A literature review on effects of regular exercise on cognitive function in older adults
DOI:
https://doi.org/10.12775/QS.2025.44.62853Keywords
cognitive function, adult health, Older adults, neuroplasticity, BDNF, brain health, ageing populationAbstract
Purpose
This review investigates how exercise affects cognitive function in older adults, focusing on recent evidence and mechanisms. The aim was to assess the impact of various exercise types on cognition in healthy and cognitively impaired older people.
Methods
A systematic review covered randomised controlled trials, systematic reviews, and meta-analyses from 2018–2025 involving participants aged 60+ and examining exercise effects on cognition.
Results
Regular physical activity benefits multiple cognitive domains. Aerobic training improves global cognition (effect sizes 0.28–0.76). Resistance training shows stronger effects on executive function (SMD up to 0.80). Combined programmes enhance attention, executive skills, and overall cognition. Mind-body exercises, e.g., Tai Chi, also improve memory and executive functions. These effects are related to higher brain-derived neurotrophic factor levels, neuroplasticity, and brain structure changes.
Conclusion
Exercise is an effective non-pharmacological method to support cognitive health in older age. Different forms provide distinct advantages: aerobic training benefits global cognition, resistance supports executive function, and multicomponent programmes offer broad cognitive improvements. Evidence supports including structured exercise in clinical guidelines and public health measures to maintain cognition in ageing populations.
References
1. Ahn, J. and Kim, M. (2023). Effects of aerobic exercise on global cognitive function and sleep in older adults with mild cognitive impairment: A systematic review and meta-analysis. Geriatric Nursing, 51, pp. 9-16. doi: 10.1016/j.gerinurse.2023.02.008
2. Biazus-Sehn, L.F., Schuch, F.B., Firth, J. and Stigger, F.S. (2020). Effects of physical exercise on cognitive function of older adults with mild cognitive impairment: A systematic review and meta-analysis. Archives of Gerontology and Geriatrics, 89, p. 104048. doi: 10.1016/j.archger.2020.104048
3. Castro, H.F., Coelho-Júnior, H.J., Freire, Y.A., Fernandes, J., Rodrigues, B., Frajacomo, F.T., Dani, C., García-Hermoso, A., Cabral-Santos, C., Picada, J.N. and Uchida, M.C. (2022). Resistance Training Combined with Cognitive Training Increases Brain Derived Neurotrophic Factor and Improves Cognitive Function in Healthy Older Adults. Frontiers in Psychology, 13, p. 870561. doi: 10.3389/fpsyg.2022.870561
4. Coelho-Junior, H., Marzetti, E., Calvani, R., Picca, A., Arai, H. and Uchida, M. (2022). Resistance training improves cognitive function in older adults with different cognitive status: a systematic review and Meta-analysis. Aging & Mental Health, 26(2), pp.213–224. doi: https://doi.org/10.1080/13607863.2020.1857691
5. Dinoff, A., Herrmann, N., Swardfager, W., Gallagher, D., & Lanctot, K. L. (2018). The effect of exercise on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF) in major depressive disorder: A meta-analysis. Journal of psychiatric research, 105, 123-131. doi: https://doi.org/10.1016/j.jpsychires.2018.08.021
6. Edman, S., Horwath, O., Van der Stede, T., Blackwood, S. J., Moberg, I., Strömlind, H., ... & Moberg, M. (2024). Pro-brain-derived neurotrophic factor (BDNF), but not mature BDNF, is expressed in human skeletal muscle: implications for exercise-induced neuroplasticity. Function, 5(3), zqae005. doi: https://doi.org/10.1093/function/zqae005
7. Erickson, K. I., Hillman, C., Stillman, C. M., Ballard, R. M., Bloodgood, B., Conroy, D. E., ... and Powell, K. E. (2019). Physical activity, cognition, and brain outcomes: a review of the 2018 physical activity guidelines. Medicine and science in sports and exercise, 51(6), 1242. doi: https://doi.org/10.1249/MSS.0000000000001936
8. Gallardo-Gómez, D., del Pozo-Cruz, J., Noetel, M., Álvarez-Barbosa, F., Alfonso-Rosa, R.M. and del Pozo Cruz, B. (2022). Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs. Ageing Research Reviews, 76, p.101591. doi: https://doi.org/10.1016/j.arr.2022.101591
