The Impact of Endurance Running Training on the Lipid Profile in Professional and Amateur Athletes: A Comprehensive Review
DOI:
https://doi.org/10.12775/QS.2025.42.60824Keywords
dyslipidemia, endurance running, cardiovascular, lipoprotein lipaseAbstract
Endurance running is one of the most popular forms of physical activity, influencing many aspects of health, including lipid metabolism. Regular endurance exercise positively affects the lipid profile, which plays a key role in preventing cardiovascular diseases (CVD). Dyslipidemia, characterized by abnormal levels of cholesterol and triglycerides, is a significant risk factor for the development of these diseases. The purpose of this study is to analyze the impact of endurance running on the lipid profile of amateur and professional athletes, considering the differences in metabolic adaptations resulting from training intensity and lifestyle. A review of the available literature was conducted by searching official databases such as Pubmed and Google Scholar using the following keywords: dyslipidemia, endurance running, cardiovascular, lipoprotein lipase. The results indicate that regular endurance running enhances LPL activity, fatty acid oxidation, and cholesterol transport. Both moderate and high-intensity training lower LDL-C and triglycerides, while raising HDL-C. Lipid responses vary between amateur and professional athletes due to differences in training and lifestyle. Overall, endurance running with a healthy lifestyle effectively improves lipid profiles and reduces cardiovascular risk.References
[1] WHO. Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and Region, 2000-2019. Geneva: World Health Organization; 2021. English.
[2] Grundy SM, Stone NJ, Bailey AL, Beam C, et al. Guideline on the Management of Blood Cholesterol. Journal of the American College of Cardiology. 2018;73(24):285-350. https://doi.org/10.1016/j.jacc.2018.11.003. English.
[3] Stone NJ, Robinson JG, Lichtenstein AH, et al. Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults. Circulation. 2013;129:1-45. https://doi.org/10.1161/01.cir.0000437738.63853.7a. English.
[4] Thompson PD, Buchner D, Piña IL, et al. Exercise and Physical Activity in the Prevention and Treatment of Atherosclerotic Cardiovascular Disease. Circulation. 2003;107(24):3109-3116. https://doi.org/10.1161/01.CIR.0000075572.40158.77. English.
[5] Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, Bales CW, Henes S, Samsa GP, Otvos JD, Kulkarni KR, Slentz CA. Effects of the Amount and Intensity of Exercise on Plasma Lipoproteins. New England Journal of Medicine. 2002;347(19):1483-1492. https://doi.org/10.1056/NEJMoa020194. English.
[6] Mann S, Beedie C, Jimenez A. Differential Effects of Aerobic Exercise, Resistance Training and Combined Exercise Modalities on Cholesterol and the Lipid Profile. Sports Medicine. 2014;44(2):211-221. https://doi.org/10.1007/s40279-013-0110-5. English.
[7] Mora S, Cook N, Buring JE, Ridker PM, Lee I. Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms. Circulation. 2007;116(19):2110-2118. https://doi.org/10.1161/CIRCULATIONAHA.107.729939. English.
[8] Leon AS, Sanchez OA. Response of Blood Lipids to Exercise Training Alone or Combined with Dietary Intervention. Medicine & Science in Sports & Exercise. 2001;33(6):502-515. https://doi.org/10.1097/00005768-200106001-00022. English.
[9] Holloszy JO, Coyle EF. Adaptations of Skeletal Muscle to Endurance Exercise and Their Metabolic Consequences. Journal of Applied Physiology. 1984;56(4):831-838. https://doi.org/10.1152/jappl.1984.56.4.831. English.
[10] Seip RL, Mair K, Cole TG, Semenkovich CF. Induction of Human Skeletal Muscle Lipoprotein Lipase Gene Expression by Short-Term Exercise. Circulation Research. 1993;72(6):1225-1230. English.
[11] Halverstadt A, Phares DA, Wilund KR, Goldberg AP, Hagberg JM. Endurance Exercise Training Raises High-Density Lipoprotein Cholesterol and Lowers Small Low-Density Lipoprotein and Very Low-Density Lipoprotein Independent of Body Fat Phenotype. Metabolism. 2007;56(4):444-450. https://doi.org/10.1016/j.metabol.2006.10.019. English.
[12] Kokkinos PF, Fernhall B. Physical Activity and High Density Lipoprotein Cholesterol Levels: What is the Relationship? Sports Medicine. 1999;28(5):307-314. https://doi.org/10.2165/00007256-199928050-00002. English.
[13] Durstine JL, Grandjean PW, Cox CA, Thompson PD. Lipid and Lipoprotein Adaptations to Exercise: A Quantitative Analysis. Sports Medicine. 2001;31(15):1033-1062. https://doi.org/10.2165/00007256-200131150-00002. English.
