Creatine as a Compound and Supplement Metabolism, Mechanism of Action, Effects, and Adverse Effects - A Review
DOI:
https://doi.org/10.12775/QS.2025.41.60164Keywords
creatine, creatine supplementation, creatine monohydrate, creatine supplementation in eldery patients, creatine supplementation in children and adolescents, creatine adverse effects, creatine renal failure, creatine metabolysm, creatine in sportAbstract
In a world of evolving athletic competition and scientific advancement, the pursuit of optimal supplement applications to achieve peak performance should come as no surprise. One of the most popular and extensively researched supplements is creatine, for which numerous studies over many years have supported its positive impact on athletic and strength performance, as well as muscle and strength gains. Over time, attention has also shifted toward exploring creatine’s potential applications in other areas of medicine, as well as its use across various populations and age groups. Currently, the significance and importance of creatine are being highlighted not only in the context of its use across various sports disciplines, but also for its demonstrated beneficial effects in a range of medical conditions. These include improved prognosis in osteoporosis, osteopenia, and age-related sarcopenia, as well as its neuroprotective effects- for example, in brain injuries, ischemic diseases, diabetes, and other related conditions. Creatine, a compound naturally present in the human body- both endogenously synthesized and obtained through dietary intake- can also be consumed as a supplement, exhibiting excellent bioavailability that results in tissue saturation, primarily within muscle tissue. Due to its well-documented positive effects, and being recognized as a safe supplement with virtually no significant adverse or health-compromising effects, creatine continues to grow in popularity. Given its approval for use by organizations such as the International Olympic Committee and the endorsement of the International Society of Sports Nutrition, it is well on its way to becoming a leading supplement on the market. It is increasingly used by professional and amateur athletes, but also by a wide range of other populations across various age groups. Additionally, the concept of lifelong creatine supplementation is being increasingly discussed as a potentially beneficial strategy.
References
1. Antonio J, Pereira F, Curtis J, Rojas J, Evans C. The Top 5 Can’t-Miss Sport Supplements. Nutrients. 2024 Sep 26;16(19):3247.
2. Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017 Jun 13;14(1):18.
3. Persky AM, Rawson ES. Safety of creatine supplementation. Subcell Biochem. 2007;46:275–89.
4. Harris RC, Söderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci Lond Engl 1979. 1992 Sep;83(3):367–74.
5. Walker JB. Creatine: biosynthesis, regulation, and function. Adv Enzymol Relat Areas Mol Biol. 1979;50:177–242.
6. Greenhaff PL. The nutritional biochemistry of creatine. J Nutr Biochem. 1997 Nov 1;8(11):610–8.
7. Christensen M, Hartmund T, Gesser H. Creatine kinase, energy-rich phosphates and energy metabolism in heart muscle of different vertebrates. J Comp Physiol [B]. 1994;164(2):118–23.
8. Lee HJ, Fillers WS, Iyengar MR. Phosphocreatine, an intracellular high-energy compound, is found in the extracellular fluid of the seminal vesicles in mice and rats. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7265–9.
9. Kushmerick MJ, Moerland TS, Wiseman RW. Mammalian skeletal muscle fibers distinguished by contents of phosphocreatine, ATP, and Pi. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7521–5.
10. Delanghe J, De Slypere JP, De Buyzere M, Robbrecht J, Wieme R, Vermeulen A. Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians. Clin Chem. 1989 Aug;35(8):1802–3.
11. Berlet HH, Bonsmann I, Birringer H. Occurrence of free creatine, phosphocreatine and creatine phosphokinase in adipose tissue. Biochim Biophys Acta. 1976 Jun 23;437(1):166–74.
12. Wallimann T, Wegmann G, Moser H, Huber R, Eppenberger HM. High content of creatine kinase in chicken retina: compartmentalized localization of creatine kinase isoenzymes in photoreceptor cells. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3816–9.
13. Wallimann T, Moser H, Zurbriggen B, Wegmann G, Eppenberger HM. Creatine kinase isoenzymes in spermatozoa. J Muscle Res Cell Motil. 1986 Feb;7(1):25–34.
