The influence of diet on patients suffering from Fibromyalgia Syndrome
DOI:
https://doi.org/10.12775/QS.2025.41.60298Keywords
Fibromyalgia, anti-inflammatory diet, chronic pain, lifestyle modification, Vitamin DAbstract
Fibromyalgia is a chronic centralized pain syndrome characterized by disordered transmission of pain stimuli. The symptoms of fibromyalgia are very diverse and patients often experience musculoskeletal pain, fatigue, psychiatric disorders (especially depression), sleep disturbances and gastrointestinal disorders. Since there is no cure for fibromyalgia, the proper diagnosis of the illness and consequently treating fibromyalgia effectively are key factors for reducing symptoms and improving a patient's quality of life. The review article shows different nutritional approaches on FM patients that have been researched in recent years and are key factor for integrated recovery plan and managing symptoms. Patients may benefit not only from proper treatment, physiotherapy and psychotherapy, but also from concrete nutritional approach which can influence inflammatory processes and central sensitization which are considered nowadays to play a major role in pathogenesis of the illness. There is not enough evidence that specific diet therapy is to be considered for the treatment of FM. However, overall studies revealed that weight control, anti-inflammatory diets, and vitamin D supplementation are beneficial in managing FM symptoms but further research is needed in this matter.
Materials and Methods
Systematic literature review was conducted using PubMed, Web of Science and Google Scholar databases. The search covered studies published between 2001 and 2024. The review was performed according to preferred reporting items for peer-reviewed articles, randomized controlled trials, systematic reviews and meta-analyses. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.
References
1. Bellato, Enrico, Eleonora Marini, Filippo Castoldi, Nicola Barbasetti, Lorenzo Mattei, Davide Edoardo Bonasia, and Davide Blonna. 2012. “Fibromyalgia Syndrome: Etiology, Pathogenesis, Diagnosis, and Treatment.” Pain Research and Treatment 2012 (November): 426130.
2.Siracusa, Rosalba, Rosanna Di Paola, Salvatore Cuzzocrea, and Daniela. Impellizzeri.2021. “Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update.” International Journal of Molecular Sciences 22 (8): 3891.
3. Mease, Philip. 2005. “Fibromyalgia Syndrome: Review of Clinical Presentation, Pathogenesis, Outcome Measures, and Treatment.” The Journal of Rheumatology. Supplement 75 (August): 6–21.
4. Badaeva, Anastasiia, Alexey Danilov, Anastasiia Kosareva, Mariia Lepshina, Viacheslav Novikov, Yulia Vorobyeva, and Andrey Danilov. 2024. “Neuronutritional Approach to Fibromyalgia Management: A Narrative Review.” Pain and Therapy 13 (5): 1047–61.
5. Wallace, D. J., M. Linker-Israeli, D. Hallegua, S. Silverman, D. Silver, and M. H. Weisman. 2001. “Cytokines Play an Aetiopathogenetic Role in Fibromyalgia: A Hypothesis and Pilot Study.” Rheumatology (Oxford, England) 40 (7): 743–49.
6. Haghighatdoost, Fahimeh, Nick Bellissimo, Julia O. Totosy de Zepetnek, and Mohammad Hossein Rouhani. 2017. “Association of Vegetarian Diet with Inflammatory Biomarkers: A Systematic Review and Meta-Analysis of Observational Studies.” Public Health Nutrition 20 (15): 2713–21.
7. Melina, Vesanto, Winston Craig, and Susan Levin. 2016. “Position of the Academy of Nutrition and Dietetics: Vegetarian Diets.” Journal of the Academy of Nutrition and Dietetics 116 (12): 1970–80.
8. Craddock, Joel C., Elizabeth P. Neale, Gregory E. Peoples, and Yasmine C. Probst. 2019. “Vegetarian-Based Dietary Patterns and Their Relation with Inflammatory and Immune Biomarkers: A Systematic Review and Meta-Analysis.” Advances in Nutrition (Bethesda, Md.) 10 (3): 433–51.
9. Aleksandrova, Krasimira, Liselot Koelman, and Caue Egea Rodrigues. 2021. “Dietary Patterns and Biomarkers of Oxidative Stress and Inflammation: A Systematic Review of Observational and Intervention Studies.” Redox Biology 42 (101869): 101869.
10. Martínez-Rodríguez, Alejandro, Jacobo Á. Rubio-Arias, Domingo J. Ramos-Campo, Cristina Reche-García, Belén Leyva-Vela, and Yolanda Nadal-Nicolás. 2020. “Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia.” International Journal of Environmental Research and Public Health 17 (7): 2227.
11. Silva, Ana Rita, Alexandra Bernardo, João Costa, Alexandra Cardoso, Paula Santos, Maria Fernanda de Mesquita, José Vaz Patto, Pedro Moreira, Maria Leonor Silva, and Patrícia Padrão. 2019. “Dietary Interventions in Fibromyalgia: A Systematic Review.” Annals of Medicine 51 (sup1): 2–14.
12. Marum, Ana Paula, Cátia Moreira, Fernando Saraiva, Pablo Tomas-Carus, and Catarina Sousa-Guerreiro. 2016. “A Low Fermentable Oligo-Di-Mono Saccharides and Polyols (FODMAP) Diet Reduced Pain and Improved Daily Life in Fibromyalgia Patients.” Scandinavian Journal of Pain 13 (October): 166–72.