9. Herold, F., Müller, P., Gronwald, T. and Müller, N.G. (2019a). Dose–Response Matters! – A Perspective on the Exercise Prescription in Exercise–Cognition Research. Frontiers in Psychology, 10. doi: https://doi.org/10.3389/fpsyg.2019.02338
10. Herold, F., Törpel, A., Schega, L. and Müller, N.G. (2019b). Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review. European Review of Aging and Physical Activity, 16(1). doi: https://doi.org/10.1186/s11556-019-0217-2
11. Jeong, M. K., Park, K. W., Ryu, J. K., Kim, G. M., Jung, H. H., and Park, H. (2021). Multi-component intervention program on habitual physical activity parameters and cognitive function in patients with mild cognitive impairment: a randomised controlled trial. International Journal of Environmental Research and Public Health, 18(12), 6240. doi: https://doi.org/10.3390/ijerph18126240
12. Liu, H., Sun, Z., Zeng, H., Han, J., Hu, M., Mao, D., Tian, X. and Li, R. (2025). Meta-analysis of the effects of multi-component exercise on cognitive function in older adults with cognitive impairment. Frontiers in Aging Neuroscience, 17. doi: https://doi.org/10.3389/fnagi.2025.1551877
13. Nicastri, C.M., McFeeley, B.M., Simon, S.S., Ledreux, A., Håkansson, K., Granholm, A., Mohammed, A.H. and Daffner, K.R. (2022). BDNF mediates improvement in cognitive performance after computerised cognitive training in healthy older adults. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 8(1). doi: https://doi.org/10.1002/trc2.12337
14. Sanders, L.M.J., Hortobágyi, T., la Bastide-van Gemert, S., van der Zee, E.A. and van Heuvelen, M.J.G. (2019). Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis. PLOS ONE, [online] 14(1), p.e0210036. doi: https://doi.org/10.1371/journal.pone.0210036
15. Stern, Y., MacKay-Brandt, A., Lee, S., McKinley, P., McIntyre, K., Razlighi, Q., Agarunov, E., Bartels, M. and Sloan, R.P. (2019). Effect of aerobic exercise on cognition in younger adults. Neurology, 92(9), p.10.1212/WNL.0000000000007003. doi: https://doi.org/10.1212/wnl.0000000000007003
16. Venegas-Sanabria, L.C., Cavero-Redondo, I., Martínez-Vizcaíno, V., Cano-Gutierrez, C.A. and Álvarez-Bueno, C. (2022). Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis. BMC Geriatrics, 22(1), p. 617. doi: https://doi.org/10.1186/s12877-022-03302-1
17. Vints, W. A., Gökçe, E., Šeikinaitė, J., Kušleikienė, S., Česnaitienė, V. J., Verbunt, J., ... and Masiulis, N. (2024). Resistance training's impact on blood biomarkers and cognitive function in older adults with low and high risk of mild cognitive impairment: a randomised controlled trial. European Review of Aging and Physical Activity, 21(1), 9. doi: https://doi.org/10.1186/s11556-024-00344-9
18. Wang, X., Wang, H., Ye, Z., Ding, G., Li, F., Ma, J., and Hua, W. (2020). The neurocognitive and BDNF changes of multicomponent exercise for community-dwelling older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis. Aging (Albany NY), 12(6), 4907. doi: https://doi.org/10.18632/aging.102918
19. World Health Organisation (2025). Dementia. [online] World Health Organisation. Available at: https://www.who.int/news-room/fact-sheets/detail/dementia
20. Xu, L., Gu, H., Cai, X., Zhang, Y., Hou, X., Yu, J., and Sun, T. (2023). The effects of exercise for cognitive function in older adults: a systematic review and meta-analysis of randomised controlled trials. International journal of environmental research and public health, 20(2), 1088. doi: https://doi.org/10.3390/ijerph20021088
21. Yu, A.P., Chin, E.C., Yu, D.J., Fong, D.Y., Cheng, C.P., Hu, X., Wei, G.X. and Siu, P.M. (2022). Tai Chi versus conventional exercise for improving cognitive function in older adults: a pilot randomised controlled trial. Scientific reports, 12(1), p.8868. doi: https://doi.org/10.1038/s41598-022-12526-5
22. Zhang, M., Jia, J., Yang, Y., Zhang, L. and Wang, X. (2023). Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis. Ageing Research Reviews, 92, pp.102116–102116. doi: https://doi.org/10.1016/j.arr.2023.102116
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Albert Lompart, Michał Wabiszczewicz, Albert Kosarewicz, Łukasz Woźniak, Patrycja Krysiak

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 375
Number of citations: 0