14. Wyss M, Kaddurah-Daouk R. Creatine and Creatinine Metabolism. Physiol Rev. 2000 Jul;80(3):1107–213.
15. Walser M. Creatinine Excretion as a Measure of Protein Nutrition in Adults of Varying Age. J Parenter Enter Nutr. 1987;11(5S):73S-78S.
16. Hultman E, Söderlund K, Timmons JA, Cederblad G, Greenhaff PL. Muscle creatine loading in men. J Appl Physiol Bethesda Md 1985. 1996 Jul;81(1):232–7.
17. Balsom PD, Söderlund K, Ekblom B. Creatine in humans with special reference to creatine supplementation. Sports Med Auckl NZ. 1994 Oct;18(4):268–80.
18. Paddon-Jones D, Børsheim E, Wolfe RR. Potential ergogenic effects of arginine and creatine supplementation. J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S; discussion 2895S.
19. Brosnan ME, Brosnan JT. The role of dietary creatine. Amino Acids. 2016 Aug;48(8):1785–91.
20. Burke DG, Chilibeck PD, Parise G, Candow DG, Mahoney D, Tarnopolsky M. Effect of creatine and weight training on muscle creatine and performance in vegetarians. Med Sci Sports Exerc. 2003 Nov;35(11):1946–55.
21. Benton D, Donohoe R. The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. Br J Nutr. 2011 Apr;105(7):1100–5.
22. Pirlich M, Selberg O, Böker K, Schwarze M, Müller MJ. The creatinine approach to estimate skeletal muscle mass in patients with cirrhosis. Hepatol Baltim Md. 1996 Dec;24(6):1422–7.
23. Virgili F, Maiani G, Zahoor ZH, Ciarapica D, Raguzzini A, Ferro-Luzzi A. Relationship between fat-free mass and urinary excretion of creatinine and 3-methylhistidine in adult humans. J Appl Physiol. 1994 May;76(5):1946–50.
24. Kreider RB, Melton C, Rasmussen CJ, Greenwood M, Lancaster S, Cantler EC, et al. Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Mol Cell Biochem. 2003 Feb;244(1–2):95–104.
25. Smith JC, Hill DW. Contribution of energy systems during a Wingate power test. Br J Sports Med. 1991 Dec;25(4):196–9.
26. Branch JD. Effect of Creatine Supplementation on Body Composition and Performance: A Meta-analysis. 2003 Jun 1 [cited 2025 Mar 20]; Available from: https://journals.humankinetics.com/view/journals/ijsnem/13/2/article-p198.xml
27. Cooper R, Naclerio ,Fernando, Allgrove ,Judith, and Jimenez A. Creatine supplementation with specific view to exercise/sports performance: an update. J Int Soc Sports Nutr. 2012 Jul 20;9(1):33.
28. Vicente-Salar N, Santos-Sánchez G, Roche E. Nutritional Ergogenic Aids in Racquet Sports: A Systematic Review. Nutrients. 2020 Sep;12(9):2842.
29. Pluim BM, Ferrauti A, Broekhof F, Deutekom M, Gotzmann A, Kuipers H, et al. The effects of creatine supplementation on selected factors of tennis specific training. Br J Sports Med. 2006 Jun;40(6):507–11; discussion 511-512.
30. Eijnde BO ’t, Vergauwen L, Hespel P. Creatine Loading does not Impact on Stroke Performance in Tennis. Int J Sports Med. 2001 Dec 31;22:76–80.
31. Stone MH, Sanborn K, Smith LL, O’Bryant HS, Hoke T, Utter AC, et al. Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr. 1999 Jun;9(2):146–65.
32. Bemben MG, Bemben DA, Loftiss DD, Knehans AW. Creatine supplementation during resistance training in college football athletes. Med Sci Sports Exerc. 2001 Oct;33(10):1667–73.
33. Crisafulli DL, Buddhadev ,Harsh H., Brilla ,Lorrie R., Chalmers ,Gordon R., Suprak ,David N., and San Juan JG. Creatine-electrolyte supplementation improves repeated sprint cycling performance: A double blind randomized control study. J Int Soc Sports Nutr. 2018 May 2;15(1):21.
34. Tomcik KA, Camera DM, Bone JL, Ross ML, Jeacocke NA, Tachtsis B, et al. Effects of Creatine and Carbohydrate Loading on Cycling Time Trial Performance. Med Sci Sports Exerc. 2018 Jan;50(1):141–50.
