Influence of pulmonary sequestration on growth and body weight: Case report and literature review
DOI:
https://doi.org/10.12775/QS.2025.42.61001Keywords
pulmonary sequestration, thoracotomy, congenital lung anomalies, growth, body weightAbstract
Background: Pulmonary sequestration is a rare congenital anomaly involving non-functional lung tissue with systemic arterial blood supply. Its implications for pediatric growth and weight are poorly documented.
Case report: An 8-years-and-10-month-old previously healthy boy was diagnosed with pulmonary sequestration following pneumonia. Chest imaging revealed emphysematous changes, and computed tomography confirmed intralobar sequestration. Surgical removal was performed, revealing significant growth impairment with weight (18.9 kg) and height (117 cm), both below the 3rd percentile at admission, despite normal laboratory findings.
Discussion: Pulmonary sequestration can negatively influence pediatric growth due to chronic inflammation and hypoxia from recurrent infection. Surgical intervention typically results in clinical improvement and significant catch-up growth.
Conclusion: This case highlights pulmonary sequestration’s potential negative impact on pediatric growth and underscores the importance of early surgical intervention for improving growth outcomes.
References
Savic, B., Birtel, F. J., Tholen, W., Funke, H. D., & Knoche, R. (1979). Lung sequestration: report of seven cases and review of 540 published cases. Thorax, 34(1), 96–101.
Bratu, I., Flageole, H., Chen, M. F., Di Lorenzo, M., Yazbeck, S., & Laberge, J. M. (2005). The multiple facets of pulmonary sequestration. Journal of Pediatric Surgery, 40(5), 784–790.
Sun, X., & Xiao, Y. (2012). Pulmonary sequestration in children: a clinical analysis of 48 cases. Journal of Pediatric Surgery, 47(12), 2244–2248.
Lee, E. Y., Boiselle, P. M., & Cleveland, R. H. (2008). Multidetector CT evaluation of congenital lung anomalies. Radiology, 247(3), 632–648.
Wang, H., Duan, L., Zhong, L., Zhong, W., & Wang, Q. (2015). Pulmonary sequestration: A retrospective analysis of 2625 cases in China. Pediatrics and Neonatology, 56(1), 45–49.
Riedlinger, W. F., Vargas, S. O., Jennings, R. W., et al. (2011). Embryologic basis of pulmonary sequestration: A histopathologic and immunohistochemical study. Pediatric and Developmental Pathology, 14(6), 427–432.
Hardy, O. T., Czech, M. P., & Corvera, S. (2012). What causes the insulin resistance underlying obesity? Current Opinion in Endocrinology, Diabetes and Obesity, 19(2), 81–87.
Wit, J. M., Oostdijk, W., Losekoot, M., van Duyvenvoorde, H. A., & van Schaik, R. H. N. (2016). Mechanisms in endocrinology: Novel genetic causes of short stature. Hormone Research in Paediatrics, 86(6), 361–377.
Gozal, D., & Kheirandish-Gozal, L. (2006). Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines. Chest, 130(6), 1913–1919.
Gore, D. C., Honeycutt, D., Jahoor, F., Barrow, R. E., Wolfe, R. R., & Herndon, D. N. (2008). Propranolol diminishes extremity blood flow in severely burned patients. Journal of Burn Care & Research, 29(2), 288–292.
Marcinow, A., Wroński, J., Barczuk-Falęcka, M., et al. (1998). Pulmonary sequestration: A comparison between pediatric and adult patients. European Journal of Cardio-Thoracic Surgery, 19(4), 388–395.
Matsubara, Y., et al. (2023). Sublobar resection utilizing near-infrared thoracoscopy with intravenous indocyanine green for intralobar pulmonary sequestration: a case report and literature review. Surgical Case Reports, 9(1), 176.
Corbett, H. J., Dickinson, R. J., & Hindle, D. (2022). Modern surgical approaches to pulmonary sequestration: A systematic review. Annals of Pediatric Surgery, 18(1), 24.
Tong, Z., et al. (2023). Pulmonary sequestration in adult patients: a single-center retrospective study. Respiratory Research, 24(1), 13.
Molinari, J. V., et al. (2023). Case report: Pulmonary sequestration with gastric fistula in a 20-year-old woman. Seven Editora.
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Copyright (c) 2025 Joanna Rypel-Bośka, Natalia Siuta, Kamil Ciechomski, Izabela Brynczka, Marcin Migiel, Jakub Miaśnikiewicz, Klaudia Goleniowska, Aleksandra Gieras, Elżbieta Siuda, Wiktoria Cecuła

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