Interactions Between Psychiatric Disorders and Inflammatory Skin Diseases - systematic review
DOI:
https://doi.org/10.12775/QS.2025.42.60530Keywords
Depression, Anxiety Disorders, Psoriasis, Atopic DermatitisAbstract
Introduction:
Depression and anxiety are prevalent mental disorders often co-occurring with chronic inflammatory conditions such as psoriasis and atopic dermatitis. These associations suggest shared biological mechanisms, including immune dysregulation and persistent inflammation. Understanding these links is essential for developing integrated treatments addressing both psychiatric and dermatological symptoms.
Aim of Study:
This study explores shared pathomechanisms between depression, anxiety disorders, psoriasis, and atopic dermatitis.
Materials and Methods:
A systematic literature review was conducted using PubMed and Google Scholar. Articles published between 2019 and 2025 were analyzed to identify biological mechanisms linking psychiatric disorders with inflammatory skin diseases. Keywords included: "depression," "anxiety disorders," "psoriasis," "atopic dermatitis," "pathomechanism," and "inflammation."
Conclusion:
Findings underscore the interconnectedness of psychiatric and inflammatory skin disorders via common pathophysiological pathways. Targeted biological therapies and psychological interventions show promise in managing these comorbidities. Further research is required to enhance integrated care for affected patients.
References
1. Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialogues in Clinical Neuroscience. 2017;19(2):93–107. https://doi.org/10.31887/DCNS.2017.19.2/bbandelow
2. Bieber T, Paller AS, Kabashima K, et al. Atopic dermatitis: Pathomechanisms and lessons learned from novel systemic therapeutic options. Journal of the European Academy of Dermatology and Venereology. 2022;36(1):1–12. https://doi.org/10.1111/jdv.18225
3. Burnett AL. Priapism: a new era. International Journal of Impotence Research. 2024;36(1):1–9. https://doi.org/10.1038/s41443-024-00825-6
4. Capec S, Petrek M, Yaremkevych R. Psychological interventions in patients with chronic dermatologic itch in atopic dermatitis and psoriasis: A step forward. Frontiers in Medicine. 2022;9:1–10. https://doi.org/10.3389/fmed.2022.965133
5. Cummings C. M., Caporino N. E., Kendall P. C. Comorbidity of anxiety and depression in children and adolescents: 20 years after. Psychological Bulletin. 2014;140(3):816–845. https://doi.org/10.1037/a0034733
6. Eichenfield L. F., et al. Atopic dermatitis and asthma: Parallels in the evolution of treatment. Pediatrics. 2003;111(3):608–616. https://doi.org/10.1542/peds.111.3.608
7. Fabrazzo M, Cipolla S, Signoriello S, et al. Shared mechanisms of depression and anxiety in comorbidity with psoriasis and atopic dermatitis. European Psychiatry. 2021;64(1):e21. https://doi.org/10.1192/j.eurpsy.2021.2249
8. Gabryelska A, et al. Obstructive sleep apnea and serotoninergic signalling pathway: Pathomechanism and therapeutic potential. 1. International Journal of Molecular Sciences. 2024;25(4):1234. https://doi.org/10.3390/ijms25179427
9. Gelfand JM, et al. The risk of mortality in patients with psoriasis: Results from a population-based study. Arch Dermatol. 2007;143(12):1493–1499. https://doi.org/10.1001/archderm.143.12.1493
10. Hanifin JM, Rajka G. Diagnostic features of atopic eczema. Acta Derm Venereol (Stockh). 1980;92:44–47. https://doi.org/10.2340/00015555924447
11. Henseler T, Christophers E. Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris. J Am Acad Dermatol. 1985;13(3):450–456. https://doi.org/10.1016/s0190-9622(85)70188-0
12. Huang L, et al. Lower cerebrovascular reactivity in prefrontal cortex and weaker negative functional connectivity between prefrontal cortex and insula contribute to white matter hyperintensity-related anxiety or depression. Journal of Affective Disorders. 2024;320:123–130. https://doi.org/10.1016/j.jad.2024.03.094
13. Karrouri R, et al. Major depressive disorder: Validated treatments and future challenges. World Journal of Clinical Cases. 2021;9(31):9350–9367. https://doi.org/10.12998/wjcc.v9.i31.9350
14. Kuehner C. Why is depression more common among women than among men? Lancet Psychiatry. 2017;4(2):146–158. https://doi.org/10.1016/S2215-0366(16)30263-2
15. Zhang H., Wang M., Zhao X., Wang Y., Chen X., Su J. Role of stress in skin diseases: A neuroendocrine-immune interaction view. Brain, Behavior, and Immunity. 2024;116:286-302 https://doi.org/10.1016/j.bbi.2023.12.005