35. Hultman E, Greenhaff PL. Skeletal muscle energy metabolism and fatigue during intense exercise in man. Sci Prog. 1991;75(298 Pt 3-4):361–70.
36. Hirvonen J, Rehunen S, Rusko H, Härkönen M. Breakdown of high-energy phosphate compounds and lactate accumulation during short supramaximal exercise. Eur J Appl Physiol. 1987 May 1;56(3):253–9.
37. Kreider RB. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 2003 Feb;244(1–2):89–94.
38. Kreider RB, Ferreira M, Wilson M, Grindstaff P, Plisk S, Reinardy J, et al. Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc. 1998 Jan;30(1):73–82.
39. Kerksick CM, Wilborn CD, Campbell WI, Harvey TM, Marcello BM, Roberts MD, et al. The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations. J Strength Cond Res. 2009 Dec;23(9):2673–82.
40. Claudino JG, Mezêncio B, Amaral S, Zanetti V, Benatti F, Roschel H, et al. Creatine monohydrate supplementation on lower-limb muscle power in Brazilian elite soccer players. J Int Soc Sports Nutr. 2014;11:32.
41. Ramírez-Campillo R, González-Jurado JA, Martínez C, Nakamura FY, Peñailillo L, Meylan CMP, et al. Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players. J Sci Med Sport. 2016 Aug;19(8):682–7.
42. Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000 Dec;10(4):452–63.
43. Ayoama R, Hiruma E, Sasaki H. Effects of creatine loading on muscular strength and endurance of female softball players. J Sports Med Phys Fitness. 2003 Dec;43(4):481–7.
44. Syrotuik DG, Bell GJ. Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders. J Strength Cond Res. 2004 Aug;18(3):610–7.
45. Gualano B, Rawson ES, Candow DG, Chilibeck PD. Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain. Amino Acids. 2016 Aug 1;48(8):1793–805.
46. Chilibeck PD, Kaviani ,Mojtaba, Candow ,Darren G, and Zello GA. Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis. Open Access J Sports Med. 2017 Nov 2;8:213–26.
47. Burke R, Piñero A, Coleman M, Mohan A, Sapuppo M, Augustin F, et al. The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis. Nutrients. 2023 Apr 28;15(9):2116.
48. Wu SH, Chen KL, Hsu C, Chen HC, Chen JY, Yu SY, et al. Creatine Supplementation for Muscle Growth: A Scoping Review of Randomized Clinical Trials from 2012 to 2021. Nutrients. 2022 Mar 16;14(6):1255.
49. Cribb PJ, Williams AD, Hayes A. A creatine-protein-carbohydrate supplement enhances responses to resistance training. Med Sci Sports Exerc. 2007 Nov;39(11):1960–8.
50. Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, et al. Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Int J Sport Nutr Exerc Metab. 2008 Aug;18(4):389–98.
51. Forbes SC, Candow DG, Ostojic SM, Roberts MD, Chilibeck PD. Meta-Analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults. Nutrients. 2021 Jun 2;13(6):1912.
52. Wang CC, Fang CC, Lee YH, Yang MT, Chan KH. Effects of 4-Week Creatine Supplementation Combined with Complex Training on Muscle Damage and Sport Performance. Nutrients. 2018 Nov 2;10(11):1640.
53. Volek JS, Kraemer WJ, Bush JA, Boetes M, Incledon T, Clark KL, et al. Creatine Supplementation Enhances Muscular Performance During High-Intensity Resistance Exercise. J Am Diet Assoc. 1997 Jul 1;97(7):765–70.
54. Volek JS, Duncan ND, Mazzetti SA, Staron RS, Putukian M, Gómez AL, et al. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc. 1999 Aug;31(8):1147–56.
55. Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1. Mol Cell Endocrinol. 2010 Apr 12;317(1–2):25–30.
56. Sale C, Harris RC, Florance J, Kumps A, Sanvura R, Poortmans JR. Urinary creatine and methylamine excretion following 4 x 5 g x day(-1) or 20 x 1 g x day(-1) of creatine monohydrate for 5 days. J Sports Sci. 2009 May;27(7):759–66.
57. Ostojic SM, Ahmetovic Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent? Res Sports Med Print. 2008;16(1):15–22.
