Impact of diet and vitamins on Mental Health - A systematic review
DOI:
https://doi.org/10.12775/QS.2025.43.61423Keywords
mental health disorders,, depression, folate, Vitamin B6, vitamin B12, diet habits, vitamin DAbstract
The process of determining risk factors and direct causes that contributed to the development of mental health disorders is not yet completely understood and it is considered multifactorial. Numerous studies have examined the correlation between lifestyle factors, health habits, vitamin levels or consumed supplements with the development of depression. Therefore, observed associations established the importance of dietary patterns, deficiencies of vitamin D or B-complex vitamins (B6, B9, B12) in patients with depressive symptoms. Moreover, these vitamins are involved in essential neurobiological processes such as neurotransmitter synthesis, homocysteine metabolism, neuroinflammation regulation, and oxidative stress reduction. Studies have also shown that the supplementation of the essential nutrients provide promising benefits and may improve the quality of life and well-being. Acknowledging the nutritional impact on mental health can contribute to a better understanding of its etiology and plan more effective treatment strategies.
References
[1] Ekinci GN, Sanlier N. The relationship between nutrition and depression in the life process: A mini-review. Exp Gerontol. 2023;172:112072. doi:10.1016/j.exger.2022.112072
[2] Katon WJ. Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci. 2011;13(1):7-23. doi:10.31887/DCNS.2011.13.1/wkaton
[3] Kennedy GJ, Kelman HR, Thomas C. Persistence and remission of depressive symptoms in late life. Am J Psychiatry. 1991;148(2):174-178. doi:10.1176/ajp.148.2.174
[4] Katon W, Russo J, Lin EH, et al. Depression and diabetes: factors associated with major depression at five-year follow-up. Psychosomatics. 2009;50(6):570-579. doi:10.1176/appi.psy.50.6.570
[5] Paans NPG, Bot M, van Strien T, Brouwer IA, Visser M, Penninx BWJH. Eating styles in major depressive disorder: Results from a large-scale study. J Psychiatr Res. 2018;97:38-46. doi:10.1016/j.jpsychires.2017.11.003
[6] Nouri Saeidlou S, Kiani A, Ayremlou P. Association between Dietary Patterns and Major Depression in Adult Females: A Case-Control Study. J Res Health Sci. 2021;21(1):e00506. Published 2021 Jan 12. doi:10.34172/jrhs.2021.37
[7] Almeida OP, Ford AH, Hirani V, et al. B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial. Br J Psychiatry. 2014;205(6):450-457. doi:10.1192/bjp.bp.114.145177
[8] Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Yoon JS. Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. Br J Psychiatry. 2008;192(4):268-274. doi:10.1192/bjp.bp.107.039511
[9] Gilbody S, Lightfoot T, Sheldon T. Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol Community Health. 2007;61(7):631-637. doi:10.1136/jech.2006.050385
[10] Firth J, Teasdale SB, Allott K, et al. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials. World Psychiatry. 2019;18(3):308-324. doi:10.1002/wps.20672
[11] Loughman A, Staudacher HM, Rocks T, et al. Diet and Mental Health. Mod Trends Psychiatry. 2021;32:100-112. doi:10.1159/000510422
[12] Bremner JD, Moazzami K, Wittbrodt MT, et al. Diet, Stress and Mental Health. Nutrients. 2020;12(8):2428. Published 2020 Aug 13. doi:10.3390/nu12082428
[13] Durrani D, Idrees R, Idrees H, Ellahi A. Vitamin B6: A new approach to lowering anxiety, and depression?. Ann Med Surg (Lond). 2022;82:104663. Published 2022 Sep 15. doi:10.1016/j.amsu.2022.104663
[14] Field DT, Cracknell RO, Eastwood JR, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37(6):e2852. doi:10.1002/hup.2852
[15] Rizzo R, Prato A, Scerbo M, Saia F, Barone R, Curatolo P. Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients. 2022;14(4):852. Published 2022 Feb 18. doi:10.3390/nu14040852
[16] Merrell BJ, McMurry JP. Folic Acid. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 8, 2023.
[17] Muscaritoli M. The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature. Front Nutr. 2021;8:656290. Published 2021 Mar 8. doi:10.3389/fnut.2021.656290
[18] Firth J, Teasdale SB, Allott K, et al. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials. World Psychiatry. 2019;18(3):308-324. doi:10.1002/wps.20672
[19] Ankar A, Kumar A. Vitamin B12 Deficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; September 10, 2024.
[20] Syed EU, Wasay M, Awan S. Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial. Open Neurol J. 2013;7:44-48. Published 2013 Nov 15. doi:10.2174/1874205X01307010044
[21] Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, Pouteau E. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress Health. 2021;37(5):1000-1009. doi:10.1002/smi.3051
[22] Bopape PG, Wagenaar C, Poka M, Bronkhorst E. Vitamin D supplementation in a post-pandemic era: A narrative review. S Afr Fam Pract (2004). 2023;65(1):e1-e6. Published 2023 Oct 17. doi:10.4102/safp.v65i1.5752
[23] Högberg G, Gustafsson SA, Hällström T, Gustafsson T, Klawitter B, Petersson M. Depressed adolescents in a case-series were low in vitamin D and depression was ameliorated by vitamin D supplementation. Acta Paediatr. 2012;101(7):779-783. doi:10.1111/j.1651-2227.2012.02655.x
[24] Imai CM, Halldorsson TI, Eiriksdottir G, et al. Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study. J Nutr Sci. 2015;4:e37. Published 2015 Nov 20. doi:10.1017/jns.2015.27
[25] von Känel R, Fardad N, Steurer N, et al. Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode: A Factor Analytic Study. PLoS One. 2015;10(9):e0138550. Published 2015 Sep 23. doi:10.1371/journal.pone.0138550
[26] Vellekkatt F, Menon V. Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials. J Postgrad Med. 2019;65(2):74-80. doi:10.4103/jpgm.JPGM_571_17
[27] Głąbska D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, Guzek D. The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review. Nutrients. 2021;13(3):952. Published 2021 Mar 16. doi:10.3390/nu13030952
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Copyright (c) 2025 Zuzanna Cichowska, Kacper Kiereta, Bartłomiej Józef Rdzanek, Klaudia Głodowska, Laura Chmielowiec, Małgorzata Bacik, Jakub Żelazo, Katarzyna Wacławek, Kamil Janawa, Anna Ciesielka, Aleksandra Rechcińska

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