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Quality in Sport

The impact of garlic use on human health. A review of its therapeutic potential and application in athletes
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  3. Vol. 41 (2025) /
  4. Health Sciences

The impact of garlic use on human health. A review of its therapeutic potential and application in athletes

Authors

  • Michał Borawski https://orcid.org/0009-0008-4864-7336
  • Aleksandra Ciuła Brothers Hospitallers of Saint John of God Hospital in Cracow Trynitarska 11, 31-061 Cracow, Poland https://orcid.org/0009-0000-0425-863X
  • Anna Jakubiak National Medical Institute of the Ministry of the Interior and Administration Wołoska 137, 02-507 Warsaw, Poland https://orcid.org/0009-0004-0973-7591
  • Joanna Miśkiewicz Provincial Combined Hospital in Kielce, Grunwaldzka 45, 25-736 Kielce, Poland https://orcid.org/0009-0002-3300-940X
  • Klaudia Mularczyk Międzylesie Specialist Hospital in Warsaw Bursztynowa 2, 04-749 Warsaw, Poland https://orcid.org/0009-0008-3250-7806
  • Łukasz Karaban Międzylesie Specialist Hospital in Warsaw Bursztynowa 2, 04-749 Warsaw, Poland https://orcid.org/0009-0001-9285-469X
  • Magdalena Kupis Casimir Pulaski University of Radom, Faculty of Medical Sciences and Health Sciences https://orcid.org/0009-0009-4454-5866
  • Tadeusz Kuźnieców Międzylesie Specialist Hospital in Warsaw, Bursztynowa 2, 04-749 Warsaw, Poland https://orcid.org/0009-0000-2120-9549
  • Patrycja Znamirowska Specialist Hospital Dr. Tytus Chałubiński in Radom Lekarska 4, 26-610 Radom, Poland https://orcid.org/0009-0002-7538-5315
  • Monika Paszkowska Międzylesie Specialist Hospital in Warsaw Bursztynowa 2, 04-749 Warsaw, Poland https://orcid.org/0009-0009-2006-0098

DOI:

https://doi.org/10.12775/QS.2025.41.60337

Keywords

garlic, hypertension, cardiovascular disease, exercise, muscle adaptation, phytochemicals, cancer, retinopathy, brain perfusion

Abstract

The abundance of bioactive compounds present in garlic positions it as a promising agent in the support of human health. This paper constitutes a review of scientific literature published over the past five years, with sources identified through a search of the PubMed database. The review explores the effects of garlic on hypertension, lipid metabolism, atherosclerosis, retinopathy, physical performance, organ perfusion, and the risk of developing certain malignancies — particularly gastric and prostate cancers. Current research indicates that regular garlic consumption may contribute to the reduction of blood pressure, improvement of lipid profiles, and attenuation of oxidative stress and inflammatory markers. Furthermore, it may decrease the risk of vascular complications and the incidence of selected cancers. Evidence also suggests a beneficial impact on cerebral perfusion and a reduction in symptoms of erectile dysfunction. Nonetheless, further clinical trials employing rigorous methodologies are required to definitively establish its efficacy.

References

[1] Serrano JCE, Castro-Boqué E, García-Carrasco A, et al. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. Nutrients. 2023; 15(17):3691. Published 2023 Aug 23. doi:10.3390/nu15173691

[2] Canoy D, Nazarzadeh M, Copland E, et al. How Much Lowering of Blood Pressure Is Required to Prevent Cardiovascular Disease in Patients With and Without Previous Cardiovascular Disease?. Curr Cardiol Rep. 2022; 24(7):851-860. DOI:10.1007/S11886-022-01706-4

[3] Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016; 387(10022):957-967. doi:10.1016/S0140-6736(15)01225-8

[4] Lewington S, Clarke R, Qizilbash N, Peto R, Collins R; Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies [published correction appears in Lancet. 2003 Mar 22; 361(9362):1060]. Lancet. 2002; 360(9349):1903-1913. doi:10.1016/s0140-6736(02)11911-8

[5] Bliziotis IA, Destounis A, Stergiou GS. Home versus ambulatory and office blood pressure in predicting target organ damage in hypertension: a systematic review and meta-analysis. J Hypertens. 2012; 30(7):1289-1299. doi:10.1097/HJH.0b013e3283531eaf

[6] Valls RM, Companys J, Calderón-Pérez L, et al. Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustained, and Controlled Study. Nutrients. 2022; 14(3):405. Published 2022 Jan 18. doi:10.3390/nu14030405

[7] Cheng IS, Tsao JP, Bernard JR, Tsai TW, Chang CC, Liao SF. Oral post-exercise garlic extract supplementation enhances glycogen replenishment but does not up-regulate mitochondria biogenesis mRNA expression in human-exercised skeletal muscle. J Int Soc Sports Nutr. 2024; 21(1):2336095. doi:10.1080/15502783.2024.2336095

[8] Tsao JP, Bernard JR, Tu TH, et al. Garlic supplementation attenuates cycling exercise-induced oxidative inflammation but fails to improve time trial performance in healthy adults. J Int Soc Sports Nutr. 2023; 20(1):2206809. doi:10.1080/15502783.2023.2206809

[9] Villaño D, Marhuenda J, Arcusa R, et al. Effect of Black Garlic Consumption on Endothelial Function and Lipid Profile: A Before-and-After Study in Hypercholesterolemic and Non-Hypercholesterolemic Subjects. Nutrients. 2023; 15(14):3138. Published 2023 Jul 14. doi:10.3390/nu15143138