13. Shapiro, Jennifer R., Drew A. Anderson, and Sharon Danoff-Burg. 2005. “A Pilot Study of the Effects of Behavioral Weight Loss Treatment on Fibromyalgia Symptoms.” Journal of Psychosomatic Research 59 (5): 275–82.
14. Casini, Ilenia, Valeria Ladisa, Livio Clemente, Marianna Delussi, Elvira Rostanzo, Sofia Peparini, Anna Maria Aloisi, and Marina de Tommaso. 2024. “A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia.” Pain and Therapy 13 (3): 609–20.
15. Berbert, Alair Alfredo, Cacilda Rosa Mitiko Kondo, Cecília Lisete Almendra, Tiemi Matsuo, and Isaias Dichi. 2005. “Supplementation of Fish Oil and Olive Oil in Patients with Rheumatoid Arthritis.” Nutrition (Burbank, Los Angeles County, Calif.) 21 (2): 131–36.
16. Shapiro, Jennifer R., Drew A. Anderson, and Sharon Danoff-Burg. 2005. “A Pilot Study of the Effects of Behavioral Weight Loss Treatment on Fibromyalgia Symptoms.” Journal of Psychosomatic Research 59 (5): 275–82.
17. Senna, Mohammed Kamal, Rehab Abd-El Raouf Sallam, Hala Salah Ashour, and Mohammed Elarman. 2012. “Effect of Weight Reduction on the Quality of Life in Obese Patients with Fibromyalgia Syndrome: A Randomized Controlled Trial.” Clinical Rheumatology 31 (11): 1591–97.
18. Aman, Mansoor M., R. Jason Yong, Alan David Kaye, and Richard D. Urman. 2018. “Evidence-Based Non-Pharmacological Therapies for Fibromyalgia.” Current Pain and Headache Reports 22 (5): 33.
19. Rodrigo, Luis, Ignacio Blanco, Julio Bobes, and Frederick J. de Serres. 2013. “Clinical Impact of a Gluten-Free Diet on Health-Related Quality of Life in Seven Fibromyalgia Syndrome Patients with Associated Celiac Disease.” BMC Gastroenterology 13 (1): 157.
20. Rodrigo, Luis, Ignacio Blanco, Julio Bobes, and Frederick J. de Serres. 2014. “Effect of One Year of a Gluten-Free Diet on the Clinical Evolution of Irritable Bowel Syndrome plus Fibromyalgia in Patients with Associated Lymphocytic Enteritis: A Case-Control Study.” Arthritis Research & Therapy 16 (4): 421.
21. Isasi, Carlos, Isabel Colmenero, Fernando Casco, Eva Tejerina, Natalia Fernandez, José I. Serrano-Vela, Maria J. Castro, and Luis F. Villa. 2014. “Fibromyalgia and Non-Celiac Gluten Sensitivity: A Description with Remission of Fibromyalgia.” Rheumatology International 34 (11): 1607–12.
22. Slim, Mahmoud, Elena P. Calandre, Juan M. Garcia-Leiva, Fernando Rico-Villademoros, Rocio Molina-Barea, Carmen M. Rodriguez-Lopez, and Piedad Morillas-Arques. 2017. “The Effects of a Gluten-Free Diet versus a Hypocaloric Diet among Patients with Fibromyalgia Experiencing Gluten Sensitivity-like Symptoms: A Pilot, Open-Label Randomized Clinical Trial.” Journal of Clinical Gastroenterology 51 (6): 500–507.
23. Ellis, Shawn D., Sam T. Kelly, Jonathan H. Shurlock, and Alastair L. N. Hepburn. 2018. “The Role of Vitamin D Testing and Replacement in Fibromyalgia: A Systematic Literature Review.” BMC Rheumatology 2 (1): 28.
24. Habib, Abdella M., Karim Nagi, Nagendra Babu Thillaiappan, Vijayakumar Sukumaran, and Saghir Akhtar. 2020. “Vitamin D and Its Potential Interplay with Pain Signaling Pathways.” Frontiers in Immunology 11 (May): 820.
25. Holick, Michael F. 2007. “Vitamin D Deficiency.” The New England Journal of Medicine 357 (3): 266–81.
26. Al-Allaf, A. W., P. A. Mole, C. R. Paterson, and T. Pullar. 2003. “Bone Health in Patients with Fibromyalgia.” Rheumatology (Oxford, England) 42 (10): 1202–6.
27. Arvold, David S., Marilyn J. Odean, Maude P. Dornfeld, Ronald R. Regal, Judith G. Arvold, Gene C. Karwoski, David J. Mast, Paul B. Sanford, and Robert J. Sjoberg. 2009. “Correlation of Symptoms with Vitamin D Deficiency and Symptom Response to Cholecalciferol Treatment: A Randomized Controlled Trial.” Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 15 (3): 203–12.
28. Mirzaei, Alireza, Mozhdeh Zabihiyeganeh, Seyed Adel Jahed, Elnaz Khiabani, Marzieh Nojomi, and Salman Ghaffari. 2018. “Effects of Vitamin D Optimization on Quality of Life of Patients with Fibromyalgia: A Randomized Controlled Trial.” Medical Journal of the Islamic Republic of Iran 32 (1): 29.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Monika Wendland, Justyna Janikowska, Agata Żak-Gontarz, Julia Piotrowska, Adrianna Domańska, Aleksandra Łubińska-Kowalska, Aleksandra Minda, Antonina Teresa Witkowska, Krzysztof Julian Długosz, Barbara Anna Zapalska, Adrianna Witkowska

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Stats
Number of views and downloads: 135
Number of citations: 0