, Micheletto G, Guglielmo Guerrazzi, Gianluca Bonitta, Campanelli G, Bona D. Minimally invasive surgical management of Boerhaave’s syndrome: a narrative literature review. Journal of Thoracic Disease. 2020;12(8):4411-4417. doi:https://doi.org/10.21037/jtd-20-1020
22. João Estorninho, Pimentel R, Gravito-Soares M, Gravito-Soares E, Amaro P, Figueiredo P. Successful Endoscopic Closure of Esophageal Perforation in Boerhaave Syndrome Using the Over-the-Scope Clip. GE Portuguese Journal of Gastroenterology. 2022;30(6):444-450. doi:https://doi.org/10.1159/000527317
23. Tanaka Y, Ohno S, Sato Y, Nobuhisa Matsuhashi, Takahashi T, Yoshida K. Subtotal esophagectomy followed by subtotal gastric reconstruction for Boerhaave’s syndrome: Case report with literature review. International Journal of Surgery Case Reports.
2021;90:106720-106720. doi:https://doi.org/10.1016/j.ijscr.2021.106720
24. Kim JD. Prognostic factors of esophageal perforation and rupture leading to mortality: a retrospective study. Journal of Cardiothoracic Surgery. 2021;16(1). doi:https://doi.org/10.1186/s13019-021-01680-y
25. T Triantafyllou, Lamb P, Skipworth R, Couper G, Deans C. Surgical treatment of Boerhaave syndrome in the past, present and future: updated results of a specialised surgical unit. Annals of The Royal College of Surgeons of England. 2024;106(6):509 514. doi:https://doi.org/10.1308/rcsann.2024.0020
26. Yan XL, Jing L, Guo LJ, et al. Surgical management of Boerhaave's syndrome with early and delayed diagnosis in adults: a retrospective study of 88 patients. Revista Española de Enfermedades Digestivas. 2020;112(9). doi:https://doi.org/10.17235/reed.2020.6746/2019
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