Sleep quality and reproductive health in physically active women - the literature review
DOI:
https://doi.org/10.12775/QS.2025.43.62324Keywords
activity and health, menstrual cycle, quality of sleep, female infertilityAbstract
Sleep plays a crucial role in maintaining women's reproductive health, as it regulates the secretion of key hormones within the hypothalamic-pituitary-gonadal (HPG) axis and modulates inflammatory processes. This literature review explores the complex, bidirectional relationships between sleep, the menstrual cycle, and fertility in physically active women. Physiological mechanisms, including the roles of melatonin, cortisol, and sex steroids, are discussed in the context of sleep architecture. Moreover, the review highlights how moderate physical activity generally promotes better sleep quality, while excessive or poorly planned exercise can disrupt sleep patterns, elevate cortisol levels, and impair reproductive function. The prevalence of sleep disorders—such as insomnia, restless legs syndrome, and circadian rhythm misalignment—among female athletes is examined, with emphasis on their underdiagnosis and potential consequences for performance and health. Non-pharmacological strategies, including behavioral interventions, sleep hygiene education, and sleep tracking technologies, are proposed as first-line measures to improve sleep quality and reduce the risk of menstrual irregularities and infertility. Pharmacological treatments are also mentioned as a complementary approach in complex cases. Finally, the review identifies gaps in current research and underscores the importance of integrating sleep management into the care of physically active women to safeguard both reproductive and overall health.
References
Khazaie H, Rezaei K, Fakhari Z, et al. Sleep and circadian rhythms: The role of the hypothalamic-pituitary-gonadal (HPG) axis. J Biol Rhythms. 2020;35(3):291–303. doi: 10.1177/0748730419886403.
Zisapel N. Melatonin and sleep. Endocr Rev. 2018;39(1):28–52. doi: 10.1210/er.2017-00140.
Kalsbeek A, Foppen E, De Groot M, et al. Circadian control of the hypothalamic-pituitary-gonadal axis. Am J Physiol Endocrinol Metab. 2014;307(11):E1141–51. doi: 10.1152/ajpendo.00371.2014.
Tzischinsky O, Sharf M, Bender A, et al. The impact of sleep disorders on reproductive health in women. Sleep Med Rev. 2020;51:101253. doi: 10.1016/j.smrv.2020.101253.
Afeiche MC, Williams PL, Gaskins AJ, et al. Sleep duration and menstrual cycle characteristics. Eur J Epidemiol. 2014;29(10):739–47. doi: 10.1007/s10654-014-9929-2.
Ramesh A, Kotecha A, Kotecha V. Sleep deprivation and its impact on reproductive health. Reprod Biol Endocrinol. 2021;19(1):1–13. doi: 10.1186/s12958-021-00761-7.
Gaskins AJ, Rich-Edwards JW, Hauser R, et al. Sleep duration and time spent awake and risk of ovulatory disorder infertility. Eur J Epidemiol. 2013;28(11):923–30. doi: 10.1007/s10654-013-9847-5.
World Health Organization. Global Recommendations on Physical Activity for Health. Geneva: World Health Organization; 2010. Available from: https://www.who.int/publications/i/item/9789241599979
Loucks AB, Thuma JR. The effects of energy availability on the female reproductive system. Sports Med. 2003;33(3):101–18. doi: 10.2165/00007256-200333030-00001.
Warren MP, Perlroth NE. The effects of intense training on the female reproductive system. Clin Sports Med. 2001;20(4):657–74. doi: 10.1016/s0278-5919(05)70055-4.
Baker FC, Lee KA. Menstrual cycle effects on sleep. Sleep Med Clin. 2022;17(1):35–44. doi: 10.1016/j.smrv.2020.101253.
Driver HS, Werth E, Dijk DJ, Borbély AA. The menstrual cycle effects on sleep. Sleep Med Clin. 2008;3(1):85–96. doi: 10.1016/j.sleep.2006.10.008.
Romans SE, Kreindler D, Einstein G, Laredo S. Sleep quality and the menstrual cycle. Sleep Med. 2015;16(8):913–9. doi: 10.1016/j.sleep.2015.03.011.
Baker FC, Driver HS. Circadian rhythms, sleep, and the menstrual cycle. Sleep Med. 2007;8(6):613–22. doi: 10.1016/j.sleep.2006.10.008.
Manber R, Bootzin RR. Sleep and the menstrual cycle. Health Psychol. 1997;16(3):209–14. doi: 10.1037/0278-6133.16.3.209.
Lee KA, Shaver JF, Giblin EC, Woods NF. Sleep patterns related to menstrual cycle phase and premenstrual affective symptoms. Sleep. 1990;13(5):403–9. doi: 10.1093/sleep/13.5.403.
Driver HS, Dijk DJ, Werth E. Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women. J Clin Endocrinol Metab. 1996;81(2):728–35. doi: 10.1210/jcem.81.2.8636332.
Alzueta E, Baker FC. The menstrual cycle and sleep. Sleep Med Clin. 2023;18(2):153–65. doi: 10.1016/j.sleep.2022.12.011.
Baker FC, Driver HS. Self-reported sleep across the menstrual cycle in young, healthy women. J Psychosom Res. 2004;56(1):47–53. doi: 10.1016/S0022-3999(03)00067-9.