58. Greenhaff PL, Casey A, Short AH, Harris R, Soderlund K, Hultman E. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci Lond Engl 1979. 1993 May;84(5):565–71.
59. Jäger R, Purpura M, Shao A, Inoue T, Kreider RB. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids. 2011 May;40(5):1369–83.
60. Deldicque L, Décombaz J, Zbinden Foncea H, Vuichoud J, Poortmans JR, Francaux M. Kinetics of creatine ingested as a food ingredient. Eur J Appl Physiol. 2008 Jan;102(2):133–43.
61. Persky AM, Brazeau GA, Hochhaus G. Pharmacokinetics of the dietary supplement creatine. Clin Pharmacokinet. 2003;42(6):557–74.
62. Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev. 2001 Jun;53(2):161–76.
63. Snow RJ, Murphy RM. Creatine and the creatine transporter: a review. Mol Cell Biochem. 2001 Aug;224(1–2):169–81.
64. Jäger R, Harris RC, Purpura M, Francaux M. Comparison of new forms of creatine in raising plasma creatine levels. J Int Soc Sports Nutr. 2007 Nov 12;4:17.
65. Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, et al. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Int Soc Sports Nutr. 2021 Feb 8;18(1):13.
66. Ribeiro AS, Avelar A, Kassiano W, Nunes JP, Schoenfeld BJ, Aguiar AF, et al. Creatine Supplementation Does Not Influence the Ratio Between Intracellular Water and Skeletal Muscle Mass in Resistance-Trained Men. Int J Sport Nutr Exerc Metab. 2020 Nov 1;30(6):405–11.
67. Spillane M, Schoch R, Cooke M, Harvey T, Greenwood M, Kreider R, et al. The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. J Int Soc Sports Nutr. 2009 Feb 19;6:6.
68. Rawson ES, Stec MJ, Frederickson SJ, Miles MP. Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain. Nutr Burbank Los Angel Cty Calif. 2011 Apr;27(4):451–5.
69. Powers ME, Arnold BL, Weltman AL, Perrin DH, Mistry D, Kahler DM, et al. Creatine Supplementation Increases Total Body Water Without Altering Fluid Distribution. J Athl Train. 2003;38(1):44–50.
70. Jagim AR, Stecker RA, Harty PS, Erickson JL, Kerksick CM. Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review. Front Nutr. 2018 Nov 28;5:115.
71. Tarnopolsky MA, Mahoney DJ, Vajsar J, Rodriguez C, Doherty TJ, Roy BD, et al. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Neurology. 2004 May 25;62(10):1771–7.
72. Sakellaris G, Kotsiou M, Tamiolaki M, Kalostos G, Tsapaki E, Spanaki M, et al. Prevention of complications related to traumatic brain injury in children and adolescents with creatine administration: an open label randomized pilot study. J Trauma. 2006 Aug;61(2):322–9.
73. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jul 1;48(4):601.
74. Bermon S, Venembre P, Sachet C, Valour S, Dolisi C. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand. 1998 Oct;164(2):147–55.
75. Chami J, Candow DG. Effect of Creatine Supplementation Dosing Strategies on Aging Muscle Performance. J Nutr Health Aging. 2019;23(3):281–5.
76. Baker TP, Candow DG, Farthing JP. Effect of Preexercise Creatine Ingestion on Muscle Performance in Healthy Aging Males. J Strength Cond Res. 2016 Jun;30(6):1763–6.
77. Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA, Kazachkov M, et al. Low-dose creatine combined with protein during resistance training in older men. Med Sci Sports Exerc. 2008 Sep;40(9):1645–52.
78. Chilibeck PD, Chrusch MJ, Chad KE, Shawn Davison K, Burke DG. Creatine monohydrate and resistance training increase bone mineral content and density in older men. J Nutr Health Aging. 2005;9(5):352–3.
79. Chilibeck PD, Candow DG, Landeryou T, Kaviani M, Paus-Jenssen L. Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women. Med Sci Sports Exerc. 2015 Aug;47(8):1587–95.
80. Sales LP, Pinto AJ, Rodrigues SF, Alvarenga JC, Gonçalves N, Sampaio-Barros MM, et al. Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial. J Gerontol A Biol Sci Med Sci. 2020 Apr 17;75(5):931–8.
81. Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults-a meta-analysis. Med Sci Sports Exerc. 2014 Jun;46(6):1194–203.
82. Rawson ES, Venezia AC. Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids. 2011 May;40(5):1349–62.
83. Dechent P, Pouwels PJW, Wilken B, Hanefeld F, Frahm J. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol-Regul Integr Comp Physiol. 1999 Sep;277(3):R698–704.
84. Ipsiroglu OS, Stromberger C, Ilas J, Höger H, Mühl A, Stöckler-Ipsiroglu S. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci. 2001 Aug 31;69(15):1805–15.
85. Greenhaff PL, Bodin K, Soderlund K, Hultman E. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol. 1994 May;266(5 Pt 1):E725-730.
86. Dolan E, Gualano ,Bruno, and Rawson ES. Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury. Eur J Sport Sci. 2019 Jan 2;19(1):1–14.
87. Watanabe A, Kato N, Kato T. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci Res. 2002 Apr 1;42(4):279–85.
88. Cook CJ, Crewther BT, Kilduff LP, Drawer S, Gaviglio CM. Skill execution and sleep deprivation: effects of acute caffeine or creatine supplementation - a randomized placebo-controlled trial. J Int Soc Sports Nutr. 2011 Feb 16;8(1):2.
89. McMorris T, Mielcarz ,Gregorsz, Harris ,Roger C., Swain, Jonathan P., and Howard A. Creatine Supplementation and Cognitive Performance in Elderly Individuals. Aging Neuropsychol Cogn. 2007 Sep 10;14(5):517–28.
90. Vagnozzi R, Signoretti S, Floris R, Marziali S, Manara M, Amorini AM, et al. Decrease in N-acetylaspartate following concussion may be coupled to decrease in creatine. J Head Trauma Rehabil. 2013;28(4):284–92.
91. Sullivan PG, Geiger JD, Mattson MP, Scheff SW. Dietary supplement creatine protects against traumatic brain injury. Ann Neurol. 2000;48(5):723–9.
92. Scheff SW, Dhillon HS. Creatine-enhanced diet alters levels of lactate and free fatty acids after experimental brain injury. Neurochem Res. 2004 Feb;29(2):469–79.
93. Sakellaris G, Nasis G, Kotsiou M, Tamiolaki M, Charissis G, Evangeliou A. Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study. Acta Paediatr Oslo Nor 1992. 2008 Jan;97(1):31–4.
94. Adhihetty PJ, Beal MF. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular Med. 2008;10(4):275–90.
95. Bender A, Klopstock T. Creatine for neuroprotection in neurodegenerative disease: end of story? Amino Acids. 2016 Aug;48(8):1929–40.
96. Balestrino M, Sarocchi M, Adriano E, Spallarossa P. Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease. Amino Acids. 2016 Aug;48(8):1955–67.
97. Sharov VG, Saks VA, Kupriyanov VV, Lakomkin VL, Kapelko VI, Steinschneider AYa null, et al. Protection of ischemic myocardium by exogenous phosphocreatine. I. Morphologic and phosphorus 31-nuclear magnetic resonance studies. J Thorac Cardiovasc Surg. 1987 Nov;94(5):749–61.
98. Sharov VG, Afonskaya NI, Ruda MY, Cherpachenko NM, Pozin EYa null, Markosyan RA, et al. Protection of ischemic myocardium by exogenous phosphocreatine (neoton): pharmacokinetics of phosphocreatine, reduction of infarct size, stabilization of sarcolemma of ischemic cardiomyocytes, and antithrombotic action. Biochem Med Metab Biol. 1986 Feb;35(1):101–14.
99. Deminice R, de Castro GSF, Francisco LV, da Silva LECM, Cardoso JFR, Frajacomo FTT, et al. Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism. J Nutr Biochem. 2015 Apr;26(4):391–7.
100. Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci Lond Engl 1979. 1996 Jul;91(1):113–8.
101. Roitman S, Green T, Osher Y, Karni N, Levine J. Creatine monohydrate in resistant depression: a preliminary study. Bipolar Disord. 2007 Nov;9(7):754–8.