[14] Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, Yamamoto S, Kondo K, Ohashi Y, Yamada N, Sone H. Effect of Aerobic Exercise Training on Serum Levels of High-Density Lipoprotein Cholesterol: A Meta-Analysis. Archives of Internal Medicine. 2007;167(10):999-1008. https://doi.org/10.1001/archinte.167.10.999. English.
[15] Tambalis K, Panagiotakos DB, Kavouras SA, Sidossis LS. Responses of Blood Lipids to Aerobic, Resistance, and Combined Exercise Training: A Systematic Review of Current Evidence. Angiology. 2009;60(5):614-632. https://doi.org/10.1177/0003319708324927. English.
[16] Basset FA, Howley ET. Limiting Factors for Maximum Oxygen Uptake and Determinants of Endurance Performance. Medicine & Science in Sports & Exercise. 2000;32(1):70-84. https://doi.org/10.1097/00005768-200001000-00012. English.
[17] Laukkanen JA, Lakka TA, Rauramaa R, Kuhanen R. Cardiorespiratory Fitness and Physical Activity as Predictors of Cardiovascular Disease Mortality in Men. JAMA Internal Medicine. 2014;174(8):1335-1340. English.
[18] Lee DC, Xuemei S, Church TS, Lavie CJ, Jackson AS, Blair SN. Changes in Fitness and Fatness on the Development of Cardiovascular Disease Risk Factors. Journal of the American College of Cardiology. 2012;59(7):665-672. https://doi.org/10.1016/j.jacc.2011.11.013. English.
[19] Fisher-Wellman K, Bloomer RJ. Oxidative Stress and Antioxidant Defense Mechanisms Linked to Exercise. Journal of Cardiopulmonary Rehabilitation and Prevention. 2009;29(4):178-185. English.
[20] Jeukendrup A, Gleeson M. Sport Nutrition: An Introduction to Energy Production and Performance. 3rd ed. Champaign: Human Kinetics; 2018. English.
[21] Gibala MJ, Little JP, MacDonald MJ, Hawley JA. Physiological Adaptations to Low-Volume, High-Intensity Interval Training in Health and Disease. The Journal of Physiology. 2012;590(5):1077-1084. https://doi.org/10.1113/jphysiol.2011.224725. English.
[22] Wewege M, van den Berg R, Ward RE, Keech A. The Effects of High-Intensity Interval Training vs Moderate-Intensity Continuous Training on Body Composition in Overweight and Obese Adults: A Systematic Review and Meta-Analysis. Obesity Reviews. 2017;18(6):635-646. https://doi.org/10.1111/obr.12532. English.
[23] Little JP, Safdar A, Wilkin GP, Tarnopolsky MA, Gibala MJ.A Practical Model of Low-Volume High-Intensity Interval Training Induces Mitochondrial Biogenesis in Human Skeletal Muscle: Potential Mechanisms. The Journal of Physiology. 2011;588(6):1011-1022. English.
[24] Maillard F, Rousset S, Pereira B, Traore A, de Pradel Del Amaze P, Boirie Y, Duclos M, Boisseau N. High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes Metab. 2016 Dec;42(6):433-441. English.
[25] Wilmore JH, Costill DL, Kenney WL. Physiology of Sport and Exercise. 4th ed. Champaign: Human Kinetics; 2001. English.
[26] Mozaffarian D, Micha R, Wallace S. Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS Medicine. 2005;2(6):e123. https://doi.org/10.1371/journal.pmed.0020123. English.
[27] Laufs U, Wassmann S, Czech T, Münzel T, Eisenhauer M, Böhm M, Nickenig G. Physical Inactivity Increases Oxidative Stress, Endothelial Dysfunction, and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25(4):809-814. https://doi.org/10.1161/01.ATV.0000158311.24443.af. English.
[28] Nocon M, Hiemann T, Müller-Riemenschneider F, Thalau F, Roll S, Willich SN. Association of Physical Activity with All-Cause and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. European Journal of Cardiovascular Prevention & Rehabilitation. 2008;15(3):239-246. https://doi.org/10.1097/HJR.0b013e3282f55e09. English.
[29] Simoneau JA, Bouchard C. Genetic Determinants of Nonresponse to Training. Canadian Journal of Applied Physiology. 1995;20(3):312-319. https://doi.org/10.1139/h95-024. English.
[30] Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A. Physical Activity and Public Health: Updated Recommendation for Adults. Medicine & Science in Sports & Exercise. 2007;39(8):1423-1434. https://doi.org/10.1249/mss.0b013e3180616b27. English.
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Copyright (c) 2025 Adam Zarzycki, Dominika Nowak, Magdalena Próchnicka, Michał Siwek, Jakub Hamouta, Patrycja Długosz, Julia Konat, Wiktor Doroszuk, Jan Noskowicz, Jan Urban
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