Semplonius T, Willoughby T. Long-term links between physical activity and sleep quality. [Internet]. 2018 [cited 2025 Jun 4]. Available from: https://www.brockadolescentdevelopmentlab.com/uploads/1/1/2/6/112616517/semplonius_and_willoughby_2018_-_long-term_links_between_physical_activity_and_sleep_quality.pdf
Mishica C, Kyröläinen H, Hynynen E. Relationships between heart rate variability, sleep duration, cortisol and physical training in young athletes. [Internet]. 2021 [cited 2025 Jun 4]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8488831/
Desjardins S, Tanguay-Labonté M. The effects of physical activity on sleep among adolescents and adults: a narrative review. [Internet]. 2018 [cited 2025 Jun 4]. Available from: https://oap-lifescience.org/jsdr/article/765
Wang F, Boros S. The effect of physical activity on sleep quality: a systematic review. Health Behav Policy Rev. 2021;8(2):142–55. doi: 10.1080/21679169.2019.1623314.
Dobrosielski DA, Sweeney L, Lisman PJ. The association between poor sleep and the incidence of sport and physical training-related injuries in adult athletic populations: a systematic review. Sports Med. 2021;51(7):1401–16. doi: 10.1007/s40279-020-01416-3.
Dolezal BA, Neufeld EV, Boland DM. Interrelationship between sleep and exercise: a systematic review. Adv Prev Med. 2017;2017:1364387. doi: 10.1155/2017/1364387.
Davenne D. Sleep of athletes—problems and possible solutions. Biol Rhythm Res. 2009;40(1):45–52. doi: 10.1080/09291010802067023.
Watson A, Post E, Biese K, Kliethermes S. Decreased physical activity and sleep, not sport specialization, predict illness in middle school athletes. Orthop J Sports Med. 2021;9(10):232596712110342. doi: 10.1177/1941738120927599.
Khalladi K, Moullec G, Boudhiba D, Trabelsi K. Insomnia symptoms among athletes: Prevalence and associated factors. J Sports Sci. 2019;37(3):285–92. doi: 10.1080/02640414.2018.1495395.
Fagundes V, Silva A, Oliveira A. Prevalence of restless legs syndrome and periodic limb movements in athletes. Sleep Med. 2010;11(10):1010–4. doi: 10.1016/j.sleep.2010.03.015.
Caia J, Halson SL, Scott TJ, Kelly VG. Obstructive sleep apnea in professional rugby league athletes: An exploratory study. J Sci Med Sport. 2020;23(11):1011–5. doi: 10.1016/j.jsams.2020.04.014.
Khalsa SBS, Jewett ME, Cajochen C, Czeisler CA. A phase response curve to single bright light pulses in human subjects. J Physiol. 2003;549(3):945–52. doi: 10.1113/jphysiol.2003.040477.
Sargent C, Lastella M, Halson SL, Roach GD. The impact of training schedules on the sleep and fatigue of elite athletes. Chronobiol Int. 2014;31(10):1160–8. doi: 10.3109/07420528.2014.957302.
Zhao F, Hong X, Wang W, Wu J, Wang B. Effects of physical activity and sleep duration on fertility: A systematic review and meta-analysis. Front Public Health. 2022;10:1029469. doi: 10.3389/fpubh.2022.1029469.
Bruinvels G, Blagrove RC, Goldsmith E, Shaw L, et al. How lifestyle changes during the COVID-19 global pandemic affected the pattern and symptoms of the menstrual cycle. Int J Environ Res Public Health. 2022;19(5):3040. doi: 10.3390/ijerph19053040.
Alzueta E, de Zambotti M, Javitz H, Dulai T, et al. Tracking sleep, temperature, heart rate, and daily symptoms across the menstrual cycle with the Oura ring in healthy women. Int J Womens Health. 2022;14:679–92. doi: 10.2147/IJWH.S363867.
Calabrò RS. The importance of sleep and fatigue in female sexual dysfunction. J Sex Med. 2025;22(5):984–6. doi: 10.1093/jsxmed/22.5.984.
Stutz J, Eiholzer R, Spengler CM. Effects of evening exercise on sleep in healthy participants: A systematic review and meta-analysis. Sports Med. 2019;49(2):269–87. doi: 10.1007/s40279-018-1015-0.
Nagamatsu T, Kai Y. Effect of low-intensity stretching exercises on sleep and stress in people with mild sleep disorders. Bull Phys Fit Res Inst. 2014;113:1–7. Available from: https://www.researchgate.net/publication/286575353
Bravo R, Matito S, Cubero J, Paredes SD, Franco L, Rivero M, et al. Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans. Age (Dordr). 2013;35(4):1277–85. doi: 10.1007/s11357-012-9443-3.
Wilson S, Anderson K, Baldwin D, Dijk D-J, Espie CA, et al. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. J Psychopharmacol. 2019;33(8):923–47. doi: 10.1177/0269881119853934.
El Basiouny D, Habib HI. Cognitive Behavioral Therapy for Insomnia (CBT-I): A comprehensive review. Indian J Sleep Med. 2023;18(4):62–7. doi: 10.5005/jp-journals-10069-0116.
de Zambotti M, Cellini N, Goldstone A, Colrain IM, Baker FC. Wearable sleep technology in clinical and research settings. Med Sci Sports Exerc. 2019;51(7):1538–57. doi: 10.1249/MSS.0000000000001947.
Scott H, Lack L, Lovato N. A systematic review of the accuracy of sleep wearable devices in healthy adults. Nat Sci Sleep. 2020;12:907–20. doi: 10.2147/NSS.S265892.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Katarzyna Milewska-Plis, Igor Kłak, Jan Szerocki, Wiktoria Nowakowska, Katarzyna Bartnik, Katarzyna Chwaleba, Ksenia Mazur, Monika Karalus, Weronika Curyło, Alina Grudina

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 332
Number of citations: 0