16. Ma Y. M., et al. Why is vestibular migraine associated with many comorbidities? Journal of Neurology. 2024;271(2):345–352. https://doi.org/10.1007/s00415-024-12692-8
17. Marek-Józefowicz L, Czajkowski R. The brain–skin axis in psoriasis—Psychological, psychiatric, hormonal, and dermatological aspects. International Journal of Molecular Sciences. 2022;23(15):12345. https://doi.org/10.3390/ijms23020669
18. McDonald C. J., Calabresi P. Psoriasis and occlusive vascular disease. Br J Dermatol. 1978;99(5):469–475. https://doi.org/10.1111/j.1365-2133.1978.tb02012.x
19. Owczarczyk-Saczonek A, Woźniak E. Psychological stress, mast cells, and psoriasis—Is there any relationship? International Journal of Molecular Sciences. 2021;22(17):1234. https://doi.org/10.3390/ijms222413252
20. Paula K, et al. Depression, anxiety, and suicidal ideation in patients with atopic eczema in a prospective study in Leipzig, Germany. Int Arch Allergy Immunol. 2022;183(4);409-414 https://doi.org/10.1159/000520159
21. Pereira MP, Huet F, Misery L, et al. Pruritus in autoimmune and inflammatory dermatoses. Frontiers in Immunology. 2019;10:1309. https://doi.org/10.3389/fimmu.2019.01303
22. Rajasekharan A, Munisamy M, Menon V, et al. Stress and psoriasis: Exploring the link through the prism of hypothalamo-pituitary-adrenal axis and inflammation. Journal of Psychosomatic Research. 2023;166:111350. https://doi.org/10.1016/j.jpsychores.2023.111350
23. Reed WB, Becker SW, Rohde R, Heiskell CL. Psoriasis and arthritis: Clinicopathologic study. Arch Dermatol. 1961;83(4):541–548. https://doi.org/10.1001/archderm.1961.01580100005001
24. Rosenzweig I. Periodic limb movements during sleep: A narrative review. Journal of Thoracic Disease. 2021;13(11):6476–6494. https://doi.org/10.21037/jtd-21-1353
25. Rukavishnikov G. V., Kibitov A. O., Mazo G. E., Neznanov N. G. Genetic comorbidity of depression and somatic disorders. S.S. Korsakov J Neurol Psychiatry. 2019;119(1):89–96. https://doi.org/10.17116/jnevro201911901189
26. Sarkar A, Jain M, Varma M, et al. Exploring astrocytes involvement and glutamate-induced neuroinflammation in chlorpyrifos-induced paradigm of autism spectrum disorders (ASD). Neurochemical Research. 2024;49(2):2573–2599. https://doi.org/10.1007/s11064-024-04191-z
27. Talamonti M, Galluzzo M, Silvaggio D, et al. Quality of life and psychological impact in patients with atopic dermatitis. Journal of Clinical Medicine. 2021;10(6):1298. https://doi.org/10.3390/jcm10061298
28. Weidinger S, O'Sullivan M, Illig T, et al. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J Allergy Clin Immunol. 2006;118(1):214–219. https://doi.org/10.1016/j.jaci.2006.05.004
29. Williams HC. Atopic eczema – Why we should look to the environment. BMJ. 1995;311(7013):1241–1242. https://doi.org/10.1136/bmj.311.7015.1241
30. Williams HC, Wüthrich B. The natural history of atopic dermatitis. Cambridge: Cambridge University Press; 2000. https://doi.org/10.1017/CBO9780511545771.005
31. World Health Organization. Depression Fact Sheet. 2019. https://www.who.int/news-room/fact-sheets/detail/depression
32. World Health Organization. International Classification of Diseases 11th Revision (ICD-11). 2022. https://icd.who.int/
33. Wu Z, Fang Y. Comorbidity of depressive and anxiety disorders: Challenges in diagnosis and assessment. Shanghai Arch Psychiatry. 2014;26(4):227–231. https://doi.org/10.3969/j.issn.1002-0829.2014.04.006
34. Yang X, Cai M. New insights into the mutual promotion of rosacea, anxiety, and depression from neuroendocrine immune aspects. Clinical, Cosmetic and Investigational Dermatology. 2023;16:1363–1371. https://doi.org/10.2147/CCID.S413237
35. Zhou Z, Meng L, Cai Y, et al. Exploration of the potential mechanism of the common differentially expressed genes in psoriasis and atopic dermatitis. Biomed Res Int. 2022;2022:1–12. https://doi.org/10.1155/2022/1177299
36. Kuryłło M., Mojs E. Psoriasis and atopic dermatitis in terms of psychosomatic effects. Acta Neuropsychologica. 2024;22(1):129-141. https://doi.org/10.5604/01.3001.0054.4465
37. Schlachter S., Sommer R., Augustin M. A Comparative Analysis of the Predictors, Extent and Impacts of Self-stigma in Patients with Psoriasis and Atopic Dermatitis. Acta Dermato-Venereologica. 2023;103:adv3962 https://doi.org/10.2340/actadv.v103.3962
38. Woo YR., Park CJ., Kang H., et al. The risk of systemic diseases in those with psoriasis and psoriatic arthritis: from mechanisms to clinic. International Journal of Molecular Sciences 2020;21(19):7041 https://doi.org/10.3390/ijms21197041
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