[10] Vezza T, Guillamón E, García-García J, et al. LDL-Cholesterol-Lowering Effects of a Dietary Supplement Containing Onion and Garlic Extract Used in Healthy Volunteers. Nutrients. 2024; 16(16):2811. Published 2024 Aug 22. doi:10.3390/nu16162811

[11] Włosińska M, Nilsson AC, Hlebowicz J, et al. The effect of aged garlic extract on the atherosclerotic process - a randomized double-blind placebo-controlled trial. BMC Complement Med Ther. 2020; 20(1):132. Published 2020 Apr 29. doi:10.1186/s12906-020-02932-5

[12] Afarid M, Sadeghi E, Johari M, Namvar E, Sanie-Jahromi F. Evaluation of the Effect of Garlic Tablet as a Complementary Treatment for Patients with Diabetic Retinopathy. J Diabetes Res. 2022;2022:6620661. Published 2022 Jul 14th doi:10.1155/2022/6620661

[13] Guo Y, Li ZX, Zhang JY, et al. Association Between Lifestyle Factors, Vitamin and Garlic Supplementation, and Gastric Cancer Outcomes: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2020; 3(6):e206628. Published 2020 Jun 1. doi:10.1001/jamanetworkopen.2020.6628

[14] Gail MH, You WC, Chang YS, et al. Factorial trial of three interventions to reduce the progression of precancerous gastric lesions in Shandong, China: design issues and initial data. Control Clin Trials. 1998; 19(4):352-369. doi:10.1016/s0197-2456(98)00016-6

[15] You WC, Brown LM, Zhang L, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst. 2006; 98(14):974-983. DOI:10.1093/jnci/DJJ264

[16] Ma JL, Zhang L, Brown LM, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 2012; 104(6):488-492. doi:10.1093/jnci/djs003

[17] Li WQ, Ma JL, Zhang L, et al. Effects of Helicobacter pylori treatment on gastric cancer incidence and mortality in subgroups. J Natl Cancer Inst. 2014; 106(7):d ju116. Published 2014 Jun 12. doi:10.1093/jnci/dju116

[18] Li WQ, Zhang JY, Ma JL, et al. Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. BMJ. 2019; 366:L5016. Published 2019 Sep 11. doi:10.1136/bmj.l5016

[19] Milner JA. A historical perspective on garlic and cancer. J Nutr. 2001; 131(3s):1027S-31S. doi:10.1093/jn/131.3.1027S

[20] Capurso G, Lahner E. The interaction between smoking, alcohol and the gut microbiome. Best Pract Res Clin Gastroenterol. 2017; 31(5):579-588. doi:10.1016/j.bpg.2017.10.006

[21] Lee IC, Baek HS, Kim SH, et al. Effect of diallyl disulfide on acute gastric mucosal damage induced by alcohol in rats. Hum Exp Toxicol. 2015; 34(3):227-239. doi:10.1177/0960327114537095

[22] Livingstone TL, Saha S, Bernuzzi F, et al. Accumulation of Sulforaphane and Alliin in Human Prostate Tissue. Nutrients. 2022; 14(16):3263. Published 2022 Aug 10. doi:10.3390/nu14163263

[23] Baik JS, Min JH, Ju SM, et al. Effects of Fermented Garlic Extract Containing Nitric Oxide Metabolites on Blood Flow in Healthy Participants: A Randomized Controlled Trial. Nutrients. 2022; 14(24):5238. Published 2022 Dec 8. doi:10.3390/nu14245238

[24] Bhat G.S., Shastry A. Prospective, randomized, placebo-controlled, two-arm study to evaluate the efficacy of coadministration of garlic as a hydrogen sulfide donor and tadalafil in patients with erectile dysfunction not responding to tadalafil alone - A pilot study. Indian J Pharmacol. 2024; 56(4):242-247. doi:10.4103/ijp.ijp_310_23

[25] Bara-Ledesma N, Jimenez-Esteban J, Fabregate M, et al. Effect of Encapsulated Purple Garlic Oil on Microvascular Function and the Components of Metabolic Syndrome: A Randomized Placebo-Controlled Study-The ENDOTALLIUM Study. Nutrients. 2024; 16(11):1755. Published 2024 Jun 3. doi:10.3390/nu16111755

[26] Lindstedt S, Włosinska M, Nilsson AC, Hlebowicz J, Fakhro M, Sheikh R. Successful improved peripheral tissue perfusion was seen in patients with atherosclerosis after 12 months of treatment with aged garlic extract. Int Wound J. 2021; 18(5):681-691. doi:10.1111/iwj.13570

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Published

2025-05-12

How to Cite

1.
BORAWSKI, Michał, CIUŁA, Aleksandra, JAKUBIAK, Anna, MIŚKIEWICZ, Joanna, MULARCZYK, Klaudia, KARABAN, Łukasz, KUPIS, Magdalena, KUŹNIECÓW, Tadeusz, ZNAMIROWSKA, Patrycja and PASZKOWSKA, Monika. The impact of garlic use on human health. A review of its therapeutic potential and application in athletes. Quality in Sport. Online. 12 May 2025. Vol. 41, p. 60337. [Accessed 15 May 2025]. DOI 10.12775/QS.2025.41.60337.
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Issue

Vol. 41 (2025)

Section

Health Sciences

License

Copyright (c) 2025 Michał Borawski, Aleksandra Ciuła, Anna Jakubiak, Joanna Miśkiewicz, Klaudia Mularczyk, Łukasz Karaban, Magdalena Kupis, Tadeusz Kuźnieców, Patrycja Znamirowska, Monika Paszkowska

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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