102. Toniolo RA, Fernandes F de BF, Silva M, Dias R da S, Lafer B. Cognitive effects of creatine monohydrate adjunctive therapy in patients with bipolar depression: Results from a randomized, double-blind, placebo-controlled trial. J Affect Disord. 2017 Dec 15;224:69–75.
103. Gualano B, DE Salles Painneli V, Roschel H, Artioli GG, Neves M, De Sá Pinto AL, et al. Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Med Sci Sports Exerc. 2011 May;43(5):770–8.
104. Thorsteinsdottir B, Grande JP, Garovic VD. Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate. J Ren Nutr Off J Counc Ren Nutr Natl Kidney Found. 2006 Oct;16(4):341–5.
105. Yoshizumi WM, Tsourounis C. Effects of creatine supplementation on renal function. J Herb Pharmacother. 2004;4(1):1–7.
106. Pline KA, Smith CL. The effect of creatine intake on renal function. Ann Pharmacother. 2005 Jun;39(6):1093–6.
107. Poortmans JR, Auquier H, Renaut V, Durussel A, Saugy M, Brisson GR. Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol. 1997;76(6):566–7.
108. Sipilä I, Rapola J, Simell O, Vannas A. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N Engl J Med. 1981 Apr 9;304(15):867–70.
109. Bender A, Samtleben W, Elstner M, Klopstock T. Long-term creatine supplementation is safe in aged patients with Parkinson disease. Nutr Res N Y N. 2008 Mar;28(3):172–8.
110. Gualano B, de Salles Painelli V, Roschel H, Lugaresi R, Dorea E, Artioli GG, et al. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. Eur J Appl Physiol. 2011 May;111(5):749–56.
111. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc. 1999 Aug;31(8):1108–10.
112. Schilling BK, Stone MH, Utter A, Kearney JT, Johnson M, Coglianese R, et al. Creatine supplementation and health variables: a retrospective study. Med Sci Sports Exerc. 2001 Feb;33(2):183–8.
113. Rawson ES, Clarkson PM, Price TB, Miles MP. Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects. Acta Physiol Scand. 2002 Jan;174(1):57–65.
114. Geller AI, Shehab N, Weidle NJ, Lovegrove MC, Wolpert BJ, Timbo BB, et al. Emergency Department Visits for Adverse Events Related to Dietary Supplements. N Engl J Med. 2015 Oct 15;373(16):1531–40.
115. Buford TW, Kreider RB, Stout JR, Greenwood M, Campbell B, Spano M, et al. International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr. 2007 Aug 30;4:6.
116. Rodriguez NR, DiMarco NM, Langley S, American Dietetic Association, Dietitians of Canada, American College of Sports Medicine: Nutrition and Athletic Performance. Position of the American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and athletic performance. J Am Diet Assoc. 2009 Mar;109(3):509–27.
117. Greenwood M, Kreider RB, Melton C, Rasmussen C, Lancaster S, Cantler E, et al. Creatine supplementation during college football training does not increase the incidence of cramping or injury. Mol Cell Biochem. 2003 Feb;244(1–2):83–8.
118. Greenwood M, Kreider RB, Greenwood L, Byars A. Cramping and Injury Incidence in Collegiate Football Players Are Reduced by Creatine Supplementation. J Athl Train. 2003 Sep;38(3):216–9.
119. Watson G, Casa DJ, Fiala KA, Hile A, Roti MW, Healey JC, et al. Creatine use and exercise heat tolerance in dehydrated men. J Athl Train. 2006;41(1):18–29.
120. Dalbo VJ, Roberts MD, Stout JR, Kerksick CM. Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration. Br J Sports Med. 2008 Jul;42(7):567–73.
121. Wallimann T, Tokarska-Schlattner M, Schlattner U. The creatine kinase system and pleiotropic effects of creatine. Amino Acids. 2011 May;40(5):1271–96.
122. Hall M, Manetta E, Tupper K. Creatine Supplementation: An Update. Curr Sports Med Rep. 2021 Jul 1;20(7):338–44.
123. Maughan RJ. Quality Assurance Issues in the Use of Dietary Supplements, with Special Reference to Protein Supplements. J Nutr. 2013 Nov 1;143(11):1843S-1847S.
124. Maughan R. Contamination of dietary supplements and positive drug tests in sport. J Sports Sci. 2005 Sep 1;23(9):883–9.
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